Patents Assigned to University of Utrecht
  • Outer membrane vesicles and uses thereof
    Patent number: 8163295
    Abstract: The present invention discloses a Gram negative bacterium in which the expression of a protein involved in LPS transport to the outer membrane is functionally down-regulated such that the level of LPS in the outer membrane is decreased compared to a wild-type Gram negative bacterium. Down regulation of Imp and MsbA proteins can result in such a bacterium. Outer membrane vesicle preparations derived from the Gram negative bacterium of the invention can be used in vaccines to provide protection against bacterial infection.
    Type: Grant
    Filed: August 17, 2011
    Date of Patent: April 24, 2012
    Assignees: GlaxoSmithKline Biologicals S.A., University of Utrecht
    Inventors: Martine Petronella Bos, Jan Poolman, Boris Tefson, Johannes Petrus Maria Tommassen
  • Outer membrane vesicles and uses thereof
    Patent number: 8029807
    Abstract: The present invention discloses a Gram negative bacterium in which the expression of a protein involved in LPS transport to the outer membrane is functionally downregulated such that the level of LPS in the outer membrane is decreased compared to a wild-type Gram negative bacterium. Down regulation of Imp and MsbA proteins can result in such a bacterium. Outer membrane vesicle preparations derived from the Gram negative bacterium of the invention can be used in vaccines to provide protection against bacterial infection.
    Type: Grant
    Filed: November 3, 2009
    Date of Patent: October 4, 2011
    Assignees: GlaxoSmithKline Biologicals S.A., University of Utrecht
    Inventors: Martine Petronella Bos, Jan Poolman, Boris Tefson, Johannes Petrus Maria Tommassen
  • Outer membrane vesicles and uses thereof
    Patent number: 7628995
    Abstract: The present invention discloses a Gram negative bacterium in which the expression of a protein involved in LPS transport to the outer membrane is functionally downregulated such that the level of LPS in the outer membrane is decreased compared to a wild-type Gram negative bacterium. Down regulation of Imp and MsbA proteins can result in such a bacterium. Outer membrane vesicle preparations derived from the Gram negative bacterium of the invention can be used in vaccines to provide protection against bacterial infection.
    Type: Grant
    Filed: December 21, 2004
    Date of Patent: December 8, 2009
    Assignees: GlaxoSmithKline Biologicals S.A., University of Utrecht
    Inventors: Martine Petronella Bos, Jan Poolman, Boris Tefsen, Johannes Petrus Maria Tommassen
  • lactoferrin binding protein
    Patent number: 7105316
    Abstract: LbpB polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing LbpB polypeptides and polynucleotides in the design of protocols for the treatment of neisserial disease, among others, and diagnostic assays for such conditions.
    Type: Grant
    Filed: December 12, 2003
    Date of Patent: September 12, 2006
    Assignees: University of Utrecht, Technology Foundation
    Inventors: Annika Margareta Pettersson-Fernholm, Johannes Petrus Maria Tommassen
  • Neisseria lactoferrin binding protein
    Publication number: 20040131634
    Abstract: LbpB polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing LbpB polypeptides and polynucleotides in the design of protocols for the treatment of neisserial disease, among others, and diagnostic assays for such conditions.
    Type: Application
    Filed: December 12, 2003
    Publication date: July 8, 2004
    Applicant: University of Utrecht & Technology Foundation (Technologiestichting Stw)
    Inventors: Annika Margareta Pettersson-Fernholm, Johannes Petrus Maria Tommassen