Patents Assigned to University of Vermont and State Agricultural College
  • Publication number: 20200000869
    Abstract: Methods and products for producing an antigen specific immune response are provided. The methods involve administration of a caspase inhibitor to a subject.
    Type: Application
    Filed: September 17, 2019
    Publication date: January 2, 2020
    Applicant: The University of Vermont and State Agricultural College
    Inventors: Ralph C. Budd, Cheryl Collins
  • Patent number: 10512652
    Abstract: Organometallic compounds comprising a chloroquinoline moiety for use in the prophylaxis and treatment of malaria. The compounds can be manganese or rhenium complexes of a ligand comprising a chloroquinoline moiety.
    Type: Grant
    Filed: July 20, 2016
    Date of Patent: December 24, 2019
    Assignees: University of Vermont and State Agricultural College, Drexel University
    Inventors: William E. Geiger, Kevin Lam, Lawrence W. Bergman
  • Patent number: 10487146
    Abstract: Methods for diagnosing and treating conditions associated with life-threatening neurological complications are provided. The methods involve in some aspects the identification of oxLDL and LOX-1 as critical players in pregnant subjects and in some cases subjects having severe preeclampsia (early onset preeclampsia). Related products and kits are also provided.
    Type: Grant
    Filed: January 11, 2017
    Date of Patent: November 26, 2019
    Assignee: The University of Vermont and State Agricultural College
    Inventor: Marilyn J. Cipolla
  • Patent number: 10456441
    Abstract: Methods and products for producing an antigen specific immune response are provided. The methods involve administration of a caspase inhibitor to a subject.
    Type: Grant
    Filed: February 8, 2018
    Date of Patent: October 29, 2019
    Assignee: The University of Vermont and State Agricultural College
    Inventors: Ralph C. Budd, Cheryl Collins
  • Patent number: 10412906
    Abstract: Sap-collecting devices, systems and methods for sap-producing saplings are disclosed. The saplings each have at least one stem, which is cut to form a top end at a reasonable height above ground. The sap-collecting system includes a sap-collecting device that fits over the top end and forms a vacuum-tight seal with the stem. The sap-collecting device includes an interior and an access port open to the interior. The access port can be connected to a line system. A vacuum system is operably connected to the line system and forms a vacuum within the sap-collecting device. This serves to draw the sap from the top end of the sapling, through the sap-collecting device, through the line system and to a collecting tank. A plantation growth, management, and sap-collecting system that comprises the sap-collecting system and a stand of saplings is also disclosed.
    Type: Grant
    Filed: March 1, 2013
    Date of Patent: September 17, 2019
    Assignee: University of Vermont and State Agricultural College
    Inventors: Timothy D. Perkins, Abby K. van den Berg
  • Patent number: 10370395
    Abstract: Organometallic compounds comprising a chloroquinoline moiety and uses the compounds. The compounds are, for example, manganese or rhenium complexes of a ligand comprising a chloroquinoline moiety. The compounds can be used in, for example, methods of inhibiting cell growth.
    Type: Grant
    Filed: January 4, 2016
    Date of Patent: August 6, 2019
    Assignee: University of Vermont and State Agricultural College
    Inventors: William E. Geiger, Kevin Lam, Jon E. Ramsey, Claire F. Verschraegen
  • Patent number: 10363254
    Abstract: Methods for treating or prophylaxis of a Cryptosporidium infection using compositions comprising a structure disclosed herein. Also provided are pharmaceutical compositions and kits for alleviating the symptoms of, for treating, or for preventing the occurrence of Cryptosporidium infection. The kits comprise one or more compounds having a structure disclosed herein, such as in an oral composition, and instructions for use, storage, and the like.
    Type: Grant
    Filed: March 31, 2016
    Date of Patent: July 30, 2019
    Assignee: University of Vermont and State Agricultural College
    Inventors: Christopher D. Huston, Kovi Bessoff, Rajiv Satish Jumani
  • Publication number: 20190221948
    Abstract: In various embodiments, a three-dimensional (3D) printed tripolar antenna fabricated through additive manufacturing techniques to match the geometries of various commercial wireless node packages is provided. The antenna systems are designed to mitigate harsh channel conditions by implementing polarization diversity between three mutually orthogonal monopoles.
    Type: Application
    Filed: January 14, 2019
    Publication date: July 18, 2019
    Applicants: University of South Florida, The University of Vermont and State Agricultural College
    Inventors: Ramiro A. Ramirez, Marcia Golmohamadi, Thomas M. Weller, Jeffrey Frolik
  • Patent number: 10350262
    Abstract: The invention relates, in part, to compounds, compositions, and methods useful to treat cancer in cells and subjects. In some aspects the invention includes contacting a cancer cell with one or more exogenous methylation-controlled J protein (MCJ) agonist compounds to increase sensitivity of the cancer cell to one or more chemotherapeutic agents. In certain aspects the invention includes compounds and methods useful to kill cancer cells.
    Type: Grant
    Filed: February 18, 2016
    Date of Patent: July 16, 2019
    Assignee: University of Vermont and State Agricultural College
    Inventors: Mercedes Rincon, Thomas Roberts, Tina Thornton
  • Publication number: 20190196074
    Abstract: A laser light containment dome providing increased safety to microscopy users while allowing the microscopy instrument to be used in an effective and efficient manner is provided. The laser light containment dome includes a hemisphere or dome shaped enclosure that prevents dangerous intensities of laser light from exiting an objective lens and or microscopy sample holder while still allowing the user to witness and measure the direction of laser light in three dimensions.
    Type: Application
    Filed: February 28, 2019
    Publication date: June 27, 2019
    Applicant: The University of Vermont and State Agricultural College
    Inventor: Guy G. Kennedy
  • Publication number: 20190127441
    Abstract: The invention relates, in part, to compounds, compositions, and methods to reduce infectivity of virus particles and to treat viral infections in subjects.
    Type: Application
    Filed: April 13, 2017
    Publication date: May 2, 2019
    Applicant: University of Vermont and State Agricultural College
    Inventors: Jason Botten, Joseph Klaus, Anne Mason
  • Publication number: 20190121109
    Abstract: A multi-plane imaging system for imaging multiple reflection planes of a regular or irregular shaped three-dimensional (3D) specimen having top, side and bottom views simultaneously. The system includes an inverted watertight pyramid well having at least four reflective side surfaces for reflecting the specimen side views, wherein each of the at least four reflective sides surfaces define an angle, ?, relative to the base horizontal plane, and wherein each reflective side surface comprises a plurality of reflective zones; A specimen is positioned horizontally equidistant from the at least four reflective side surfaces and positioned vertically from the base horizontal plane a predetermined vertical distance; wherein the predetermined vertical distance, the at least four reflective side surfaces, and the angle ? comprise a reflection image plane for reflecting the specimen bottom views.
    Type: Application
    Filed: October 25, 2018
    Publication date: April 25, 2019
    Applicant: The University of Vermont and State Agricultural College
    Inventors: Nathan R. Tykocki, Grant Hennig
  • Publication number: 20190099470
    Abstract: The invention relates, in part, to compounds, compositions, and methods to assess characteristics of mitochondrial antiviral-signaling (MAVS) polypeptides and also to methods of modulating MAVS polypeptide characteristics. In addition, the invention relates, in part, to assays to assess characteristics of polypeptides.
    Type: Application
    Filed: April 21, 2017
    Publication date: April 4, 2019
    Applicant: University of Vermont and State Agricultural College
    Inventors: Iwona A. Buskiewicz, Andreas Koenig
  • Publication number: 20190078086
    Abstract: Methods and compounds useful to treat drug-induced diseases and conditions are provided. Methods of administering one or more MCJ-inhibiting compounds to decrease MCJ polypeptide activity in cells, tissues, and/or subjects as a treatment for a drug-induced disease or condition are provided.
    Type: Application
    Filed: July 9, 2016
    Publication date: March 14, 2019
    Applicants: University of Vermont and State Agricultural College, Asociacion Centro de Investigacion Cooperativa en Biociencias-CIC bioGUNE
    Inventors: Mercedes Rincon, Maria Luz Martinez Chantar, Juan Anguita, Oliver Dienz
  • Patent number: 10228378
    Abstract: The present disclosure provides methods for diagnosing and treating anxiety disorders in female subjects. Diagnosis and treatment of such anxiety disorders are based, in part, on an analysis of pituitary adenylate cyclase-activating polypeptide (PACAP) expression levels in tissue collected from female subjects.
    Type: Grant
    Filed: June 5, 2017
    Date of Patent: March 12, 2019
    Assignees: The University of Vermont and State Agricultural College, Emory University
    Inventors: Victor May, Kerry J. Ressler, Sayamwong E. Hammack, Donna Toufexis, Karen M. Braas
  • Publication number: 20190062722
    Abstract: The invention includes, in part, methods and compounds for treating diseases and conditions characterized by elevated threonyl-tRNA synthetase (TARS) activity, which include, but are not limited to diseases and conditions in which angiogenesis is elevated as compared to normal. In some embodiments of the invention, a level of a TARS molecule is determined and compared to a control level of TARS to assess a treatment for a disease or condition characterized by elevated TARS activity.
    Type: Application
    Filed: September 18, 2018
    Publication date: February 28, 2019
    Applicant: University of Vermont and State Agricultural College
    Inventors: Christopher Francklyn, Karen M. Lounsbury, Jason Botten
  • Patent number: 10175237
    Abstract: The invention includes, in part, methods and compounds for diagnosing diseases and conditions characterized by altered threonyl-tRNA synthetase (TARS) activity, which include, but are not limited to diseases and conditions in which angiogenesis is altered. In some embodiments of the invention, a level of a TARS molecule is determined and compared to a control level of TARS to assess onset, progression, and/or regression of a disease or condition associated with altered TARS activity.
    Type: Grant
    Filed: July 24, 2013
    Date of Patent: January 8, 2019
    Assignee: University of Vermont and State Agricultural College
    Inventors: Christopher Francklyn, Karen M. Lounsbury, Tamara Williams
  • Patent number: 10143718
    Abstract: The present invention generally relates to inhibitors of DUOX1. In some aspects, an inhibitor may be applied to a subject having or being at risk for asthma or other conditions. The inhibitor may be applied by various techniques, such as pulmonary or topical delivery. In some embodiments, the inhibitor may include a peptide or other moiety having a reactive electrophile. The reactive electrophile can target cysteine or other residues within DUOX1 to inhibit its activity, e.g., by covalently binding to the residue. Other non-limiting examples of suitable inhibitors include hydroxynonenal, curcumin, sulforaphane, cinnamaldehyde, dimethyl fumarate, or phenyl vinyl sulfonate. Other aspects of the invention are generally directed to methods of making or using such inhibitors, kits involving such inhibitors, devices or formulations containing such inhibitors, or the like.
    Type: Grant
    Filed: October 21, 2016
    Date of Patent: December 4, 2018
    Assignee: The University of Vermont and State Agricultural College
    Inventors: Albert van der Vliet, David Earl Heppner, Karamatullah Danyal
  • Patent number: 10125358
    Abstract: The invention includes, in part, methods and compounds for treating diseases and conditions characterized by reduced threonyl-tRNA synthetase (TARS) activity, which include, but are not limited to diseases and conditions in which angiogenesis is reduced as compared to normal. In some embodiments of the invention, a level of a TARS molecule is determined and compared to a control level of TARS to assess a treatment for a disease or condition characterized by reduced TARS activity.
    Type: Grant
    Filed: July 24, 2013
    Date of Patent: November 13, 2018
    Assignee: University of Vermont and State Agricultural College
    Inventors: Christopher Francklyn, Karen M. Lounsbury, Jason Botten
  • Patent number: 10087435
    Abstract: The invention includes, in part, methods and compounds for treating diseases and conditions characterized by elevated threonyl-tRNA synthetase (TARS) activity, which include, but are not limited to diseases and conditions in which angiogenesis is elevated as compared to normal. In some embodiments of the invention, a level of a TARS molecule is determined and compared to a control level of TARS to assess a treatment for a disease or condition characterized by elevated TARS activity.
    Type: Grant
    Filed: July 24, 2013
    Date of Patent: October 2, 2018
    Assignee: University of Vermont and State Agricultural College
    Inventors: Christopher Francklyn, Karen M. Lounsbury, Jason Botten