Patents Assigned to University of Vermont and State Agricultural College
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Patent number: 11976330Abstract: Methods and kits for detecting cancer-associated miRNA are disclosed herein. Methods of identifying and treating a human patient at risk for cancer are also disclosed herein.Type: GrantFiled: April 6, 2018Date of Patent: May 7, 2024Assignee: The University of Vermont and State Agricultural CollegeInventors: Marie E. Wood, Jane B. Lian, Nicholas Farina, Janet L. Stein
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Patent number: 11883395Abstract: Compositions and methods involving protein disulfide isomerase (PDI) inhibitors, such as protein disulfide isomerase A3 (PDIA3) inhibitory compounds, for human coronavirus, such as severe acute respiratory syndrome (SARS) virus (e.g., SARS-CoV-2), therapies are disclosed herein.Type: GrantFiled: May 13, 2021Date of Patent: January 30, 2024Assignee: The University of Vermont and State Agricultural CollegeInventors: Vikas Anathy, Nicolas Chamberlain, Amit Kumar
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Patent number: 11878276Abstract: A nanobiocatalytic membrane for a filtration system is provided which includes a filtration membrane and a plurality of nanobiocatalyst nanoparticles associated with the membrane, each of the nanobiocatalyst nanoparticles including a core, a coating at least partially surrounding the core, and a plurality of nanobiocatalysts coupled to the coating. Each of the plurality of nanobiocatalysts includes an antibacterial nanoparticle comprising bismuth, and a quorum quenching agent coupled to the antibacterial nanoparticle. A nanobiocatalyst nanoparticle for use with a water purification system is also provided. A method of forming a nanobiocatalytic membrane for a filtration system and a method of using a nanobiocatalytic membrane in a filtration system are also provided.Type: GrantFiled: February 2, 2022Date of Patent: January 23, 2024Assignee: University of Vermont and State Agricultural CollegeInventors: Appala Raju Badireddy, Huijie Lu
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Patent number: 11878997Abstract: This invention relates to methods of administering compounds containing selenium, selenocysteine, or a selenocysteine peptide to treat, for example, conditions associated with selenium deficiency, or ferroptoptic, parthanototic, and endoplasmic reticulum stress, and/or cancer. The methods of treatment may activate or inhibit (via TFAP2C and Sp1 proteins) the adaptive homeostatic response of the selenome. The compounds may contain a targeting sequence that causes them to be delivered to specific organs and/or tissues. The compounds may be administered, for example, orally, intranasally, intravenously, or by a minimally invasive catheter or BrainPath.Type: GrantFiled: June 30, 2021Date of Patent: January 23, 2024Assignees: Burke Neurological Institute, University of Vermont and State Agricultural CollegeInventors: Rajiv R. Ratan, Ishraq Alim, Saravanan Karuppagounder, Robert Hondal
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Patent number: 11752193Abstract: The invention relates, in part, to methods and compositions that are useful to modulate metabolic function of cells in vivo or in vitro. In some aspects the invention includes methods and/or compositions that increase metabolism in cells, tissues, organs, and/or subjects. In certain aspects the invention includes methods and/or compositions useful to decrease metabolism in cells, tissues, organs, and/or in subjects.Type: GrantFiled: October 2, 2020Date of Patent: September 12, 2023Assignee: University of Vermont and State Agricultural CollegeInventors: Mercedes Rincon, Ketki M. Hatle
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Patent number: 11719696Abstract: The invention includes, in part, methods and compounds for diagnosing diseases and conditions characterized by altered threonyl-tRNA synthetase (TARS) activity, which include, but are not limited to diseases and conditions in which angiogenesis is altered. In some embodiments of the invention, a level of a TARS molecule is determined and compared to a control level of TARS to assess onset, progression, and/or regression of a disease or condition associated with altered TARS activity.Type: GrantFiled: October 11, 2020Date of Patent: August 8, 2023Assignee: The University of Vermont and State Agricultural CollegeInventors: Christopher Francklyn, Karen M. Lounsbury, Tamara Williams
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Publication number: 20220252594Abstract: Provided herein are compositions and methods relating to ?? T cells. Specifically, methods of screening samples for human ?? T cells surface ligands using a soluble human ?? T cell receptor tetramer are provided. Such ligands may be useful in the treatment of diseases, for example, cancer.Type: ApplicationFiled: May 27, 2020Publication date: August 11, 2022Applicant: The University of Vermont and State Agricultural CollegeInventors: Ralph C. Budd, Cheryl Collins
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Publication number: 20220248939Abstract: Techniques for operating and monitoring an endoscopic balloon dilation system.Type: ApplicationFiled: May 15, 2020Publication date: August 11, 2022Applicant: The University of Vermont and State Agricultural CollegeInventors: Richard Zubarik, Silas Hill
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Publication number: 20220215536Abstract: Techniques for diagnosing a patient having an AAA. The techniques include using a computer hardware processor to perform: accessing computed tomography angiography (CTA) images of a portion of the patient, the portion of the patient including the AAA of the patient; providing the CTA images as input to a trained machine learning model, the trained machine learning model being configured to classify a property of the AAA based on the CTA images; and determining, based on the classified property of the AAA, a diagnosis of the patient, the diagnosis including information identifying at least one condition (e.g., an endoleak, an AAA rupture) of the patient.Type: ApplicationFiled: April 8, 2020Publication date: July 7, 2022Applicant: The University of Vermont and State Agricultural CollegeInventors: Daniel Bertges, Safwan Wshah, Christopher S. Morris, Sage Hahn
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Publication number: 20220203100Abstract: According to some aspects, a cardiac pacemaker for implantation within a subject is provided, the pacemaker including a housing, at least one sensor configured to detect an activity level of the subject, and at least one processor coupled to the sensor configured to detect inactivity of the subject based on output from the at least one sensor, produce a first signal configured to increase the heart rate of the subject to a first heart rate during a first time period, wherein the first heart rate is above a resting heart rate and below 100 beats per minute, and in response to determining that the first time period has elapsed, producing a second signal configured to increase the heart rate of the subject to a second heart rate during a second time period, wherein the second heart rate is between 100 and 140 beats per minute.Type: ApplicationFiled: February 4, 2022Publication date: June 30, 2022Applicant: The University of Vermont and State Agricultural CollegeInventor: Markus Meyer
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Publication number: 20220169746Abstract: Compositions and methods involving anti-neoantigen antibodies and/or effector cells armed with anti-neoantigen antibodies are disclosed herein. Such compositions may also include immune checkpoint inhibitors and may be used, for example, in the treatment of cancers.Type: ApplicationFiled: February 26, 2020Publication date: June 2, 2022Applicant: The University of Vermont and State Agricultural CollegeInventors: David N. Krag, Girja S. Shukla, Stephanie C. Fournier, Sunny Yujing Sun
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Patent number: 11340227Abstract: The invention includes, in part, methods and compounds for diagnosing diseases and conditions characterized by altered threonyl-tRNA synthetase (TARS) activity, which include, but are not limited to diseases and conditions in which angiogenesis is altered. In some embodiments of the invention, a level of a TARS molecule is determined and compared to a control level of TARS to assess onset, progression, and/or regression of a disease or condition associated with altered TARS activity.Type: GrantFiled: November 28, 2018Date of Patent: May 24, 2022Assignee: University of Vermont and State Agricultural CollegeInventors: Christopher Francklyn, Karen M. Lounsbury, Tamara Williams
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Patent number: 11331415Abstract: The present invention relates to the unexpected discovery of novel hydrogel formulations that allow for the encapsulation and delivery of living cells and/or drugs to a subject in need thereof. In certain embodiments, the hydrogel compositions of the invention comprise bound bioactive molecules that promote long-term cell viability and allows for the development of vasculature. The invention further provides methods of delivering viable cells and/or drugs to a subject comprising administering the compositions of the invention to the subject in need thereof.Type: GrantFiled: April 11, 2019Date of Patent: May 17, 2022Assignee: UNIVERSITY OF VERMONT AND STATE AGRICULTURAL COLLEGEInventors: Rachael A. Oldinski, Jennifer N. Etter
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Publication number: 20220125762Abstract: The invention relates to compounds that demonstrate efficacy in blocking PACAP receptors (e.g. PAC1) and associated methods of treating neurological diseases or disorders using the disclosed compounds. The neurological diseases or disorders include, but are not limited to, stress-related diseases (e.g. chronic stress, post-traumatic stress disorder (PTSD), anxiety, or general anxiety disorder), pain-related diseases (e.g. chronic pain, primary headache disorders, or migraines), or addiction (e.g. addiction to a substance (e.g. addiction to cocaine, amphetamines, methamphetamine, methylphenidate, nicotine, alcohol, prescription medication, marijuana, tobacco, or an opioid selected from heroin, fentanyl, codeine, hydrocodone, morphine, oxycodone, hydromorphone, and methadone)).Type: ApplicationFiled: February 13, 2020Publication date: April 28, 2022Applicant: The University of Vermont and State Agricultural CollegeInventors: Victor May, Matthias Brewer, Jianing Li
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Publication number: 20220072089Abstract: The invention relates, in part, to compounds, compositions, and methods comprising Thiostreopton (TS) that are useful to treat cancer in cells and subjects.Type: ApplicationFiled: December 19, 2019Publication date: March 10, 2022Applicant: University of Vermont and State Agricultural CollegeInventors: Brian CUNNIFF, Nicholas HEINTZ, Terri MESSIER
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Patent number: 11267867Abstract: The invention relates, in part, to compounds, compositions, and methods to reduce infectivity of virus particles and to treat viral infections in subjects.Type: GrantFiled: April 13, 2017Date of Patent: March 8, 2022Assignee: University of Vermont and State Agricultural CollegeInventors: Jason Botten, Joseph Klaus, Anne Mason
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Patent number: 11266955Abstract: A nanobiocatalytic membrane for a filtration system is provided which includes a filtration membrane and a plurality of nanobiocatalyst nanoparticles associated with the membrane, each of the nanobiocatalyst nanoparticles including a core, a coating at least partially surrounding the core, and a plurality of nanobiocatalysts coupled to the coating. Each of the plurality of nanobiocatalysts includes an antibacterial nanoparticle comprising bismuth, and a quorum quenching agent coupled to the antibacterial nanoparticle. A nanobiocatalyst nanoparticle for use with a water purification system is also provided. A method of forming a nanobiocatalytic membrane for a filtration system and a method of using a nanobiocatalytic membrane in a filtration system are also provided.Type: GrantFiled: January 30, 2018Date of Patent: March 8, 2022Assignee: University of Vermont and State Agricultural CollegeInventors: Appala Raju Badireddy, Huijie Lu
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Patent number: 11260090Abstract: Provided are modified arenaviruses and populations thereof, wherein the modified arenaviruses include i) an introduced PPXY domain; ii) an increased number of PPXY domains; iii) a substituted amino acid in place of S41 in a viral Z protein that is not a substrate for a serine or tyrosine kinase, or a combination of i)-iii). A PPXY domain can include a phosphomimetic replacement of the Y amino acid. Modified Old World and New World arenaviruses are included. Arenavirus production is provided using cell cultures that contain a kinase inhibitor that inhibits a kinase that can phosphorylate the Y amino acid of the PPXY domain, or by cells that have disrupted kinase gene expression, or by cells that have a disrupted ESCRT system. Also provided are pharmaceutical formulations that contain modified arenaviruses, and methods of using such formulations for stimulating an immune response hat is fully or partially protective against arenavirus infection.Type: GrantFiled: March 8, 2017Date of Patent: March 1, 2022Assignee: University of Vermont and State Agricultural CollegeInventors: Emily Adaline Bruce, Jason William Botten, Christopher Michael Ziegler
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Patent number: 11260233Abstract: According to some aspects, a cardiac pacemaker for implantation within a subject is provided, the pacemaker including a housing, at least one sensor configured to detect an activity level of the subject, and at least one processor coupled to the sensor configured to detect inactivity of the subject based on output from the at least one sensor, produce a first signal configured to increase the heart rate of the subject to a first heart rate during a first time period, wherein the first heart rate is above a resting heart rate and below 100 beats per minute, and in response to determining that the first time period has elapsed, producing a second signal configured to increase the heart rate of the subject to a second heart rate during a second time period, wherein the second heart rate is between 100 and 140 beats per minute.Type: GrantFiled: October 6, 2017Date of Patent: March 1, 2022Assignee: The University of Vermont and State Agricultural CollegeInventor: Markus Meyer
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Publication number: 20220056539Abstract: The invention relates, in part, to compounds, compositions, and methods to assess molecular characteristics papillary microcarcinoma (PMC) of the thyroid and indicators of indolent compared to aggressive PMC of the thyroid. In addition, the invention relates, in part, to methods of assessing characteristics of microRNAs associated with PMC of the thyroid.Type: ApplicationFiled: November 1, 2021Publication date: February 24, 2022Applicant: University of Vermont and State Agricultural CollegeInventors: Frances Carr, Nikoletta Sidiropoulos