Patents Assigned to University of Vermont and State Agriculture College
  • COMPOSITIONS AND METHODS FOR CARDIAC TISSUE REPAIR
    Publication number: 20230285507
    Abstract: The invention features compositions featuring (a) one or more of connective tissue growth factor (CTGF) and human C-terminal CTGF peptide; and (b) one or more of insulin and IGF-1; and methods of using such compositions to reduce cardiac tissue damage associated with an ischemic event or to enhance engraftment of a cell in a cardiac tissue.
    Type: Application
    Filed: January 25, 2023
    Publication date: September 14, 2023
    Applicant: The University of Vermont and State Agriculture College
    Inventor: Jeffrey SPEES
  • Compositions and methods for assaying platelet reactivity and treatment selection
    Patent number: 11747335
    Abstract: Compositions and methods are provided for determining platelet reactivity where the levels of Fc?RIIa on the surface of platelets is measured and if the levels of Fc?RIIa are greater than a reference value, the platelets have enhanced reactivity.
    Type: Grant
    Filed: October 30, 2019
    Date of Patent: September 5, 2023
    Assignee: University of Vermont And State Agriculture College
    Inventor: David Schneider
  • Methods for cardiac tissue repair with compositions comprising CTGF
    Patent number: 11576949
    Abstract: The invention features compositions featuring (a) one or more of connective tissue growth factor (CTGF) and human C-terminal CTGF peptide; and (b) one or more of insulin and IGF-1; and methods of using such compositions to reduce cardiac tissue damage associated with an ischemic event or to enhance engraftment of a cell in a cardiac tissue.
    Type: Grant
    Filed: April 24, 2020
    Date of Patent: February 14, 2023
    Assignee: The University of Vermont and State Agriculture College
    Inventor: Jeffrey Spees
  • COMPOUNDS AND METHODS FOR THE TREATMENT OF CRYPTOSPORIDIOSIS
    Publication number: 20230009323
    Abstract: Cryptosporidium is a leading contributor to early childhood mortality, and fully effective treatment for this important infectious disease is lacking. A bicyclic azetidine compound series is disclosed having potent in vitro activity against all C. parvum isolates tested, comparable potencies against C. hominis and C. parvum, and cured cryptosporidiosis in highly susceptible immunosuppressed mice with once-daily dosing.
    Type: Application
    Filed: October 23, 2020
    Publication date: January 12, 2023
    Applicants: The Broad Institute, Inc., President and Fellows of Harvard College, The University of Vermont and State Agriculture College
    Inventors: Eamon COMER, Bruno MELILLO, Christopher D. HUSTON
  • Compositions and methods for vascular protection against reperfusion injury after myocardial ischemia
    Patent number: 11111282
    Abstract: As described herein, the present invention features compositions comprising an HGF/IgG complex and methods of using such compositions to reduce ischemic reperfusion injury.
    Type: Grant
    Filed: February 7, 2019
    Date of Patent: September 7, 2021
    Assignee: THE UNIVERSITY OF VERMONT AND STATE AGRICULTURE COLLEGE
    Inventor: Jeffrey Spees
  • COMPOSITIONS AND METHODS FOR TREATING VASCULAR DISEASE IN SELECTED PATIENTS
    Publication number: 20210231682
    Abstract: As described below, the present invention features methods for treating selected subjects at increased risk of a cardiovascular event, wherein the subjects are selected as having elevated platelet Fc?gamma RIIa.
    Type: Application
    Filed: April 16, 2019
    Publication date: July 29, 2021
    Applicant: The University of Vermont and State Agriculture College
    Inventor: David Schneider
  • COMPOSITIONS AND METHODS FOR CARDIAC TISSUE REPAIR
    Publication number: 20200338163
    Abstract: The invention features compositions featuring (a) one or more of connective tissue growth factor (CTGF) and human C-terminal CTGF peptide; and (b) one or more of insulin and IGF-1; and methods of using such compositions to reduce cardiac tissue damage associated with an ischemic event or to enhance engraftment of a cell in a cardiac tissue.
    Type: Application
    Filed: April 24, 2020
    Publication date: October 29, 2020
    Applicant: University of Vermont and State Agriculture College
    Inventor: Jeffrey Spees
  • Composition comprising connective tissue growth factor (CTGF) for cardiac tissue repair
    Patent number: 10675329
    Abstract: The invention features compositions featuring (a) one or more of connective tissue growth factor (CTGF) and human C-terminal CTGF peptide; and (b) one or more of insulin and IGF-1; and methods of using such compositions to reduce cardiac tissue damage associated with an ischemic event or to enhance engraftment of a cell in a cardiac tissue.
    Type: Grant
    Filed: June 14, 2017
    Date of Patent: June 9, 2020
    Assignee: University of Vermont and State Agriculture College
    Inventor: Jeffrey Spees
  • COMPOSITIONS AND METHODS FOR ASSAYING PLATELET REACTIVITY AND TREATMENT SELECTION
    Publication number: 20200166508
    Abstract: Compositions and methods are provided for determining platelet reactivity where the levels of Fc?RIIa on the surface of platelets is measured and if the levels of Fc?RIIa are greater than a reference value, the platelets have enhanced reactivity.
    Type: Application
    Filed: October 30, 2019
    Publication date: May 28, 2020
    Applicant: University of Vermont And State Agriculture College
    Inventor: David Schneider
  • Compositions and methods for cardiac tissue repair
    Patent number: 10632153
    Abstract: The invention features compositions comprising agents having cardiac protective activity isolated from epicardial progenitor cells and derivatives thereof, and methods for the use of such compositions.
    Type: Grant
    Filed: January 29, 2018
    Date of Patent: April 28, 2020
    Assignee: THE UNIVERSITY OF VERMONT AND STATE AGRICULTURE COLLEGE
    Inventor: Jeffrey Spees
  • Anti-thrombotic compositions and methods for assaying platelet reactivity and treatment selection
    Patent number: 10502737
    Abstract: Compositions and methods are provided for determining platelet reactivity where the levels of Fc?RIIa on the surface of platelets is measured and if the levels of Fc?RIIa are greater than a reference value, the platelets have enhanced reactivity.
    Type: Grant
    Filed: May 23, 2013
    Date of Patent: December 10, 2019
    Assignee: The University of Vermont And State Agriculture College
    Inventor: David Schneider
  • Compositions and Methods for Vascular Protection Against Reperfusion Injury After Myocardial Ischemia
    Publication number: 20190225661
    Abstract: As described herein, the present invention features compositions comprising an HGF/IgG complex and methods of using such compositions to reduce ischemic reperfusion injury.
    Type: Application
    Filed: February 7, 2019
    Publication date: July 25, 2019
    Applicant: The University of Vermont and State Agriculture College
    Inventor: JEFFREY SPEES
  • Compositions and methods for vascular protection against reperfusion injury after myocardial ischemia
    Patent number: 10239926
    Abstract: As described herein, the present invention features compositions comprising an HGF/IgG complex and methods of using such compositions to reduce ischemic reperfusion injury.
    Type: Grant
    Filed: February 23, 2016
    Date of Patent: March 26, 2019
    Assignee: The University of Vermont and State Agriculture College
    Inventor: Jeffrey Spees
  • Methods for dynamic visualization of clinical parameters over time
    Patent number: 10188302
    Abstract: Featured is a method for assessing risk of a patient condition. Such a method includes providing criteria that relate predetermined parameters to each other, inputting observations into given criterion and relating observations of one or more acquired parameters, and converging the given criterion so as to provide an output representative of a patient condition. Such a method further includes translating the output into a visual form such as displaying the output on a display device.
    Type: Grant
    Filed: December 26, 2012
    Date of Patent: January 29, 2019
    Assignee: The University of Vermont and State Agriculture College
    Inventors: Kathleen B. Ziedins, Christopher M. Danforth, Thomas Orfeo, Stephen J. Everse, Kenneth G. Mann
  • Compositions and Methods for Vascular Protection Against Reperfusion Injury After Myocardial Ischemia
    Publication number: 20180237483
    Abstract: As described herein, the present invention features compositions comprising an HGF/IgG complex and methods of using such compositions to reduce ischemic reperfusion injury.
    Type: Application
    Filed: February 23, 2016
    Publication date: August 23, 2018
    Applicant: The University of Vermont and State Agriculture College
    Inventor: JEFFREY SPEES
  • COMPOSITIONS AND METHODS FOR CARDIAC TISSUE REPAIR
    Publication number: 20180228847
    Abstract: The invention features compositions comprising agents having cardiac protective activity isolated from epicardial progenitor cells and derivatives thereof, and methods for the use of such compositions.
    Type: Application
    Filed: January 29, 2018
    Publication date: August 16, 2018
    Applicant: THE UNIVERSITY OF VERMONT AND STATE AGRICULTURE COLLEGE
    Inventor: JEFFREY SPEES
  • COMPOSITIONS AND METHODS FOR CARDIAC TISSUE REPAIR
    Publication number: 20180140671
    Abstract: The invention features compositions featuring (a) one or more of connective tissue growth factor (CTGF) and human C-terminal CTGF peptide; and (b) one or more of insulin and IGF-1; and methods of using such compositions to reduce cardiac tissue damage associated with an ischemic event or to enhance engraftment of a cell in a cardiac tissue.
    Type: Application
    Filed: June 14, 2017
    Publication date: May 24, 2018
    Applicant: University of Vermont and State Agriculture College
    Inventor: Jeffrey Spees
  • Compositions and methods for cardiac tissue repair
    Patent number: 9913864
    Abstract: The invention features compositions comprising agents having cardiac protective activity isolated from epicardial progenitor cells and derivatives thereof, and methods for the use of such compositions.
    Type: Grant
    Filed: August 14, 2015
    Date of Patent: March 13, 2018
    Assignee: THE UNIVERSITY OF VERMONT AND STATE AGRICULTURE COLLEGE
    Inventor: Jeffrey Spees
  • Methods for enhancing cardiac function with the combination of CTGF and insulin or IGF-1
    Patent number: 9707271
    Abstract: The invention features compositions featuring (a) one or more of connective tissue growth factor (CTGF) and human C-terminal CTGF peptide; and (b) one or more of insulin and IGF-1; and methods of using such compositions to reduce cardiac tissue damage associated with an ischemic event or to enhance engraftment of a cell in a cardiac tissue.
    Type: Grant
    Filed: March 7, 2014
    Date of Patent: July 18, 2017
    Assignee: University of Vermont and State Agriculture College
    Inventor: Jeffrey Spees
  • Oxidized LDL as a biomarker for neurological complications of pregnancy
    Patent number: 9568487
    Abstract: Methods for diagnosing and treating conditions associated with life-threatening neurological complications are provided. The methods involve in some aspects the identification of oxLDL and LOX-1 as critical players in pregnant subjects and in some cases subjects having severe preeclampsia (early onset preeclampsia). Related products and kits are also provided.
    Type: Grant
    Filed: October 3, 2013
    Date of Patent: February 14, 2017
    Assignee: The University of Vermont and State Agriculture College
    Inventor: Marilyn J. Cipolla