Abstract: Methods and compositions are provided for determining polypeptide-nucleic acid interactions.

Abstract: A maple syrup production spout assembly (10) with a backflow check valve (79) is disclosed. The spout assembly is designed for use with vacuum-based maple syrup productions systems (200) and is used to prevent the backflow of sap (270) into the maple tree (100) and thus prevent the drying out of the taphole (110) due to microbial contamination. Certain existing maple production spout assemblies can be retrofitted to form the backflow check valve spout assembly disclosed herein. Methods of using the spout assembly in maple syrup production are also disclosed.

Abstract: The invention relates to methods and compositions for regulation of GSK3? activity. The invention provides phosphorylated GSK3? polypeptides and antibodies that recognize such polypeptides. The invention further includes methods for treating disorders that are associated with elevated or reduced GSK3? activity.

Abstract: Certain embodiments relate to systems and methods providing wires, circuits, or circuit elements comprised of one or more chromophores. The chromophores can be “tuned” to the critical edge between quantum order and quantum chaos providing long coherence times combined with quantum delocalization resulting in coherent transport of excitons. Such tuned chromophore systems provide coherent transport at room temperature.

Abstract: Systems for and methods of assessing urinary flow rate via sound analysis. Embodiments of the uroflow measurement systems include a computer and a telephone or a digital recording mechanism to capture the sound of one or more urination events, which are stored as audio files in a database. The uroflow measurement systems may include sound analysis software for analyzing the strength and duration of each urination event and may include a web-based uroflow software application for viewing the results via the Internet or other network. In one embodiment, the sound analysis software performs the steps of reading in the raw data of a selected audio file, generating a plot of the audio signal amplitude vs.

Abstract: The invention relates to methods of treating cancer by administering one or more chemokines that are downregulated in cancerous cells. More specifically, the invention provides methods for treating or preventing cancers such as malignant melanoma by administering a chemokine such as CCL18 and/or CCL3. The invention further provides methods for diagnosing cancer such as melanoma.

Abstract: The invention relates to methods and compositions for regulation of GSK3? activity. The invention provides phosphorylated GSK3? polypeptides and antibodies that recognize such polypeptides. The invention further includes methods for treating disorders that are associated with elevated or reduced GSK3? activity.

Abstract: Disclosed are antibodies that selectively bind to blood coagulation factor FVIII, and highly sensitive immunological assays comprising these antibodies. Preferred assays can detect FVIII at about 3500-fold below the normal physiological levels, and have a wide array of applications including accurate monitoring of FVIII concentration in pharmaceutical products for treatment of blood coagulation disorders, and determination of FVIII levels in plasma of human patients, including those with blood coagulation disorders such as hemophilia.

Abstract: A detection circuit for detecting changes in capacitance. The detection circuit includes a tuned ratio circuit and an alternating current (AC) source AC-coupled to the tuned ratio circuit. The tuned ratio circuit includes first and second tuned circuits that are tuned to, or close, to the frequency of the AC source. Output circuitry is coupled between the two tuned circuits. During use as a transducer, an active capacitive transducer is inductively coupled to the first tuned circuit. Changes in the capacitance of the active capacitive transducer cause changes in the tuning of the first tuned circuit. The output circuitry generates an output signal that is a function of the difference between the tunings of the first and second tuned circuits.

Abstract: A dual-line spout for maple syrup production is disclosed. The spout has a nose section with an input channel, and an interior chamber having first and second flow paths each fluidly connected to the input channel and to respective first and second output channels. The spout is designed for use with vacuum-based maple syrup productions systems that use a dual-line line system. The dry-line portion of the line system fluidly connects to the first output channel and the wet-line portion of the line system fluidly connected to the second output channel. Example spouts have no chambers, a single chamber or two sub-chambers, to facilitate air-liquid separation. Methods of using the spout in a vacuum-based, dual-line maple syrup production system are also disclosed.

Abstract: Systems and methods of digitally recording and reproducing tactile drawings are disclosed. The method includes moving a stylus over a path on the first tactile drawing medium to form a tactile feature thereon, and digitally recording the path of the moving stylus to generate digital path data. The method also include reproducing the tactile feature on a second tactile drawing medium operably disposed in a tactile printer based on the digital path data. The systems and methods include forming tactile drawings based on a digital graphics file, including filtering the digital graphics file to form a .RLD file suitable for forming a tactile drawing having features capable of being tactilely sensed.

Abstract: A thermal eraser for erasing tactile drawing features from a tactile drawing medium, along with methods of erasing tactile drawing features formed on a tactile drawing medium, are disclosed. The thermal eraser has a heated tip that can be heated to a temperature sufficient to cause the tactile drawing feature to flow back into the surface of the tactile drawing medium. The heated tip has a tip temperature that can be controlled by a temperature-regulating circuit. A set-point temperature can be used to set the tip temperature and maintain the tip temperature. The thermal eraser can be controlled by hand or by an electro-mechanical device such as a tactile printer.

Abstract: Algorithms and concepts for maintaining uniform random samples of streaming data and stream joins. These algorithms and concepts are used in systems and methods, such as wireless sensor networks and methods for implementing such networks, that generate and handle such streaming data and/or stream joins. The algorithms and concepts directed to streaming data allow one or more sample reservoirs to change size during sampling. When multiple reservoirs are maintained, some of the algorithms and concepts periodically reallocate memory among the multiple reservoirs to effectively utilize limited memory. The algorithms and concepts directed to stream joins allow reservoir sampling to proceed as a function of the probability of a join sampling operation. In memory limited situations wherein memory contains the sample reservoir and a join buffer, some of the stream join algorithms and concepts progressively increase the size of the sampling reservoir and reallocate memory from the join buffer to the reservoir.

Abstract: This application includes, in part, methods of preparing antibodies that specifically bind to methylation-controlling J (MCJ) polypeptide. In some aspects, the application also includes, hybridoma cell lines that produce antibodies that specifically MCJ polypeptide; antibodies and antigen-binding fragments thereof produced with the methods of the application, and methods of using antibodies and antigen-binding fragments that specifically bind MCJ polypeptide for diagnosis and treatment of cancer.

Abstract: The invention involves methods of regulating cell growth and division to control disease processes by manipulating mitochondrial metabolism and the expression of cell surface immune proteins. The invention also involves related compositions and screening assays.

Abstract: The invention relates to methods and products for treatment of a neurological defect such as a subarachnoid hemorrhage or cerebral vasospasm. Specifically, R-type voltage-gated calcium channel inhibitors and related compositions and kits are described.

Abstract: Selective, radically initiated oxidative decarboxylation may produce low viscosity renewable fuels from biologically derived fats and oils. Fatty acids and triglycerides may be decarboxylated using oxidants at a water/oil interface. The oxidants may be produced using photo-Fenton reagents. The reaction advantageously can be carried out at room temperature and pressure and has fewer unwanted byproducts than traditional decarboxylation techniques.

Abstract: Control devices and kits of components of control devices are provided. The subject invention also provides systems for designing control devices and/or kits of components of control devices. A system user can provide data about an end user to an expert system via a user interface, and the expert system can use the data and a method for selecting appropriate components to design a control device and/or kit. The control device can be a self-referenced control device and can include a controller and a wearable interface.

Abstract: Disclosed are antibodies that selectively bind to blood coagulation factor FVIII, and highly sensitive immunological assays comprising these antibodies. Preferred assays can detect FVIII at about 3500-fold below the normal physiological levels, and have a wide array of applications including accurate monitoring of FVIII concentration in pharmaceutical products for treatment of blood coagulation disorders, and determination of FVIII levels in plasma of human patients, including those with blood coagulation disorders such as hemophilia.