Patents Assigned to University of Vermont
  • METHODS AND COMPOSITIONS TO TREAT DRUG-INDUCED DISEASES AND CONDITIONS
    Publication number: 20190078086
    Abstract: Methods and compounds useful to treat drug-induced diseases and conditions are provided. Methods of administering one or more MCJ-inhibiting compounds to decrease MCJ polypeptide activity in cells, tissues, and/or subjects as a treatment for a drug-induced disease or condition are provided.
    Type: Application
    Filed: July 9, 2016
    Publication date: March 14, 2019
    Applicants: University of Vermont and State Agricultural College, Asociacion Centro de Investigacion Cooperativa en Biociencias-CIC bioGUNE
    Inventors: Mercedes Rincon, Maria Luz Martinez Chantar, Juan Anguita, Oliver Dienz
  • Diagnostic and therapeutic methods and products related to anxiety disorders
    Patent number: 10228378
    Abstract: The present disclosure provides methods for diagnosing and treating anxiety disorders in female subjects. Diagnosis and treatment of such anxiety disorders are based, in part, on an analysis of pituitary adenylate cyclase-activating polypeptide (PACAP) expression levels in tissue collected from female subjects.
    Type: Grant
    Filed: June 5, 2017
    Date of Patent: March 12, 2019
    Assignees: The University of Vermont and State Agricultural College, Emory University
    Inventors: Victor May, Kerry J. Ressler, Sayamwong E. Hammack, Donna Toufexis, Karen M. Braas
  • METHODS AND COMPOUNDS FOR REDUCING THREONYL-tRNA SYNTHETASE ACTIVITY
    Publication number: 20190062722
    Abstract: The invention includes, in part, methods and compounds for treating diseases and conditions characterized by elevated threonyl-tRNA synthetase (TARS) activity, which include, but are not limited to diseases and conditions in which angiogenesis is elevated as compared to normal. In some embodiments of the invention, a level of a TARS molecule is determined and compared to a control level of TARS to assess a treatment for a disease or condition characterized by elevated TARS activity.
    Type: Application
    Filed: September 18, 2018
    Publication date: February 28, 2019
    Applicant: University of Vermont and State Agricultural College
    Inventors: Christopher Francklyn, Karen M. Lounsbury, Jason Botten
  • Methods for dynamic visualization of clinical parameters over time
    Patent number: 10188302
    Abstract: Featured is a method for assessing risk of a patient condition. Such a method includes providing criteria that relate predetermined parameters to each other, inputting observations into given criterion and relating observations of one or more acquired parameters, and converging the given criterion so as to provide an output representative of a patient condition. Such a method further includes translating the output into a visual form such as displaying the output on a display device.
    Type: Grant
    Filed: December 26, 2012
    Date of Patent: January 29, 2019
    Assignee: The University of Vermont and State Agriculture College
    Inventors: Kathleen B. Ziedins, Christopher M. Danforth, Thomas Orfeo, Stephen J. Everse, Kenneth G. Mann
  • Methods and compounds for diagnosing threonyl-tRNA synthetase-associated diseases and conditions
    Patent number: 10175237
    Abstract: The invention includes, in part, methods and compounds for diagnosing diseases and conditions characterized by altered threonyl-tRNA synthetase (TARS) activity, which include, but are not limited to diseases and conditions in which angiogenesis is altered. In some embodiments of the invention, a level of a TARS molecule is determined and compared to a control level of TARS to assess onset, progression, and/or regression of a disease or condition associated with altered TARS activity.
    Type: Grant
    Filed: July 24, 2013
    Date of Patent: January 8, 2019
    Assignee: University of Vermont and State Agricultural College
    Inventors: Christopher Francklyn, Karen M. Lounsbury, Tamara Williams
  • Covalent inhibitors of dual oxidase 1 (DUOX 1)
    Patent number: 10143718
    Abstract: The present invention generally relates to inhibitors of DUOX1. In some aspects, an inhibitor may be applied to a subject having or being at risk for asthma or other conditions. The inhibitor may be applied by various techniques, such as pulmonary or topical delivery. In some embodiments, the inhibitor may include a peptide or other moiety having a reactive electrophile. The reactive electrophile can target cysteine or other residues within DUOX1 to inhibit its activity, e.g., by covalently binding to the residue. Other non-limiting examples of suitable inhibitors include hydroxynonenal, curcumin, sulforaphane, cinnamaldehyde, dimethyl fumarate, or phenyl vinyl sulfonate. Other aspects of the invention are generally directed to methods of making or using such inhibitors, kits involving such inhibitors, devices or formulations containing such inhibitors, or the like.
    Type: Grant
    Filed: October 21, 2016
    Date of Patent: December 4, 2018
    Assignee: The University of Vermont and State Agricultural College
    Inventors: Albert van der Vliet, David Earl Heppner, Karamatullah Danyal
  • Methods and compounds for increasing threonyl-tRNA synthetase activity
    Patent number: 10125358
    Abstract: The invention includes, in part, methods and compounds for treating diseases and conditions characterized by reduced threonyl-tRNA synthetase (TARS) activity, which include, but are not limited to diseases and conditions in which angiogenesis is reduced as compared to normal. In some embodiments of the invention, a level of a TARS molecule is determined and compared to a control level of TARS to assess a treatment for a disease or condition characterized by reduced TARS activity.
    Type: Grant
    Filed: July 24, 2013
    Date of Patent: November 13, 2018
    Assignee: University of Vermont and State Agricultural College
    Inventors: Christopher Francklyn, Karen M. Lounsbury, Jason Botten
  • Methods and compounds for reducing threonyl-tRNA synthetase activity
    Patent number: 10087435
    Abstract: The invention includes, in part, methods and compounds for treating diseases and conditions characterized by elevated threonyl-tRNA synthetase (TARS) activity, which include, but are not limited to diseases and conditions in which angiogenesis is elevated as compared to normal. In some embodiments of the invention, a level of a TARS molecule is determined and compared to a control level of TARS to assess a treatment for a disease or condition characterized by elevated TARS activity.
    Type: Grant
    Filed: July 24, 2013
    Date of Patent: October 2, 2018
    Assignee: University of Vermont and State Agricultural College
    Inventors: Christopher Francklyn, Karen M. Lounsbury, Jason Botten
  • Compositions and Methods for Vascular Protection Against Reperfusion Injury After Myocardial Ischemia
    Publication number: 20180237483
    Abstract: As described herein, the present invention features compositions comprising an HGF/IgG complex and methods of using such compositions to reduce ischemic reperfusion injury.
    Type: Application
    Filed: February 23, 2016
    Publication date: August 23, 2018
    Applicant: The University of Vermont and State Agriculture College
    Inventor: JEFFREY SPEES
  • Methods and products relating to GSK3? regulation
    Patent number: 10052365
    Abstract: The invention relates to methods and compositions for regulation of GSK3? activity. The invention provides phosphorylated GSK3? polypeptides and antibodies that recognize such polypeptides. The invention further includes methods for treating disorders that are associated with elevated or reduced GSK3? activity.
    Type: Grant
    Filed: December 5, 2014
    Date of Patent: August 21, 2018
    Assignee: University of Vermont and State Agricultural College
    Inventors: Mercedes Rincon, Tina M. Thornton
  • COMPOSITIONS AND METHODS FOR CARDIAC TISSUE REPAIR
    Publication number: 20180228847
    Abstract: The invention features compositions comprising agents having cardiac protective activity isolated from epicardial progenitor cells and derivatives thereof, and methods for the use of such compositions.
    Type: Application
    Filed: January 29, 2018
    Publication date: August 16, 2018
    Applicant: THE UNIVERSITY OF VERMONT AND STATE AGRICULTURE COLLEGE
    Inventor: JEFFREY SPEES
  • TREATMENTS OF OXIDATIVE STRESS CONDITIONS
    Publication number: 20180221436
    Abstract: The present invention generally relates to systems and methods for treating certain oxidative stress conditions. In one aspect, compositions and methods of the invention can be used to treat a subject having an oxidative stress condition, for example, a subject having pulmonary fibrosis. In some embodiments, an inhibitor of ERp57 (for example, thiomuscimol) and/or an inhibitor of GSTP (for example, TLK-199) may be used to treat the subject. Also provided in certain aspects of the present invention are kits for such therapies, methods for promoting such therapies, and the like.
    Type: Application
    Filed: January 18, 2018
    Publication date: August 9, 2018
    Applicant: The University of Vermont and State Agricultural College
    Inventors: Yvonne M. Janssen-Heininger, Vikas Anathy
  • DETECTION OF GLUTATHIONYLATED PROTEINS
    Publication number: 20180224452
    Abstract: The present invention, in some aspects, relates to systems and methods for determining oxidized proteins, including glutathionylated proteins such as S-glutathionylated proteins. The systems and methods of the invention can be used in vitro (e.g., in cell or tissue culture) or in vivo, for example, to diagnose a person having an oxidative stress condition. For instance, in some cases, the invention can be used to spatially determine the location and/or concentration of oxidized proteins within cells and/or tissues (e.g., through visual detection). In one set of embodiments, a glutathionylated or otherwise oxidized moiety on a protein may be reacted with a detection entity, which may be, for example, fluorescent, radioactive, electron-dense, able to bind to a signaling entity or a binding partner in order to produce a signal, etc.
    Type: Application
    Filed: February 1, 2018
    Publication date: August 9, 2018
    Applicants: The University of Vermont and State Agricultural College, Universiteit Maastricht
    Inventors: Yvonne M. Janssen-Heininger, Niki Reynaert
  • AUGMENTING THE IMMUNE RESPONSE BY PROMOTING CELL DEATH OF IMMUNE CELLS
    Publication number: 20180169178
    Abstract: Methods and products for producing an antigen specific immune response are provided. The methods involve administration of a caspase inhibitor to a subject.
    Type: Application
    Filed: February 8, 2018
    Publication date: June 21, 2018
    Applicant: The University of Vermont and State Agricultural College
    Inventor: Ralph C. Budd
  • COMPOSITIONS AND METHODS FOR CARDIAC TISSUE REPAIR
    Publication number: 20180140671
    Abstract: The invention features compositions featuring (a) one or more of connective tissue growth factor (CTGF) and human C-terminal CTGF peptide; and (b) one or more of insulin and IGF-1; and methods of using such compositions to reduce cardiac tissue damage associated with an ischemic event or to enhance engraftment of a cell in a cardiac tissue.
    Type: Application
    Filed: June 14, 2017
    Publication date: May 24, 2018
    Applicant: University of Vermont and State Agriculture College
    Inventor: Jeffrey Spees
  • METHODS AND COMPOSITONS FOR METABOLIC REGULATION
    Publication number: 20180125930
    Abstract: The invention relates, in part, to methods and compositions that are useful to modulate metabolic function of cells in vivo or in vitro. In some aspects the invention includes methods and/or compositions that increase metabolism in cells, tissues, organs, and/or subjects. In certain aspects the invention includes methods and/or compositions useful to decrease metabolism in cells, tissues, organs, and/or in subjects.
    Type: Application
    Filed: November 7, 2017
    Publication date: May 10, 2018
    Applicant: University of Vermont and State Agricultural College
    Inventors: Mercedes Rincon, Ketki M. Hatle
  • MOLECULAR PATHOGENESIS OF MICROCARCINOMA OF THE THYROID
    Publication number: 20180105887
    Abstract: The invention relates, in part, to compounds, compositions, and methods to assess molecular characteristics papillary microcarcinoma (PMC) of the thyroid and indicators of indolent compared to aggressive PMC of the thyroid. In addition, the invention relates, in part, to methods of assessing characteristics of microRNAs associated with PMC of the thyroid.
    Type: Application
    Filed: October 19, 2017
    Publication date: April 19, 2018
    Applicant: University of Vermont and State Agricultural College
    Inventors: Frances Carr, Nikoletta Sidiropoulos
  • Diagnostic and therapeutic methods and products related to anxiety disorders
    Patent number: 9939449
    Abstract: The present disclosure provides methods for diagnosing and treating anxiety disorders in female subjects. Diagnosis and treatment of such anxiety disorders are based, in part, on an analysis of pituitary adenylate cyclase-activating polypeptide (PACAP) expression levels in tissue collected from female subjects.
    Type: Grant
    Filed: February 1, 2012
    Date of Patent: April 10, 2018
    Assignee: The University of Vermont and State Agricultural College
    Inventors: Victor May, Kerry J. Ressler, Sayamwong E. Hammack, Donna Toufexis, Karen M. Braas
  • Augmenting the immune response by promoting cell death of immune cells
    Patent number: 9925230
    Abstract: Methods and products for producing an antigen specific immune response are provided. The methods involve administration of a caspase inhibitor to a subject.
    Type: Grant
    Filed: July 22, 2015
    Date of Patent: March 27, 2018
    Assignee: The University of Vermont and State Agricultural College
    Inventor: Ralph C. Budd
  • Compositions and methods for cardiac tissue repair
    Patent number: 9913864
    Abstract: The invention features compositions comprising agents having cardiac protective activity isolated from epicardial progenitor cells and derivatives thereof, and methods for the use of such compositions.
    Type: Grant
    Filed: August 14, 2015
    Date of Patent: March 13, 2018
    Assignee: THE UNIVERSITY OF VERMONT AND STATE AGRICULTURE COLLEGE
    Inventor: Jeffrey Spees