Patents Assigned to University of Vienna
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Patent number: 10266850Abstract: The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target DNA and/or a polypeptide associated with the target DNA. The present disclosure further provides site-specific modifying polypeptides. The present disclosure further provides methods of site-specific modification of a target DNA and/or a polypeptide associated with the target DNA The present disclosure provides methods of modulating transcription of a target nucleic acid in a target cell, generally involving contacting the target nucleic acid with an enzymatically inactive Cas9 polypeptide and a DNA-targeting RNA. Kits and compositions for carrying out the methods are also provided. The present disclosure provides genetically modified cells that produce Cas9; and Cas9 transgenic non-human multicellular organisms.Type: GrantFiled: March 15, 2013Date of Patent: April 23, 2019Assignees: The Regents of the University of California, University of Vienna, Emmanuelle CharpentierInventors: Jennifer A. Doudna, Martin Jinek, Emmanuelle Charpentier, Krzysztof Chylinski
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Patent number: 10227611Abstract: The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target DNA and/or a polypeptide associated with the target DNA. The present disclosure further provides site-specific modifying polypeptides. The present disclosure further provides methods of site-specific modification of a target DNA and/or a polypeptide associated with the target DNA The present disclosure provides methods of modulating transcription of a target nucleic acid in a target cell, generally involving contacting the target nucleic acid with an enzymatically inactive Cas9 polypeptide and a DNA-targeting RNA. Kits and compositions for carrying out the methods are also provided. The present disclosure provides genetically modified cells that produce Cas9; and Cas9 transgenic non-human multicellular organisms.Type: GrantFiled: November 16, 2015Date of Patent: March 12, 2019Assignees: The Regents of the University of California, University of ViennaInventors: Jennifer A. Doudna, Martin Jinek, Krzysztof Chylinski, Emmanuelle Charpentier
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Patent number: 10113167Abstract: The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target DNA and/or a polypeptide associated with the target DNA. The present disclosure further provides site-specific modifying polypeptides. The present disclosure further provides methods of site-specific modification of a target DNA and/or a polypeptide associated with the target DNA The present disclosure provides methods of modulating transcription of a target nucleic acid in a target cell, generally involving contacting the target nucleic acid with an enzymatically inactive Cas9 polypeptide and a DNA-targeting RNA. Kits and compositions for carrying out the methods are also provided. The present disclosure provides genetically modified cells that produce Cas9; and Cas9 transgenic non-human multicellular organisms.Type: GrantFiled: April 26, 2016Date of Patent: October 30, 2018Assignees: The Regents of the University of California, University of ViennaInventors: Jennifer A. Doudna, Martin Jinek, Krzysztof Chylinski, Emmanuelle Charpentier
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Patent number: 10077445Abstract: The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target DNA and/or a polypeptide associated with the target DNA. The present disclosure further provides site-specific modifying polypeptides. The present disclosure further provides methods of site-specific modification of a target DNA and/or a polypeptide associated with the target DNA The present disclosure provides methods of modulating transcription of a target nucleic acid in a target cell, generally involving contacting the target nucleic acid with an enzymatically inactive Cas9 polypeptide and a DNA-targeting RNA. Kits and compositions for carrying out the methods are also provided. The present disclosure provides genetically modified cells that produce Cas9; and Cas9 transgenic non-human multicellular organisms.Type: GrantFiled: April 26, 2016Date of Patent: September 18, 2018Assignees: The Regents of the University of California, University of ViennaInventors: Jennifer A. Doudna, Martin Jinek, Krzysztof Chylinski, Emmanuelle Charpentier
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Publication number: 20180228955Abstract: Apparatus for determining opening of an aortic valve of a biological subject, the apparatus including an electronic processing device that determines a pump speed of a ventricular assist device that is assisting cardiac function of the biological subject, analyses the pump speed to determine a pump speed indicator at least partially indicative of changes in pump speed and uses the pump speed indicator to determine an opening indicator indicative of opening of the aortic valve.Type: ApplicationFiled: September 22, 2015Publication date: August 16, 2018Applicant: Medical University of ViennaInventors: Marcus Granegger, Francesco Moscato, Heinrich Schima, Christopher Simon Hayward
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Patent number: 10000772Abstract: The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target DNA and/or a polypeptide associated with the target DNA. The present disclosure further provides site-specific modifying polypeptides. The present disclosure further provides methods of site-specific modification of a target DNA and/or a polypeptide associated with the target DNA The present disclosure provides methods of modulating transcription of a target nucleic acid in a target cell, generally involving contacting the target nucleic acid with an enzymatically inactive Cas9 polypeptide and a DNA-targeting RNA. Kits and compositions for carrying out the methods are also provided. The present disclosure provides genetically modified cells that produce Cas9; and Cas9 transgenic non-human multicellular organisms.Type: GrantFiled: April 13, 2015Date of Patent: June 19, 2018Assignees: The Regents of the University of California, University of ViennaInventors: Jennifer A. Doudna, Martin Jinek, Emmanuelle Charpentier, Krzysztof Chylinski
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Patent number: 9968686Abstract: The invention relates to an antisense or siRNA oligonucleotide or conjugate with improved pharmacokinetic properties, methods of producing the same as well as the use of such compounds and conjugates, e.g. as pharmaceutical composition, a pharmaceutical kit, a medicament or a tool in biomedical research. The conjugates of the invention have the formula I being P-(L-S—S—Y—X)n, wherein P represents a natural, artificial and/or modified oligonucleotide, L represents a linker group attached to one or more nucleosides at any position within the oligonucleotides sequence; S represents sulfur; X represents a ligand; Y represents a spacer and n is an integer ranging from 1 to the oligonucleotide length of P.Type: GrantFiled: September 9, 2014Date of Patent: May 15, 2018Assignee: UNIVERSITY OF VIENNAInventors: Christian R. Noe, Mehrdad Dirin, Johannes Winkler, Bodo Lachmann, Ernst Urban
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Patent number: 9952422Abstract: Methods and systems are provided for enhancing the imaging resolution of three dimensional imaging using light field microscopy. A first approach enhances the imaging resolution by modeling the scattering of light that occurs in an imaging target, and using the model to account for the effects of light scattering when de-convolving the light field information to retrieve the 3-dimensional (3D) volumetric information of the imaging target. A second approach enhances the imaging resolution by using a second imaging modality such as two-photon, multi-photon, or confocal excitation microscopy to determine the locations of individual neurons, and using the known neuron locations to enhance the extraction of time series signals from the light field microscopy data.Type: GrantFiled: January 14, 2016Date of Patent: April 24, 2018Assignee: UNIVERSITY OF VIENNAInventors: Alipasha Vaziri, Tobias Nöbauer
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Patent number: 9924889Abstract: A method for transcranial magnetic stimulation (TMS) of a stimulation area of medical interest, combined with functional magnetic resonance imaging (fMRI) for visualization of the response of, for example neurons, is disclosed. An ultra-thin magnetic resonance coil, MR coil, positioned in the immediate vicinity over an area where the response of, for example neurons, is to be detected, and preferably sandwiched between the TMS coil and the area, provides an excellent signal-to-noise ratio. The TMS can be performed directly through the MR coil. A great deal of flexibility in the number of the TMS and MR coils in use and their spatial arrangement is provided. A corresponding system for the TMS/fMRI studies is also provided.Type: GrantFiled: October 3, 2013Date of Patent: March 27, 2018Assignee: MEDICAL UNIVERSITY OF VIENNAInventors: Lucia Isabel Navarro de Lara, Christian Windischberger, Elmar Laistler, Jürgen Sieg, Ewald Moser, André Kühne
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Patent number: 9557262Abstract: A method comprises: generating a first and a second correlated photon beam with wavelengths ?1 and ?2, respectively, wherein preferably ?1??2; separating the first photon beam and the second photon beam; illuminating an object with the first photon beam; generating a third and a fourth correlated photon beam with wavelength ?1 and wavelength ?2, respectively; overlapping the first photon beam with the third photon beam such that photons of wavelength ?1 in either photon beam are indistinguishable; overlapping the second photon beam with the fourth photon beam such that photons of wavelength ?2 in either photon beam are indistinguishable; and using the overlapped photons of wavelength ?2 for imaging and/or spectroscopy of the object such that the photons that illuminate the object are not detected.Type: GrantFiled: December 15, 2014Date of Patent: January 31, 2017Assignees: University of Vienna, The Austrian Academy of SciencesInventors: Anton Zeilinger, Sven Ramelow, Radek Lapkiewicz, Victoria Borish, Gabriela Barreto Lemos
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Publication number: 20160069794Abstract: Devices and methods for recording dynamics of cellular and/or biochemical processes, including a device including one or more dispersive elements configured to receive a pulsed laser beam with a spectrum of different wavelengths and disperse the spectrum of the pulsed laser beam; and one or more first elements configured to receive the dispersed spectrum of the pulsed laser beam, and generate a multiphoton excitation area in a biological sample by re-overlapping in time and space the dispersed spectrum of the pulsed laser beam on an area in the biological sample, wherein the device is configured to record at high speed changes of cellular and biochemical processes of a population of cells of the biological sample based on generation of the multiphoton excitation area in the biological sample.Type: ApplicationFiled: September 7, 2015Publication date: March 10, 2016Applicant: UNIVERSITY OF VIENNAInventors: Alipasha Vaziri, Robert Prevedel
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Publication number: 20150099963Abstract: A method for transcranial magnetic stimulation (TMS) of a stimulation area of medical interest, combined with functional magnetic resonance imaging (fMRI) for visualization of the response of, for example neurons, is disclosed. An ultra-thin magnetic resonance coil, MR coil, positioned in the immediate vicinity over an area where the response of, for example neurons, is to be detected, and preferably sandwiched between the TMS coil and the area, provides an excellent signal-to-noise ratio. The TMS can be performed directly through the MR coil. A great deal of flexibility in the number of the TMS and MR coils in use and their spatial arrangement is provided. A corresponding system for the TMS/fMRI studies is also provided.Type: ApplicationFiled: October 3, 2013Publication date: April 9, 2015Applicant: Medical University of ViennaInventors: Lucia Isabel Navarro de Lara, Christian Windischberger, Elmar Laistler, Jürgen Sieg, Ewald Moser, André Kühne
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Patent number: 8824602Abstract: A method of equalizing an OFDM signal received over a transmission channel defined by a channel matrix includes: windowing the received signal in the time domain with at least two different tapers to obtain at least two tapered received signals; stacking the tapered received signals in the form of a joint matrix equation [ y 1 ? y ? ? y ? ] = [ D 1 ? D ? ? D ? ] ? y = [ D 1 ? D ? ? D ? ] ? ( Hx + ? ) with y being the received signal, ? being the number of tapers, D? being the ?th taper in form of a diagonal matrix, y? being the ?th tapered received signal, H being the channel matrix, x being the time domain transmitted signal, ? being optional noise; and solving said joint matrix equation for x as a least squares problem.Type: GrantFiled: January 10, 2013Date of Patent: September 2, 2014Assignee: University of ViennaInventors: Saptarshi Das, Tomasz Hrycak
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Publication number: 20140068797Abstract: The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target DNA and/or a polypeptide associated with the target DNA. The present disclosure further provides site-specific modifying polypeptides. The present disclosure further provides methods of site-specific modification of a target DNA and/or a polypeptide associated with the target DNA The present disclosure provides methods of modulating transcription of a target nucleic acid in a target cell, generally involving contacting the target nucleic acid with an enzymatically inactive Cas9 polypeptide and a DNA-targeting RNA. Kits and compositions for carrying out the methods are also provided. The present disclosure provides genetically modified cells that produce Cas9; and Cas9 transgenic non-human multicellular organisms.Type: ApplicationFiled: March 15, 2013Publication date: March 6, 2014Applicants: UNIVERSITY OF VIENNA, THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Jennifer A. Doudna, Martin Jinek, Emmanuelle Charpentier, Krzysztof Chylinski, James Harrison Doudna Cate, Wendell Lim, Lei Qi
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Publication number: 20130182754Abstract: A method of equalizing an OFDM signal received over a transmission channel defined by a channel matrix comprises: windowing the received signal in the time domain with at least two different tapers to obtain at least two tapered received signals; stacking the tapered received signals in the form of a joint matrix equation [ y 1 ? y ? ? y ? ] = [ D 1 ? D ? ? D ? ] ? y = [ D 1 ? D ? ? D ? ] ? ( Hx + ? ) with y being the received signal, ? being the number of tapers, D? being the ?th taper in form of a diagonal matrix, y? being the ?th tapered received signal, H being the channel matrix, x being the time domain transmitted signal, ? being optional noise; and solving said joint matrix equation for x as a least squares problem.Type: ApplicationFiled: January 10, 2013Publication date: July 18, 2013Applicant: UNIVERSITY OF VIENNAInventor: UNIVERSITY OF VIENNA
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Publication number: 20130177939Abstract: The present invention relates to the field of analyzing the age and/or quality of certain natural products, for example foods. The invention also relates to devices for analyzing said age and/or quality as well as to methods for preparing such devices, to methods for analyzing natural products and to their use.Type: ApplicationFiled: January 16, 2013Publication date: July 11, 2013Applicant: UNIVERSITY OF VIENNAInventor: University of Vienna
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Patent number: 8294967Abstract: A system and method for the controlled generation, manipulation, and conversion of individual photons in and for a quantum computing environment or a quantum communication environment are provided. Systems and methods for doubling a single photon in a first propagation mode into two new photons in one or two new propagation modes, combining two photons in one or two propagation modes into a single photon of a single propagation mode, and implementing a pi phase shift on a two-photon state but not on the one-photon state in a fully controlled, consistent, and repeatable fashion are also provided, as well as a source of individual photons having clearly defined and fully controllable properties. Embodiments of the above allow for generation and conversion operations that are up to 100% efficient. The generation, conversion, combination, and phase shifting operations are preferably carried out inside a non-linear ?3 material of a predetermined length.Type: GrantFiled: September 28, 2009Date of Patent: October 23, 2012Assignee: University of ViennaInventors: Nathan K. Langford, Sven Ramelow
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Publication number: 20100068749Abstract: The present invention relates to the field of analyzing the age and/or quality of certain natural products, for example foods. The invention also relates to devices for analyzing said age and/or quality as well as to methods for preparing such devices, to methods for analyzing natural products and to their use.Type: ApplicationFiled: June 13, 2007Publication date: March 18, 2010Applicant: UNIVERSITY OF VIENNAInventors: Maria Bauer, Fritz Pittner