Abstract: An anti-C3d antibody or antibody fragment; method for use thereof to kill cancer cells; and related methods and compositions.

Abstract: The present disclosure relates to systems and methods for automatically optimizing a reporting architecture of an application. In one implementation, a system for automatically optimizing a reporting architecture of an application may include a memory storing instructions and an automata processor configured to execute the instructions. The instructions may include identifying one or more state transition elements in the application; determining if two or more state transition elements have disjoint character sets; grouping two or more state transition elements having disjoint character sets into one or more groups; merging state transition elements included in the one or more groups; and outputting a merged report configured for disambiguation on a second processor.

Abstract: A method, system, and computer program product for producing an organism specific diagnosis of septicemia in infants is disclosed. The method involves measuring the levels of one or more biomarkers against predefined threshold values and interpreting these levels to arrive at the diagnosis. Other techniques may introduce a preliminary step of identifying higher risk subjects, as well as the integration of such methods into the final diagnostic methodology. One aspect of a technique of this method may involve measuring one more cytokines to detect specific classes of infective organisms, such as Gram-negative bacteria.

Abstract: An apparatus comprises a system on a chip (SoC). In some embodiments, the SoC includes a power supply circuit, a power management circuit operatively coupled to the power supply circuit, a first wireless communications circuit and a second wireless communications circuit. The first wireless communications circuit is configured to receive an RF signal and is operatively coupled to the power supply circuit and the power management circuit. The first wireless communications circuit has a net radio frequency (RF) power gain no more than unity before at least one of downconversion of the RF signal or detection of the RF signal. The second wireless communications circuit is operatively coupled to the power supply circuit and the power management circuit.

Abstract: According to some illustrative embodiments of the invention, a method is performed that includes using a representation of a computer software program, using identified addresses which correspond to a part of the representation, and converting the representation into a created binary program, which includes reserving spaces at the identified addresses in the created binary program's address space at the same addresses as the identified addresses in the representation.

Abstract: Macrophages within the tumor microenvironment, also called tumor associated macrophages (TAMs) have been shown to play a major role in the growth and spread of many types of cancer. Cancer cells produce cytokines that cause the macrophages to differentiate into an M2 subtype. We have designed a mannosylated liposome (MAN-LIPs) and successfully showed it to accumulate in TAMs in a mouse model of pulmonary adenocarcinoma. These liposomes are loaded with 64Cu to allow tracking by PET imaging, and contain a fluorescent dye in the lipid bilayer permitting subsequent fluorescence microscopy. MAN-LIPs are a promising new vehicle for the delivery of imaging agents to lung TAMs. In addition to imaging, they hold the potential for delivery of therapeutic agents to the tumor microenvironment.

Abstract: The invention provides for the use of antimicrobial chemical entities based on a nitrothiazolide backbone that exhibit anti-mycobacteria activity, including the mycobacterium causing tuberculosis. Multiple compounds were synthesized and screened for anti-tuberculosis activity. Disclosed herein are a series of compounds with anti-tuberculosis activity, including six leads that completely inhibited bacterial growth at 5 micrograms per ml or less. Three of these compounds were tested to determine MIC and these ranged between 1 and 4 micrograms per ml against both drug susceptible Mycobacterium tuberculosis strains and strains that are multi-drug resistant (MDR) including XDR strains. The compounds developed are derived from parent compound nitazoxanide, which had no inhibitory activity in the stringent testing format used herein.

Abstract: The present invention provides for enhancing engraftment by co-infusing at least two partially HLA matched umbilical cord blood (“UCB”) units. The invention further provides for positive C3a mediated priming on responsiveness to doses of SDF-1 and C3a induced incorporation of CXCR4 in membranes in HSC and progenitors. The invention further provides for enhancing the homing of UCB HSC and progenitors via the SDF-1/CXCR4 pathway and that C3a and LL-37 are useful for this method. It is also disclosed herein that fragments of C3a (e.g., des-Arg) are effective in the methods of the invention, including enhancing homing of HSPCs to BM. The invention further encompasses the disclosure herein of NFAT1 regulation post-transcriptionally by both mir-184 and IFN-?. The present invention further provides for measuring and using differences between UCB and adult CD4+/45RA+ T-cells as a means of defining strategies to enhance optimal allogeneic stem cell transplantation outcomes.

Abstract: An insertion tongue of the retractor device may be pushed into the subject through the trocar incision, along one side of the organ. The tip of the insertion tongue pushes the impacted organ and its endoscopic recovery bag slightly away from the cavity wall. A scalpel is passed through the insertion guide with the tip of the scalpel blade in the retention guide on the back of the insertion tongue, and with the sharp side of the scalpel blade facing away from the organ and from the tongue of the retractor device. The scalpel is then passed down through the cavity wall, with its tip in the retention guide, while tension on the retractor device handle away from the organ, and gentle outward traction on the organ (and bag) permits removal of the organ (and bag) as soon as the opening is just large enough to allow it.

Abstract: A system for digital network map development and maintenance. The system provides for optimizing digital network maps that serve as the reference basis for location-based systems such as, but not limited to, route guidance, multi-modal transportation system monitoring, location-based consumer applications, and vehicle fleet administration. The system provides the ability to develop and maintain digital route maps derived at least in part from data on the routes that drivers or users actually travel to update a digital map. For a route defined between two or more points, costs may be assigned to each road segment. As such, given a collection of route preferences, an algorithm is provided that is capable of generating an optimized route planning digital map by finding and assigning a set of costs to road segments in a way that is consistent with these preferences.

Abstract: The present invention relates to compositions and methods by which surface modification techniques can be used to modify wide range polymeric or metal substrates using metal nanoparticles.

Abstract: The present application discloses compositions and methods useful for targeting and treating injured or diseased muscle, including cardiac and skeletal muscle. Disclosed herein are adenoviral vectors modified to contain enhancers, promoters, and genes to target muscle with high efficiency and to induce tissue specific gene expression of transgenes.

Abstract: A system or device for providing medical suction, particularly for intubating patients, wherein the system or device helps prevent clogging from solids dispersed in the liquid to be suctioned. This device will allow the user to effectively clear an airway or other region of the patient while minimizing the occurrence of clogs and providing for the effective and expedited unclogging of the device without the necessity of removing the device from the patient or requiring two hands to unclog.

Abstract: The monolithic application of a high speed TWPDA with impedance matching. Use of the high speed monolithic TWPDA will allow for more efficient transfer of optical signals within analog circuits and over distances.

Abstract: The present invention proposes an electronic memory device comprising a memory line including a memory domain. The memory line may contain a number of memory domains and a number of fixed domains, wherein each memory domain stores a single binary bit value. A multiferroic element may be disposed proximate to each memory domain allowing the magnetization of the memory domain to be changed using a spin torque current, and ensuring the stability of the magnetization of the domain when it is not being written. The domain boundary between the memory domain and one of its adjacent fixed domains may thereby be moved. An antiferromagnetic element may be disposed proximate to each fixed domain to ensure the stability of the magnetization of these. The value of each memory domain may be read by applying a voltage to a magnetic tunnel junction comprising the memory domain and measuring the current flowing through it.

Abstract: The surface of a material is textured and by exposing the surface to pulses from an ultrafast laser. The laser treatment causes pillars to form on the treated surface. These pillars provide for greater light absorption. Texturing and crystallization can be carried out as a single step process. The crystallization of the material provides for higher electric conductivity and changes in optical and electronic properties of the material. The method may be performed in vacuum or a gaseous environment. The gaseous environment may aid in texturing and/or modifying physical and chemical properties of the surfaces. This method may be used on various material surfaces, such as semiconductors, metals and their alloys, ceramics, polymers, glasses, composites, as well as crystalline, nanocrystalline, polycrystalline, microcrystalline, and amorphous phases.