Abstract: Systems and methods for promoting neuroplasticity in a brain of a subject to improve and/or restore neural function are disclosed herein. One such method includes detecting residual movement and/or muscular activity in a limb of the subject, such as a paretic limb. The method further includes generating a stimulation pattern based on the detected movement and/or muscular activity, and stimulating the brain of the subject with the stimulation pattern. It is expected that delivering stimulation based on the detected residual movement and/or muscular activity of the limb will induce neuroplasticity for restoring neural function, such as control of the limb. A second method involves detecting brain signals and delivering contingent stimulation. A third method involves delivering pairs of successive stimulus patterns to two brain sites, controlled either by preprogrammed sequences or contingent on neural or muscular activity or movement.

Abstract: A system (10) is disclosed for use in detecting and analyzing cell and tissue microstructure as part of the diagnosis of a variety of pathological conditions, including cataracts, as well as aging, disease and certain traumatic events. The system includes a data input system (12), which may produce data regarding the microstructure to be evaluated either invasively or noninvasively. An electron microscope (20) may be employed to collect data regarding the microstructure of any tissue to be evaluated for the existence of a pathological condition. The system (12) also includes a computer (14) programmed to analyze the output of the data collection system by using signal processing techniques that are applicable to the data output characterizing the nonrandom microstructure. These techniques include fractal analysis, oscillatory analysis, and a modified Fourier/fractal analysis. The outcome of the signal processing is then compared to empirical data to effect a diagnosis.