Abstract: Compositions and methods for the treatment of toxoplasmosis, caused by the infectious eukaryotic parasite Toxoplasma gondii (T. gondii) and for the treatment of cryptosporidiosis, caused by the infectious eukaryotic parasites Cryptosporidium parvum (C. parvum) and Cryptosporidium hominus (C. hominus) are described. In particular, the present disclosure is directed to compositions and methods for inhibiting either T. gondii calcium dependent protein kinases (TgCDPKs) or C. parvum and C. hominus calcium dependent protein kinases (CpCDPKs) using pyrazolopyrimidine and/or imidazo[1,5-a]pyrazine inhibitors, of the formula, wherein the variables X, Y, Z, L, R1, and R3 are defined herein.

Abstract: An integrated circuit, such as included as a portion of a sensor node, can include a regulator circuit having an input coupleable to an energy harvesting transducer. The integrated circuit can include a wireless receiver circuit coupled to the regulator circuit and configured to wirelessly receive at least enough operating energy to establish operation of the sensor node without requiring the energy harvesting transducer. The integrated circuit can include a digital processor circuit coupled to the regulator circuit and a power management processor circuit. The digital processor circuit or one or more other circuits can include a subthreshold operational mode established by the power management processor circuit based on the selected energy consumption level. For example, establishing the subthreshold operational mode can include adjusting or selecting a supply voltage so as to establish subthreshold operation of a field effect transistor (FET) in the digital processor circuit or other circuits.

Abstract: The present disclosure provides methods of treating brain injuries or conditions, or symptoms of brain injuries or conditions, including intranasal administration of a therapeutically effective amount of a taxane. The intranasally administered taxane can bypass the blood-brain barrier (BBB) via the olfactory epithelium and thereby provide therapeutic effect to a subject.

Abstract: The present invention relates to improved ion mobility analysis (IMA) methods that can accurately quantify particle concentration in a sample solution. Specifically, reference particles of known solution-phase concentration are used for calibration. In addition, by exploiting spectral deconvolution techniques, the concentrations of subpopulations within the particles can also be accurately quantified. The improved IMA methods permit, for the first time, the quantification of absolute concentrations of HDL particles and subpopulations thereof in a biological sample. The correlations of HDL particle concentrations and conditions such as LCAT deficiency and cardiovascular diseases have been established. Accordingly, the present invention also provide methods to determine whether a subject is at risk to develop or is suffering from these conditions by using HDL particle concentration as a clinical metric.

Abstract: A pile and method for driving a pile includes a pile having a structural outer tube, and an inner member disposed generally concentrically with the outer tube. The outer tube and inner member are fixed to a driving shoe. The pile is constructed and driven such that the pile driver impacts only the inner member. The impact loads are transmitted to the driving shoe to drive the pile into the sediment, such that the outer tube is thereby pulled into the sediment. In a particular embodiment the outer tube is formed of steel, and the inner member also comprises a steel tube. In an alternative embodiment one or both of the inner member and the outer tube are formed of an alternative material, for example, concrete. In an embodiment, the outer tube has a recess that captures a flange on the inner member. In an embodiment the outer tube is attached to the inner member with an elastic spring.

Abstract: Systems and methods for manipulating light with high index contrast waveguides clad with substances having that exhibit large nonlinear electro-optic constants such as ?3. Waveguides fabricated on SOI wafers and clad with electro-optic polymers are described. Embodiments of waveguides having slots and input waveguide couplers are discussed. Waveguides having closed loop structures (such as rings and ovals) as well as linear or serpentine waveguides, are described. All-optical signal processing systems and methods for implementing devices such as variable delay lines, optical logic gates (for example an AND gate), optical multiplexers, optical self-oscillators, and optical clock generators are disclosed.