Abstract: Systems, methods, and devices are provided for estimating bilirubin levels. In one aspect, a method for estimating the level of bilirubin in a patient includes receiving image data for at least one image including a region of the patient's skin and a color calibration target. Color-balanced image data for the skin region is generated based on a subset of the image data corresponding to the color calibration target and the skin region. The bilirubin level in the patient is estimated based on the color-balanced image data for the skin region.

Abstract: Functionalized zwitterionic and mixed charge polymers and copolymers, methods for making the polymers and copolymers, hydrogels prepared from the functionalized zwitterionic and mixed charge polymers and copolymers, methods for making and using the hydrogels, and zwitterionic and mixed charge polymers and copolymers for administration for therapeutic agents.

Abstract: The present disclosure relates to a composition that includes a particle and a surface species, where the particle has a characteristic length between greater than zero nm and 100 nm inclusively, and the surface species is associated with a surface of the particle such that the particle maintains a crystalline form when the composition is at a temperature between ?180° C. and 150° C.

Abstract: The present disclosure is directed to methods of making a polymer, including exposing a reaction mixture including a strained cyclic unsaturated monomer and an organic initiator to a stimulus to provide an activated organic initiator, whereby the activated organic initiator is effective to polymerize the strained cyclic unsaturated monomer via a 4-membered carbocyclic intermediate to provide a polymer having constitutional units derived from the strained cyclic unsaturated monomer.

Abstract: Apparatus and method for improved cavitation-induced drug delivery is disclosed. In one embodiment, a method for delivering a treatment composition to a target tissue using ultrasound includes: directing ultrasound waveforms toward the target tissue of a patient; generating ultrasound shock fronts at the target tissue of a patient; generating a cavitation inside the target tissue of a patient by the ultrasound shock front; and delivering the treatment composition to the patient. Absorption of the treatment composition by the target tissue is increased by the cavitation inside the target tissue. In some embodiments, the treatment composition may be delivered within a time period of +/?1 week from generating the cavitation.

Abstract: Apparatuses, systems, ambient RF backscatter transceivers, and methods for communicating using MIMO and spread spectrum coding of backscattered ambient RF signals are described. An example system may include an ambient RF backscatter transceiver that include an antenna configured to receive a backscattered ambient radio frequency (RF) signal, and a receiver coupled to the antenna. The receiver may be configured to demodulate the backscattered ambient RF signal using one of multiple input, multiple output multiplexing demodulation or spread spectrum code demodulation to retrieve the first data. The backscattered ambient RF signal may be generated by backscattering an ambient RF signal at a first frequency. The ambient RF signal may be configured to provide other data at a second frequency.

Abstract: The invention provides compositions and methods for treating celiac sprue.

Abstract: The present disclosure provides method and systems for improving nanopore-based analysis of polymers. The disclosure provides methods for selectively modifying one or more monomeric subunit(s) of a kind in a re-analyte polymer that results in a polymer analyte with a modified subunit. The polymer analyte produces a detectable signal in a nanopore-based system. The detectable signal, and/or its deviation from a reference signal, indicates the location of the modified subunit in the polymer analyte and, thus, permits the identification of the subunit at that location in the original pre-analyte polymer.

Abstract: Methods, computing devices, and a computer-readable medium are described herein related to fragmenting or comminuting an object in a subject using a burst wave lithotripsy (BWL) waveform. A computing device, such a computing device coupled to a transducer, may carry out functions for producing a BWL waveform. The computing device may determine a burst frequency for a number of bursts in the BWL waveform, where the number of bursts includes a number of cycles. Further, the computing device may determine a cycle frequency for the number of cycles. Yet further, the computing device may determine a pressure amplitude for the BWL waveform, where the pressure amplitude is less than or equal to 8 MPa. In addition, the computing device may determine a time period for producing the BWL waveform.

Abstract: Provided is an implantable medical device for predicting and treating electrical disturbances in tissue. The medical device includes an implantable telemetry unit (ITU), and an implantable leads assembly including a first and a second electrode implanted in the tissue. A processor of the ITU is configured to perform training by receiving electrical signals input to the electrode circuit, parsing the electrical signals into dynamic event states using Bayesian Non-Parametric Markov Switching, and modeling each event state as a multi-dimensional probability distribution. The processor of the ITU is further configured to perform analysis of the electrical signals and therapy to the tissue by applying other electrical signals to the multi-dimensional distribution to predict future electrical disturbances in the tissue, and controlling the electrode circuit to apply an electrical therapy signal to the first and second electrodes to mitigate effects of the future electrical disturbances in the tissue.

Abstract: Synthetic nanostructures, proteins that are useful, for example, in making synthetic nanostructures, and methods for designing such synthetic nanostructures are disclosed herein.

Abstract: An impact mitigating assembly includes an elongate member formed from a plurality of triangulated cylindrical origami (TCO) unit cells that exhibit coupled rotational and axial motion. The unit cells include an end portion and a tubular member fixed to the end portion. The tubular member has a plurality of concave sides. Each side has a first triangular portion and a second triangular portion sharing an elastic connecting edge with the second triangular portion. The first triangular portion also shares an angled upright edge with the second triangular portion of an adjacent side. Compressing the tubular member longitudinally causes the connecting edge and the angled upright edge to elastically deform, for example by stretching, and causes the second end of the tubular member to rotate with respect to the first end of the tubular member.

Abstract: Compositions of and methods for using synthetic retinoids as retinoid replacements and opsin agonists are provided.

Abstract: A method of measuring a subject's strength of associations of multidimensional traits involving each of a first pair of first and second categories with each of a second pair of third and fourth categories includes selecting a first target concept for the first category and a second target concept for the second category and selecting a first trait for the third category and, for the fourth category, a plurality of alternative traits to provide a basis for contrasting with the first trait. The method further includes having the subject respond to a first set of trials in a first manner when there is presented an exemplar of either the first category or the third category and in a second manner when there is presented an exemplar of either the second category or the fourth category and presenting the subject with a first series of exemplars in the first set of trials, the first series including exemplars in all four categories.

Abstract: The present disclosure describes devices and methods capable of generating multi¬phase emulsions, including double emulsion droplets in a gas phase. The present disclosure also describes interfaces for coupling a multi-phase emulsion droplet source to an analytical instrument such as a mass spectrometer. The present disclosure further describes methods, systems, and apparatuses for using the devices and interfaces described to perform analysis, including mass spectrometry. The present disclosure also describes methods, systems, and apparatuses for generating and using multi-phase emulsions to perform analysis.

Abstract: A biocompatible polymer to which a plurality of clot-modulating peptides (CMPs) are bound. The polymer comprises repeating units of hydrophilic monomers and display monomers to which the CMPs are bound. For example, the CMPs can be fibrin binding peptides (FBPs) that enhance clot formation by cross-linking that occurs within and between fibers by the plurality of fibrin-binding peptides during fibrin polymerization. The polymers of the invention can be used to modulate clotting in a variety of ways via multivalent display of fibrin-binding peptides and other clot-binding and clot-modulating moieties on polymer or co-polymer backbones. In addition to clot-modulating moieties, imaging agents and therapeutic agents can be conjugated to the polymers to facilitate imaging of blood flow and thrombosis, and for treatment of clotting-related disorders.

Abstract: A cooling tourniquet system (100) includes a cooling component (110) with a tourniquet (112) at a proximal end and a control component (130). The cooling component includes a cooling pad (120) configured to be wrapped about an extremity, and a cover (111) that wraps around the cooling pad. An inner surface of the cooling pad includes one or more sensors for detecting the temperature of the extremity. The tourniquet is configured to be applied to the extremity to stop blood flow distally from the tourniquet. The control component receives temperature data from the sensors, and controls the cooling pad based on the received data rapidly cooling the extremity at depth, without causing frostbite tissue damage. In one embodiment the control component circulates a chilled fluid with a time-varying temperature profile through passages in the cooling pad. In an embodiment the cover includes an air bladder that holds the cooling pad in contact against the extremity.

Abstract: The present invention relates to the use of at least one biomarker for predicting the severity of a disease caused by the infection of an individual with an influenza virus, wherein said biomarker is selected in a group comprising (i) the alpha diversity value of the microbiome present in a respiratory sample of said individual and (ii) the microbiome profile of the said respiratory sample.

Abstract: Apparatus and methods for defining and utilizing virtual fixtures for haptic navigation within real-world environments, including underwater environments, are provided. A computing device can determine a real-world object within a real-world environment. The computing device can receive an indication of the real-world object. The computing device can determine a virtual fixture that corresponds to the real-world object based on the indication, where aspects of the virtual fixture are configured to align with aspects of the real-world object. The computing device can provide a virtual environment for manipulating the robotic tool to operate on the real-world object utilizing the virtual fixture. The virtual fixture is configured to provide haptic feedback based on a position of a virtual robotic tool in the virtual environment that corresponds to the robotic tool in the real-world environment.

Abstract: The invention provides methods for preparing DNA sequencing libraries by assembling short read sequencing data into longer contiguous sequences for genome assembly, full length cDNA sequencing, metagenomics, and the analysis of repetitive sequences of assembled genomes.