Patents Assigned to University of Western Australia
  • METHOD FOR GENERATING MATURE BETA-LIKE CELLS
    Publication number: 20160045554
    Abstract: The present invention relates to methods for generating mature insulin-producing ?-like cells comprising the steps: (a) isolating, purifying and/or enriching ?-cell progenitor cells from a population of cells; (b) differentiation of the ?-cell progenitor cells into immature insulin-producing ?-like cells; and (c) maturation of the immature insulin-producing ?-like cells into mature insulin-producing ?-like cells, comprising exposing the immature insulin-producing ?-like cells to calcitriol or an analogue thereof. More particularly, the present invention relates to methods for generating mature insulin-producing ?-like cells for use in treating diabetes.
    Type: Application
    Filed: March 28, 2014
    Publication date: February 18, 2016
    Applicant: The University of Western Australia
    Inventor: Fang-Xu Jiang
  • Terpene synthases from
    Patent number: 9260728
    Abstract: An isolated nucleic acid molecule that encodes a terpene synthase and is selected from among: a) a nucleic acid molecule comprising the sequence of nucleotides set forth in SEQ ID NO: 1, SEQ ID NO: 3 or SEQ ID NO: 5; b) a nucleic acid molecule that is a fragment of (a); c) a nucleic acid molecule comprising a sequence of nucleotides that is complementary to (a) or (b); and d) a nucleic acid molecule that encodes a terpene synthase having at least or at least about 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, 96%, 97%, 98%, 99% identity to any one of (a)-(c); wherein the nucleic acid molecule encodes a terpene synthase.
    Type: Grant
    Filed: February 20, 2015
    Date of Patent: February 16, 2016
    Assignees: University of British Columbia, University of Western Australia, Forest Products Commission
    Inventors: Katherine Zulak, Christopher Jones, Jessie Moniodis, Joerg Bohlmann
  • Antisense oligonucleotides for inducing exon skipping and methods of use thereof
    Patent number: 9249416
    Abstract: An antisense molecule capable of binding to a selected target site to induce exon skipping in the dystrophin gene, as set forth in SEQ ID NO: 1 to 202.
    Type: Grant
    Filed: September 11, 2015
    Date of Patent: February 2, 2016
    Assignee: The University of Western Australia
    Inventors: Stephen Donald Wilton, Sue Fletcher, Graham McClorey
  • Antisense molecules and methods for treating pathologies
    Patent number: 9228187
    Abstract: An antisense molecule capable of binding to a selected target site to induce exon skipping in the dystrophin gene, as set forth in SEQ ID NO: 1 to 59.
    Type: Grant
    Filed: December 16, 2013
    Date of Patent: January 5, 2016
    Assignee: The University of Western Australia
    Inventors: Stephen Donald Wilton, Sue Fletcher, Abbie Adams, Penny Meloni
  • Antisense oligonucleotides for inducing exon skipping and methods of use thereof
    Patent number: 9175286
    Abstract: An antisense molecule capable of binding to a selected target site to induce exon skipping in the dystrophin gene, as set forth in SEQ ID NO: 1 to 202.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: November 3, 2015
    Assignee: The University of Western Australia
    Inventors: Stephen Donald Wilton, Sue Fletcher, Graham McClorey
  • Method of assessing diabetic nephropathy using CD5 antigen-like
    Patent number: 9146243
    Abstract: Biomarkers for pre-Diabetes, Diabetes and/or a Diabetes related conditions, and methods of their use, including the biomarkers in Tables 1 and 2 such as peroxiredoxin-2, complement C1q subcomponent subunit B, sulfhydryl oxidase 1 and apolipoprotein A-IV.
    Type: Grant
    Filed: May 14, 2014
    Date of Patent: September 29, 2015
    Assignees: Proteomics International Pty Ltd, The University of Western Australia
    Inventors: Thomas Stoll, Scott Bringans, Kaye Winfield, Tammy Casey, Wendy Davis, Kirsten Peters, Timothy Davis, Richard Lipscombe
  • Optical cantilever based analyte detection
    Patent number: 9057706
    Abstract: An apparatus for detecting a deflection of a beam, the apparatus comprising a beam having a first side and a second side; and a grating structure positioned adjacent the second side of the beam, the grating structure including an interrogating grating coupler configured to direct light towards the beam; wherein the beam and the interrogating grating coupler form a resonant cavity, and light input to the resonant cavity is modulated according to the deflection of the beam.
    Type: Grant
    Filed: December 30, 2013
    Date of Patent: June 16, 2015
    Assignee: UNIVERSITY OF WESTERN AUSTRALIA
    Inventors: John Marcel Dell, Mariusz Martyniuk, Adrian John Keating, Gino Michael Putrino, Lorenzo Faraone, Dilusha Silva
  • Methods and compositions for increasing sensitivity to tyrosine kinase inhibitors
    Patent number: 9051551
    Abstract: The present invention relates to a method for sensitizing a disease cell expressing the epidermal growth factor receptor (EGFR) to a tyrosine kinase inhibitor selective or specific for EGFR and/or its signalling pathway, the method comprising contacting the cell with a miR-7 miRNA, a precursor or variant thereof, or a miRNA comprising a seed region comprising the sequence GGAAGA.
    Type: Grant
    Filed: November 24, 2010
    Date of Patent: June 9, 2015
    Assignee: The University of Western Australia
    Inventors: Peter Jeffery Leedman, Keith Michael Giles, Felicity Caris Kalinowski
  • Antisense oligonucleotides for inducing exon skipping and methods of use thereof
    Patent number: 9035040
    Abstract: An antisense molecule capable of binding to a selected target site to induce exon skipping in the dystrophin gene, as set forth in SEQ ID NO: 1 to 202.
    Type: Grant
    Filed: June 27, 2014
    Date of Patent: May 19, 2015
    Assignee: The University of Western Australia
    Inventors: Stephen Donald Wilton, Sue Fletcher, Graham McClorey
  • MicroRNAs and Uses Thereof
    Publication number: 20150126581
    Abstract: Provided herein are methods for inhibiting expression of DOHH in a cell, and for inhibiting hypusination of eIF5A in a cell, the methods comprising contacting a cell with a miRNA or a nucleic acid molecule encoding the miRNA, wherein the miRNA binds to the 3?UTR of the DOHH mRNA and wherein binding results in a reduction in DOHH expression. Also provided are methods for reducing cellular proliferation and for treating diseases associated with abnormal cellular proliferation.
    Type: Application
    Filed: March 8, 2013
    Publication date: May 7, 2015
    Applicant: The University of Western Australia
    Inventors: Peter Leedman, Keith Giles, Michael Epis, Andrew Barker
  • Antisense oligonucleotides for inducing exon skipping and methods of use thereof
    Patent number: 9024007
    Abstract: An antisense molecule capable of binding to a selected target site to induce exon skipping in the dystrophin gene, as set forth in SEQ ID NO: 1 to 202.
    Type: Grant
    Filed: June 26, 2014
    Date of Patent: May 5, 2015
    Assignee: The University of Western Australia
    Inventors: Stephen Donald Wilton, Sue Fletcher, Graham McClorey
  • Antisense oligonucleotides for inducing exon skipping and methods of use thereof
    Patent number: 9018368
    Abstract: An antisense molecule capable of binding to a selected target site to induce exon skipping in the dystrophin gene, as set forth in SEQ ID NO: 1 to 202.
    Type: Grant
    Filed: June 26, 2014
    Date of Patent: April 28, 2015
    Assignee: The University of Western Australia
    Inventors: Stephen Donald Wilton, Sue Fletcher, Graham McClorey
  • Terpene synthases from
    Patent number: 8993284
    Abstract: An isolated nucleic acid molecule that encodes a terpene synthase and is selected from among: a) a nucleic acid molecule comprising the sequence of nucleotides set forth in SEQ ID NO: 1, SEQ ID NO: 3 or SEQ ID NO: 5; b) a nucleic acid molecule that is a fragment of (a); c) a nucleic acid molecule comprising a sequence of nucleotides that is complementary to (a) or (b); and d) a nucleic acid molecule that encodes a terpene synthase having at least or at least about 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, 96%, 97%, 98%, 99% identity to any one of (a)-(c); wherein the nucleic acid molecule encodes a terpene synthase.
    Type: Grant
    Filed: September 24, 2013
    Date of Patent: March 31, 2015
    Assignees: The University of British Columbia, The University of Western Australia, Forest Products Commission
    Inventors: Katherine Zulak, Christopher Jones, Jessie Moniodis, Joerg Bohlmann
  • ANTISENSE OLIGONUCLEOTIDES FOR INDUCING EXON SKIPPING AND METHODS OF USE THEREOF
    Publication number: 20150057330
    Abstract: An antisense molecule capable of binding to a selected target site to induce exon skipping in the dystrophin gene, as set forth in SEQ ID NO: 1 to 202.
    Type: Application
    Filed: March 24, 2014
    Publication date: February 26, 2015
    Applicant: The University of Western Australia
    Inventors: Stephen Donald Wilton, Sue Fletcher, Graham McClorey
  • COLLAGEN SCAFFOLD FOR CELL GROWTH AND A METHOD FOR PRODUCING SAME
    Publication number: 20150017861
    Abstract: A bioscaffold and method of manufacture is described. The bioscaffold has greater than 80% type I collagen fibers or bundles having a knitted structure providing tensile load strength. A method of manufacture incorporates the steps of: (a) isolating collagen fibers or bundles; (b) incubating the fibers or bundles in a mixture of NaOH, alcohol, acetone, HCl and ascorbic acide; and (c) mechanical manipulation of the fibers or bundles to produce knitted structure.
    Type: Application
    Filed: July 7, 2014
    Publication date: January 15, 2015
    Applicant: The University of Western Australia
    Inventor: Ming Hao Zheng
  • ANTISENSE MOLECULES AND METHODS FOR TREATING PATHOLOGIES
    Publication number: 20140350067
    Abstract: An antisense molecule capable of binding to a selected target site to induce exon skipping in the dystrophin gene, as set forth in SEQ ID NO: 1 to 59.
    Type: Application
    Filed: December 16, 2013
    Publication date: November 27, 2014
    Applicant: The University of Western Australia
    Inventors: Stephen Donald Wilton, Sue Fletcher, Abbie Adams, Penny Meloni
  • METHOD FOR CHARACTERISING A MECHANICAL PROPERTY OF A MATERIAL
    Publication number: 20140316237
    Abstract: A method for characterising a mechanical property of a material. The method comprises the steps of providing the material having a deformable portion and providing a device having an optical element that is arranged to detect electromagnetic radiation.
    Type: Application
    Filed: May 12, 2014
    Publication date: October 23, 2014
    Applicant: THE UNIVERSITY OF WESTERN AUSTRALIA
    Inventors: Robert Ainsley McLaughlin, Kelsey Marie Kennedy, Brendan Francis Kennedy, David Douglas Sampson
  • METHOD FOR PRODUCING A COLLAGEN MEMBRANE AND USES THEREOF
    Publication number: 20140288271
    Abstract: The present invention relates to a method of producing a collagen membrane that has particular mechanical properties.
    Type: Application
    Filed: March 19, 2014
    Publication date: September 25, 2014
    Applicant: University of Western Australia
    Inventor: Ming Hao Zheng
  • USE OF CD5 ANTIGEN-LIKE AS A BIOMARKER FOR DIABETIC NEPHROPATHY
    Publication number: 20140249049
    Abstract: Biomarkers for pre-Diabetes, Diabetes and/or a Diabetes related conditions, and methods of their use, including the biomarkers in Tables 1 and 2 such as peroxiredoxin-2, complement C1q subcomponent subunit B, sulfhydryl oxidase 1 and apolipoprotein A-IV.
    Type: Application
    Filed: May 14, 2014
    Publication date: September 4, 2014
    Applicants: PROTEOMICS INTERNATIONAL PTY LTD, THE UNIVERSITY OF WESTERN AUSTRALIA
    Inventors: Thomas STOLL, Scott BRINGANS, Kaye WINFIELD, Tammy CASEY, Wendy DAVIS, Kirsten PETERS, Timothy DAVIS, Richard LIPSCOMBE
  • ANTISENSE OLIGONUCLEOTIDES FOR INDUCING EXON SKIPPING AND METHODS OF USE THEREOF
    Publication number: 20140243515
    Abstract: An antisense molecule capable of binding to a selected target site to induce exon skipping in the dystrophin gene, as set forth in SEQ ID NO: 1 to 202.
    Type: Application
    Filed: May 8, 2014
    Publication date: August 28, 2014
    Applicant: THE UNIVERSITY OF WESTERN AUSTRALIA
    Inventors: Stephen Donald WILTON, Sue FLETCHER, Graham MCCLOREY