Patents Assigned to University Patents, Inc.
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Patent number: 4268676Abstract: Compounds of the formula, I, ##STR1## wherein: Y is hydrogen or lower alkyl; and X is a thiazolamino radical, a furfurylamino radical or a radical of the formula, ##STR2## in which R, R.sup.1, and R.sup.2 are the same or different and selected from the group consisting of hydrogen and lower alkyl, and R.sup.3 is selected from the group consisting of lower alkenyl, halo-lower alkenyl, lower alkynyl, lower akloxycarbonyl, thienyl, formamyl, tetrahydrofuryl and benzene sulfonamide.Also disclosed are novel methods for treatment of neoplastic disease states in animals, which methods comprise administering a therapeutically effective amount of a compound of the formula, Ia, ##STR3## wherein: Y is hydrogen or lower alkyl; and Z is a thiazolamino radical, a furfurylamino radical, a cyclpropylamino radical, a pyridylamino radical, or a radical of the formula, ##STR4## in which R.sup.4, R .sup.5, and R.sup.6 are the same or different and selected from the group consisting of hydrogen and lower alkyl, and R.sup.Type: GrantFiled: December 5, 1979Date of Patent: May 19, 1981Assignee: University Patents, Inc.Inventor: William A. Remers
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Patent number: 4263010Abstract: A control method and apparatus is provided for the on-line control of crystallizer apparatus and the like to maintain predetermined operating parameters including crystal size distribution and growth rate to achieve stable, predetermined optimum continuous crystallizer operation for optimum crystal product output and purity and to avoid process transients, undesirable cycling behavior, system malfunctions and crystallizer downtime. The control method and apparatus develops on-line control signals for the process control of predetermined manipulated process variables in a closed-loop fashion. The control signals are obtained by the on-line measurement of a preconditioned, classified sample of the population distribution of the crystallizer. A zone sensing or light scattering particle analyzer is utilized by the on-line control apparatus to provide population distribution data to the control apparatus.Type: GrantFiled: October 31, 1979Date of Patent: April 21, 1981Assignee: University Patents, Inc.Inventor: Alan D. Randolph
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Patent number: 4260737Abstract: Radioiodination of aminoacyl-transfer RNAs with either .sup.125 I or .sup.131 I resulted in the preferential addition of radioiodine to bound tyrosine. The radioiodinated tyrosyl-tRNA was 10-fold purified by chromatography and was found to consist essentially of monoiodo- and diiodo-tRNA in approximately equal isotopic proportions. The radioiodinated tyrosine was readily incorporated into proteins synthesized in broken cell reactions.The specific activity of the iodine-labeled proteins can be modulated up to the highest theoretical value (radioiodine in each tyrosine) yielding products that are valuable for use in immunoassay procedures in research and in the determination of proteins of clinical importance. In addition to the mature proteins (processed by natural post-synthetic reactions) the product proteins can comprise prohormone-type molecules which represent the precursor of normal circulating forms of hormones. The .sup.Type: GrantFiled: March 16, 1979Date of Patent: April 7, 1981Assignee: University Patents, Inc.Inventor: Neal H. Scherberg
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Patent number: 4259295Abstract: Metal values of ferromanganese nodules harvested from ocean floors are placed in aqueous solution suitable for partition as by selective extraction with chelating agents by treating the nodules with aqueous solutions which contain oxalic acid or mixture of oxalic acid with a strong acid. These unique reagents may be used alone or in combination with other reducing, complexing or acidic treating agents.Type: GrantFiled: December 11, 1979Date of Patent: March 31, 1981Assignee: University Patents, Inc.Inventors: Harry Zeitlin, Quintus Fernando
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Patent number: 4258204Abstract: Acrylate ester monomers are produced in high yield and without polymerization by reacting an .alpha.,.beta.-unsaturated organic acid halide and a hydroxyl containing organic compound in the presence of molecular sieves. In the absence of molecular sieves the same reactants produce the monomer ester products in low yield and/or form polymers.Type: GrantFiled: November 24, 1978Date of Patent: March 24, 1981Assignee: University Patents, Inc.Inventors: Allen R. Banks, Richard F. Fibiger, Ted Jones
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Patent number: 4251233Abstract: Liquid hydrocarbon-soluble rare earth chelates prepared from the novel ligand 2,2,7-trimethyl-3,5-octanedione when dissolved in fuels such as gasoline and diesel oil prevent formation and/or effect removal of carbonaceous deposits during the combustion thereof. The use of fuels containing these chelates promotes more efficient operations of devices such as internal combustion engines in which the fuels are burned by minimizing or eliminating the accumulation of harmful carbonaceous materials in the combustion chambers and by preventing knocking and/or other undesirable performance characteristics.Type: GrantFiled: March 5, 1979Date of Patent: February 17, 1981Assignee: University Patents, Inc.Inventors: Robert E. Sievers, Thomas J. Wenzel
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Patent number: 4232001Abstract: Antibodies specifically immunologically reactive with estrophilin. Methods and materials for detection and quantification of estrophilin in tissue samples, notably those of human breast cancer tissue.Type: GrantFiled: September 22, 1978Date of Patent: November 4, 1980Assignee: University Patents, Inc.Inventors: Elwood V. Jensen, Eugene R. DeSombre
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Patent number: 4226836Abstract: A process for separating molybdenum values from sea nodules which includes sulfation of the sea nodules, volatilization of the molybdenum values from the sea nodules and collection of the volatile molybdenum values.Type: GrantFiled: January 3, 1979Date of Patent: October 7, 1980Assignee: University Patents, Inc.Inventors: Harry Zeitlin, Quintus Fernando
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Patent number: 4226856Abstract: Bouvardin (C.sub.40 H.sub.48 N.sub.6 O.sub.10) and deoxybouvardin (C.sub.40 H.sub.48 -N.sub.6 O.sub.9), bicyclic hexapeptides isolated from Bouvardia ternifolia are provided in the form of pure materials, individually, and as a mixture with each other. The pure materials exhibit significant anti-neoplastic disease activity in vivo and in vitro.Type: GrantFiled: November 20, 1978Date of Patent: October 7, 1980Assignee: University Patents, Inc.Inventor: Jack R. Cole
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Patent number: 4222903Abstract: Electrically conducting organic polymeric material having a preselected room temperature p-type electrical conductivity which may vary over the entire range characteristic of semiconductor behavior and into the range characteristic of metallic behavior, is prepared by controlled chemical doping of polyacetylene in the form of a polycrystalline film. Exceptionally high room temperature p-type electrical conductivity within the range of from about 0.1 to of the order of 10.sup.3 ohm.sup.-1 cm.sup.-1 is achieved with several electron acceptor dopants, including bromine, iodine, iodine chloride, iodine bromide and arsenic pentafluoride.Type: GrantFiled: May 4, 1978Date of Patent: September 16, 1980Assignee: University Patents, Inc.Inventors: Alan J. Heeger, Alan G. MacDiarmid, Chwan K. Chiang, Hideki Shirakawa
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Patent number: 4222672Abstract: An improved static mixer is disclosed which is capable of efficient mixing and is of a construction which allows relatively inexpensive manufacture. A pair of flow channels are provided for respectively receiving the fluids to be mixed at respective ends thereof. The flow channels have at least one common wall element therebetween, the common wall element having an undulating shape which alternately enlarges and restricts one of the channels while simultaneously alternately restricting and enlarging the other of the channels in opposing relationship. The common wall has openings therein at about the peaks and valleys of the undulations. In operation, two fluids to be mixed are introduced to the respective flow channels. At each peak or valley of the undulating wall element, the opposing enlargement and restriction of the two channels causes a pressure difference and results in a cross flow through the openings in the common wall element.Type: GrantFiled: April 19, 1979Date of Patent: September 16, 1980Assignee: University Patents, Inc.Inventor: Milton C. Shaw
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Patent number: 4219568Abstract: Certain N,N-dialkyl substituted derivatives of dopamine (DA) increase renal blood flow without affecting cardiac contractility. Particularly effective are N,N-di-n-propyl DA; N-n-propyl-N-n-butyl DA; N-n-propyl-N-n-pentyl DA; N-n-propyl-N-isobutyl DA; and N-n-propyl-N-phenethyl DA. Orally effective versions of these derivatives are obtained by acylating the hydroxyl functions.Type: GrantFiled: March 1, 1978Date of Patent: August 26, 1980Assignee: University Patents, Inc.Inventors: Leon I. Goldberg, Joseph G. Cannon, John P. Long
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Patent number: 4209316Abstract: Plant seed and seedlings are treated with compositions including nucleosides and/or nucleotides and with a buffering agent to achieve enhancement of emergence and seedling growth characteristics. In a preferred embodiment, seed is surface treated with an aqueous solution of 2.times.10.sup.-2 M adenosine monophosphate buffered at about pH 7.0 with phosphoric acid salts.Type: GrantFiled: June 2, 1978Date of Patent: June 24, 1980Assignee: University Patents, Inc.Inventors: Robert G. McDaniel, B. Brooks Taylor
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Patent number: 4207315Abstract: A process and pharmaceutical compositions for alleviating proliferative skin diseases such as psoriasis, atopic dermatitis, etc., comprising administering to humans or domesticated animals, topically and/or parenterally, and/or systemically a composition comprising a pharmaceutical carrier and at least one diamino compound selected from the diamines of saturated and unsaturated aliphatic hydrocarbons having 3 to 6 carbon atoms and the diamines of saturated monocarboxylic acids having 4 to 6 carbon atoms and the alkyl esters thereof containing from 1 to 4 carbon atoms. These diamino compounds are usable alone or in combination with certain prostaglandin compounds, certain phosphodiesterase inhibitor compounds and certain cyclic adenosine monophosphate compounds.Type: GrantFiled: August 11, 1978Date of Patent: June 10, 1980Assignees: University Patents, Inc., University of MichiganInventors: John J. Voorhees, Diane H. Russell
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Patent number: 4206276Abstract: A battery is provided in which the anode contains an alkali metal in a high state of thermodynamic activity; the cathode comprises a partially alkali metal-intercalated chalcogenide of the formula A.sub.y MZ.sub.x wherein A is an alkali metal more electropositive and larger than the anode alkali metal, M is a transition metal of Group IV or V, x is a numerical value of from about 1.8 to about 2.1, y is a numerical value of from about 0.01 to about 1 and Z is sulfur, selenium or tellurium; and the electrolyte comprises ions of the anode metal in a medium which is compatible with the anode and cathode allowing transport of the ion from anode to intercalate into the cathode.In the discharged state the battery includes a cathode characterized by the presence of A'.sub.z A.sub.y MZ.sub.x in which A' is alkali metal more electronegative than A and z is a numerical value in the range 0<z.ltoreq.3.25.Type: GrantFiled: September 18, 1978Date of Patent: June 3, 1980Assignee: University Patents, Inc.Inventors: Samarnath Basu, Wayne L. Worrell
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Patent number: 4204929Abstract: The disclosure is directed to a method and apparatus for isoelectric focusing of fluids. In accordance with the disclosed method, the flow of fluids to be processed is established in a first direction. This flow of fluids is streamlined by providing a plurality of permeable microporous membranes which define generally parallel channels oriented in the first direction. An electrical potential is applied across the streamlined channels of flowing fluid, and isoelectric focusing is achieved on the fluids during the flow thereof since the membranes allow interchange of fluid constituents therebetween while providing the desired streamlining. An approximation of "plug" type flow is achieved within the streamlined channels; i.e., flow having an approximately uniform cross-sectional characteristic.Type: GrantFiled: April 18, 1978Date of Patent: May 27, 1980Assignee: University Patents, Inc.Inventor: Milan Bier
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Patent number: 4204216Abstract: Electrically conducting organic polymeric film material exhibiting a preselected room temperature n-type electrical conductivity ranging from that characteristic of semiconductor behavior to that characteristic of metallic behavior, is prepared by controlled electron donor doping of a polycrystalline film of polyacetylene with a metal dopant whose Pauling electronegativity value is no greater than 1.6. Preferred metal dopants are the alkali metals. The procedure may be employed in preparing polyacetylene film with a p-n junction formed by two adjacent portions of the film respectively provided wth p-type and n-type electrical conductivities.Type: GrantFiled: May 4, 1978Date of Patent: May 20, 1980Assignee: University Patents, Inc.Inventors: Alan J. Heeger, Alan G. MacDiarmid, Chwan K. Chiang, Shek-Chung Gau
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Patent number: 4201788Abstract: A process and pharmaceutical compositions for alleviating proliferative skin diseases such as psoriasis, atopic dermatitis, etc., comprising administering to humans or domesticated animals, topically and/or parenterally, and/or systemically a composition comprising a pharmaceutical carrier and at least one diamino compound selected from the diamines of saturated and unsaturated aliphatic hydrocarbons having 3 to 6 carbon atoms and the diamines of saturated monocarboxylic acids having 4 to 6 carbon atoms and the alkyl esters thereof containing from 1 to 4 carbon atoms. These diamino compounds are usable alone or in combination with certain prostaglandin compounds, certain phosphodiesterase inhibitor compounds and certain cyclic adenosine monophosphate compounds.Type: GrantFiled: August 11, 1978Date of Patent: May 6, 1980Assignees: University Patents, Inc., The Regents of the University of MichiganInventors: John J. Voorhees, Diane H. Russell
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Patent number: 4197393Abstract: Polymers of the following formulas, and cross-linked resins formed therefrom through thermal cleavage of the four-membered rings of the biphenylene nuclei, are useful as molding and laminating materials: ##STR1## wherein Ar.sub.1, Ar.sub.2, Ar.sub.3, Ar.sub.4 and Ar.sub.5 are the same or different bivalent aromatic hydrocarbon radicals containing six to ten carbons, n is an integer from 100 to 200, m is an integer from 5 to 25, x is an integer from 50 to 100, and y is an integer from 3 to 12. In the preferred modifications, n is an integer from 50 to 190 and m is an integer from 8 to 15, and the preferred ratio of n to m is from about 18:1 to about 20:1; in one species n is about 152 and m is about 8, while in a related species n is about 190 and m is about 10.Type: GrantFiled: May 30, 1978Date of Patent: April 8, 1980Assignee: University Patents, Inc.Inventors: Raymond J. Swedo, Carl S. Marvel
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Patent number: 4188189Abstract: Errors in the radioisotope dilution assay (RIDA) of the vitamin B.sub.12 level of human blood have been traced to the presence of vitamin B.sub.12 analogues. These previously unrecognized analogues bind with proteins normally included with binding proteins used in the prior art RIDA techniques. The errors caused by the B.sub.12 analogues are avoided by using a composition for binding vitamin B.sub.12 which is substantially free of substances which bind vitamin B.sub.12 analogues. Moreover, by using both types of binders in separate assays, the amount of analogue present may be arrived at by taking the difference of the assays. Compositions that are effectively substantially pure intrinsic factor (IF) are used as binders.Type: GrantFiled: April 4, 1978Date of Patent: February 12, 1980Assignee: University Patents, Inc.Inventor: Robert H. Allen