Abstract: The present invention concerns an in vitro method for diagnosing a myeloid tumour or a lymphoid tumour in a subject, which comprises the step of analyzing a biological sample from said subject by (i) detecting the presence of a mutation in the Ten Eleven Translocation protein family member 2 gene (TET2) coding for the polypeptide having the sequence SEQ ID NO: 2, and/or (ii) analyzing the expression of the TET2 gene; wherein the detection of such a TET2 mutation, of the absence of expression of TET2 or of the expression of a truncated TET2 is indicative of a subject developing or predisposed to develop a myeloid tumour or a lymphoid tumour.
Type:
Grant
Filed:
June 8, 2016
Date of Patent:
May 26, 2020
Assignees:
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), INSTITUT GUSTAVE-ROUSSY, ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS, CENTRE HENRI BECQUEREL, UNIVERSITE PARIS DESCARTES, UNIVERSITY PIERRE ET MARIE CURIE (PARIS 6), UNIVERSITE PARIS-SUD
Inventors:
Franck Viguie, Olivier Bernard, Michaela Fontenay, Christian Bastard, Francois Delhommeau, William Vainchenker
Abstract: A method for producing a metal fluoride ceramic, comprising: providing a sedimented compound comprising metal fluoride particles having an average particle size lower than 30 nm and a solvent, partially drying the sedimented compound at a temperature lower than 65° C. until the partially dried compound comprises from 5 wt % to 45 wt % of the solvent, and sintering, for example in air, the partially dried and sedimented compound.
Type:
Grant
Filed:
April 3, 2015
Date of Patent:
January 9, 2018
Assignees:
PARIS SCIENCES ET LETTRES—QUARTIER LATIN, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITY PIERRE ET MARIE CURIE (PARIS 6)
Inventors:
Michel Mortier, Pierre Aballea, Patrick Gredin, Akiko Suganuma