Abstract: Methods employing chemiluminescent agents as therapeutically active agents in the treatment of proliferative disorders are disclosed. The chemiluminiscent agents are used in the disclosed method without a therapeutically effective amount of a photosensitizer. Novel chemiluminescent agents having the general formula: are also disclosed, wherein X, Y, Z, R3 and R5-R9 are as defined herein.
Type:
Application
Filed:
March 22, 2012
Publication date:
January 9, 2014
Applicants:
Ariel-University Research and Development Company Ltd., Semorex Technologies Ltd.
Inventors:
Bernard S. Green, Galia Luboshits, Michael A. Firer
Abstract: The invention, in some embodiments, relates to the field of global navigation satellite systems, and more particularly to the field of methods and devices for improving accuracy of position determination by receivers of global navigation satellite systems. Some embodiments of the invention relate to methods for generating a three-dimensional (3-D) representation of an urban area by a receiver of a global navigation satellite system using blocked lines of sight to satellites of the system. Additional embodiments of the invention relate to methods for transmitting a three-dimensional (3-D) representation of an urban area by a receiver of a global navigation satellite system for improving calculation of location by the global navigation satellite system receiver.
Type:
Application
Filed:
December 22, 2011
Publication date:
October 31, 2013
Applicant:
ARIEL-UNIVERSITY RESEARCH AND DEVELOPMENT COMPANY, LTD.
Abstract: The described subject matter relates to the use of incensole, incensole acetate, and derivatives thereof, for the treatment, prevention or amelioration of diseases or conditions, including inflammatory-associated conditions; a disease or condition where neuroprotection is required; and a disease or condition selected from depression, anxiety, obsessive compulsive behaviors, deterioration in cognitive function, and deterioration in neurobehavioral function. Pharmaceutical compositions and method of treatment, prevention or amelioration of the above-mentioned diseases or conditions are also provided.
Type:
Application
Filed:
December 4, 2012
Publication date:
July 25, 2013
Applicants:
ARIEL-UNIVERSITY RESEARCH AND DEVELOPMENT COMPANY LTD., YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM, LTD.
Inventors:
YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM, LTD., ARIEL-UNIVERSITY RESEARCH AND DEVELOPMENT COMPANY LTD.
Abstract: A method for compressing an elevation map by means of digital image processing, according to which local and global parameters of an elevation map are calculated for sorting the elevation map into a corresponding category and the elevation map is categorized according to the calculated local and global parameters. Optimal parameters for compressing the elevation map are determined according to the calculated local and global parameters and according to the corresponding category and then the elevation map is compressed by applying on it digital image processing by using the determined optimal compression parameters.
Type:
Grant
Filed:
March 31, 2008
Date of Patent:
May 28, 2013
Assignee:
Ariel-University Research and Development Company Ltd.
Abstract: Disclosed are methods and devices for wireless transmission of content using Wi-Fi infrastructure to multiple user-devices devices that does not require maintaining a Wi-Fi session with each user-device.
Type:
Application
Filed:
June 12, 2011
Publication date:
April 11, 2013
Applicant:
ARIEL UNIVERSITY RESEARCH AND DEVELOPMENT COMPANY, LTD.
Inventors:
Boaz Ben-Moshe, Amit Dvir, Eyal Berliner
Abstract: N-substituted 9-aminoacridine and bis-acridino derivatives containing electron-withdrawing groups (EWG) or electron-donating groups (EDG), including amino acid residues, and one-pot methods for their synthesis are disclosed. The derivatives are potential candidates for cancer treatment.
Type:
Application
Filed:
November 1, 2010
Publication date:
August 30, 2012
Applicant:
ARIEL-UNIVERSITY RESEARCH AND DEVELOPMENT COMPANY LTD.
Abstract: Disclosed are an orientation controller based on a parallelogram linkage, a mechanical arm, an anthropomorphic gripper and components thereof such as mechanical digits suitable for use, for example, in the field of keyhole surgery.
Type:
Application
Filed:
September 21, 2010
Publication date:
July 26, 2012
Applicant:
UNIVERSITY RESEARCH AND DEVELOPMENT COMPANY, LTD
Inventors:
Nir Schvalb, Boaz Ben Moshe, Alon Vardimon, Shamur Barak
Abstract: Disclosed are pharmaceutical compositions comprising extracts of Sarcopoterium spinosum, components of the extracts and uses of the pharmaceutical compositions as well as methods of making the compositions.
Type:
Application
Filed:
June 8, 2010
Publication date:
March 29, 2012
Applicant:
Ariel-University Research and Development Company. Ltd.
Abstract: Disclosed is a method for determining an phase spectrum ?(?) of the complex spectral transfer function H(?) of a medium. In some embodiments, the method is applied for detecting or imaging an object screened by scattering medium or for determining a refractive index spectrum of a material.
Type:
Application
Filed:
February 8, 2009
Publication date:
January 27, 2011
Applicant:
Ariel-University Research And Development Company Ltd.
Abstract: A method for destroying harmful cells is provided, applicable in treating proliferative diseases. The cells are destroyed by a combined treatment with a chemiluminescent agent and with a ligand-photosensitizer conjugate. The chemiluminescent agent emits light on reacting with oxygen species present in situ, the conjugate binds to the cell through its ligand and is activated by the emitted light, thereby destroying the cell. The method is demonstrated on a conjugate of transferrin-hematoporphyrin, which destroys cancerous cells in the presence of luminol.
Type:
Grant
Filed:
April 20, 2006
Date of Patent:
August 10, 2010
Assignee:
Ariel-University Research and Development Company Ltd.
Abstract: The described subject matter relates to the use of incensole, incensole acetate, and derivatives thereof, for the treatment, prevention or amelioration of diseases or conditions, including inflammatory-associated conditions; a disease or condition where neuroprotection is required; and a disease or condition selected from depression, anxiety, obsessive compulsive behaviors, deterioration in cognitive function, and deterioration in neurobehavioral function. Pharmaceutical compositions and method of treatment, prevention or amelioration of the above-mentioned diseases or conditions are also provided.
Type:
Application
Filed:
November 29, 2007
Publication date:
April 22, 2010
Applicants:
ARIEL-UNIVERSITY RESEARCH DEVELOPMENT COMPANY LTD.
Abstract: A method for destroying harmful cells is provided, applicable in treating proliferative diseases. The cells are destroyed by a combined treatment with a chemiluminescent agent and with a ligand-photosensitizer conjugate. The chemiluminescent agent emits light on reacting with oxygen species present in situ, the conjugate binds to the cell through its ligand and is activated by the emitted light, thereby destroying the cell. The method is demonstrated on a conjugate of transferrin-hematoporphyrin, which destroys cancerous cells in the presence of luminol.
Type:
Application
Filed:
April 20, 2006
Publication date:
February 26, 2009
Applicant:
Ariel-University Research and Development Company Ltd.