Abstract: The invention provides a method for treating liver cancer in a mammal comprising administering to the mammal an inhibitory effective amount of at least one GnRH-related compound. Pharmaceutical preparations useful for the treatment of liver cancer comprising an inhibitory effective amount of at least one GnRH-related compound and a pharmaceutically acceptable carrier are also provided. A further aspect of the invention provides a method for diagnosing liver cancer by determining the presence of receptors for GnRH on a biological sample.

Abstract: A method of inhibiting or treating gastrointestinal colonization of a pathogen in an animal by administration of epidermal growth factor is described. A method of increasing weight gain in an animal by administrating epidermal growth factor is also described. The epidermal growth factor can be administered orally for example in the feed or drinking water of the animal. Since EGF is useful in inhibiting or treating intestinal colonization by a pathogen and is also effective in promoting weight gain, EGF is useful in treating a wide range of intestinal infections. In one embodiment, a method of treating or inhibiting enteric colibacillosis using epidermal growth factor is described.

Abstract: A device and method for the measurement of stiffness of cartilage, specifically intended for arthroscopic use. An tissue softness probe is formed from a stiff shaft and flexible shaft, and strain gauges continuously measure the load in the stiff shaft and the deflection of the flexible shaft as they are displaced into cartilage. The stiff shaft and flexible shaft extend away from a probe body beside each other. The stiff shaft is semi-circular in section at one end with a flat side extending along the shaft at that end, and the flexible shaft is a flat shim that is attached to the flat side of the stiff shaft. Such a design advantageously allows the more or less parallel shafts to be inserted into a human body joint for displacement against cartilage, as for example during arthroscopic surgery. The stiff shaft terminates in a plunger extending at right angles to the stiff shaft, with the tip of the plunger lying, in the rest position, between a forked tip of the flexible shaft.

Abstract: A photocatalyst compound comprising a silica-based support material having bound thereto a photocatalyst selected from the group consisting of TiO.sub.2, WO.sub.3 and mixtures thereof, the photocatalyst compound having been derivatized by reaction with an alcohol compound. The process for producing the photocatalyst compound comprises the steps of: (i) contacting a silica-based support material having bound thereto a photocatalyst selected from the group consisting of TiO.sub.2, WO.sub.

Abstract: The invention provides vaccines and methods for preventing or treating intestinal protozoal infections in an animal. In particular, vaccines and methods for prevention or treatment of giardiasis are provided. The invention also encompasses methods of preparing and methods of use of novel toxins, antibodies, vaccine strains and compositions that result from or are used in these methods.

Abstract: Vaccines and methods for preventing or treating intestinal protozoal infections in an animal. In particular, vaccines and methods for prevention or treatment of giardiasis are provided. The invention also encompasses methods of preparing and methods of use of novel toxins, antibodies, vaccine strains and compositions that result from or are used in these methods.

Abstract: The present invention relates to systems and methods for automatically and continuously regulating the level of nasal pressure to an optimal value during OSA (Obstructive Sleep Apnea) treatment. OSA therapy is implemented by a device which automatically re-evaluates an applied pressure and continually searches for a minimum pressure required to adequately distend a patient's pharyngeal airway. For example, this optimal level varies with body position and stage of sleep throughout the night. In addition, this level varies depending upon the patient's body weight and whether or not alcohol or sleeping medicine has been ingested.

Abstract: A filter has a conduit having an opening for flow of fluid into the conduit, a pump for pumping fluid into the conduit through the opening, electrodes spaced apart from each other across the opening such that fluid flowing through the opening passes between the electrodes; and an AC electrical source for the electrodes, the source of AC electrical energy having a frequency and voltage such that an electric field created by the AC electrical energy in the area around the electrodes imposes a negative dielectrophoretic force on target particles carried by the fluid, the negative dielectrophoretic force being opposed to the direction of fluid flow through the opening and having sufficient strength to prevent the target particles from passing between the electrodes into the conduit. The filter is mounted in a bioreactor for filtering viable cells and retaining them in culture medium.

Abstract: The invention provides vaccines and methods for preventing or treating intestinal protozoal infections in an animal. In particular, vaccines and methods for prevention or treatment of giardiasis are provided. The invention also encompasses methods of preparing and methods of use of novel toxins, antibodies, vaccine strains and compositions that result from or are used in these methods.

Abstract: This invention relates to novel peptides based on a thrombin receptor sequence and novel methods for synthesis of these novel peptides. These peptides, branched-chain compounds and/or derivatized solid supports containing TRPs may be used diagnostically or therapeutically.

Abstract: Use of cyclin D1 as a negative regulator of cell proliferation is disclosed. Overexpression of cyclin D1 blocks cell growth, while blocking cyclin D1 expression promotes cell proliferation.

Abstract: The invention provides a method of preventing or treating Giardia infection in dogs and cats by adminstering Giardia which has been cultured in media containing bile so as to make it protectively immunogenic.

Abstract: This invention provides a method for preventing and/or treating diabetes in a mammal in need thereof comprising administering to the mammal an effective amount of at least one compound of the formula I: ##STR1## The invention also provides methods for preventing and/or treating diabetes comprising administering an effective amount of at least one compound of the formula I previously set forth and Orthosiphon Arestatus.

Abstract: A machine methodology for designing asynchronous circuits utilizes a modular approach for the synthesis of asynchronous circuits from signal transition graphs, partitions the signal transition graph into a number of simpler and more manageable modules. Each modular graph is then individually solved. The results of the small graphs are then integrated together to provide a solution to the asynchronous circuit design problem as defined by a given asynchronous behavioral specification. A satisfiability solver for Boolean output function utilizing a binary decision diagram is incorporated in one embodiment which is comprised of a structural SAT formula preprocessor and a complete, incremental SAT processor which is specifically designed to find an optimal solution. The preprocessor compresses a large size SAT formula representing a circuit into a number of smaller SAT formulas. Each small size SAT formula is then solved by the BDD SAT processor.

Abstract: An extensometer for measuring strain in a test specimen is disclosed. The extensometer includes a frame and a flexible support structure, preferably, a loop, mounted to the frame. A measuring device is mounted to the flexible support loop at a position spaced apart from the frame and engages a surface of the specimen with a selected amount of contact force. The measuring device provides an output signal proportional to the measured strain.

Abstract: A process for producing an essentially monolayer coating of crosslinked polymer on a substrate, in which a block copolymer is introduced into a semi-solvent which solvates only one block of the copolymer, the resultant block copolymer semi-solution is contacted with a substrate, and the copolymer is then crosslinked.

Abstract: A method for the recovery of hydrocarbons from a hydrocarbon deposit overlying an aquifer, including injecting a hydrocarbon solvent in the vapour phase into the aquifer to mobilize hydrocarbons in the hydrocarbon deposit; and producing mobilized hydrocarbons from the hydrocarbon deposit. Mobilized hydrocarbons are produced from the aquifer, and the hydrocarbon solvent is injected along one or more predominantly horizontal injection wells in the aquifer that are spaced from and alternate with the production well or wells. The hydrocarbon solvent is a hydrocarbon solvent selected from the group consisting of ethane, propane, butane.

Abstract: A method and an apparatus for determining the interfacial or surface tension, static or dynamic, between two liquids or between a gas and a liquid under conditions of varying temperature and pressure; and a method for adjusting the interfacial or surface tension in a petroleum reservoir for enhanced oil recovery. A tensiometer is provided which is capable of measuring interfacial or surface tension under pressure and temperature conditions which simulate those present in an actual petroleum reservoir. Measuring the interfacial and surface tension values under actual reservoir conditions then enables the selection of surfactants and other materials for adjusting the interfacial and surface tension to desired values for optimizing the enhanced oil recovery from that reservoir. A tensiometer is provided which includes a calibration body which is imaged along with the image of the test droplet in the tensiometer chamber.

Abstract: A polymer alloy material is produced by a process including the step of heating a powdered precursor material comprising polymer particles having an average particle size less than about 1000 .mu.m to a temperature less than the melting point of the polymer at a pressure of at least about 5 MPa to produce the polymer alloy material. Preferably the powdered precursor material is produced by mechanically milling a polymer to provide a powdered precursor material having an average particle size in the range of from about 0.5 .mu.m to about 200 .mu.m. The invention is particularly suited for processing a single polymer or a mixture of two or more polymers which are otherwise difficult to process at a temperature less than the melting point of the polymer.

Abstract: A method of killing microorganisms which form a biofilm on a tissue or implant surfaces in a patient, and which are refractory to a biocide at a dose which is effective to kill the microorganism in planktonic form. The effect of the biocide is potentiated, to an effective killing level, by applying an electric field across the surface containing the biofilm.