Patents Assigned to University Technologies Transfer International
  • Compositions and methods for regulating bacterial pathogenesis
    Patent number: 6844423
    Abstract: The production of a purified extracellular bacterial signal called autoinducer-2 is regulated by changes in environmental conditions associated with a shift from a free-living existence to a colonizing or pathogenic existence in a host organism. Autoinducer-2 stimulates LuxQ luminescence genes, and is believed also to stimulate a variety of pathogenesis related genes in the bacterial species that produce it. A new class of bacterial genes is involved in the biosynthesis of autoinducer-2.
    Type: Grant
    Filed: September 21, 2001
    Date of Patent: January 18, 2005
    Assignees: Princeton University, University Technologies Transfer International
    Inventors: Bonnie L. Bassler, Michael G. Surette