Abstract: Provided herein are compounds, pharmaceutical compositions comprising such compounds, and methods of using such compounds to treat diseases or disorders associated with TRPC3 activity.

Abstract: The present disclosure provides methods of producing plants with preferred levels of cell wall biosynthesis; and uses of such plants. The inventors have identified that the GFR9, CCoAOMT and MYB41 genes are major regulators of the cell wall biosynthesis pathway. Plants with modulated cell wall biosynthesis, based on modulation of the expression or activity of the GFR9, CCoAOMT and MYB41 genes, have divergent uses including pulp and paper production, and bioproduct production.

Abstract: A small diameter surgical tool implements an agonist-antagonist deflectable joint. The deflectable joint is an actuatable bendable structure that uses push-pull, agonist-antagonist action of a pair of nested tubes to actuate the joint. The tubes are designed to have non-central, offset neutral axes, and they are fixed together at locations distal to the deflectable joint, such as at their distal ends. Axial translations of the tubes relative to each other causes a push-pull, agonist-antagonist action between the tubes, which causes the deflectable joint to bend. In one implementation, a deflectable joint can be created in nested tubes by configuring radial portions of the tube sidewalls extending along the joint to have an axial region of reduced stiffness. As a result, axial agonist-antagonist motion between the tubes can cause bending of the deflectable joint.

Abstract: An alloy includes aluminum, a rare earth element, and an alloying element selected from the following: Si, Cu, Mg, Fe, Ti, Zn, Zr, Mn, Ni, Sr, B, Ca, and a combination thereof. The aluminum (Al), the rare earth element (RE), and the alloying element are characterized by forming at least one form of an intermetallic compound. An amount of the rare earth element in the alloy is in a range of about 1 wt. % to about 12 wt. %, and an amount of the alloying element in the alloy is greater than an amount of the alloying element present in the intermetallic compound.

Abstract: This invention contemplates combined use of a rose bengal (RB) derivative with irradiation of bacteria with light to treat and kill the irradiated bacteria. In one aspect, Gram-positive bacteria are treated in a method in which the bacteria are contacted with an aqueous pharmaceutical composition containing a rose bengal (RB) compound of Formula I, discussed within, dissolved or dispersed therein at about 0.2 to about 3.1 µg/mL. Those contacted bacteria are contacted with light of the wavelength about 500 nm to about 600 nm for a time period of about 1 to about 10 minutes to provide a light dose of about 0.7 to about 7.2 J/cm2. A similar method is contemplated for treating Gram-negative bacteria that are one or more of Burkholderia, Salmonella, and Proteus using an aqueous pharmaceutical composition containing about 2 to about 15 µM concentration of the RB compound.

Abstract: Methods of microbial screening for identifying alcohol acyltransferases for ester biosynthesis and submodules for ester pathways to produce butyryl-coenzyme A derived esters are disclosed. The method includes the introduction preselected plasmids into a respective host strain to form engineered microbes, in situ fermentation thereof followed by a colorimetric assay for quantification of production of the target ester. In situ fermentation includes inoculating each well of a microplate that have a culture media for producing target esters with one of the engineered microbes, adding an overlay of a solvent to each, and incubating the same. The colorimetric assay includes transfer of a quantity of the overlay from each well to respective clean wells of a new microplate, treatment of each well to form an iron-hydroxamic acid complex aqueous phase, centrifugation of the microplate, and measurement of the absorbance at 520 nm and comparison to a standard curve for the target ester.

Abstract: A power converter circuit includes a switch including a field effect transistor, the field effect transistor being a wide bandgap field effect transistor and being configured to maintain an on operational state responsive to a maintenance signal received through a gate terminal, a current sensing circuit that is configured to estimate a drain terminal current of the field effect transistor responsive to a voltage between the gate terminal of the field effect transistor and a source terminal of the field effect transistor, and a gate driving circuit that is configured to generate the maintenance signal responsive to the estimate of the drain terminal current.

Abstract: An oral composition in the form of a lozenge or lollipop is provided. The composition comprises crosslinked polyvinylpyrrolidine (PVP), xylitol and Matcha green tea. A multi-layer lozenge or lollipop for neutralizing saliva and re-hardening tooth enamel is also provided. The lozenge or lollipop comprises an alkalinizing agent; a re-mineralizing agent comprising Matcha green tea; a base; a plasticizer; and a sugar alcohol, wherein the lozenge or lollipop upon oral administration raises the saliva pH from about 7 to about 10 in about 1 minute. Methods of making and treatment are also provided.

Abstract: A stripping lifting insert is provided for precast insulated panels having an insulating material layer between opposing wythes, the insulating material layer, wythes, and precast insulated panel having respective widths. The stripping lifting insert includes an elongated connecting shaft having a shaft axis. First and second spaced apart wythe engagement members are connected to the connecting shaft in spaced apart relation to each other. Each wythe engagement member includes a hub and a plurality of three or more protrusions connected to and emanating from hub. Each of the protrusions extending radially outward from the shaft axis. The wythe engagement members have a height less than the width of the wythes, whereby each wythe engagement member can be completely embedded in a respective wythe of the precast insulated panel. A precast insulated panel and a method of making a precast insulated panel are also disclosed.

Abstract: This invention is directed to selective androgen receptor degrader (SARD) compounds pharmaceutical compositions and uses thereof in treating early prostate cancer, prostate cancer, advanced prostate cancer, castration resistant prostate cancer, triple negative breast cancer, other cancers expressing the androgen receptor, androgenic alopecia or other hyperandrogenic dermal diseases, Kennedy's disease, amyotrophic lateral sclerosis (ALS), abdominal aortic aneurysm (AAA), and uterine fibroids, and to methods for reducing the levels of androgen receptor-full length (AR-FL) including pathogenic or resistance mutations, AR-splice variants (AR-SV), and pathogenic polyglutamine (polyQ) polymorphisms of AR in a subject.

Abstract: Apparatus and systems disclosed herein are designed to be used to study various forces acting on an athletic field or an athletic surface caused by the interaction between a shoe and the turf or athletic surface during a simulated impact. Various surfaces can be tested and analyzed, including assessing deceleration, acceleration and cutting traction potential on the surfaces. The disclosed apparatuses and systems allow for the testing of a wide variety of footwear, at any desired impact angle, and at various simulated forces.

Abstract: The system can be for the management of access authorization using an immutable ledger comprising and can include a server having a computer readable medium in communications with an immutable ledger. A set of computer readable instructions can be included in the server and can be configured for: receiving a set of data, encrypting the set of data with a data-encryption-key and storing the encrypted data on the immutable ledger, creating a key tree having a node associated with a user, creating a key-encryption-key associated with the node and the user, and, distributing the key-encryption-key to the user wherein the key-encryption-key is configured to decrypt the data-encryption-key thereby providing access to the data for the user.

Abstract: Compositions comprising preceramic resins and fumed alumina are described. The compositions can also include fillers, such as silicon carbide whiskers or zirconium diboride particles. The compositions can be used as three-dimensional printable inks for preparing ceramic composites, e.g., composites having complex geometry. Inclusion of fumed alumina as a rheology modifier in the composition can provide improved printing properties for the inks compared to preceramic resin inks that do not include fumed alumina.

Abstract: Disclosed herein are embodiments of an Al—Ce—Mn alloy for use in additive manufacturing. The disclosed alloy embodiments provide fabricated objects, such as bulk components, comprising a heterogeneous microstructure and having good mechanical properties even when exposed to conditions used during the additive manufacturing process. Methods for making and using alloy embodiments also are disclosed herein.

Abstract: Aspects of the disclosure relate to compositions and methods for predicting prognosis and classifying risk of subjects having certain cancers, for example acute myeloid leukemia (AML). In some embodiments, methods described by the disclosure comprise a step of assessing the mRNA expression of certain leukemic stem cell (LSC)-enriched genes in a subject to produce a predictive score for pediatric AML. In some embodiments, methods described by the disclosure comprise a step of assessing the mRNA expression of certain genes of pharmacological relevance for standard chemotherapy consisting of Cytarabine (also known as Ara-C), daunorubicin and etoposide in a subject to produce a predictive score for pediatric AML.

Abstract: The present invention relates to methods of treating bacterial infections and cancer in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of Formula I.

Abstract: Dimer and monomer molecules according to general formulas (I) or (II) are useful as lipid switch molecules when incorporated into a membrane of a liposome. wherein R1 is a hydrophobic tail having at least 6 carbons and wherein R2 is selected from the group consisting of —NH2, wherein, for the dimer, the linker is a saturated carbon chain having 2 to 6 carbons or is a para-xylene linker; and when R2 is charged anions are present to render the charge neutral. These molecules can bind ATP or similar small phosphorylated molecules between R2 groups, which changes the shape of the molecule or the molecules orientation within the membrane thereby acting as a “switch” to release a therapeutic agent from the liposome.

Abstract: This invention provides novel 3-amino propanamide selective androgen receptor degrader (SARD) compounds, pharmaceutical compositions and uses thereof in treating prostate cancer, advanced prostate cancer, castration resistant prostate cancer, androgenic alopecia or other 5 hyperandrogenic dermal diseases, Kennedy's disease, amyotrophic lateral sclerosis (ALS), and uterine fibroids, and to methods for reducing the levels of androgen receptor-full length (AR-FL) including pathogenic or resistance mutations, AR-splice variants (AR-SV), and pathogenic polyglutamine (polyQ) polymorphisms of AR in a subject.

Abstract: Scintillating glass ceramics are disclosed. The scintillating glass ceramics may be used as an x-ray conversion layer (screen) for a flat panel imager (FPD) and as part of an imaging system. The FPD may have a single screen or a dual screen. The scintillating glass ceramics may be used for either a front screen or a back screen. The scintillating glass ceramics may be used for high energy x-ray applications including for energies of about 0.3 to about 20 MeV. A build-up layer may be attached to the scintillating glass ceramics for high energy applications. The scintillating glass ceramics may include a glass matrix hosting luminescent centers and light scattering centers. The materials used for the luminescent centers and light scattering centers may be the same or different. The scintillating glass ceramics may be coated onto a glass substrate.

Abstract: A method of tailoring the properties of garnet-type scintillators to meet the particular needs of different applications is described. More particularly, codoping scintillators, such as Gd3Ga3Al2O12, Gd3Ga2Al3O12, or other rare earth gallium aluminum garnets, with different ions can modify the scintillation light yield, decay time, rise time, energy resolution, proportionality, and/or sensitivity to light exposure. Also provided are the codoped garnet-type scintillators themselves, radiation detectors and related devices comprising the codoped garnet-type scintillators, and methods of using the radiation detectors to detect gamma rays, X-rays, cosmic rays, and particles having an energy of 1 keV or greater.