Abstract: Disclosed herein are methods of treatment by administering SRA737 as a monotherapy or in a combination therapy that is useful for treating patients with cancer.

Abstract: The invention relates to a computer readable medium including software instructions, which when executed by a scaling parameters for processor perform a method. The method includes obtaining a first and a second pre-calculated history, wherein the first and the second pre-calculated history corresponds to a first and a second path of particles through a reference material. The method further includes obtaining a first and a second plurality of phase space points and performing a first and a second set of simulations in parallel on a first and a second GPU. Each simulation uses a distinct one of the first and second plurality of phase space points, the geometry information, and the first and second pre-calculated history. The sets of simulations are performed on the GPU's to obtain a set of simulated histories. The method further includes calculating an absorbed dose of energy in the target using the set of simulated histories.

Abstract: A continuous-time delta-sigma analog-to-digital converter (ADC) is disclosed. The ADC includes a loop filter, a loop quantizer, and a clock-jitter tolerant digital-to-analog converter (DAC). The clock-jitter tolerant DAC includes a dual switched-current (SI) DAC, a switched-capacitor (SC) DAC, an adder, and a switched-capacitor-resistor (SCR) injection circuit. The dual SI DAC provides two identical analog signals from the feedback digital signal of a loop quantizer within the ADC. The SC DAC provides an error-free reference signal from the feedback digital signal. The adder subtracts one of the two analog signals from the error-free reference signal to obtain an inverted jitter-induced error signal. The SCR injection circuit then injects the inverted jitter-induced error signal, delayed by one clock-cycle, in the form of a half-delay return-to-zero exponentially decaying waveform into the loop filter.