Abstract: A sensor system is presented comprising: a plurality of sensor units arranged in a predetermined arrangement to be exposed to an electromagnetic signal to be measured, a drive unit configured for providing one or more electromagnetic drive pulses to said sensing units to thereby affect one or more selected quantum properties associated with said plurality of sensor units, and an optical detector unit configured for detecting variation in one or more optical properties of the sensor units in response to input collected electromagnetic radiation; wherein said drive unit is configured to apply the electromagnetic drive pulses having a predetermined phase function on said plurality of sensor units.
Type:
Grant
Filed:
October 11, 2021
Date of Patent:
October 21, 2025
Assignees:
YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD., UNIVERSITY ULM
Abstract: A potent complement regulator is disclosed. The complement regulator comprises a complement regulatory region connected by a flexible linker to a multifunctional binding region that enables binding to C3b activation/inactivation products and/or oxidation end products, as well as to polyanionic surface markers on host cells. An embodiment of the invention utilizes factor H SCRs 1-4 as the complement regulatory region and factor H SCRs 19 and 20 as the multi-functional binding region, linked together by a poly-Gly linker at least 12 residues in length. Pharmaceutical compositions comprising the complement regulator and methods of using the complement regulator are also disclosed.
Type:
Application
Filed:
March 15, 2013
Publication date:
April 23, 2015
Applicant:
UNIVERSITY ULM
Inventors:
John D. Lambris, Christoph Schmidt, Daniel Ricklin