Patents Assigned to University Utah Research Foundation
  • Systems and methods for managing patient devices
    Patent number: 10262110
    Abstract: An alarm manager identifies responders that are confirmed to be available to receive an alarm notification pertaining to a patient device through one or more computing devices. An alarm of the patient device may be suppressed in response to verifying that responders are available to receive the alarm notification. The alarm notification may be transmitted to the identified responders, and verification of receipt, acceptance, and/or completion of the alarm notification is received. An alarm notification may be retransmitted in response to a failure to verify receipt, acceptance, and/or completion within a time threshold.
    Type: Grant
    Filed: November 17, 2016
    Date of Patent: April 16, 2019
    Assignee: University of Utah Research Foundation
    Inventors: Joseph Tonna, Benjamin Brooke, Julia Beynon
  • Matrix metalloproteinase cleavable protein polymers for cancer gene therapy
    Patent number: 10253089
    Abstract: A delivery system that includes a recombinantly synthesized protein polymer with protease cleavage sites such as matrix metalloproteinase responsive sequences engineered within the protein polymer. The system may be used to treat cancer, wounds, or pathological conditions in other tissues that express excess protease relative to healthy tissue.
    Type: Grant
    Filed: May 30, 2013
    Date of Patent: April 9, 2019
    Assignee: University of Utah Research Foundation
    Inventors: Hamidreza Ghandehari, Joseph Cappello, Jordan Frandsen, Joshua Gustafson, Khaled Greish, Robert Andrew Price
  • Electronic nerve stimulation
    Patent number: 10252053
    Abstract: A technology is described for an electronic nerve stimulation system. The electronic nerve stimulation system can include a stimulation device operable to generate a high-frequency alternating current. The electronic nerve stimulation system can include one or more wearable electrodes operable to apply the high-frequency alternating current from the stimulation device to peripheral nerves to provide an electrical stimulation of neuronal tissue to treat pain. The one or more wearable electrodes can interface with the stimulation device via a connection system.
    Type: Grant
    Filed: March 31, 2017
    Date of Patent: April 9, 2019
    Assignee: University of Utah Research Foundation
    Inventors: David Page, Christopher Duncan, David Kluger, Zachary Kagan, Gregory Clark
  • Compositions and methods for inducing apoptosis
    Patent number: 10251906
    Abstract: In an aspect, the invention relates to compositions, methods, and kits for inducing apoptosis. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Grant
    Filed: March 11, 2014
    Date of Patent: April 9, 2019
    Assignee: UNIVERSITY OF UTAH RESEARCH FOUNDATION
    Inventors: Jindrich Henry Kopecek, Jiyuan Yang, Te-Wei Chu
  • Identification and quantification of biomarkers for evaluating the risk of preterm birth
    Patent number: 10247736
    Abstract: Described herein are methods for evaluating the risk of preterm birth in pregnant subjects. The methods involve detecting and quantifying one or more biomarkers associated with preterm birth in a biological sample from the subject. Also described herein are isolated biomarkers and kits useful in predicting the risk of preterm birth.
    Type: Grant
    Filed: July 17, 2008
    Date of Patent: April 2, 2019
    Assignees: BRIGHAM YOUNG UNIVERSITY, UNIVERSITY OF UTAH RESEARCH FOUNDATION, IHC HEALTH SERVICES
    Inventors: Steven William Graves, Michael Sean Esplin, Craig Dan Thulin
  • High sensitivity measurement of parathyroid hormone-related peptide using LC-MS/MS and associated methods
    Patent number: 10241119
    Abstract: Methods for measuring and analyzing parathyroid hormone-related peptide (PTHrP) using LC-MS/MS, including applications of the methods thereof, are disclosed and discussed. Such methods can include, along with the use of an isotope-labeled internal standard, purifying PTHrP from a biological sample, proteolytically digesting the PTHrP, and measuring specific digestion products using the using LC-MS/MS.
    Type: Grant
    Filed: May 9, 2016
    Date of Patent: March 26, 2019
    Assignee: University of Utah Research Foundation
    Inventors: Mark M. Kushnir, Alan L. Rockwood, A. Wayne Meikle
  • Functionalized nanotube sensors and related methods
    Patent number: 10241078
    Abstract: Functionalized nanotube arrays, sensors, and related methods of detecting target compounds are presented. A functionalized nanotube array (235) can include a plurality of metal oxide nanotubes (240). The metal oxide nanotubes (240) can be formed of a metal oxide and can have an interior or exterior surface that is optionally functionalized with at least one metal ion. These metal nanotubes (240) can be used in a sensor (200) for detecting target compounds such as volatile organic compounds, and biomarkers in a fluid environment. The sensor (200) can further include a power source (245) configured to apply a voltage to the nanotube array (235) and a current sensor (250) configured to monitor and detect changes in a response current which varies upon binding with the target compounds.
    Type: Grant
    Filed: October 29, 2013
    Date of Patent: March 26, 2019
    Assignee: University of Utah Research Foundation
    Inventors: Swomitra Kumar Mohanty, Manoranjan Misra, Younghwan Kim, Jules Magda
  • CROSS-LINKING AGENTS AND ASSOCIATED METHODS
    Publication number: 20190083529
    Abstract: An ophthalmic composition or dosage form can include a therapeutically effective amount of a cross-linking agent and a pharmaceutically acceptable carrier. The composition or dosage form can be used to treat an ophthalmic condition by administering a therapeutically effective amount of the composition to an eye of a subject during a treatment period.
    Type: Application
    Filed: December 6, 2016
    Publication date: March 21, 2019
    Applicant: University of Utah Research Foundation
    Inventors: Balamurali K. Ambati, Hironori Uehara, Santosh Muddana
  • Nanoparticle light filtering method and apparatus
    Patent number: 10234608
    Abstract: Implementations of the present invention relate to apparatuses, systems, and methods for blocking, attenuating, or filtering neuroactive wavelengths of the visible light spectrum and reducing or preventing the symptoms affiliated with exposure to those wavelengths. Nanoparticles of a predetermined composition, size, and structure are dispersed in a host medium to create an optical notch filter, thereby attenuating only a narrow range of the visible spectrum.
    Type: Grant
    Filed: November 14, 2014
    Date of Patent: March 19, 2019
    Assignee: University of Utah Research Foundation
    Inventors: Steven M. Blair, Pradeep Kasinadhuni, Steve McDaniel, Bradley Jay Katz
  • Methods for treatment of and prophylaxis against inflammatory disorders
    Patent number: 10232023
    Abstract: An isolated and purified peptide, neonatal NET-inhibitory Factor (nNIF), is disclosed. Methods for treatment of and prophylaxis against inflammatory disorders are also disclosed, including methods of treatment of and prophylaxis against inflammatory disorders comprising administering NET-inhibitory peptides (NIPs), which may be a nNIF, a pharmaceutically acceptable salt of a nNIF, a nNIF analog, a pharmaceutically acceptable salt of a nNIF analog, a nNIF-Related Peptide (nNRP), including the nNRP, Cancer-Associated SCM-Recognition, Immune Defense Suppression, and Serine Protease Protection Peptide (CRISPP), a pharmaceutically acceptable salt of a nNRP, a nNRP analog, or a pharmaceutically acceptable salt of a nNRP analog, to an individual.
    Type: Grant
    Filed: February 24, 2017
    Date of Patent: March 19, 2019
    Assignee: UNIVERSITY OF UTAH RESEARCH FOUNDATION
    Inventors: Christian Con Yost, Guy A. Zimmerman, Andrew S. Weyrich
  • Methods of predicting mortality risk by determining telomere length
    Patent number: 10227649
    Abstract: The present invention provides for methods of determining telomere length of an organism and correlating the measured telomere length with mortality risk associated with telomere length in a population. The presence of shorter telomeres is associated with an increased mortality rate and increased susceptibility to certain types of diseases for an individual member of a human population.
    Type: Grant
    Filed: September 18, 2015
    Date of Patent: March 12, 2019
    Assignee: UNIVERSITY OF UTAH RESEARCH FOUNDATION
    Inventor: Richard Cawthon
  • Elongate member reinforcement with a studded collar
    Patent number: 10227786
    Abstract: An elongate member reinforcement system and associated methods are disclosed. The system can include an elongate member, a collar secured about an end portion of the elongate member, a support layer surrounding the end portion of the elongate member, and a structural filler disposed between the support layer and the end portion of the elongate member. The collar can be disposed in the structural filler and can include a structural filler interface feature that mechanically couples the collar to the structural filler to facilitate transferring loads between the elongate member and the structural filler.
    Type: Grant
    Filed: October 12, 2016
    Date of Patent: March 12, 2019
    Assignee: University of Utah Research Foundation
    Inventors: Chris P Pantelides, Lawrence D. Reaveley
  • Pharmaceutical compositions composed of low molecular weight sulfated hyaluronan
    Patent number: 10226481
    Abstract: Described herein are pharmaceutical compositions composed of low molecular weight sulfated hyaluronan.
    Type: Grant
    Filed: December 16, 2016
    Date of Patent: March 12, 2019
    Assignee: University of Utah Research Foundation
    Inventors: Glenn D. Prestwich, Siam Oottamasathien, Wanjian Jia, Lindsi M. Roundy, Won Yong Lee
  • Methods and compositions for inhibiting retinopathy of prematurity
    Patent number: 10214741
    Abstract: Disclosed are vectors and compositions comprising a pol II promoter and an shRNA wherein the shRNA has a sense RNA strand and an antisense RNA strand, wherein the sense and the antisense RNA strands form an RNA duplex, and wherein the sense RNA strand comprises a nucleotide sequence identical to a target sequence in STAT3, VEGFR, or EPOR. Also disclosed are methods of treating retinopathy of prematurity (ROP), methods of inhibiting expression of STAT3, VEGFR, and EPOR, and methods of regulating signaling events associated with intravitreal neovascularization (IVNV).
    Type: Grant
    Filed: February 13, 2015
    Date of Patent: February 26, 2019
    Assignee: UNIVERSITY OF UTAH RESEARCH FOUNDATION
    Inventor: Mary Elizabeth Hartnett
  • Implantable devices for bone or joint defects
    Patent number: 10207030
    Abstract: In one aspect, the invention provides an implantable device comprising a uniform mixture of components including degradable polymer, inorganic bone particulate either natural or synthetic, a drug, and a soluble microporagen. In some embodiments, the uniform mixture further includes a soluble polymer macroporagen. In some embodiments, the uniform mixture is coated with an immobilized outer porous layer comprising or consisting of synthetic or natural inorganic bone granules. In further aspects, the invention provides an implantable device comprising a composite core of degradable polymer, bone, and a drug, and a coating comprising or consisting of microporous bone overlayer covering the degradable composite core.
    Type: Grant
    Filed: January 11, 2018
    Date of Patent: February 19, 2019
    Assignee: University of Utah Research Foundation
    Inventors: Amanda Elaine Brooks, David W. Grainger, Kristofer D. Sinclair, Benjamin Delbert Brooks
  • Genetic alterations in glioma
    Patent number: 10202643
    Abstract: Methods and genetic sequences are described for use in determining the diagnosis, subtype, prognosis, and disease course of high-grade gliomas, such as glioblastoma multiforme. One such method includes determining increased expression of at least one gene on a chromosome segment in cells of the glioma, the segment being 17:57,851,812-17:57,973,757; 7:127,892,509-7:127,947,649; 12:33,854-12:264,310; or 19:33,329,393-19:35,322,055; and estimating, based on the expression, a predicted length of survival, a probability of survival, or a predicted response to a therapy for the glioma.
    Type: Grant
    Filed: October 31, 2012
    Date of Patent: February 12, 2019
    Assignee: UNIVERSITY OF UTAH RESEARCH FOUNDATION
    Inventor: Orly Alter
  • Omnidirectional electromagnet
    Patent number: 10199147
    Abstract: An omnidirectional electromagnet (100) is disclosed. The omnidirectional electromagnet (100) comprises a ferromagnetic core (110) and three orthogonal solenoids (120, 130, 140) disposed about the core (110). Each solenoid (120, 130, 140) is adapted to receive a current from a current source to control an orientation and a magnitude of a magnetic field generated by the omnidirectional electromagnet (100). One or more omnidirectional electromagnets (100) can be used as a single magnetic manipulation system. The magnetic field generated by the omnidirectional electromagnet system can be used to control at least one of a force, a torque, an orientation, and a position of an adjacent magnetic object.
    Type: Grant
    Filed: October 18, 2013
    Date of Patent: February 5, 2019
    Assignee: University of Utah Research Foundation
    Inventors: Andrew J. Petruska, Jacob J. Abbott
  • High temporal resolution monitoring of contact between catheter tip and target tissue during a real-time-MRI-guided ablation
    Patent number: 10194830
    Abstract: A method of monitoring a position of a catheter tip relative to a target tissue. The method includes steps of identifying a wall structure in the target tissue; guiding a catheter towards the wall structure; monitoring a location of the catheter; directing a navigator beam towards the wall structure; aligning the navigator beam with the location of the catheter; monitoring a position of the wall structure using the navigator beam; and determining the position of the wall structure relative to the location of the catheter.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: February 5, 2019
    Assignee: UNIVERSITY OF UTAH RESEARCH FOUNDATION
    Inventors: Ashvin Kurian George, Evgueni G. Kholmovski, Nassir F. Marrouche
  • Ebolavirus pre-hairpin intermediate mimics and methods of use
    Patent number: 10189878
    Abstract: Ebolavirus is a highly lethal filovirus that causes hemorrhagic fever in humans and non-human primates. With no approved treatments or preventatives, the development of an anti-ebolavirus therapy to protect against natural infections and potential weaponization is an urgent unmet global health need. The design, biophysical characterization, and validation of peptide mimics of the ebolavirus N-trimer (“N-trimer mimics”) are described herein.
    Type: Grant
    Filed: September 24, 2015
    Date of Patent: January 29, 2019
    Assignees: University of Utah Research Foundation, Navigen, Inc., The United States of America—Air Force
    Inventors: Tracy R. Clinton, Michael Thomas Jacobsen, Matthew T. Weinstock, Brett D. Welch, Debra Muir Eckert, Michael S. Kay
  • Producing a titanium product
    Patent number: 10190191
    Abstract: A method (400) for producing a titanium product is disclosed. The method (400) can include obtaining TiO2-slag (401), and producing a titanium product from the TiO2-slag using a metallic reducing agent (402) at a moderate temperature and a pressure to directly produce a titanium product chemically separated from metal impurities in the TiO2 slag (403). The titanium product can comprise TiH2 and optionally elemental titanium. Impurities in the titanium product can then removed (404) by leaching, purifying and separation to form a purified titanium product.
    Type: Grant
    Filed: August 19, 2014
    Date of Patent: January 29, 2019
    Assignee: University of Utah Research Foundation
    Inventors: Zhigang Zak Fang, Peng Fan, Scott Middlemas, Jun Guo, Ying Zhang, Michael Free, Amarchand Sathyapalan, Yang Xia