Abstract: Described herein are small molecule cap-dependent inhibitors, including the compound of the formula: which compounds that can induce the accumulation of the p53 tumor suppressor protein in cancer cells that still express wild-type p53, as well as methods of using those compounds to, among other things, treat neuroblastoma, pediatric glioblastoma multiforme or breast cancer.

Abstract: In an embodiment, a method for controlling a printer is provided. The method includes: receiving a set of parameters associated with a printer by a computing device, wherein the printer is depositing ink on a substrate to generate a line; measuring a width of the line by the computing device; receiving a duty cycle associated with the printer by the computing device; using the received duty cycle, the set of parameters, and a model, estimating one or more unknown parameters of the set of parameters by the computing device; receiving a desired width of the line by the computing device; and if the desired width is not the same as the measured width: adjusting the duty cycle associated with the printer based on the set of parameters and the model so that the measured width is closer to the desired width by the computing device.

Abstract: A treating method of a nonaqueous-electrolyte and a method of fabricating a battery are provided. The treating method is suitable for being performed prior to injecting a nonaqueous-electrolyte into a containing region of the battery. The treating method includes performing at least one first voltage process or at least one second voltage process on the nonaqueous-electrolyte. The first voltage process includes as follows. A first voltage is applied to the nonaqueous-electrolyte. The voltage is adjusted gradually from the first voltage to a second voltage. The voltage is adjusted gradually from the second voltage to the first voltage. The second voltage process includes as follows. A third voltage is applied to the nonaqueous-electrolyte for a predetermined time.

Abstract: Systems and methods for modulation and demodulation using a micro-Doppler effect are described. In an embodiment, the method includes radiating, using a picosecond pulse generator with an antenna, a train of THz pulses that form a frequency comb, where the frequency comb is reflected from an object such that the frequency several tones in the frequency comb are shifted based on the speed of the object and demodulating the reflected frequency comb to recover a THz Doppler signature of the object.

Abstract: The invention relates to the field of medical diagnostics. Provided are methods and kits for determining the health status of a subject, for early detection of tissue damage, for early diagnosis and monitoring of a disease, and/or for evaluation of treatment effectiveness in a subject using circulating tissue macrophages (CTM) as a mirror of disrupted tissue homeostasis and disease.

Abstract: Disclosed herein are methods and compositions for administering immunotherapy to a subject in need thereof and for treating a subject in need thereof, where in the methods the subject is administered an effective amount of an inhibitor of nNOS for inducing an immunotherapeutic response in the subject and for treating the subject. The disclosed methods and composition may be utilized for treating a subject having a cell proliferative disease or disorder such as melanoma.

Abstract: An embodiment in accordance with the present invention provides a robot structure that includes an MRI-Safe pneumatic stepper motor and optical encoding technologies. The present invention includes a needle guide and a needle depth limiter. The needle for biopsy is inserted through the needle guide and the depth of inserting is limited by the needle depth limiter. The robot is configured to control this procedure. The robot structure is adapted for biopsy, a novel way of setting the depth of needle insertion, image-to-robot registration. The system includes control for the robot.

Abstract: A polymeric composition includes poly(lactide-co-glycolide) (PLGA) microspheres; and at least one of a discrete RSNO adduct or a polymeric RSNO encapsulated within the microspheres, with the at least one of the discrete RSNO adduct or the polymeric RSNO adduct capable of releasing nitric oxide (NO). The polymeric composition exhibits stability under dry conditions at 37° C. and prolonged and controllable NO release rates, when exposed to light capable of photolyzing an RSNO bond, or when exposed to moisture, for a predetermined amount of time from the at least one of the discrete RSNO adduct or the polymeric RSNO adduct.

Abstract: Various examples are provided for obtaining body measurements of a user, predicting body measurements of a user, and/or the like. Examples include a coded dimensioning garment having a stretchable fabric that conforms to a wearer's body without substantial compression or distortion of the skin. The garment can include measurement markings of known sizes at one or more known locations on the fabric. Methods are provided for predicting body measurements from a user. Image(s) of a user wearing the garment in a reference pose are captured and can be uploaded to a body measurement application. The real-world dimensions can be converted to pixel dimensions in the same ratio as the real world dimensions and inputted into a prediction model to generate measurements from areas of interest on the user.

Abstract: An integrated-optics MEMS-actuated beam-steering system is disclosed, wherein the beam-steering system includes a lens and a programmable vertical coupler array having a switching network and an array of vertical couplers, where the switching network can energize of the vertical couplers such that it efficiently emits the light into free-space. The lens collimates the light received from the energized vertical coupler and directs the output beam along a propagation direction determined by the position of the energized vertical coupler within the vertical-coupler array. In some embodiments, the vertical coupler is configured to correct an aberration of the lens. In some embodiments, more than one vertical coupler can be energized to enable steering of multiple output beams. In some embodiments, the switching network is non-blocking.

Abstract: Wave energy conversion (WEC) systems and methods for harvesting wave energy by use of the systems are described. WEC systems incorporate a plurality of submerged oscillating water columns (SOWC) that encourage oscillating water motion within each submerged column to mimic the motion of waves passing the SOWC system. A WEC system includes multiple SOWC connected to one another via air pockets within each submerged column. Each SOWC includes a float connected to a power take-off. The oscillations of the floats are converted to useful energy by the power take-off of the system.

Abstract: A method for detecting whether glucose metabolism is abnormal comprises: detecting GPx2 gene expression, GPx2 protein expression or the activity of GPx2 protein in a test body, and making comparisons with GPx2 expression amount of a normal individual, when the GPx2 expression of the individual is significantly lower than that of the normal individual, indicating that the carbohydrate metabolism of the individual is in an abnormal state. Applications of GPx2 in the preparation of a medical composition for the treatment and prevention of type II diabetes.

Abstract: A method of sand consolidation is provided. The method includes injecting a consolidating fluid into a subterranean sand formation via a wellbore to saturate a portion of the subterranean sand formation in a target region surrounding the wellbore and displace a formation fluid present in the subterranean sand formation. Herein, the consolidating fluid comprises bitumen dissolved in an aromatic solvent. The method further includes injecting a composition comprising one or more heat-generating chemicals into the subterranean sand formation such that the portion of the subterranean sand formation in the target region is heated to a target temperature of at least 150° C. The method further includes injecting a gas comprising oxygen into the subterranean sand formation for a period sufficient to oxidize the bitumen in the target region into a residue present on sand grains to bind the sand grains together into a consolidated permeable matrix.

Abstract: The increasing power density and, therefore, current consumption of high performance integrated circuits (ICs) results in increased challenges in the design of a reliable and efficient on-chip power delivery network. In particular, meeting the stringent on-chip impedance of the IC requires circuit and system techniques to mitigate high frequency noise that results due to resonance between the package inductance and the onchip capacitance. In this paper, a novel circuit technique is proposed to suppress high frequency noise through the use of a hyperabrupt junction tuning varactor diode as a decoupling capacitor for noise critical functional blocks. With the proposed circuit technique, the voltage droops and overshoots on the onchip power distribution network are suppressed by up to 60% as compared to MIM or deep trench decoupling capacitors of the same capacitance.

Abstract: Methods and compositions are provided for combined transplantation of a solid organ and hematopoietic cells to a recipient, where tolerance to the graft is established through development of a persistent mixed chimerism. An individual with persistent mixed chimerism, usually for a period of at least six months, is able to withdraw from the use of immunosuppressive drugs after a period of time sufficient to establish tolerance.

Abstract: The present invention is directed to methods and compositions for targeted gene silencing that provide the ability to not only repress expression but to modulate the repression of expression of one or more target genes. In one aspect, a recombinant nucleic acid molecule is provided comprising a nucleotide sequence encoding a subset of CRISPR-cas polypeptides, or functional fragments thereof, from a type-I CRISPR-cas system. In some aspects, a recombinant nucleic acid of the invention comprises a nucleotide sequence encoding three or more Type I Cascade polypeptides having substantial identity to a type I Cascade polypeptide.

Abstract: A controller performs a first process of scanning a cylindrical irradiation region including a focused spot of laser light emitted from a laser light emitter to machine a flank face side of a workpiece to manufacture a cutting tool having a plurality of cutting edges arranged in line. In the first process, the controller scans the cylindrical irradiation region along a scanning path that has periodicity and changes a machining depth to form the plurality of cutting edges. The controller further performs a second process of scanning the cylindrical irradiation region including the focused spot of the laser light emitted in a direction different from an irradiation direction of the laser light in the first process to machine a rake face side of the workpiece.

Abstract: Methods and compositions for treating kidney injury are provided.

Abstract: Provided are a series of crocins compounds and related pharmacological applications thereof in prevention and treatment of Alzheimer's disease. The series of crocins compounds are obtained by taking the Chinese herb, namely Gardenia jasminoides Ellis, as a raw material and separating same by means of various methods. The compounds playing a role in preventing oxidative injury caused by hydrogen peroxide (H2O2) and excitatory amino acid injury caused by L-glutamic acid are screened out by in-vitro cell experiments. The results show that the crocins compounds have good effect in preventing cell injury caused by H2O2 and L-glutamic acid. The compounds have good effect in preventing and treating Alzheimer's disease due to the fact that significant rise of oxidative stress and excitatory amino acid is a key factor for nerve injury in Alzheimer's disease, and have broad development and application prospect.

Abstract: The present invention relates to refined prognostic clinical tools, methods, and kits for the evaluation of risk and treatment of distant recurrence in ER+/HER2? breast cancer patients.