Patents Assigned to University
  • Patent number: 10292865
    Abstract: The embodiments include method of nonlinear optical photodynamic therapy of tissue including the steps of providing pulsed infrared laser light for two-photon excited fluorescence tissue exposure, and selectively focusing the pulsed infrared laser light within the tissue at a focal plane to activate a photosensitizing agent to generate free radicals within a highly resolved axial and lateral spatial domain in the tissue. The invention is also directed to an apparatus for performing nonlinear optical photodynamic therapy of tissue including a pulsed infrared laser for providing two-photon excited fluorescence beam tissue exposure, a scanner for selectively and controllably moving the tissue and the beam relative to each other, and optics for selectively focusing the pulsed infrared laser light within the tissue at a point in a focal plane to activate a photosensitizing agent to generate free radicals within a highly resolved axial and lateral spatial domain in the tissue.
    Type: Grant
    Filed: July 20, 2015
    Date of Patent: May 21, 2019
    Assignee: The Regents of the University of California
    Inventors: James V. Jester, Tibor Juhasz, Donald J. Brown, Dongyul Chai, Moritz Winkler
  • Patent number: 10292943
    Abstract: Methods and compositions are disclosed for delivering lutein or other antioxidant to target tissues such as the eye, in bioactive form, while protecting the antioxidant from degradation. The antioxidant is encapsulated in nanoparticles comprising a protein such as zein or a polymer such as poly(lactic-co-glycolic acid) (PLGA). Preferably a surfactant is associated with the nanoparticles as well, further helping to protect the antioxidant. After the nanoparticles are administered to the target tissue, bioactive antioxidant is released to the tissue over time. Optionally, the nanoparticles are admixed with a thermosensitive, bioadhesive gel to promote slow release of antioxidant. The methods and compositions are useful for treating or preventing conditions such as age-related macular degeneration or cataracts.
    Type: Grant
    Filed: August 10, 2015
    Date of Patent: May 21, 2019
    Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventors: Cristina M. Sabliov, Carlos E. Astete, Ede Bodoki, Oliviu Vostinaru, Ovidiu Ciprian Samoil{hacek over (a)}, Elena Dinte
  • Patent number: 10292597
    Abstract: Methods and apparatus are provided for assessing endothelial function in a mammal. In certain embodiments the methods involve using a cuff to apply pressure to an artery in a subject to determine a plurality of baseline values for a parameter related to endothelial function as a function of applied pressure (Pm); b) applying a stimulus to the subject; and applying external pressure Pm to the artery to determine a plurality of stimulus-effected values for the parameter related to endothelial function as a function of applied pressure (Pm); where the baseline values are determined from measurements made when said mammal is not substantially effected by said stimulus and differences in said baseline values and said stimulus-effected values provide a measure of endothelial function in said mammal.
    Type: Grant
    Filed: July 23, 2018
    Date of Patent: May 21, 2019
    Assignee: The Regents of the University of California
    Inventor: Jonathan S. Maltz
  • Patent number: 10292840
    Abstract: A prosthetic device includes a phalanges portion, a metatarsals portion that is movably coupled to the phalanges portion, an ankle portion that is movably coupled to the metatarsals portion, and a calcaneus portion that is movably coupled to the ankle portion.
    Type: Grant
    Filed: June 7, 2018
    Date of Patent: May 21, 2019
    Assignee: University of South Florida
    Inventors: Millicent Kay Schlafly, Tyagi Ramakrishnan, Kyle B. Reed
  • Patent number: 10294222
    Abstract: Compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction.
    Type: Grant
    Filed: September 1, 2017
    Date of Patent: May 21, 2019
    Assignee: Vanderbilt University
    Inventors: P. Jeffrey Conn, Craig W. Lindsley, Andrew Felts
  • Patent number: 10296178
    Abstract: A system and methods for facilitation of user interactions with an electronic device. A number of user interface methods are described and may be used alone or in combination with one another to present an enhanced interface to a user. A method of providing user interaction using a compact status indicator is described. A method for providing a virtual scroll wheel to a user for interaction with content sets is described. A method for allowing a user to dynamically modify a scalable user interface is described. A method for providing gesture based input to a user via a virtual gesture pad is described. A method of providing an interactive graphic search query interface is described. A method for indicating and selecting available content type is described.
    Type: Grant
    Filed: December 15, 2010
    Date of Patent: May 21, 2019
    Assignee: Universal Electronics, Inc.
    Inventors: Christopher Chambers, Wayne Scott, Cheryl Scott, Allen Yuh, Paul D. Arling
  • Patent number: 10295971
    Abstract: A wearable embedded control system, including at least one remote device and at least one wearable hand device. The wearable hand device includes a plurality of light emitting diodes coupled to a plurality of light dependent resistors wherein the light emitting diodes and the light dependent resistors are fixed along at least one finger of the wearable hand device. The wearable hand device further includes a signal conditioning circuit configured to filter an ambient light signal, and a single board computer including processing circuitry configured to detect a presence of light emitted by the plurality of light emitting diodes and received by the plurality of light dependent resistors, determine one or more integer values corresponding to the presence of light received by the plurality of light dependent resistors, and transmit the one or more integer values to the remote device via a real-time Data Distribution Service middleware.
    Type: Grant
    Filed: January 19, 2016
    Date of Patent: May 21, 2019
    Assignee: King Fahd University of Petroleum and Minerals
    Inventors: Basem Mohammed Almadani, Farouq Muhammad Aliyu
  • Patent number: 10297315
    Abstract: Presented is a method and apparatus for solving. The method includes receiving, by a resistive memory array, a first data, the resistive memory array comprising a plurality of cells, wherein the receiving comprises setting a plurality of resistances on the plurality of cells, wherein each of the plurality of resistances are based on the first data. The method further includes receiving, by the resistive memory array, a second data, wherein the receiving comprises applying at least one of a current and a voltage based on the second data on the plurality of cells. The method still further includes determining, by the resistive memory array, an initial unknown value, the initial value based on the first data and the second data.
    Type: Grant
    Filed: July 24, 2017
    Date of Patent: May 21, 2019
    Assignee: University of Rochester
    Inventors: Eby Friedman, Isaac Richter, Xiaochen Guo, Mohammad Kazemi, Kamil Pas, Ravi Patel, Engin Ipek, Ji Liu
  • Patent number: 10298391
    Abstract: A system for generating symmetric cryptographic keys for communications between hosts. Hosts use associated devices to generate secret keys. Each key is generated based on a static seed and a dynamic seed. The dynamic seed is created from sensor data or auxiliary data. The secret key allows host machines to encrypt, or decrypt, plaintext messages sent to, or received from, other host machines.
    Type: Grant
    Filed: September 19, 2018
    Date of Patent: May 21, 2019
    Assignee: University of South Florida
    Inventors: Jay Ligatti, Cagri Cetin, Shamaria Engram, Dmitry Goldgof
  • Patent number: 10294254
    Abstract: Gold(I) complex with mixed ligands as an anticancer agent. The gold(I) ion is coordinated to a dithiocarbamate ligand and a phosphorus-containing ligand (e.g. phosphines). Also described are a pharmaceutical composition incorporating the gold(I) complex, a methods of synthesizing the gold(I) complex, and a method for treating cancer.
    Type: Grant
    Filed: August 24, 2018
    Date of Patent: May 21, 2019
    Assignees: King Fahd University of Petroleum and Minerals, King Saud University
    Inventors: Said S. Al-Jaroudi, Ali Alhoshani, Muhammad Altaf, Anvarhusein Abdulkadir Isab
  • Patent number: 10294484
    Abstract: The present invention is directed to a yeast strain, or strains, secreting a full suite, or any subset of that full suite, of enzymes to hydrolyze corn starch, corn fiber, lignocellulose, (including enzymes that hydrolyze linkages in cellulose, hemicellulose, and between lignin and carbohydrates) and to utilize pentose sugars (xylose and arabinose). The invention is also directed to the set of proteins that are well expressed in yeast for each category of enzymatic activity. The resulting strain, or strains can be used to hydrolyze starch and cellulose simultaneously. The resulting strain, or strains can be also metabolically engineered to produce less glycerol and uptake acetate. The resulting strain, or strains can also be used to produce ethanol from granular starch without liquefaction.
    Type: Grant
    Filed: November 10, 2015
    Date of Patent: May 21, 2019
    Assignees: Lallemand Hungary Liquidity Management LLC, Stellenbosch University
    Inventors: Elena Brevnova, John E. McBride, Erin Wiswall, Kevin S. Wenger, Nicky Caiazza, Heidi Lau, Aaron Argyros, Frank Agbogbo, Charles F. Rice, Trisha Barrett, John S. Bardsley, Abigail Foster, Anne K. Warner, Mark Mellon, Ryan Skinner, Indraneel Shikhare, Riaan Den Haan, Chhayal V. Gandhi, Alan Belcher, Vineet B. Rajgarhia, Allan C. Froehlich, Kristen M. Deleault, Emily Stonehouse, Shital A. Tripathi, Jennifer Gosselin, Yin-Ying Chiu, Haowen Xu
  • Patent number: 10293012
    Abstract: The present disclosure relates to methods of using Melissa officinalis extracts in inhibiting viral replication of a filovirus and in treating or preventing a filovirus infection.
    Type: Grant
    Filed: May 3, 2018
    Date of Patent: May 21, 2019
    Assignee: Arizona Board of Regents on behalf of Arizona State University
    Inventors: Jeffrey Langland, Bertram Jacobs, Karen Denzler
  • Patent number: 10294252
    Abstract: The present disclosure provides a new series of compounds exhibiting high fluorescence quantum yields in the solid state. In one embodiment, the compounds include a series of 2,3,4,5-tetraphenylgermoles with the same or different 1,1-substituents. In another embodiment, substituted germafluorenes, germa-fluoresceins/rhodamines, and germapins are described. These germanium heterocycles possess ideal photophysical and thermostability properties, which makes them excellent candidates for chemical or biological sensors, host materials for electroluminescent devices and solar cells, and emissive and for electron-transport layer components in organic light emitting diode devices.
    Type: Grant
    Filed: June 11, 2013
    Date of Patent: May 21, 2019
    Assignee: The Curators of the University of Missouri
    Inventors: Janet Braddock-Wilking, Teresa Lynn Bandrowsky, James Bryan Carroll, II
  • Patent number: 10294293
    Abstract: Compositions and methods for the treatment or prevention of Dengue virus infection in a vertebrate subject are provided. In particular, human neutralizing monoclonal antibodies to Dengue virus isolated from EBV immortalized B cells derived from patients who have recovered from Dengue infection are disclosed. Methods are provided for administering such antibodies to a vertebrate subject in an amount effective to reduce, eliminate, or prevent relapse from infection.
    Type: Grant
    Filed: June 1, 2016
    Date of Patent: May 21, 2019
    Assignees: National University of Singapore, DSO National Laboratories
    Inventors: Paul Anthony Macary, Ee Ping Evelyn Teoh, Brendon John Hanson, En Wei Teo, Angeline Pei Chiew Lim, Mah Lee Mary Ng, Shee Mei Lok, Petra Eveliina Kukkaro
  • Patent number: 10296815
    Abstract: A convolutional neural network system for detecting at least one object in at least one image. The system includes a plurality of object detectors, corresponding to a predetermined image window size in the at least one image. Each object detector is associated with a respective down-sampling ratio with respect to the at least one image. Each object detector includes a respective convolutional neural network and an object classifier coupled with the convolutional neural network. The respective convolutional neural network includes a plurality of convolution layers. The object classifier classifies objects in the image according to the results from the convolutional neural network. Object detectors associated with the same respective down-sampling ratio define at least one group of object detectors. Object detectors in a group of object detectors being associated with common convolution layers.
    Type: Grant
    Filed: April 20, 2017
    Date of Patent: May 21, 2019
    Assignee: Ramot at Tel Aviv University Ltd.
    Inventors: Lior Wolf, Assaf Mushinsky
  • Patent number: 10294266
    Abstract: The invention provides for methods and systems for engineering target proteins, based on protein sequence characteristics that influence the likelihood of obtaining a crystal suitable for X-ray structure solution, to improve protein crystallization, as well as related material.
    Type: Grant
    Filed: October 19, 2012
    Date of Patent: May 21, 2019
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Victor Naumov, William Nicholson Price, Samuel K. Handelman, John Frances Hunt
  • Patent number: 10293026
    Abstract: An object of the present invention is to provide a pharmaceutical preparation that can promote the proliferation of oligodendrocyte precursor cells to effectively prevent or treat a demyelinating disease. FGF21 acts to promote the proliferation of oligodendrocyte precursor cells, and thus, the administration of FGF21, DNA encoding FGF21, an FGF21 production-promoting substance, and/or FGF21-producing cells is effective for preventing or treating a demyelinating disease.
    Type: Grant
    Filed: September 8, 2015
    Date of Patent: May 21, 2019
    Assignee: Osaka University
    Inventors: Rieko Ikeda, Mariko Kuroda, Toshihide Yamashita
  • Patent number: 10292595
    Abstract: A method of assessing tissue health comprises the steps of obtaining depth-resolved spectra of a selected area of in vivo tissue, and assessing the health of the selected area based on the depth-resolved structural information of the scatterers. Obtaining depth-resolved spectra of the selected area comprises directing a sample beam towards the selected area at an angle, and receiving an angle-resolved scattered sample beam. The angle-resolved scattered sample beam is cross-correlated with the reference beam to produce an angle-resolved cross-correlated signal about the selected area, which is spectrally dispersed to yield an angle-resolved, spectrally-resolved cross-correlation profile having depth-resolved information about the selected area. The angle-resolved, spectrally-resolved cross-correlation profile is processed to obtain depth-resolved information about scatterers in the selected area.
    Type: Grant
    Filed: June 27, 2017
    Date of Patent: May 21, 2019
    Assignee: Duke University
    Inventors: Adam Wax, John W. Pyhtila
  • Patent number: 10297353
    Abstract: Method and system for determining glucose flux profiles in plasma during meals using continuous glucose sensors and insulin delivery. A database of plausible glucose flux profiles is encoded in dictionaries using sparse dictionary learning. A constrained Lasso minimization problem is formed that integrates a transport model for a patient with the dictionaries for estimating the glucose fluxes. Meal carbohydrates consumed by a patient is incorporated in the minimization problem through convex constraints. The estimated glucose fluxes resulting from solving the constrained Lasso minimization problem are glucose rate of appearance from the intestine, endogenous glucose production from the liver and insulin dependent glucose utilization. A method for determining patient carbohydrate to insulin ratio at the time of the meal by calculating the area under the curve of the estimated insulin dependent glucose utilization.
    Type: Grant
    Filed: May 8, 2018
    Date of Patent: May 21, 2019
    Assignee: Prince Sultan University
    Inventor: Ali Ahmed Al-Matouq
  • Patent number: 10296312
    Abstract: Methods, apparatuses, systems, and implementations of a zero silent data corruption (ZDC) compiler technique are disclosed. The ZDC technique may use an effective instruction duplication approach to protect programs from soft errors. The ZDC may also provide an effective control flow checking mechanism to detect most control flow errors. The ZDC technique may provide a failure percentage close to zero while incurring a lower performance overhead than prior art systems. The ZDC may also be effectively applied in a multi-thread environment.
    Type: Grant
    Filed: May 17, 2017
    Date of Patent: May 21, 2019
    Assignee: Arizona Board of Regents on Behalf of Arizona State University
    Inventors: Aviral Shrivastava, Moslem Didehban