Abstract: A touch and hover sensing device includes a hover sensing module is located on a first surface of a substrate, the hover sensing module includes a plurality of first electrostatic sensing elements and a plurality of second electrostatic sensing elements electrically insulated from each other. Each of the plurality of first electrostatic sensing elements and each of the plurality of second electrostatic sensing elements include a single walled carbon nanotube or few-walled carbon nanotube. A touch sensing module is located on a second surface of the substrate. The hover sensing module and the touch sensing module are connected to a control chip, the control chip controls the hover sensing module and the touch sensing module simultaneously working or working separately, to sense a position coordinate of the sensed object.

Abstract: A processor architecture utilizing a L3 translation lookaside buffer (TLB) to reduce page walks. The processor includes multiple cores, where each core includes a L1 TLB and a L2 TLB. The processor further includes a L3 TLB that is shared across the processor cores, where the L3 TLB is implemented in off-chip or die-stack dynamic random-access memory. Furthermore, the processor includes a page table connected to the L3 TLB, where the page table stores a mapping between virtual addresses and physical addresses. In such an architecture, by having the L3 TLB with a very large capacity, performance may be improved, such as execution time, by eliminating page walks, which requires multiple data accesses.

Abstract: The compositions described herein include an epitope of a peptide that may elicit an immune response in a subject following administration. The compositions may comprise nucleic acids. The compositions may comprise peptides. The methods described herein include administering a composition comprising an epitope of a peptide to a subject in need thereof.

Abstract: The present invention is based, in part, on our discovery of compositions and methods that can be used to treat a patient who has a compromised bone (due, for example, to a disease such as osteoporosis or an injury such as a bone fracture). The compositions can also be administered prophylactically. For example, they can be administered to help maintain bone health as a patient ages. More specifically, the compositions include polypeptides that constitute (or that include) a fragment of a calcitonin receptor (CR) and polypeptides that constitute (or include) biologically active variants of those fragments. Sequence-specific formulas are provided herein, and polypeptides conforming to those formulas, as well as nucleic acids encoding them, expression vectors, host cells, pharmaceutical formulations, and methods of their preparation and use are within the scope of the present invention.

Abstract: Vaccines and compositions containing an attenuated L. monocytogenes prsA2 htrA deletion mutant for use in the presentation of foreign or exogenous antigens and in the treatment or prevention of diseases such as cancer or infectious disease are provided.

Abstract: Methods and apparatus are provided for assessing endothelial function in a mammal. In certain embodiments the methods involve using a cuff to apply pressure to an artery in a subject to determine a plurality of baseline values for a parameter related to endothelial function as a function of applied pressure (Pm); b) applying a stimulus to the subject; and applying external pressure Pm to the artery to determine a plurality of stimulus-effected values for the parameter related to endothelial function as a function of applied pressure (Pm); where the baseline values are determined from measurements made when said mammal is not substantially effected by said stimulus and differences in said baseline values and said stimulus-effected values provide a measure of endothelial function in said mammal.

Abstract: The present application discloses the unexpected result that a neuroactive steroid such as B260 can act as a general anesthetic and that it has no neurotoxic side effects such as impairing brain development.

Abstract: A control system to control a multi-passenger ride vehicle includes a controller. The controller receives a first user feedback from a first user input device and a second user feedback from a second user input device. The controller selects the first user feedback, the second user feedback, or a combination thereof for a determination of a vehicle path of the multi-passenger ride vehicle. The controller determines the vehicle path using the first user feedback, the second user feedback, or the combination thereof based on the selection. The controller controls movement of the multi-passenger ride vehicle based on the vehicle path.

Abstract: The synthetic recycled plastic aggregate for use in concrete is a composite material containing between 30% and 50% by weight shredded recycled plastic, the balance being a filler embedded in a matrix of the recycled plastic. The recycled plastic includes polyethylene terephthalate (PET). The filler can include dune sand, fly ash and quarry fines. The synthetic recycled plastic aggregate is best used to make concrete with a water-to-cement ratio of at least 0.5.

Abstract: The invention generally relates to materials and methods for creating and/or utilizing upconverting luminescence. More particularly, the invention relates to novel compositions (e.g., nanoparticles) and related methods of preparation and use that enable upconverting luminescence with an efficient excitation optimized at about 800 nm. A unique class of cascade sensitized tri-doped UCNPs with a biocompatible 800 nm excitable property are disclosed herein, for example, tri-doped ?-NaYF4:Nd,Yb,Er(Tm)/NaYF4 UCNPs, which employ Nd3+ as 800 nm photon sensitizer and Yb3+ as bridging ions, having strong green or blue upconversion emissions without photobleaching.

Abstract: Compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction.

Abstract: Systems and methods that establish a pressure differential across a tissue wall to encourage complete decellularization of the wall are described. The methods can be utilized for decellularization of blood vessel tissue including heart valves and surrounding tissues. The methods and systems can essentially completely decellularize the treated tissue segments. Systems can be utilized to decellularize one or multiple tissue segments at a single time.

Abstract: Methods, systems, and computer readable media for non-parametric dependence detection using bitwise operations in a computing system are disclosed. One method for non-parametric dependence detection using bitwise operations in a computing system includes receiving a set of p variables, wherein p represents an integer greater than or equal to two. The method also includes generating a set of binary interaction designs (BIDs) using a depth value d and bitwise operations, wherein each of the set of BIDs indicates a dependence structure based on arrangement of partitions in the respective BID. The method further includes determining, using the BIDs generated using bitwise operations in a computing system, non-parametric dependence between the set of p variables. The method also includes performing data analysis involving the set of p variables using the non-parametric dependence between the set of p variables. The method further includes generating output related to the data analysis.

Abstract: An object of the present invention is to provide a pharmaceutical preparation that can promote the proliferation of oligodendrocyte precursor cells to effectively prevent or treat a demyelinating disease. FGF21 acts to promote the proliferation of oligodendrocyte precursor cells, and thus, the administration of FGF21, DNA encoding FGF21, an FGF21 production-promoting substance, and/or FGF21-producing cells is effective for preventing or treating a demyelinating disease.

Abstract: The invention provides articles and methods for making such articles including a substrate coated on at least one region thereof with a layer of nanocomposites nano-cellulose materials and nanoparticles.

Abstract: Site-selective functionalized glycopeptide antibiotics, methods of making and using are described herein. The compounds exhibit improved activity against methicillin-susceptible S. aureus (MSSA), methicillin-resistant S. aureus (MRSA), vancomycin-sensitive S. aureus (VSE), vancomycin-resistant enterococci (VRE), or combinations thereof. The compounds can be administered as the neutral free acid or free base or can be administered as a pharmaceutically acceptable acid-addition or base-addition salt. The compounds can be formulated with one or more pharmaceutically acceptable excipients to prepare pharmaceutical compositions. The compounds can be administered by a variety of routes of administration including enteral, parenteral, topical, or transmucosal.

Abstract: Video streams, either in form of on-demand streaming or live streaming, usually have to be transcoded based on the characteristics of clients' devices. Transcoding is a computationally expensive and time-consuming operation; therefore, streaming service providers currently store numerous transcoded versions of the same video to serve different types of client devices. Due to the expense of maintaining and upgrading storage and computing infrastructures, many streaming service providers recently are becoming reliant on cloud services. However, the challenge in utilizing cloud services for video transcoding is how to deploy cloud resources in a cost-efficient manner without any major impact on the quality of video streams. To address this challenge, in this paper, the Cloud-based Video Streaming Service (CVSS) architecture is disclosed to transcode video streams in an on-demand manner.

Abstract: There is disclosed an organic optoelectronic device comprising two electrodes in superposed relation comprising an anode and a cathode, at least one donor material and at least one acceptor material located between the two electrodes forming a donor-acceptor heterojunction, an anode buffer layer adjacent to the anode and a cathode buffer layer adjacent to the cathode, and an intermediate layer adjacent to at least one of the anode and cathode buffer layers, wherein when the intermediate layer is adjacent to the anode buffer layer, the intermediate layer is chosen to facilitate the transport of holes to the anode buffer layer, and when the intermediate layer is adjacent to the cathode buffer layer, the intermediate layer is chosen to facilitate the transport of electrons to the cathode buffer layer. Also disclosed are methods of making the same.

Abstract: The present disclosure relates to nucleosides, such as compositions, and methods useful for treating retinal damage and/or retinal degradation/retinal degeneration, for inhibiting inflammasome activation by Alu RNA associated with a cell, for reducing ATP-induced permeability of a cell, for reducing an amount of mitochondrial reactive oxygen species in a cell, and for reducing an amount of mitochondrial reactive oxygen species in a cell. The present disclosure further relates to nucleosides, such as compositions, and methods for use in protecting an RPE cell and/or for treating, including prophylactic and therapeutic treatment, of conditions associated with retinal damage and/or degradation including, but not limited to, dry age related macular degeneration (AMD) and wet AMD, Alzheimer disease, various forms of arthritis, atherosclerosis, diabetes mellitus, chronic obstructive pulmonary disease, inflammatory bowel disease, and Duchenne muscular dystrophy.

Abstract: Compositions for enhancing wound healing are disclosed herein. Also disclosed are methods of making the compositions and methods of using the compositions for the prevention of biofilm formation and for the inhibition of pathogen growth and proliferation.