Patents Assigned to University
  • Methods and compositions for cytomegalovirus IL-10 protein
    Patent number: 9321813
    Abstract: The present invention provides methods and compositions for treating and/or preventing a cytomegalovirus infection in a subject, comprising administering to the subject an effective amount of a cytomegalovirus interleukin-10 (IL-10) protein modified to have reduced functional activity while retaining immunogenicity. The present invention further provides nucleic acid molecules encoding a cytomegalovirus IL-10 protein or fragment thereof of this invention as well as vectors comprising such nucleic acids. Also provided herein are neutralizing antibodies that specifically bind cmvIL-10.
    Type: Grant
    Filed: March 27, 2012
    Date of Patent: April 26, 2016
    Assignees: UAB Research Foundation, The Regents of the University of California
    Inventors: Mark R. Walter, Peter A. Barry
  • Production of nanoparticles using homogeneous milling and associated products
    Patent number: 9321700
    Abstract: A method of producing nanoparticles can comprise milling a plurality of milling bodies sufficient to produce the nanoparticles from exterior surfaces of the plurality of milling bodies. In this manner, the milling bodies are simultaneously the milling media and the feedstock for production of nanoparticles such that additional solids are not present during milling. Nanoparticles can be readily formed and optional milling agent and capping agents can be provided to stabilize and/or customize the nanoparticles for a particular application.
    Type: Grant
    Filed: August 6, 2012
    Date of Patent: April 26, 2016
    Assignee: University of Utah Research Foundation
    Inventors: Scott L. Anderson, Brandon McMahon, Jesus Paulo L. Perez
  • Method of making and administering quinoline derivatives as anti-cancer agents
    Patent number: 9321730
    Abstract: The present invention relates methods of preparing quinoline derivative compounds, and administering such compounds in the treatment of solid and non-solid tumors, notably on liver cancer.
    Type: Grant
    Filed: August 21, 2007
    Date of Patent: April 26, 2016
    Assignee: The Hong Kong Polytechnic University
    Inventors: Albert Sun-chi Chan, Johnny Cheuk-on Tang, Kim-hung Lam, Chung-hin Chui, Stanton Hon-lung Kok, Sau Hing Chan, Filly Cheung, Roberto Gambari, Chor Hing Cheng
  • SPST switch, SPDT switch, SPMT switch and communication device using the same
    Patent number: 9324512
    Abstract: Various embodiments provide a single pole single throw switch. The switch may include a first terminal, a second terminal and a control terminal; a field-effect transistor having a drain connected to the first terminal, a source connected to the ground, and a gate; a bias resistor connected between the gate of the field-effect transistor and the control terminal; an inductor connected between the first terminal and the second terminal; and a capacitor having one end connected to the second terminal and another end connected to the ground.
    Type: Grant
    Filed: November 28, 2012
    Date of Patent: April 26, 2016
    Assignee: Nanyang Technological University
    Inventors: Jin He, Yue Ping Zhang
  • Constructs and methods for the assembly of biological pathways
    Patent number: 9322023
    Abstract: The present invention is directed to a synthetic nucleic acid scaffold comprising one or more subunits, each subunit comprising two or more different protein-binding sequences coupled together. The present invention further relates to systems and methods for assembling a synthetic biological pathway and producing a biological pathway product or a precursor product using the synthetic nucleic acid scaffold.
    Type: Grant
    Filed: October 9, 2012
    Date of Patent: April 26, 2016
    Assignee: Cornell University
    Inventors: Matthew Delisa, Robert Conrado
  • Compositions and methods for treating bladder cancer
    Patent number: 9321820
    Abstract: The present invention provides methods and compositions for treating bladder cancer. In particular, the present invention provides a fusion protein comprising a toxin moiety that is linked to an epithelial growth factor (EGF) moiety. The toxin moiety and the EGF moiety can be linked optionally via a linker. Typically, the fusion protein is administered intravesically into the cancerous bladder.
    Type: Grant
    Filed: October 14, 2010
    Date of Patent: April 26, 2016
    Assignees: The Regents of the University of Colorado, Scott & White Healthcare
    Inventors: Thomas Flaig, Arthur E. Frankel, Andrew Thorburn, Michael L. Glode
  • Multifunctional metal nanoparticles having a polydopamine-based surface and methods of making and using the same
    Patent number: 9320719
    Abstract: The present invention provides nanoparticles including a metallic core having a length along each axis of from 1 to 100 nanometers and a coating disposed on at least part of the surface of the metallic core, wherein the coating comprises polydopamine, along with methods for making and using such nanoparticles. The metallic core may be gold, silver or iron oxide and the polydopamine coating may have other substances bound to it, such as silver, targeting ligands or antibodies, or other therapeutic or imaging contrast agents. The disclosed nanoparticles can be targeted to cells for treating cancer or bacterial infections, and for use in diagnostic imaging.
    Type: Grant
    Filed: June 3, 2014
    Date of Patent: April 26, 2016
    Assignee: Northwestern University
    Inventors: Phillip B. Messersmith, Kvar C. L. Black, IV, Ji Yi, Jose G. Rivera
  • Small molecule inhibitors of the pleckstrin homology domain and methods for using same
    Patent number: 9320734
    Abstract: Pleckstrin homology domain binding compounds, pharmaceutical compositions including such compounds, and methods for their use are described herein.
    Type: Grant
    Filed: January 5, 2015
    Date of Patent: April 26, 2016
    Assignees: Board of Regents, The University of Texas System, Arizona Board of Regents on behalf of the University of Arizona
    Inventors: Daruka Mahadevan, Emmanuelle J. Meuillet, Eugene A. Mash, Jr., Vijay M. Gokhale, Garth Powis, Shuxing Zhang
  • Separation apparatus and processes
    Patent number: 9321057
    Abstract: An apparatus may include a separator and/or a discharger. A separator may include a separator channel, an influent portion configured to allow the passage of a first fluid into a separator channel, an effluent portion disposed above an influent portion and/or a fluid-lift portion between an influent portion and an effluent portion. A discharger may be disposed below a fluid-lift portion and/or may include a portion external to a separator channel, which may include a downward angle relative to an effluent portion and/or may be configured to minimize the passage of a second fluid into a discharger as the second fluid buoyantly travels in a separator channel from an influent portion to an effluent portion. A second fluid may have a density that is less than the density of a first and/or may be configured to lift a first fluid to a fluid-lift portion.
    Type: Grant
    Filed: November 21, 2011
    Date of Patent: April 26, 2016
    Assignee: Savannah State University
    Inventors: Christopher Hintz, Amber Wilkinson
  • Radiation pattern insulator and multiple antennae system thereof and communication device using the multiple antennae system
    Patent number: 9325063
    Abstract: A radiation pattern insulator and an antennae system thereof are proposed. The radiation pattern insulator includes a dielectric substrate and a plurality of radiation pattern insulation elements. The dielectric substrate allocated between a plurality of antennae includes a top surface and a bottom surface, and a normal direction of the dielectric substrate is substantially perpendicular to propagation directions of electromagnetic waves radiated from the antennae. In addition, the radiation pattern insulation elements are allocated on the top surface or the bottom surface of the dielectric substrate, or alternatively, all allocated on the top surface and the bottom surface.
    Type: Grant
    Filed: January 2, 2014
    Date of Patent: April 26, 2016
    Assignees: Industrial Technology Research Institute, National Sun Yat-sen University
    Inventors: Chun-Yih Wu, Hung-Hsuan Lin, Ken-Huang Lin, Hsin-Lung Su, Chih-Chun Hsu
  • Semi-rigid shoulder braces and related methods
    Patent number: 9320635
    Abstract: Shoulder braces for inhibiting secondary anterior shoulder dislocations that are configured to allow for a wide range of motion for mobility and stabilization, include a brace body with a single arm portion configured to reside about a shoulder of a user and a torso portion, a plurality of shoulder straps extending over the single arm portion shoulder, a substantially rigid thermoplastic insert releasably held by the arm portion of the brace body. The insert can have a user-specific custom shape that substantially conforms to shoulder anatomy of the shoulder of the user. The brace can also include at least one adjustable length laterally extending torso strap attached to the torso portion.
    Type: Grant
    Filed: August 20, 2013
    Date of Patent: April 26, 2016
    Assignee: Clemson University Research Foundation
    Inventors: Chelsea Lea Ex-Lubeskie, Meredith Cole Donaldson, Riley Morgan Csernica, Kaitlin Kathleen Grove, Charles Alden Thigpen
  • B-cell antigen presenting cell assay
    Patent number: 9322827
    Abstract: Disclosed herein are methods for diagnosing or predicting B-cell rejection in a subject. In one example, for assessing transplant rejection, the method includes determining an antigen presenting index by comparing uptake of a donor antigen to uptake of a reference antigen in a biological sample obtained from the subject. In another example, for assessing GVHD, the method includes determining an antigen presenting index by comparing uptake of a recipient antigen to uptake of a reference antigen in a biological sample obtained from the subject.
    Type: Grant
    Filed: April 8, 2011
    Date of Patent: April 26, 2016
    Assignee: University of Pittsburgh - Of the Commonwealth System of Higher Education
    Inventors: Rakesh Sindhi, Chethan AshokKumar
  • Method for the concentration and detection of virus
    Patent number: 9322071
    Abstract: Disclosed is an economic method for concentrating virus and detecting virus, such that virus in a sample solution having low virus concentration can be concentrated with high efficiency within a short time. Particularly, the method comprising the steps of: (A) adding Concanavalin A (Con A) to a sample solution containing a virus, and reacting the added Concanavalin A with the virus in the sample solution to form a virus-Concanavalin A conjugate; and (B) separating the virus-Concanavalin A conjugate from the sample solution.
    Type: Grant
    Filed: September 29, 2014
    Date of Patent: April 26, 2016
    Assignees: Korea Basic Science Institute, Industry Foundation of Chonnam National University
    Inventors: Joseph Kwon, Jong-Soon Choi, Duwoon Kim, Hee-Min Lee
  • Controllable normal force mechanism with minimum energy consumption
    Patent number: 9321466
    Abstract: Force control system. The system includes a first pair of permanent magnets for providing a normal force on the wheel of a robot adapted for n-pipe inspections. A second pair of magnets is provided with opposite polarity so that a rotor containing magnets may be rotated with a minimum of torque required and therefore with a minimum of energy expended.
    Type: Grant
    Filed: April 1, 2013
    Date of Patent: April 26, 2016
    Assignees: Massachusetts Institute of Technology, King Fahd University of Petroleum and Minerals
    Inventors: Changrak Choi, Dimitrios Chatzigeorgiou, Rached Ben-Mansour, Kamal Youcef-Toumi
  • Multi-beam combining apparatus
    Patent number: 9325149
    Abstract: A multi-beam combining apparatus includes a phase shifting section, a superposing section, an observing section and a phase control section. The phase shifting section generates a plurality of phase-shifted laser beams by shifting the phase of each of the plurality of laser beams. The superposing section generates a plurality of superposed laser beam by superposing the reference laser beam and each of the plurality of phase-shifted laser beams. The observing section generates interference pattern data of a spatial interference pattern which appears when observing each of the superposed laser beams. The phase control section carries out a feedback control of the phase shifts in the phase shifting section based on the interference pattern data obtained for every superposed laser beam, and thereby sets the plurality of phase-shifted laser beams to desired states.
    Type: Grant
    Filed: January 17, 2013
    Date of Patent: April 26, 2016
    Assignees: Mitsubishi Heavy Industries, Ltd., Institute for Laser Technology, Osaka University
    Inventors: Koichi Hamamoto, Takahiro Yamada, Haik Chosrowjan, Hiroaki Furuse, Masayuki Fujita, Yasukazu Izawa, Junji Kawanaka, Noriaki Miyanaga
  • Topoisomerase inhibitors
    Patent number: 9321781
    Abstract: The invention provides compounds of formula I: (I) wherein A, B, W, Y, Z, R1, R3 and R4 have any of the meanings defined in the specification and their salts as well as additional compounds and their salts. The invention also provides pharmaceutical compositions comprising a compound of the invention, processes for preparing compounds of the invention, intermediates useful for preparing compounds of the invention, and therapeutic methods for treating cancer, a bacterial infection or a fungal infection using compounds of the invention.
    Type: Grant
    Filed: November 4, 2010
    Date of Patent: April 26, 2016
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Edmond J. Lavoie, Ajit K. Parhi
  • Rapid synthesis of silicon carbide-carbon composites
    Patent number: 9321692
    Abstract: Production of pore-free carbon/carbon-silicon carbide composite materials with mechanical properties making them suitable for use in such applications as the production of aircraft landing system brake components including brake discs. The method includes: providing a porous carbon-carbon composite preform; surrounding the porous carbon-carbon composite preform with silicon powder to form an intermediate construct; applying a uniaxial load to the construct; applying direct electrical current to an assembly containing the loaded construct of porous carbon-carbon preform surrounded by silicon powder, thereby melting the silicon powder and infiltrating the pores of the carbon-carbon preform with liquid silicon; and initiating a combustion-type reaction between the silicon and carbon in the preform, thereby forming silicon carbide in the preform.
    Type: Grant
    Filed: July 31, 2009
    Date of Patent: April 26, 2016
    Assignees: Honeywell International Inc., The University of Notre Dame du Lac
    Inventors: Manuel Koucouthakis, Douglas J. Steinke, Alexander Mukasyan, Jeremiah D. E. White
  • Dendritic macroporous hydrogels prepared by crystal templating
    Patent number: 9320827
    Abstract: The present invention includes a hydrogel and a method of making a porous hydrogel by preparing an aqueous mixture of an uncrosslinked polymer and a crystallizable molecule; casting the mixture into a vessel; allowing the cast mixture to dry to form an amorphous hydrogel film; seeding the cast mixture with a seed crystal of the crystallizable molecule; growing the crystallizable molecule into a crystal structure within the uncrosslinked polymer; crosslinking the polymer around the crystal structure under conditions in which the crystal structure within the crosslinked polymer is maintained; and dissolving the crystals within the crosslinked polymer to form the porous hydrogel.
    Type: Grant
    Filed: May 14, 2014
    Date of Patent: April 26, 2016
    Assignee: Board of Regents, The University of Texas System
    Inventors: Scott Zawko, Christine Schmidt
  • Cell targeting methods and compositions
    Patent number: 9321992
    Abstract: In certain aspects, the invention relates to cell delivery compositions comprising a chondrogenic cell and a targeting moiety. Such compositions may be used, for example, in administering a targeted cell therapy to a subject.
    Type: Grant
    Filed: June 13, 2003
    Date of Patent: April 26, 2016
    Assignee: Case Western Reserve University
    Inventors: James E. Dennis, Arnold I. Caplan, Nir Cohen
  • Pants
    Patent number: D754418
    Type: Grant
    Filed: August 20, 2013
    Date of Patent: April 26, 2016
    Assignee: Respect Your Universe, Inc.
    Inventor: Daniela Caine