Abstract: Methods for inhibition of hairless protein mRNA using RNA interference is described, in particular methods for hair removal. Also described are nucleic acid constructs for RNAi-mediated inhibition of hairless protein mRNA and compositions including such constructs.

Abstract: The present invention provides a novel amphiphilic substance, a nanoparticle using the novel amphiphilic substance, which can be used as a nanocarrier having high biocompatibility, a drug delivery system and a probe useful for the system, and, a molecular imaging system and a probe useful for the system. An amphiphilic block polymer comprising a hydrophilic block; and a hydrophobic block, wherein the hydrophilic block is a hydrophilic polypeptide chain having 10 or more sarcosine units, and the hydrophobic block is a hydrophobic molecular chain comprising units selected from the group consisting of amino acid units and hydroxyl acid units as essential structural units, and having 5 or more of the essential structural units.

Abstract: A method of performing timing error detection includes receiving, by a multi-core processor, a data stream and up-sampling the data stream by a plurality of processing cores of the multi-core processor. The up-sampling is performed in parallel by the plurality of processing cores. The method includes selecting one sample per symbol of the data stream to generate a sampled data output. The method also includes performing symbol timing recovery based on the sampled data output to adjust a resampling point.

Abstract: An evaluation device is adapted for providing a transceiver system with performance information thereof. The transceiver system models a channel between a transmitter and a receiver thereof using Nakagami distribution with a fading parameter. The evaluation device includes a signal-to-noise ratio (SNR) computing module, a capacity computing module, and an output module. The SNR computing module is operable to set an average SNR for the channel between the transmitter and the receiver, and to compute an expected value and variance of an effective SNR of the transceiver system according to the fading parameter and the average SNR. The capacity computing module is operable to compute an outage capacity of the transceiver system based upon the expected value and the variance of the effective SNR and a transmission outage parameter. The output module is operable to provide the transceiver system with the average SNR and the outage capacity.

Abstract: A method for producing light emission, including the following steps: providing a transistor structure that includes a semiconductor base region disposed between a semiconductor emitter region and a semiconductor collector region; providing a cascade region between the base region and the collector region, the cascade region having a plurality of sequences of quantum size regions, the quantum size regions of the sequences varying, in the direction toward the collector region, from a relatively higher energy state to a relatively lower energy state; providing emitter, base and collector electrodes respectively coupled with the emitter, base, and collector regions; and applying electrical signals with respect to the emitter, base, and collector electrodes to cause and control light emission from the cascade region.

Abstract: An insertion device and an endoscope which are inserted and extracted through a small incision and have multiple functions. A device body has grip forceps as a treatment means. A first folding back section and a second folding back section are provided at a distal portion of the device body such that the first and second folding back sections are aligned in a row in the longitudinal direction of the device body. The first folding back section and the second folding back section respectively have image obtaining means. An operation means can move the first folding back section to a folded back position in which the first folding back section is folded back relative to the second folding back section, and can also move the second folding back section to a position in which the second folding back section is folded back relative to the device body.

Abstract: A medical instrument including a shaft rotating device for rotating a shaft of a medical instrument about its longitudinal axis relative to a handle of the medical instrument The shaft rotating device includes a operating element arranged at a proximal portion of the shaft such that the shaft is rotatable relative to the handle against frictional forces. The shaft rotating device includes a coil spring arrangement having a surface and being in frictional contact with a surface of a counterpart for keeping the shaft and the handle rotationally stationary with respect to each other and movable against frictional forces. The operating element is operatively connected with the coil spring arrangement such that torque applied to the operating element decreases the frictional forces, while the shaft and coil spring arrangement are operatively connected such that torque applied to a distal portion of the shaft increases the frictional forces.

Abstract: A process for producing ammonium nitrate is disclosed, which process comprises exposing a gaseous oxidiser feed composed at least substantially of ammonia, steam and an oxidising gas to conditions whereby the ammonia is oxidised to produce a reaction mixture including nitrogen monoxide and water vapour. The reaction mixture is cooled in a heat exchanger whereby the nitrogen monoxide is oxidised, the water vapour is condensed and the products of the nitrogen monoxide oxidation react with and are absorbed by the condensed water to form a nitric acid stream, with substantially all of the nitrogen monoxide in the reaction mixture being converted to nitric acid. The nitric acid stream is reacted with a stream of ammonia to form the ammonium nitrate.

Abstract: This invention provides a method for reducing hypertropic scarring resulting from dermal wound healing in a subject in need which comprises administering to the subject an antisense oligonucleotide which inhibits expression of connective tissue growth factor (CTGF) in an amount effective to inhibit expression of CTGF and thereby reduce hypertrophic scarring.

Abstract: The present invention provides methods for inhibiting or blocking TGF-? activity in cells and/or tissues expressing TGF-? comprising, contacting cells and/or tissues expressing TGF-? with an amount of cholesterol or cholesterol derivative effective to inhibit the activity of TGF-?. The present invention further provides a method for treating a condition associated with overactivity of TGF-? or negative regulation in normal physiology by TGF-? in a subject in need of treatment, comprising contacting cells and/or tissue overexpressing TGF-? in the subject with an amount of cholesterol or cholesterol derivative effective to inhibit activity of TGF-? thereby treating the condition. In a preferred embodiment, the cholesterol derivative is oxidized 7-DHC.

Abstract: Provided herein are polycyclic ?-lactam compounds, compositions thereof and methods for the treatment and prevention of diseases such as cancer, including pancreatic cancer and pancreatic cancers resistant to mainline chemotherapeutic agents.

Abstract: Room temperature IR and UV photodetectors are provided by electrochemical self-assembly of nanowires. The detectivity of such IR detectors is up to ten times better than the state of the art. Broad peaks are observed in the room temperature absorption spectra of 10-nm diameter nanowires of CdSe and ZnS at photon energies close to the bandgap energy, indicating that the detectors are frequency selective and preferably detect light of specific frequencies. Provided is a photodetector comprising: an aluminum substrate; a layer of insulator disposed on the aluminum substrate and comprising an array of columnar pores; a plurality of semiconductor nanowires disposed within the pores and standing vertically relative to the aluminum substrate; a layer of nickel disposed in operable communication with one or more of the semiconductor nanowires; and wire leads in operable communication with the aluminum substrate and the layer of nickel for connection with an electrical circuit.

Abstract: A light fixture includes a ballast and a plurality of lamps connected to the ballast in parallel. The ballast provides an output signal to the plurality of lamps as a function of a 1st steady state condition. When the ballast senses an end-of-life condition for a lamp of the plurality of lamps, the ballast increases the frequency of the output signal provided to the plurality of lamps until the lamp ceases to conduct current. When the lamp ceases to conduct current, the ballast decreases the frequency of the output signal to a frequency determined as a function of a 2nd steady state condition different from the 1st steady state condition. A total current of the 2nd steady state condition is proportional to a total current of the 1st steady state condition as a function of the number of lamps exhibiting an end-of-life condition.

Abstract: Computer-implemented method, system, and techniques for summarization, searching, and indexing of video are provided, wherein data related to objects detected in the video in a selected time interval is received and the objects are clustered into clusters such that each cluster includes objects that are similar in respect to a selected feature or a combination of features. A video summary is generated based on the computed clusters.

Abstract: Memory cells are described with cross-coupled inverters including unidirectional gate conductors. Gate conductors for access transistors may also be aligned with a long axis of the inverter gate conductor. Contacts of one inverter in a cross-coupled pair may be aligned with a long axis of the other inverter's gate conductor. Separately formed rectangular active regions may be orthogonal to the gate conductors across pull up, pull down and access transistors. Separate active regions may be formed such that active regions associated with an access transistor and/or a pull up transistor are noncontiguous with, and narrower than, an active region associated with a pull down transistor of the inverter. The major components of 6T SRAM, and similar, memory cell topologies may be formed essentially from an array of rectangular lines, including unidirectional gate conductors and contacts, and unidirectional rectangular active regions crossing gate conductors of the inverters and access transistors.

Abstract: The invention relates to methods for treating pain disorders including neuropathic and inflammatory pain and to methods to reduce or eliminate nociceptive tolerance induced by opiate analgesic use by administering an agent that suppresses or blocks S1P biological activity.

Abstract: The methods and compositions described herein are based, in part, on the discovery of a polypeptide of soluble CD23 (sCD23) that binds and sequesters IgE. Thus, the sCD23 peptides, polypeptides and derivatives described herein are useful for treating conditions or disorders involving increased IgE levels such as e.g., allergy, anaphylaxis, inflammation, lymphoma, and certain cancers.

Abstract: Provided herein is technology relating to deuterated amlexanox and particularly, but not exclusively, to compositions comprising deuterated amlexanox, methods of producing deuterated amlexanox, and uses of deuterated amlexanox.

Abstract: A computer-implemented process, system, and computer-readable storage medium having stored thereon, program code and instructions for 3-D triangulation-based image acquisition of a contoured surface/object-of-interest under observation by at least one camera, by projecting onto the surface-of-interest a multi-frequency pattern comprising a plurality of pixels representing at least a first and second superimposed sinusoid projected simultaneously, each of the sinusoids represented by the pixels having a unique temporal frequency and each of the pixels projected to satisfy I n p = A p + ? k = 1 K ? B k p ? cos ? ( 2 ? ? ? ? f k ? y p + 2 ? ? ? ? kn N ) Eq . ? ( 1.1 ) where Inp is the intensity of a pixel in the projector for nth projected image in a particular instant in time; K is an integer representing the number of component sinusoids (e.g.

Abstract: The present invention provides templating methods for replicating patterned metal films from a template substrate such as for use in plasmonic devices and metamaterials. Advantageously, the template substrate is reusable and can provide plural copies of the structure of the template substrate. Because high-quality substrates that are inherently smooth and flat are available, patterned metal films in accordance with the present invention can advantageously provide surfaces that replicate the surface characteristics of the template substrate both in the patterned regions and in the unpatterned regions.