Abstract: The invention relates to diazo bicyclic Smac mimetics that are tethered through a covalent linker to give a bivalent species. Bivalent diazo bicyclic Smac mimetics function as inhibitors of Inhibitor of Apoptosis Proteins (IAPs). The invention also relates to the use of bivalent diazo bicyclic Smac mimetics for inducing or sensitizing cells to the induction of apoptotic cell death. Thus, compounds of the invention are useful in the treatment, amelioration, or prevention of hyperproliferative diseases such as cancer.
Type:
Grant
Filed:
October 20, 2010
Date of Patent:
August 26, 2014
Assignee:
The Regents of the University of Michigan
Abstract: Disclosed are molecules and their synthesis, for use in blocking gated ion channels such as voltage-gated sodium channels (VGSCs) and prostate voltage sodium channels (PVSCs). These inhibitors have superior blocking efficacy, for instance in displacing the radioligand [3H]-Batrachotoxin-B ([3H]-BTX-B) that binds to site 2 of a VGSC. The molecules of the invention comprise a moiety which increases the binding affinity of molecules for the protein binding site in prostate cancer cells (PCs), and which is also fluorescent. In one embodiment the invention molecules are an inhibition system that can be used to target over-abundant or hyperactive VGSCs selectively in pain, epilepsy or prostate cancer, inhibiting the proliferation of PCs. The fluorescent moiety also facilitates screening, tracking, and pharmacodynamic studies of the drug in a biological system both in vitro and in vivo.
Type:
Grant
Filed:
August 17, 2009
Date of Patent:
August 26, 2014
Assignee:
Georgetown University
Inventors:
Milton L. Brown, Scott Grindrod, Thomas H. Walls, Todd Hansen, Simeng Suy, Mikell A. Paige
Abstract: Methods, devices, and systems for imaging tissue and other samples or samples using infrared (IR) transmissions from coherent transmission sources, such as a wide range, tunable, quantum cascade laser (QCL) designed for the rapid collection of infrared microscopic data for medical diagnostics across a wide range of discrete spectral increments. The infrared transmissions are transmitted through, reflected from, and/or transreflected through a sample, and then magnified and/or focused prior to being detected by a detector. After detection, the sample related image data is used to assess the sample. Such methods, devices, and systems may be used to detect abnormalities in tissue, for example, before such abnormalities can be diagnosed using art cytopathological methods. The methods, devices and systems may also optionally include a visible light detection subsystem and/or a motion control subsystem to assist in control and processing of imaging.
Abstract: A mirror assembly adapted for use in a panoramic imaging system for capturing a panoramic image includes a mirror for optically coupling to a fisheye lens having a first field of view, the mirror configured for reflecting an image of a second field of view through the fisheye lens. A housing has a first end and a second end, the mirror being secured proximate to the first end, and the second end having an engagement portion for securing the mirror assembly to the panoramic imaging system. When the mirror assembly is secured to the panoramic imaging system, the mirror is optically coupled to the fisheye lens and a detector for capturing a first portion of the panoramic image and a second portion of the panoramic image, the first portion of the panoramic image having a portion overlapping the second portion of the panoramic image.
Type:
Grant
Filed:
April 22, 2011
Date of Patent:
August 26, 2014
Assignee:
The Trustees of Columbia University in the City of New York
Abstract: The invention provides methods and compositions for simultaneously detecting the activation state of a plurality of proteins in single cells using flow cytometry. The invention further provides methods and compositions of screening for bioactive agents capable of coordinately modulating the activity of a plurality of proteins in single cells. The methods and compositions can be used to determine the protein activation profile of a cell for predicting or diagnosing a disease state, and for monitoring treatment of a disease state.
Type:
Grant
Filed:
April 26, 2011
Date of Patent:
August 26, 2014
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Abstract: The present invention provides novel chemical compounds characterized as Rho kinase (ROCK) inhibitors, methods for their discovery, and their therapeutic, research, and diagnostic use. In particular, the present invention provides 1,4-benzodiazepine-2,5-dione compounds and related compounds having ROCK inhibitory activity, and methods of using such compounds as therapeutic agents to treat a number of conditions associated with ROCK activity.
Type:
Grant
Filed:
November 3, 2010
Date of Patent:
August 26, 2014
Assignee:
The Regents of the University of Michigan
Abstract: A system for use in forming polymer compositions, including as a replacement for phenolic based resin systems, for instance, in preparing foundry molds. In a preferred embodiment, the system includes the use of a) a polyermizable hydroxyl-containing component comprising a humic substance (as can be provided by lignite), b) an isocyanate component, and c) a catalyst, and preferably amine catalyst, component adapted to catalyze the polymerization of a) and b). The system is optionally used as binder system in the presence of a filler, such as, in combination with a foundry aggregate such as sand. A polymer system of this invention can be substantially free of formaldehyde or phenol, and preferably contains little or no aromatic solvents.
Type:
Grant
Filed:
November 14, 2008
Date of Patent:
August 26, 2014
Assignee:
University of Northern Iowa Research Foundation
Abstract: The present disclosure relates to photosensitive optoelectronic devices including a compound blocking layer located between an acceptor material and a cathode, the compound blocking layer including: at least one electron conducting material, and at least one wide-gap electron conducting exciton blocking layer. For example, 3,4,9,10 perylenetetracarboxylic bisbenzimidazole (PTCBI) and 1,4,5,8-napthalene-tetracarboxylic-dianhydride (NTCDA) function as electron conducting and exciton blocking layers when interposed between the acceptor layer and cathode. Both materials serve as efficient electron conductors, leading to a fill factor as high as 0.70. By using an NTCDA/PTCBI compound blocking layer structure increased power conversion efficiency is achieved, compared to an analogous device using a conventional blocking layers shown to conduct electrons via damage-induced midgap states.
Type:
Grant
Filed:
February 21, 2012
Date of Patent:
August 26, 2014
Assignee:
The Regents of the University of Michigan
Abstract: A nanostructured particulate material, which includes a redox active luminescent organic and/or ionic compound, is provided herein. The nanostructured particulate material may be used for determining the presence of an analyte of interest in a sample by detecting the emitted electromagnetic radiation generated by exposing a reagent mixture, which includes the nanostructured material and the target analyte, to chemical or electrochemical energy.
Type:
Grant
Filed:
February 8, 2013
Date of Patent:
August 26, 2014
Assignee:
Board of Regents of the University of Texas System
Inventors:
Allen J. Bard, Fu-Ren F. Fan, Jiaguo Yu, Khalid Omer
Abstract: This present invention relates to methods, compositions, and kits useful for treating a patient having or at risk for developing a disorder associated with decreased expression of ?2 adrenergic receptors or need for increased 132 adrenergic receptor activity.
Abstract: The present invention is directed to the biosynthetic pathway for a nonribosomal peptide synthetase (NRPS) derived drug and analogs thereof. The invention also discloses polynucleotide sequences useful for heterologous expression in a convenient microbial host for the synthesis of the NRPS derived drug.
Type:
Grant
Filed:
April 15, 2011
Date of Patent:
August 26, 2014
Assignees:
The Regenys of the University of Michigan, Allegheny-Singer Research Institute, Colorado State University Research Foundation
Inventors:
David H. Sherman, Garth D. Ehrlich, Benjamin Janto, Robert M. Williams, Christopher M. Rath
Abstract: An electrochemistry apparatus comprises a supporting body and a reaction layer for generating electromotive force. The supporting body is made of a first material. The reaction layer covers the surface of the supporting body and comprises an ion conductive layer, a first film electrode and a second film electrode. The first and the second film electrodes are separately formed on two opposite surfaces of the ion conductive layer. The ion conductive layer is made of a second material having a thermal expansion coefficient approximating to the thermal expansion coefficient of the first material. The second material has an ionic conductivity greater than the ionic conductivity of the first material. The first material has a toughness greater than the second material. The electrochemistry apparatus employs the supporting body with improved toughness and the ion conductive layer with improved ion conductivity, so as to increase sensitivity and thermal shock resistance.
Type:
Grant
Filed:
April 18, 2011
Date of Patent:
August 26, 2014
Assignee:
National Taiwan University of Science and Technology
Abstract: A new analytical technique, instrument and method of testing a material utilizing same is provided. The method of analyzing a test material comprises the steps of (vii) inducing an acoustic emission from a vessel containing a solvent and measuring said emissions; (viii) dissolving a known amount of the test material in the solvent; measuring changes in resonance and absorbance frequencies before and after dissolution to produce a broadband acoustic resonant dissolution emission profile.
Type:
Grant
Filed:
April 21, 2009
Date of Patent:
August 26, 2014
Assignee:
University College Cork—National University of Ireland
Abstract: A system and method for protecting information on a mobile device. The method and apparatus obtain a predetermined portion of asymmetric information upon an input of the asymmetric information in the mobile device; generate an identifier by using a first generating algorithm that uses the predetermined portion of the asymmetric information as an algorithm input; generate an encryption key by using a second generating algorithm that uses the predetermined portion of the asymmetric information as an algorithm input; generate ciphered information by using an encryption algorithm that uses the encryption key and the information as algorithm inputs; associate the identifier with the ciphered information; and store the ciphered information as associated with the identifier.
Type:
Grant
Filed:
April 29, 2011
Date of Patent:
August 26, 2014
Assignee:
Georgetown University
Inventors:
Ophir Frieder, Micah Sherr, Jordan Wilberding
Abstract: The present invention provides methods for universally detecting citrus viroids in plant material such as germplasm. In particular embodiments, the invention enables the determination of citrus viroid infection and plant resistance. Accordingly, the present method provides methods for improved universal detection of any citrus viroid.
Type:
Grant
Filed:
November 7, 2012
Date of Patent:
August 26, 2014
Assignee:
The Regents of the University of California
Abstract: A microfiltration apparatus and method for separating cells, such as circulating tumor cells, from a sample using a microfiltration device having a top porous membrane and a bottom porous membrane. The porous membranes are formed from parylene and assembled using microfabrication techniques. The porous membranes are arranged so that the pores in the top membrane are offset from the pores in the bottom membrane.
Type:
Grant
Filed:
December 29, 2011
Date of Patent:
August 26, 2014
Assignees:
California Institute of Technology, University of Southern California
Inventors:
Siyang Zheng, Richard Cote, Henry Lin, Bo Lu, Yu-Chong Tai
Abstract: 9-aminonoscapine, prodrugs thereof, and pharmaceutically acceptable salts thereof, are disclosed. Pharmaceutical compositions including 9-aminonoscapine, and methods of preparation and use thereof are disclosed. 9-aminonoscapine is a noscapine analog that can be used to treat and/or prevent a wide variety of cancers, including drug resistant cancers, by binding tubulin and inducing apoptosis selectively in tumor cells (ovarian and T-cell lymphoma) resistant to paclitaxel, vinblastine and teniposide. 9-aminonoscapine can perturb the progression of cell cycle by mitotic arrest, followed by apoptotic cell death associated with increased caspase-3 activation and appearance of TUNEL-positive cells. Thus, 9-aminonoscapine is a novel therapeutic agents for a variety of cancers, including ovarian and T-cell lymphoma cancers, even those that have become drug-resistant to currently available chemotherapeutic drugs.
Type:
Grant
Filed:
February 8, 2013
Date of Patent:
August 26, 2014
Assignee:
Emory University
Inventors:
Harish C. Joshi, Ritu Aneja, Surya N. Vangapandu
Abstract: A method of increasing the insulin sensitivity of insulin resistant cells includes administering to the cells an amount of all-trans-retinoic acid effective to activate transcription factor perosixome proliferator-activated receptor (PPAR) ?/? of the cells.
Abstract: In one embodiment, a silicon-based atomic clock for use in an electronic device includes a single-isotope silicon crystal and energy level transitions within the silicon are used as a frequency resonance of the clock.
Abstract: The present invention relates to a method of embodying a cooperation system between SEND and IPSec in an IPv6 environment. The cooperation system between SEND and IPSec in accordance with the present invention includes: receiving an authentication completion report message including a first IP address of a host whose authentication is completed by the SEND; generating new authentication information corresponding to the host and storing the new authentication information in a temporary storage area, if authentication information for the host is not present in the temporary storage area, wherein the authentication information includes the first IP address; and if an authentication check request message including a second IP address is received from the IPSec, checking whether the second IP address is present in the temporary storage area, and sending the result of checking to the IPSec.
Type:
Grant
Filed:
February 29, 2008
Date of Patent:
August 26, 2014
Assignee:
Sungkyunkwan University Foundation for Corporate Collaboration