Patents Assigned to University
  • Patent number: 8673872
    Abstract: The present invention relates to a method for modulating the expression of epidermal growth factor receptor (EGFR) and its downstream signalling effectors. In particular, the present invention relates to a method for modulating the expression of epidermal growth factor receptor (EGFR) or like molecule in a cell comprising contacting said cell with an agent capable of directly or indirectly interacting with the 3?-untranslated region (UTR) of the mRNA of said EGFR or like molecule, wherein the UTR is encoded by a sequence which comprises a sequence having at least about 70% identity with at least one sequence selected from the group consisting of the sequences set forth in SEQ ID NOs: 1-36.
    Type: Grant
    Filed: August 28, 2007
    Date of Patent: March 18, 2014
    Assignee: The University of Western Australia
    Inventors: Peter Leedman, Keith Giles, Rebecca Jane Webster
  • Patent number: 8675119
    Abstract: A system (100) for the adaptive imaging of a scene includes a digital light processing apparatus (150) adapted for controllably reflecting an image of the scene in at least a first direction to thereby reflect an intensity modulated image of the scene along at least the first direction, an image detector (140) for detecting the intensity modulated image of the scene and generating corresponding image data, and an image data processor (154) for processing the image data into control data and providing the control data to the digital light processing (150) apparatus for control thereof.
    Type: Grant
    Filed: August 8, 2002
    Date of Patent: March 18, 2014
    Assignee: Trustees of Columbia University in the City of New York
    Inventors: Shree K. Nayar, Terrance E. Boult
  • Patent number: 8673031
    Abstract: A product comprising at least one densified biomass particulate of a given mass having no added binder and comprised of a plurality of lignin-coated plant biomass fibers is provided, wherein the at least one densified biomass particulate has an intrinsic density substantially equivalent to a binder-containing densified biomass particulate of the same given mass and h a substantially smooth, non-flakey outer surface. Methods for using and making the product are also described.
    Type: Grant
    Filed: August 24, 2010
    Date of Patent: March 18, 2014
    Assignee: Board of Trustees of Michigan State University
    Inventors: Bruce E. Dale, Bryan Ritchie, Derek Marshall
  • Patent number: 8673913
    Abstract: A method of treating SHP-2 phosphatase associated diseases in a subject includes administering a SHP-2 inhibitor to the subject.
    Type: Grant
    Filed: November 15, 2010
    Date of Patent: March 18, 2014
    Assignee: Case Western Reserve University
    Inventors: Cheng-Kui Qu, Wen-Mei Yu, Olgun Guvench, Alexander D. Mackerell, Jr.
  • Patent number: 8673984
    Abstract: Perfluorocarbon emulsions having a high stability and good oxygen release are disclosed and described. These perfluorocarbon emulsions are typically for use as artificial oxygen carriers. The perfluorocarbon emulsions include a disperse phase of a perfluorocarbon and an emulsion stabilizer, and continuous phase. The emulsion stabilizer can primarily include a poly(ethylene oxide) block copolymer. These stabilized perfluorocarbon emulsions can be used in liquid and/or hydrogel phases of perfusion bioreactors or various other culture systems to enhance cell viability in thick tissue constructs, or as blood substitutes, although other applications may also be considered.
    Type: Grant
    Filed: December 8, 2009
    Date of Patent: March 18, 2014
    Assignee: University of Utah Research Foundation
    Inventors: Natalya Y. Rapoport, Glenn D. Prestwich, Russell Morris Condie
  • Patent number: 8673748
    Abstract: An apparatus (100) for fabricating a semiconductor thin film includes: substrate surface pretreatment means (101) for pretreating a surface of a substrate; organic layer coating means (102) for coating, with an organic layer, the substrate thus pretreated; focused light irradiation means (103) for irradiating, with focused light, the substrate coated with the organic layer, and for forming a growth-mask layer while controlling layer thickness; first thin film growth means (104) for selectively growing a semiconductor thin film over an area around the growth-mask layer; substrate surface treatment means (105) for, after exposing the surface of the substrate by removing the growth-mask layer, modifying the exposed surface of the substrate; and second thin film growth means (106) for further growing the semiconductor thin film and growing a semiconductor thin film over the modified surface of the substrate.
    Type: Grant
    Filed: March 5, 2010
    Date of Patent: March 18, 2014
    Assignee: Osaka University
    Inventors: Hisashi Matsumura, Shunro Fuke, Yasuo Kanematsu, Kazuyoshi Itoh
  • Patent number: 8673897
    Abstract: The invention provides 1,4-benzodiazepinone compounds, pharmaceutical compositions, and methods of treating autoimmune disorders, chronic inflammatory disorders, and hyperproliferative disorders. For example, the 1,4-benzodiazepinone compounds and pharmaceutical compositions are contemplated to be useful for treating rheumatoid arthritis, graft-versus-host disease, inflammatory bowel disease, and the like.
    Type: Grant
    Filed: September 17, 2010
    Date of Patent: March 18, 2014
    Assignee: The Regents of the University of Michigan
    Inventors: Gary D. Glick, Alexander Ross Hurd, Chad Alan Van Huis
  • Patent number: 8674594
    Abstract: A light-emitting device comprises a substrate; a light-emitting layer formed on the substrate; a transparent electrode layer formed on the light-emitting layer, the transparent electrode layer having a curved surface; and a reflective layer formed on and along the curved surface of the transparent electrode layer such that the curved surface of the transparent electrode layer is transferred so as to reflect the light generated from the light-emitting layer toward the light-emitting layer.
    Type: Grant
    Filed: December 15, 2011
    Date of Patent: March 18, 2014
    Assignee: Korea University Industrial & Academic Collaboration Foundation
    Inventors: Tae-Geun Kim, Wan-Ho Lee
  • Patent number: 8675139
    Abstract: There is provided an image/video processor comprises an embedded memory for image/video data that including a plurality of unit memory blocks including a plurality of memory cells; and a controller configured to store each bit of image/video data received through an input/output unit in each memory cell, read the image/video data stored in each memory cell of the embedded memory, and output the image/video data through the input/output unit, wherein at least two or more memory cells included in the plurality of memory cells have different sizes, the controller assign each bit of the image/video data depending on the importance of the image/video data and a size of the memory cell, and as the size of the memory cell is larger, a bit of image/video data of high importance is assigned.
    Type: Grant
    Filed: December 29, 2011
    Date of Patent: March 18, 2014
    Assignee: Korea University Research and Business Foundation
    Inventors: Jongsun Park, Jinmo Kwon
  • Patent number: 8673371
    Abstract: Disclosed is a composition for treating or preventing vitiligo or canities comprising Sophora japonica extract as an active ingredient. The Sophora japonica extract enhances melanin synthesis by increasing the activity of tyrosinase which is critical in intracellular melanin synthesis and promoting the expression of tyrosinase and TRP-2 mRNA. Furthermore, since the Sophora japonica extract is a natural substance with little cytotoxicity, it may be developed into a therapeutic agent for vitiligo and canities caused by depigmentation in skin and hair.
    Type: Grant
    Filed: October 20, 2011
    Date of Patent: March 18, 2014
    Assignee: Keimyung University Industry Academic Cooperation Foundation
    Inventors: Young Chul Kim, Chul Ho Kang, Eun Ye Park, Sang Nam Kim
  • Patent number: 8674695
    Abstract: For example, the present disclosure provides exemplary embodiments of a coil arrangement that can include, e.g., a plurality of elements which can be provided at an angle from one another. The angle can be selected to effectuate an imaging of a target region of interest at least one of a predetermined depth or range of depths, for example. In certain exemplary embodiments according to the present disclosure, the angle can be selected to effectuate an exemplary predetermined transmit efficiency for at least one of the elements. Additionally, the exemplary angle can be selected to effectuate a predetermined receive sensitivity for at least one of the elements. Further, according to certain exemplary embodiments of a coil arrangement in according to the present disclosure, the angle can be adjusted manually and/or automatically.
    Type: Grant
    Filed: April 1, 2010
    Date of Patent: March 18, 2014
    Assignee: New York University
    Inventor: Graham Charles Wiggins
  • Patent number: 8673633
    Abstract: The present invention provides a method for producing customized pluripotent stem cells. Specifically, the present invention comprises following steps: extracting proteins from any of the dedifferentiated stem cells or induced pluripotent stem cells, the said dedifferentiated or pluripotent stem cells being prepared by any known method; introducing the protein extract into the adult somatic cells; and culturing the adult somatic cells to produce pluripotent stem cells having the same pluripotency as that of embryonic stem cells. In addition, pluripotent stem cells produced according to the present method and cell therapeutics comprising the same are provided. The method allows pluripotent stem cells to be produced very easily and at a significantly higher yield, compared to typical methods.
    Type: Grant
    Filed: September 17, 2010
    Date of Patent: March 18, 2014
    Assignee: Seoul National University Hospital
    Inventors: Young-Bae Park, Hyo-Soo Kim, Yoo-Wook Kwon, Hyun-Jai Cho, Jae-Seung Paek
  • Patent number: 8673926
    Abstract: Compounds, methods, and compositions for the treatment of infections in or exposure to humans and other host animals of Flaviviridae viruses, including HCV, that includes the administration of an effective amount of a spiro[2.4]heptane as described herein or a pharmaceutically acceptable salt or prodrug thereof, optionally in a pharmaceutically acceptable carrier, are provided. The spiro[2.4]heptane compounds either possess antiviral activity, or are metabolized to a compound that exhibits such activity.
    Type: Grant
    Filed: February 14, 2013
    Date of Patent: March 18, 2014
    Assignee: University of Georgia Research Foundation, Inc.
    Inventor: Chung K. Chu
  • Patent number: 8674461
    Abstract: The invention provides combination semiconductor and plasma devices, including transistors and phototransistors. A preferred embodiment hybrid plasma semiconductor device has active solid state semiconductor regions; and a plasma generated in proximity to the active solid state semiconductor regions. Devices of the invention are referred to as hybrid plasma-semiconductor devices, in which a plasma, preferably a microplasma, cooperates with conventional solid state semiconductor device regions to influence or perform a semiconducting function, such as that provided by a transistor. The invention provides a family of hybrid plasma electronic/photonic devices having properties previously unavailable. In transistor devices of the invention, a low temperature, glow discharge is integral to the hybrid transistor. Example preferred devices include hybrid BJT and MOSFET devices.
    Type: Grant
    Filed: July 16, 2013
    Date of Patent: March 18, 2014
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Paul A. Tchertchian, Clark J. Wagner, J. Gary Eden
  • Patent number: 8673316
    Abstract: Chimeric flaviviruses that are avirulent and immunogenic are provided. The chimeric viruses are constructed to contain amino acid mutations in the nonstructural viral proteins of a flavivirus. Chimeric viruses containing the attenuation-mutated nonstructural genes of the virus are used as a backbone into which the structural genes of a second flavivirus strain are inserted. These chimeric viruses elicit pronounced immunogenicity yet lack the accompanying clinical symptoms of viral disease. The attenuated chimeric viruses are effective as immunogens or vaccines and may be combined in a pharmaceutical composition to confer simultaneous immunity against several strains of pathogenic flaviviruses.
    Type: Grant
    Filed: August 18, 2011
    Date of Patent: March 18, 2014
    Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services, Centers for Disease Control and Prevention, Mahidol University
    Inventors: Richard M. Kinney, Claire Y. H. Kinney, Duane J. Gubler, Siritorn Butrapet, Natth Bhamarapravati
  • Patent number: 8673672
    Abstract: In the present invention, copper(I) selenide (Cu2-xSe) nanoparticles are fabricated by pyrolysis in an inert atmosphere. Uniformly dispersed Cu2-xSe particles are synthesized by altering Cu/Se ratio, the concentration of Se Precursors (TOP Se), reaction time and temperature. Analysis by inductively coupled plasma atomic emission spectroscopy (ICP-AES) of said Cu2-xSe nanoparticles reveals that the composition of the nanoparticles is Cu 1.95Se, wherein x=0.05. In addition, Cu2-xSe is dissolved in ethanol to deposit thin films by electrophoretical deposition (EPD) in an inert atmosphere, wherein a positive electrode and a negative electrode are employed. The positive electrode is made of stainless steel plate and the negative electrode is made of indium tin oxide on a glass substrate. Investigations on properties and surface morphology thereof in different electrophoretical conditions are carried out. The rate of EPD is found to significantly influence the quality of thin films.
    Type: Grant
    Filed: July 12, 2012
    Date of Patent: March 18, 2014
    Assignee: National Chung Cheng University
    Inventors: Chu-Chi Ting, Wen-Yuan Lee
  • Patent number: 8673285
    Abstract: The present invention concerns the use of a sphingoid-polyalkylamine conjugate as a capturing agent of biologically active molecules, such as antigens. In a particular embodiment, the spinogid-polyalkylamines are used for the preparation of pharmaceutical composition for modulating the immune response of a subject. Other aspects of the invention concern methods for modulating the immune response of a subject by the use of the conjugate, complexes comprising, the sphingoid-polyalkylamine conjugate in combination with a biologically active molecule capable of modulating an immune response of a subject, compositions comprising the conjugate as well as kits making use of said conjugate. A preferred conjugate according to the invention is N palmitoyl D-erythro sphingosyl 1 carbamoyl spermine.
    Type: Grant
    Filed: June 17, 2004
    Date of Patent: March 18, 2014
    Assignees: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd., Biolab Ltd.
    Inventors: Yechezkel Barenholz, Aviva Joseph, Eliezer Kedar
  • Patent number: 8673294
    Abstract: An immunoisolation patch system, and particularly a patch system comprising multiple immunoisolation microcapsules, each encapsulating biological material such as cells for transplantation, which can be used in the prophylactic and therapeutic treatment of disease in large animals and humans without the need for immunosuppression.
    Type: Grant
    Filed: April 23, 2009
    Date of Patent: March 18, 2014
    Assignee: Vanderbilt University
    Inventor: Taylor G. Wang
  • Patent number: 8673363
    Abstract: A method is provided for mineralizing a dental surface or subsurface including contacting the dental surface with a protein disrupting agent and stabilized amorphous calcium phosphate (ACP) or amorphous calcium fluoride phosphate (ACFP).
    Type: Grant
    Filed: June 7, 2006
    Date of Patent: March 18, 2014
    Assignee: The University of Melbourne
    Inventor: Eric Charles Reynolds
  • Patent number: RE44807
    Abstract: A method and system for real-time tracking of objects is are disclosed. A region is repeatedly scanned providing a plurality of images or data sets having points corresponding to ojbects objects in the region to be tracked. Given a previously determined track for each object in the region, an M-dimensional combinatorial optimization assignment problem is formulated using the points from M-1 of the images or data sets, wherein each point is preferably used in extending at most one track. The M-dimensional problem is subsequently solved for an optimal or near-optimal assignment of the points to the tracks, extending the tracking of the objects so that a response to each object can be initiated by the system in real-time. Speed and accuracy is provided by an iterative Lagrangian Relaxation technique wherein a plurality of constraint dimensions are relaxed simultaneously to yield a reduced dimensional optimization problem whose solution is used to formulate an assignment problem of dimensionality less than M.
    Type: Grant
    Filed: May 25, 2001
    Date of Patent: March 18, 2014
    Assignee: Colorado State University Research Foundation
    Inventor: Aubrey B. Poore, Jr.