Abstract: Compounds comprising peptides and peptidomimetics capable of binding C3 protein and inhibiting complement activation are disclosed. These compounds display greatly improved complement activation-inhibitory activity as compared with currently available compounds.

Abstract: The present invention concerns an assay for the detection of polyketide synthetase (PKS) mRNA from the red tide dinoflagellate Karenia brevis. Another aspect of the invention concerns NASBA primers and a molecular beacon that enable detection of mRNA of one of the PKS genes. In another aspect, the present invention includes an internal control RNA (IC-RNA) that enables quantitative detection of the target as well as correction for inhibition of amplification. The assay of the invention provides a rapid and specific detection of the putative toxin-producing genes of the Florida Red Tide Organism. The assay of the invention is useful for determining the virulence of red tide blooms.

Abstract: The present invention relates to the use of TROY, also called tumor necrosis factor receptor superfamily, member 19 (TNFRSF 19) also called toxicity and JNK inducer (TAJ), in diagnosis and therapy of non-epithelial cancers, such as melanoma. Accordingly, the invention provides in vitro and in vivo diagnostic and/or prognostic methods for cancers, other than epithelial cancers, preferably melanoma, comprising analyzing TROY expression in a biological sample from an individual or in an individual, wherein expression of TROY in non-epithelial cells, such as in melanocytes, in indicative the biological sample or the individual containing malignant cells, such as malignant melanoma cells. The invention also provides therapeutic use of TROY targeting molecules, such as TROY antibodies or TROY targeting RNA interfering agents for treatment of cancer wherein the cancer cells express TROY.

Abstract: The invention provides an AtCel5 promoter isolated from Arabidopsis thaliana that is expressed exclusively in root cap cells of both primary and secondary roots. AtCel5 is believed to be a soluble and secreted protein that plays a role in the sloughing of root cap cells from the root tip. The sloughing of root cap cells from the root tip is important because it assists the growing root in penetrating the soil. The AtCel5 gene promoter provides a new molecular marker to further analyze the process of root cap cell separation and also provides a root cap specific promoter for targeting to the environment genes with beneficial properties for plant growth.

Abstract: Disclosed is a weight vector computing unit using a symbol-rate, a chip-rate and/or a mixed-rate in a Smart Antenna System. The weight vector computing unit is useful in a wireless communication network having a reverse pilot channel. Further, by using such the weight vector computing unit, high-speed broadband communications are available in a smart antenna system. In such 3-G wireless communications where both traffic signals and pilot signals are transmitted from a terminal, the weight vector computing unit calculates optimized weight vectors using the pilot signal and the calculated weight vectors are adapted to each traffic signal. The weight vector computing unit is configured to receive the received signal and/or the integrated signal in order to produce a weight vector for beamforming without any training signal.

Abstract: Included in the digital filtering equipment for extracting a feature quantity from a speech signal in order to execute a speech recognition based on an inputted speech signal are: a) an waveform determining section for obtaining an inputted speech signal and quantizing the speech signal waveform; b) a division value operating section for summing a quantized signal data in a prescribed adjoining region to divide the summation value by the number of summed data, with respect to a data quantized at each point by the waveform determining section, whereby a division value is obtained with the data being centered; c) a comparison section for comparing a division value calculated by the division value operating section and the quantized data calculated in the division value operating section to output logical truth of a comparison result, with respect to each data; and d) a conversion section for converting the quantized data into the selected data points based on an output from the comparison section.

Abstract: A system and method in accordance with the present invention include means for providing interactive assistance for the performance of a set of predefined steps, including selecting the set of predefined steps and automatically generating a step-sensitive grammar for each step. Generating the step-sensitive grammar includes generating a set of navigation commands related to each step and generating a set of rules to recognize potential queries related to each step. A recognizer is configured for determining if a received utterance forms one of the navigation commands or one of the potential queries, within a context of the current step. Form this determination, provided are navigation to a different step if the utterance was a navigation command or a response if the utterance was a query.

Abstract: A ballast having fused leads protects against uncommon, but harmful, ballast failures. The fused leads prevent a current in the primary coil of the ballast from exceeding a potentially damaging value. A thermal protector shorts the primary ballast coil if the temperature of the secondary ballast coil exceeds a potentially damaging value. Since the thermal protector permanently disables the ballast, potentially damaging repetitive overheating of the ballast is prevented.

Abstract: Methods and systems for determining a location of a photon event for an imaging system including a plurality of 3-D detectors. For one of the photons in the photon pair, an interaction in a first 3-D detector is detected. For the other of the photons in the photon pair, at least two interactions in a second 3-D detector are detected. A cone-surface projector function is produced based on the at least two interaction locations in the second 3-D detector. A projector function is produced based on the produced cone-surface projector function, the detected interaction in the first 3-D detector, and the at least two detected interactions in the second 3-D detector.

Abstract: A biocomposite is produced from natural fiber fabrics embedded in a matrix of biosynthetic polyhydroxy-alkanoate (PHA) polymers. The PHA is synthesized using aerobic microbial biosynthesis using mixed bacterial cultures and a feedstock containing anaerobic degradation products such as methane and volatile fatty acids derived from microbial biodegradation of organic waste materials, which may include waste biocomposites. Monomers may be added to the synthesized PHA polymer to control mechanical properties of the resulting biocomposite. The natural fibers and/or PHA may be pretreated using various techniques to improve the bond between the fibers and the PHA resin matrix and water absorption resistance of the fibers. The composite may be a laminate of treated and untreated fabric layers, or differently treated layers, to achieve good in-service performance as well as rapid and/or optimal biogas production when taken out of service and put in an anaerobic environment to degrade.

Abstract: Racemic mixtures and enantiomerically pure forms of novel 1-[(2?-substituted)-piperazin-1?-yl]-isoquinolines are norepinephrine (NE) transporter (NET) inhibitor compounds. Compounds of the invention are considered therapeutic agents for central nervous system (CNS) diseases and disorders, without limitation, including neurodegeneration, anxiety, depression, attention deficit disorders, drug dependency, and post traumatic stress disorder. Examples of the chemical syntheses of the compounds of the invention are provided. The isoquinoline compounds of the invention competitively bind at NET at nanomolar concentrations. The isoquinoline agents of the invention bind selectively to NET over other competitive transporter targets and receptor binding sites, including those of serotonin and dopamine, amongst others. The chemical syntheses of the invention are suitable for labeling with radionuclide atoms.

Abstract: The present invention relates to methods and compositions for predicting drug responses. In particular, the present invention provides methods and compositions for determining individualized Warfarin dosages based on genotype of DNA polymorphisms and haplotypes derived from them in the VKORC1 gene.

Abstract: The present methods are exemplified by a process in which maternal blood containing fetal DNA is diluted to a nominal value of approximately 0.5 genome equivalent of DNA per reaction sample. Digital PCR is then be used to detect aneuploidy, such as the trisomy that causes Down Syndrome. Since aneuploidies do not present a mutational change in sequence, and are merely a change in the number of chromosomes, it has not been possible to detect them in a fetus without resorting to invasive techniques such as amniocentesis or chorionic villi sampling. Digital amplification allows the detection of aneuploidy using massively parallel amplification and detection methods, examining, e.g., 10,000 genome equivalents.

Abstract: Methods are provided for identifying and selecting candidate molecules that activate glucose transport through binding of the insulin receptor at a site other than the insulin binding site. The methods include analyzing the properties of one or more candidate molecules in terms of the ability to bind the insulin receptor and activate glucose transport. Optionally the methods include, competitive assays in the presence of the glucose receptor, a candidate molecule, and one or more of insulin, alpha PGG and beta PGG.

Abstract: The present invention provides a method of forming coatings of at least two different coating molecules on at least two electrodes, the method comprising: (a) providing an array of at least two individually-addressable electrodes, (b) allowing a layer of a masking molecule to adsorb onto all electrodes, (c) inducing electrochemical desorption of the masking molecule from at least one but not all electrodes to expose a first set of exposed electrodes, (d) allowing a first coating molecule to adsorb onto the first set of exposed electrodes, (e) exposing all electrodes to a masking molecule to allow adsorption of the masking molecule onto all electrodes, (f) inducing electrochemical desorption of masking molecule from a second set of electrodes to expose a second set of exposed electrodes, (g) allowing a second coating molecule to adsorb onto the second set of exposed electrodes.

Abstract: The invention relates to a method for increasing biogas production of thermophilic anaerobe systems. More closely, a biomass containing a consortium comprising polymer-degrading, acetogenic and methanogenic microorganisms is inoculated with a microorganism culture before the start of or during biogas production. Said microorganism is a thermophilic, acetogenic, hydrogen producing bacterium. As an example, Caldicellulosiruptor saccharolyticus is applied. According to the invention production if methane containing biogas is significantly increased. The invention is useful for intensifying biogas production and thereby increasing its feasibility.

Abstract: The present invention concerns antibodies that neutralize at least one biological activity of pleiotrophin. The antibodies can inhibit cancer cell growth and angiogenesis in vitro or in vivo. The present invention provides for methods of inhibiting cancer cell growth or angiogenesis in a subject comprising administering to said subject an effective amount of the antibodies described herein. The present invention also provides for methods of making the neutralizing antibodies described herein.

Abstract: Algorithms are described that facilitate the inference of a network topology by estimating router co-ordinates and merging anonymous routers. The algorithms have practical applications in the inference of a network topology as part of the provision of a network service that is based on the underlying topology and where knowledge of the actual topology allows improved performance.

Abstract: A computer-implemented method for correcting transmission errors. According to the method, a transmitted vector corrupted by error can be recovered solving a linear program. The method has applications in the transmission of Internet media, Internet telephony, and speech transmission. In addition, error correction is embedded as a key building block in numerous algorithms, and data-structures, where corruption is possible; corruption of digital data stored on a hard-drive, CD, DVD or similar media is a good example. In short, progress in error correction has potential to impact several storage and communication systems.

Abstract: A substrate comprises a surface, and a plurality of moieties, on at least a portion of the surface. The moieties are moieties of formula: Surf-L-Q-T, where -T comprises a reactant ligand, and Surf- designates where the moiety attaches to the surface. The substrate can be made into a protein chip by the reaction of a reactant ligand and a fusion polypeptide, where the fusion polypeptide includes a capture polypeptide moiety which corresponds to the reactant ligand.