Abstract: This is a method and an apparatus for the introduction of therapeutic compounds into tissue, particularly cardiac tissue. The apparatus includes a catheter having an elongated flexible body and a tissue infusion apparatus including a hollow infusion needle configured to secure the needle into the tissue when the needle is at least partially inserted into the tissue to help prevent inadvertent removal of the needle from the tissue. This permits the selected therapeutic compound to be delivered to a specific site. The catheter may also include a visualization assembly including a transducer at the distal end of the body.
Type:
Grant
Filed:
August 12, 2003
Date of Patent:
September 14, 2010
Assignee:
The Regents of the University of California
Abstract: The invention provides a colorimetric and/or fluorescent detector, which is a solid organic matrix, most preferably in the form of a gel, comprising polydiacetylene(s) and one or more lipids. Processes for preparing the detector and methods for using the same, including for the detection of microorganism suspected to be present in food products, are also provided.
Type:
Grant
Filed:
January 9, 2006
Date of Patent:
September 14, 2010
Assignee:
Ben-Gurion University of the Negev Research and Development Authority
Abstract: Nucleic acid and amino acid sequences of the Omp85 proteins of N. gonorrhoeae and N. meningitidis, and fragments thereof are useful in vaccine compositions, therapeutic compositions and diagnostic compositions for use in the prevention, treatment and diagnosis of non-symptomatic gonococcal infection or symptomatic disease and non-symptomatic meningococcal infection and symptomatic disease. Antibodies are developed to these proteins and also useful in the compositions and methods described herein.
Abstract: An electrode for an electro-optic device has a wetting layer of electrically conductive material formed on a substrate. A second layer of electrically conductive material is formed on the wetting layer of electrically conductive material. The wetting layer has a first wetting ability with respect to a surface of the substrate and the second layer has a second wetting ability with respect to the surface of said substrate. The first wetting ability is different from the second wetting ability and the wetting layer acts to alter an optical property of the electrode due to the wetting ability of the wetting layer on the surface of the substrate.
Type:
Grant
Filed:
October 24, 2005
Date of Patent:
September 14, 2010
Assignee:
The Regents of the University of California
Abstract: A method of optimizing a flow process in resin transfer molding can include the steps of pre-infusing a vacuum-assisted resin transfer mold with a liquid. A sequence of the mold pre-infusion step is detected, from which a flow inhomogeneity adjacent the auxiliary infusion gate is determined. Such a flow inhomogeneity can include, for example, a region where air bubbles can collect, leaving a dry spot in the mold that is not adequately reached by flowing liquid or resin. A resin infusion sequence can then be created, including an opening of the auxiliary infusion gate following a passage of resin therepast to prevent the formation of dry spots.
Type:
Grant
Filed:
January 9, 2008
Date of Patent:
September 14, 2010
Assignee:
Florida State University Research Foundation, Inc.
Inventors:
Chun Zhang, Zhiyong Liang, Hsu-Pin Wang
Abstract: A bymixer device and method which provides fast-response, accurate measurements of mixed inspired and/or expired gas fractions in open or closed ventilation circuits and/or in circle circuits used in anesthesia and/or critical care. The bymixer device may include a main flow channel and a bypass flow channel. The bypass flow channel includes a flow-restrictor (e.g, an orifice) that partially blocks the flow of respiratory gas through the bypass flow channel, a mixing chamber positioned upstream of the flow restrictor and a sampling apparatus (e.g., a port for withdrawing samples of gas from said mixing chamber and/or sensor(s) positioned within the mixing chamber).
Type:
Grant
Filed:
October 14, 2003
Date of Patent:
September 14, 2010
Assignee:
The Regents of the University of California
Abstract: The invention is directed to novel cells that are derived from human embryoid bodies. Such embryoid body-derived (EBD) cells are relatively uncommitted or progenitor (e.g., pluripotent) cells. EBD cells, while not immortal, display long-term proliferation in culture with a normal karyotype and can be cryopreserved and cloned. They can be efficiently transfected with retroviruses and lentivirus and genetically manipulated. Although they have a developmentally broad multilineage expression profile, they do not form tumors when injected into severe combined immunodeficiency (SCID) mice. As a result, EBD cells have a variety of uses, for example, in transplantation therapies.
Type:
Grant
Filed:
January 22, 2001
Date of Patent:
September 14, 2010
Assignee:
The Johns Hopkins University School of Medicine
Abstract: In one embodiment of the present invention, an information identification device, an information identification method, and an information identification system each of which can maintain a high security level and which can be used for a long time without any restrictions on use conditions are realized. An ID identification system includes: an ID identifying medium containing a rare-earth complex; and an ID identification device for identifying identification information corresponding to the rare-earth complex.
Type:
Grant
Filed:
August 22, 2006
Date of Patent:
September 14, 2010
Assignees:
National University Corporation, Nara Institute of Science and Technology
Abstract: A cell of a semiconductor device comprises a substrate of n-type with a trench formed in a portion of a first main surface of the substrate and filled with insulator. Two device-feature regions are formed beneath the first main surface of the substrate, the first one at one side and the second one at the other side of the trench. A region of a p-type and/or a region of metal is formed in the first device feature region and is connected to a first electrode. A p-n junction is formed in the second device feature region and the p-region of the p-n junction is connected to a second electrode. A U-shaped region is formed between the two device regions. An IGBT without tail during turning-off can be fabricated with a simple process at a low cost.
Type:
Grant
Filed:
August 25, 2008
Date of Patent:
September 14, 2010
Assignee:
University of Electronic Science and Technology
Abstract: The present invention provides for a method to circumvent the problem of using antibiotic resistant selectable markers. In particular, target plants are transformed using a plastid vector which contains heterologous DNA sequences coding for a phytotoxin detoxifying enzyme or protein. The selection process involves converting a antibiotic-free phytotoxic agent by the expressed phytotoxin detoxifying enzyme or protein to yield a nontoxic compound. The invention provides for various methods to use antibiotic-free selection in chloroplast transformation.
Type:
Grant
Filed:
December 19, 2003
Date of Patent:
September 14, 2010
Assignees:
University of Central Florida Research Foundation, Inc., Auburn University
Abstract: A method is provided for measurement of dispersion or other optical and mechanical properties within a waveguide by inducing four-photon mixing at different locations within the waveguide by timing a pump signal to counter-collide with and abruptly amplify or attenuate one or both of a probe pulse and a signal pulse at each location. The measurement of the components of the resulting mixing signal created by each collision is used to calculate dispersion defined by the location at which the collision occurred. By combining the measurements from all of the locations, a spatial map of dispersion or other optical or mechanical properties within the waveguide can be generated.
Type:
Grant
Filed:
September 18, 2008
Date of Patent:
September 14, 2010
Assignee:
The Regents of the University of California
Abstract: The present invention relates to a coating composition including a sol-gel matrix and a dendrimeric organochalcogeno derivative and a system including the coating composition and a substrate. The present invention also relates to a method of preventing fouling of surfaces subjected to a marine environment.
Type:
Grant
Filed:
July 6, 2007
Date of Patent:
September 14, 2010
Assignee:
The Research Foundation of State University of New York
Inventors:
Michael R. Detty, Michael D. Drake, Ying Tang, Frank V. Bright
Abstract: The invention provides a fusion protein comprising a flagellin adjuvant and a Yersinia pestis antigen. Also provided are compositions comprising a flagellin adjuvant and a Yersinia pestis antigen. The invention also discloses methods of making a fusion protein comprising a flagellin adjuvant and a Yersinia pestis antigen. The invention further provides pharmaceutical formulations and methods for inducing an immune response against Yersinia pestis.
Abstract: Methods of producing carbon nanostructures utilizing a polymer and a nanostructure template to form carbon nanostructures are disclosed. The method does not require a metal catalyst.
Type:
Grant
Filed:
June 20, 2006
Date of Patent:
September 14, 2010
Assignee:
The Hong Kong University of Science and Technology
Abstract: This invention provides a nanodisk, which can be formed of a wide variety of materials and has a high level of application, and a method for manufacturing the same. The nanodisk comprises fundamental units formed of two-molecule block copolymers arranged in series in a main chain direction, the fundamental units having been aggregated in a plane direction. The nanodisk has a thickness of 1 nm to 100 nm, a diameter of 10 nm to 5 ?m, and an aspect ratio of not less than 1. Since the thickness of the nanodisk is not more than 100 nm, the nanodisk is transparent to light in a visible region. Further, when a metal element is held on the crosslinked structure part, the nanodisk can be utilized as a nanodisk having magnetic properties and electroconductive properties, or a nanodisk having catalytic activity and a high refractive index. Thus, the nanodisk can be applied to a wide variety of fields such as fine particle/powder technology, colloid surface science, electronic materials, and optical materials.
Type:
Grant
Filed:
February 2, 2007
Date of Patent:
September 14, 2010
Assignee:
National University Corporation Hokkaido University
Abstract: Compounds of Formulas I-II are described, along with methods of using such compounds for the treatment of cancer and pharmaceutical formulations thereof.
Type:
Grant
Filed:
January 16, 2009
Date of Patent:
September 14, 2010
Assignee:
The University of North Carolina at Chapel Hill
Inventors:
Kuo-Hsiung Lee, Xihong Wang, Kenneth F. Bastow, Tian-Shung Wu
Abstract: Compositions and methods are described for non-viral nucleic acid delivery. A targeting peptide capable of mediating targeting to a cell or subcellular compartment is derivatized with a photoaffinity label. Following an ionic interaction with a polynucleotide, such as DNA, and photolysis, the bioactive peptide becomes covalently attached to the DNA. Upon contact with a cell, the peptide facilities uptake of the peptide-polynucleotide conjugate into the cell or subcellular compartment. Methods for using this system for delivery of structural genes, including reporter genes, and detection of expression using bioluminescence are also described.
Type:
Grant
Filed:
June 4, 2007
Date of Patent:
September 14, 2010
Assignee:
University of Iowa Research Foundation
Inventors:
Kevin G. Rice, Garrett R. Rettig, Nicholas J. Baumhover
Abstract: Example scalable multi-protocol label switching (MPLS) based virtual private networks (VPNs) and methods to implement the same are disclosed. A disclosed example spoke provider edge (PE) router for an MPLS-based VPN includes a truncated virtual routing and forwarding (VRF) table containing a first value referencing a hub PE router and a second value referencing a first customer edge (CE) router coupled to the VPN via the PE router, and a forwarding module to forward a packet received from the first CE router to the hub PE router when the packet contains an address referencing a second CE router coupled to the VPN via a second spoke PE router.
Type:
Grant
Filed:
May 30, 2008
Date of Patent:
September 14, 2010
Assignees:
AT&T Intellectual Property I, L.P., Trustees of Princeton University
Inventors:
Alexandre Gerber, Subhabrata Sen, Carsten Lund, Dan Pei, MohammadTaghi Hajiaghayi, Changhoon Kim
Abstract: The present invention is directed to mutants of lysine decarboxylase, nucleic acids encoding the mutants, and vaccines comprising the mutants for inhibiting and reducing the development of periodontal diseases, including gingivitis and chronic periodontitis. The vaccine composition comprises a recombinant lysine decarboxylase mutant which is based on a native version of the enzyme from E. corrodens and induces production of antibodies that inhibit the activity of the lysine decarboxylase enzyme in the oral cavity. The recombinant lysine decarboxylase mutant, in one version, comprises a mutation at residue 365 or at other locations within the active site, and in a preferred embodiment is produced from E. coli in large amounts and to form inclusion bodies. The purified inclusion bodies can then be used in the vaccine composition to induce in vivo production of antibodies that inhibit the activity of native E. corrodens lysine decarboxylase.
Type:
Grant
Filed:
December 5, 2008
Date of Patent:
September 14, 2010
Assignee:
The Boards of Regents of the University of Oklahoma
Abstract: A method of magnetic resonance analysis of a body having therein at least one molecular species and water is disclosed. The method comprises, subtracting magnetic resonance signals induced by a second radiofrequency pulse sequence from magnetic resonance signals induced by a first radiofrequency pulse sequence followed by a evolution period. The first radiofrequency pulse sequence is selected so as to suppress magnetization for the water while preserving a generally longitudinal magnetization to the at least one molecular species. The second radiofrequency pulse sequence being selected so as to suppress transverse and longitudinal magnetization for both the water and the at least one molecular species.