Abstract: The present invention is to provide an inhibitor that inhibits differentiation of T cells into Th1 cells. The inhibitor that inhibits differentiation of T cells into Th1 cells contains, as an active ingredient, pitavastatin or a salt thereof.

Abstract: The present invention relates to compounds capable of acting as androgen receptor antagonists, pharmaceutical formulations containing the same, and methods of use thereof. Such uses include, but are not limited to, use as antitumor agents, particularly for the treatment of cancers such as colon, skin and prostate cancer and to induce androgen receptor antagonist activity in a subject afflicted with an androgen-related affliction. Examples of androgen-related afflictions include, but are not limited to, baldness, hirsutism, behavioral disorders, acne, and uninhibited spermatogenesis wherein inhibition of spermatogenesis is so desired.

Abstract: Disclosed is a novel anti-obesity agent. Also disclosed is a therapeutic method using the anti-obesity agent. The anti-obesity agent comprises a GABAB receptor agonist or a pharmacologically acceptable salt thereof as an active ingredient.

Abstract: One aspect of the invention relates to isoform-selective HDAC inhibitors. Also provided are methods of sensitizing a cancer cell to the cytotoxic effects of radiotherapy. The invention also provides methods for treating cancer, methods for treating neurological diseases and methods for treating malaria. Additionally, the invention provides pharmaceutical compositions comprising an HDAC inhibitor of the invention; and kits comprising a an HDAC inhibitor of the invention.

Abstract: A method and system for cancelling body movement effect for non-contact vital sign detection is described. The method begins with sending on a first electromagnetic wave transceiver a first electromagnetic signal with a first frequency to a first side of a body, such as a person or animal. Simultaneously using a second electromagnetic wave transceiver a second electromagnetic signal is sent with a second frequency to a second side of a body, wherein the first frequency and the second frequency are different frequencies. A first reflected electromagnetic signal reflected back in response to the first electromagnetic wave on the first transceiver is received and a first baseband complex signal is extracted. Likewise a second reflected electromagnetic signal reflected back in response to the second electromagnetic wave on the second transceiver is received and a second baseband complex signal is extracted.

Abstract: Compositions comprising nanoparticles (e.g., nanocrystals) of stishovite silica are described. Such nanoparticles may be made by (1) subjecting a mesoporous silica starting material (e.g., SBA-16 or KIT-6) to a pressure of less than about 20 GPa (e.g., about 12 GPa); (2) heating the mesoporous silica starting material while under pressure to an elevated temperature of less than about 1000° C. (e.g., a temperature of between about 300° C. and about 400° C.); and thereafter isolating the nanoparticles. The nanoparticles may be used in a work tool that is configured and adapted for cutting, drilling, abrading, polishing, machining, or grinding, among other uses.

Abstract: A method of producing biological products using bacteria with an inactivated ptsHI and wild type err and no added glucose transport activity and which consumes nearly all glucose in the media is described. The ?ptsHI bacteria produce large quantities of recombinant protein without producing significant amounts of acetate. The bacteria grow well on standard LB broth without additional supplementation.

Abstract: A semiconductor laser that includes an active region, claddings and electrical contacts to stimulate emissions from the active region, where a coupled waveguide guides emission. The waveguide includes a broad area straight coupling region that fans out into an array of narrower Individual curved coupled waveguides at an output facet of the laser. The individual curved coupled waveguides are curved according to Lorentzian functions that define the waveguide curvature as a function of position along the device. The integral length of each individual curved coupled waveguide differs from adjacent individual curved coupled waveguides by an odd number of half- wavelengths. The coupled waveguide array shapes the optical field output of the semiconductor laser such that a large fraction of the power is emitted into a small angular distribution using interference phenomena. A laser of the invention produces high power output with a very high quality, narrow beam shape.

Abstract: In certain aspects, the preproghrelin gene, but not the ghrelin receptor (GHS-R1a) is required for normal integration of thermoregulation and sleep in mice. Particular aspects provide methods for modulation of thermoregulation and other ghrelin-mediated conditions (e.g., reduction of appetite or food intake, reduction of body weight or treatment of obesity, reduction of body temperature or induction of hypothermia, etc.), comprising administration of an inhibitor of ghrelin expression, and including, e.g., siRNA inhibition for treatment of obesity and for modulation of thermoregulation (e.g., induction of hypothermia in surgical settings benefiting from same). Additionally provided are methods for reducing body temperature or induction of hypothermia, comprising administration to a mammalian subject in need thereof an amount of an anti-obestatin antibody agent sufficient to reduce body temperature or induce hypothermia. Further methods comprise administration of a ghrelin peptide antagonist.

Abstract: A method for production of a chemical library is provided, where the method involves: reacting, in a single vessel, a) a plurality, x, of aldehydes and/or ketones; and b) either (i) a plurality, y, of nucleophiles, (ii) a plurality, z, of electrophiles or both (i) and (ii); in the presence of c) a cascade catalyst capable of catalyzing reaction between said plurality of aldehydes and/or ketones and said plurality of nucleophiles, said plurality of electrophiles or both; to obtain a mixture of x-y ?-nucleophile substituted aldehydes and/or ketones, xz ?-electrophile substituted aldehydes and/or ketones or xyz ?-nucleophile substituted, ?-electrophile substituted aldehydes and/or ketones; and the chemical libraries thus produced.

Abstract: Featured is a manipulation device the ability to navigate virtual microscopy slides. The device includes an inverted light emitting diode (LED) reflecting light off a textured slide to a complimentary metal oxide semiconductor (CMOS) sensor that indicates the movement of the slide. The slide is freely moved by hand or traditional X-Y-mechanical stage on a raised platform akin to a slide stage. Finger touch controls are provided to zoom to higher or lower power images. The device plugs into a standard computer system by USB port running software to image a virtual microscope slide. Also featured are systems and methods related thereto.

Abstract: A method for making a carbon nanotube-based device is provided. A substrate having a shadow mask layer to define an unmasked surface area thereon is provided. A sputter source is disposed on the shadow mask layer. The sputter source is configured for supplying a catalyst material and depositing the catalyst material onto the substrate. A catalyst layer including at least one catalyst block is formed on the substrate. A thickness of the at least one catalyst block is gradually decreased from one end to another opposite end thereof. The at least one catalyst block has a region with a thickness proximal or equal to an optimum thickness. A carbon source gas is introduced. At least one carbon nanotube array extending from the catalyst layer using a chemical vapor deposition process is formed. The at least one carbon nanotube array is arc-shaped, and bend in a direction of deviating from the region.

Abstract: There is disclosed a method of creating an LDPC code that is defined by a parity-check matrix H. The parity-check matrix H is derived from a (0,1)-geometry which is induced by a finite inversive space. This inversive space has an order q where every circle in the inversive space contains exactly q+1 points, q is preferably even, and most preferably equal to 2. Where the inversive space has a dimension n. Where the (0,1)-geometry is formed as a derived geometric structure based on pencils of degree m?n in the inversive space. The method includes construction of a binary K by N matrix H labelled by K circles and N pencils of the inversive space, wherein the (i, j)-entry of the matrix is 1 if circle i belongs to pencil j, and 0 otherwise. If the degree of the pencil is given by 2 then the parity-check matrix H needs to be transposed, i.e. HT is used instead of H. A method of transmitting a message, a coder, a decoder and a data transmission system using such codes are also disclosed.

Abstract: Disclosed is a system and method for computing out of plane motion between two ultrasound images. The method identifies regions of fully developed speckle that are common to the two images, computes a correlation coefficient corresponding to the two fully developed speckle image regions, and then computing an elevation distance corresponding to the correlation coefficient. The method exploits the measurable and characterizable relation between inter-image correlation and elevation distance, which may be determined from fully developed speckle regions. The method also identifies regions within the ultrasound images related to structure (e.g., vein or bone), and disregards these regions.

Abstract: A method of reducing aerodynamic drag on a moving blunt-edged body, the method comprising actively generating a flow of air at a blunt edge of a body and using the generated flow of air to control an external flow of air moving relative to an edge of a moving blunt-body.

Abstract: A sequence online analytical processing (S-OLAP) system 50 for analysing an event database (41) storing events (12), the system (50) comprising: an S-OLAP engine (53) to compute an S-cuboid (49) for a query on the event database (41); a sequence query engine (54) to form part of the S-cuboid (49) by performing the steps of: selection, clustering, sequence formation and sequence grouping; a cuboid repository (52) to store computed S-cuboids (49) and to be searched by the S-OLAP engine (53) for an S-cuboid query to determine whether an S-cuboid has previously been computed; and a sequence cache (56) to cache constructed sequence groups.

Abstract: A delay locked loop controls a plurality of delay blocks included in a delay line and thus generate a plurality of clock signals which have a frequency obtained by multiplying a frequency of a reference clock signal, an accurate phase delay, and a constant duty cycle. The delay locked loop calculates an initial delay value and applies it to the delay blocks, thereby preventing harmonic locking and reducing locking time.

Abstract: A system to measure a subject's gaze stability, comprising: a display device; a data processor in communication with the display device; a data input device in communication with the data processor; and a motion detector in communication with the data processor, the motion detector being adapted to be worn by the subject under observation, wherein the data processor is configured to cause the display device to display a predetermined visual target based on a motion signal detected by the motion detector, the data processor is adapted to receive information from the data input device concerning a response of the subject in identifying the predetermined visual target, and the data processor is further adapted to generate an output characterizing the subject's gaze stability based on the received information.

Abstract: The invention relates to wireless biotelemetry of low level bioelectric and biosensor signals by means of directly modulating the backscatter of a resonant circuit. Low level electrical analog or digital signals are directly applied to a resonant circuit containing a voltage-variable capacitor such as a varactor diode, that proportionally shifts the resonant frequency and so amplitude of radiofrequency backscatter in a way that represents analog bioelectric or biosensor waveform data. By strongly driving the resonant circuit with a radiofrequency source, a voltage variable capacitance can be caused to amplify the bio-signal level by a parametric process and so provide sufficient sensitivity to telemeter for low millivolt and microvolt level signals without additional amplification. A feature of the device is its simplicity and that it accomplishes both modulation and preamplification of low level sensor signals by the same variable capacitance circuit which reduces the device size and power consumption.

Abstract: The invention provides novel mesoporous particles and methods for the selective sequestration of organic compounds from microorganisms, such as from various genera and species of algae that produce important organic compounds. The organic compounds can be selectively sequestered, for example, in favor of biodiesel impurities such as sterols and chlorophyll, to provide substantially pure free fatty acids. The free fatty acids can then be esterified to provide pure biodiesel.