Abstract: The present invention provides compositions and methods for light-activated cation channel proteins and their uses within cell membranes and subcellular regions. The invention provides for proteins, nucleic acids, vectors and methods for genetically targeted expression of light-activated cation channels to specific cells or defined cell populations. In particular the invention provides millisecond-timescale temporal control of cation channels using moderate light intensities in cells, cell lines, transgenic animals, and humans. The invention provides for optically generating electrical spikes in nerve cells and other excitable cells useful for driving neuronal networks, drug screening, and therapy.
Type:
Grant
Filed:
July 24, 2006
Date of Patent:
March 8, 2016
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Abstract: This invention relates generally to stimulating neurogenesis (e.g., post-natal neurogenesis, e.g., post-natal hippocampal neurogenesis) and protection from neuron cell death.
Type:
Grant
Filed:
December 9, 2013
Date of Patent:
March 8, 2016
Assignee:
Board of Regents of The University of Texas System
Inventors:
Steven L. McKnight, Joseph M. Ready, Andrew A. Pieper, Jef K. De Brabander
Abstract: A high isolation electromagnetic transmitter and receiver is revealed. An isolation portion, a first antenna body and a second antenna body are extended from and formed over a grounding portion. The isolation portion is extended to and formed between the first antenna body and the second antenna body. A parasitic element corresponding to the isolation portion is disposed between the first antenna body and the second antenna body. The isolation portion is T-shaped. The parasitic element is reverse T-shaped and arranged over the grounding portion. The structure is simple and able to be applied to the design of planar printed antennas. The production is easy and the cost is reduced. The volume is minimized to be used in various mini wireless mobile communication devices. No interference occurs even that the first and the second antennas are close due to good isolation.
Type:
Grant
Filed:
January 27, 2014
Date of Patent:
March 8, 2016
Assignee:
Southern Taiwan University of Science and Technology
Abstract: A rubber foam oil-absorbing material and preparation method thereof, the rubber foam oil-absorbing material including: 100 parts of a mixture of natural rubber and butadiene rubber, 4-8 parts of N,N-dinitroso pentamethylene tetramine, 1-8 parts of 4,4?-oxydibenzenesulfonyl hydrazide, 1-6 parts of sodium bicarbonate, 0.3-0.8 part of diphenyl guanidine, 0.2-0.5 part of zinc dimethyl dithiocarbamate, 0.1-0.5 part of 2,2?-dithio-dibenzo thiazole, 0.1-0.3 part of tetramethyl thiuram disulfide, 3-5 parts of zinc oxide, 1-3 parts of stearic acid, and 0.5-1.5 parts of sulfur. The rubber foam oil-absorbing material uses the mixture of the natural rubber and butadiene rubber as the matrix, which is low in cost and has higher oil-absorption rate. The rate of oil-absorption from dimethylbenzene by the rubber foam oil-absorbing material can reach 48.6 g/g, and the rate of oil-absorption from dimethylbenzene is also above 30 g/g. The preparation method is simple and convenient to realize industrial production.
Abstract: Provided are various methods and devices for electrohydrodynamic (E-jet) printing. The methods relate to sensing of an output current during printing to provide control of a process parameter during printing. The sensing and control provides E-jet printing having improved print resolution and precision compared to conventional open-loop methods. Also provided are various pulsing schemes to provide high frequency E-jet printing, thereby reducing build times by two to three orders of magnitude. A desktop sized E-jet printer having a sensor for real-time sensing of an electrical parameter and feedback control of the printing is provided.
Type:
Grant
Filed:
September 23, 2013
Date of Patent:
March 8, 2016
Assignee:
The Board of Trustees of the University of Illinois
Inventors:
Andrew Alleyne, Kira Barton, Sandipan Mishra, Placid Ferreira, John Rogers
Abstract: The disclosure relates to the inclusion of an image embedded in or on a single crystal diamond such that the image is part of the single crystal diamond structure. The disclosed methods use a combination of gemstone deposition processes and patterning processes to create single crystal gemstones with embedded color variations that can create externally visible two-dimensional or three-dimensional images in a seamless single crystal matrix without visible internal lines/interfacial boundaries. The image embedded image is differently colored from the surrounding diamond matrix. The color variation is accomplished by a change in the diamond growth conditions or treatment of the diamond.
Type:
Grant
Filed:
August 23, 2011
Date of Patent:
March 8, 2016
Assignee:
BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY
Abstract: Serotonin reuptake inhibitor compounds which are designed to exert serotonin uptake inhibitory activity in the peripheral system while being devoid of CNS activity, and a process of preparing same are disclosed. Further disclosed are pharmaceutical compositions containing same and uses thereof in the treatment of medical conditions associated with peripheral serotonin levels and/or activity, and/or platelet aggregation.
Abstract: A method of fabricating a III-nitride semiconductor device, including growing an III-nitride semiconductor and an oxide sequentially to form an oxide/III-nitride interface, without exposure to air in between growth of the oxide and growth of the III-nitride semiconductor.
Type:
Grant
Filed:
January 15, 2015
Date of Patent:
March 8, 2016
Assignee:
The Regents of the University of California
Inventors:
Xiang Liu, Umesh K. Mishra, Stacia Keller, Jeonghee Kim, Matthew Laurent, Jing Lu, Ramya Yeluri, Silvia H. Chan
Abstract: The subject matter described herein includes methods for visual odometry using rigid structures identified by an antipodal transform. One exemplary method includes receiving a sequence of images captured by a camera. The method further includes identifying rigid structures in the images using an antipodal transform. The method further includes identifying correspondence between rigid structures in different image frames. The method further includes estimating motion of the camera based on motion of corresponding rigid structures among the different image frames.
Type:
Grant
Filed:
May 8, 2015
Date of Patent:
March 8, 2016
Assignee:
The Trustees of the University of Pennsylvania
Abstract: An interactive camera calibration tool is presented that provides live feedback on the state of the calibration and produces tightly-distributed calibration parameters even when used by novices. Target positions are suggested by the calibration tool. Once the target has been aligned with the target positions, image data of the target is captured and used to compute calibration parameters. This process is repeated until the computed parameters meet the accuracy requirements specified by the user. A novel calibration quality metric is also leveraged to automatically determine whether a calibration is sufficiently accurate.
Type:
Grant
Filed:
October 28, 2014
Date of Patent:
March 8, 2016
Assignee:
The Regents Of The University Of Michigan
Inventors:
Edwin B. Olson, Johannes Strom, Andrew Richardson
Abstract: Provided herein are compositions and medical devices, and in particular, biodegradable scaffolds capable of repairing and replacing cartilagenous meniscuses. Also provided herein are methods of using scaffolds for treating degenerative tissue disorders. In certain embodiments, such scaffolds can promote tissue regeneration of a temporal mandibular joint (TMJ) meniscus.
Type:
Grant
Filed:
February 26, 2010
Date of Patent:
March 8, 2016
Assignee:
University of Pittsburgh—Of the Commonwealth System of Higher Education
Inventors:
Stephen F. Badylak, Bryan N. Brown, William L. Chung
Abstract: The invention provides a device for detecting non-cavitated caries lesions, including a measuring electrode having an electrically conductive tip. The tip is dimensionally configured to fit within a fissure and provide electrical contact with a patient's tooth. A reference electrode is also included, the reference electrode being configured for electrical contact with the patient's body. A measuring means is also provided for determining electrical conductance between the measuring electrode and the reference electrode, wherein the device is further configured to receive a current source for providing electrical current between the measuring electrode and the reference electrode.
Type:
Grant
Filed:
November 5, 2010
Date of Patent:
March 8, 2016
Assignee:
The Research Foundation for the State University of New York
Inventors:
Israel Kleinberg, Fred Confessore, Robi Chatterjee
Abstract: Subjecting a heterogeneous cell population (one with both stem cells and non-stem cells) to extreme stress selectively eliminated the non-stem cells and resulted in the enrichment of stem cells in the population. The stress can take many forms, including without limitation, cell toxins, high temperature, high salt, and low oxygen (hypoxic) conditions. The number of stem cells remaining after stress were increased, and showed increased expression of traditional stem cell markers. The stem cells were shown to be capable of proliferation and differentiation into multiple types of cells. This method allows purification of stem cells from adult heterogeneous cell populations on a large scale basis without requirement of expensive equipment, and without requiring the presence of cell surface markers. Stem cells produced by the above method can be used for clinical applications, including tissue engineering.
Type:
Grant
Filed:
July 18, 2013
Date of Patent:
March 8, 2016
Assignee:
Board of Supervisors of Louisiana State University And Agricultural and Mechanical College
Abstract: According to the invention, there is provided a method for producing a gallium trichloride gas, the method including: a first step of reacting a metallic gallium and a chlorine gas to produce a gallium monochloride gas; and a second step of reacting the produced gallium monochloride gas and a chlorine gas to produce a gallium trichloride gas.
Type:
Grant
Filed:
May 11, 2011
Date of Patent:
March 8, 2016
Assignee:
National University Corporation Tokyo University of Agriculture
Abstract: A processing system for cell cultures for carrying out cell/tissue culturing processes in the field of regenerative medicine, etc. which is a processing system for cell cultures which prevents viruses and human-derived cells, etc. other than a culturing processing target from entering the interior of a closed space from outside of the system to maintain sterility, maintains sealability of the closed spaces of modules, and couples or detaches the plurality of modules in accordance with a wide variety of cell culturing processing steps so that cell culturing processes can be carried out by combining the plurality of culturing processing modules is provided.
Abstract: A charging control system includes a flattened charging speed calculation unit that calculates a flattened charge speed for fully charging EVs at a constant speed according to permitted charging time for the EVs and the amount of charging required by the EVs; a charging speed calculation unit that calculates a charging speed for the EVs by multiplying the flattened charging speed by a request demand ratio function based on change over time in electric power demand requested from the electric power supply side; and a control unit that controls the charging of the EVs on the basis of the charging speed calculated by the charging speed calculation unit.
Type:
Grant
Filed:
February 13, 2012
Date of Patent:
March 8, 2016
Assignees:
NEC Corporation, The University of Tokyo
Abstract: Conductive concrete mixtures are described that are configured to provide EMP shielding and reflect and/or absorb, for instance, EM waves propagating through the conductive concrete mixture. The conductive concrete mixtures include cement, aggregate, water, metallic conductive material, and conductive carbon particles and/or magnetic material. The conductive material may include steel fibers, and the magnetic material may include taconite aggregate. The conductive concrete mixture may also include graphite powder, silica fume, and/or other supplementary cementitious materials (SCM). The conductive carbon particles may comprise from about zero to twenty-five percent (0-25%) of the conductive concrete mixture by weight and/or the magnetic material may comprise from about zero to fifty percent (0-50%) of the conductive concrete mixture by weight.
Type:
Grant
Filed:
January 28, 2015
Date of Patent:
March 8, 2016
Assignee:
The Board of Regents of the University of Nebraska
Abstract: A dispensing device has a cantilever comprising a plurality of thin films arranged relative to one another to define a microchannel in the cantilever and to define at least portions of a dispensing microtip proximate an end of the cantilever and communicated to the microchannel to receive material therefrom. The microchannel is communicated to a reservoir that supplies material to the microchannel. One or more reservoir-fed cantilevers may be formed on a semiconductor chip substrate. A sealing layer preferably is disposed on one of the first and second thin films and overlies outermost edges of the first and second thin films to seal the outermost edges against material leakage. Each cantilever includes an actuator, such as for example a piezoelectric actuator, to impart bending motion thereto. The microtip includes a pointed pyramidal or conical shaped microtip body and an annular shell spaced about the pointed microtip body to define a material-dispensing annulus thereabout.
Type:
Grant
Filed:
July 26, 2011
Date of Patent:
March 8, 2016
Assignee:
Northwestern University
Inventors:
Horacio D. Espinosa, Nicolaie A. Moldovan, Keun-Ho Kim