Abstract: A carrier for in vivo delivery of a therapeutic agent comprising a thiol group is provided, wherein the therapeutic agent is conjugated to the carrier via a biodegradable disulfide bond. Since extracellular fluids in vivo do not provide the appropriate environment to efficiently reduce a disulfide bond, while cellular cytosol does provide an appropriate environment, the agent will remain substantially coupled to the carrier while circulating through the body until the carrier crosses a cell membrane. As a result, the therapeutic agent is protected from degradation and renal clearance, and the potential for the therapeutic agent to elicit an immune response is limited.

Abstract: The invention is a process and reactors designs for simultaneous ultraviolet light/ultrasound(UV/US) treatment of halogenated organic compounds contaminants in water. The reactors are preferably circular cylindrical reaction vessels that accept a central ultrasonic horn. UV light is provided by lamps placed generally parallel to the reactor walls. Or, UV light may be centrally provided in an immersion well near the ultrasonic horn. This way, simultaneous UV/US energy may be effectively provided to the reactors for the remediation of toxic compounds in the water in the reactors. Also, this way, compact and portable reactors may be constructed to permit mobile applications of the UV/US processes.

Abstract: C8-substituted purine nucleotide analogs, such as ATP analogs, and their use is described, including their use as inhibitors of NTPDases and thereby as tools to modulate the conversion of nucleotides into nucleoside derivatives, and thus modulate the levels of these compounds. Such modulation further provides for the modulation of the activity and function of many processes which are affected by these compounds.

Abstract: The present invention provides a sensor that can be operated at high temperatures. The sensor comprises a first electrode, a second electrode, and an aluminum nitride film which lies between the first and second electrode. The sensor can be used to measure pressure, acceleration, or force at high temperatures.

Abstract: A polyalkylene carbonate, an alternating copolymer, may be prepared by the ring opening of an alkene oxide or an alkene oxide precursor in the presence of carbon dioxide or any substance delivering carbon oxide, in the presence of at least one catalyst comprising a metal-organic framework material, wherein said framework material comprises pores and a metal ion and an at least bidentate organic compound, said bidentate organic compound being coordinately bound to the metal ion.

Abstract: A spectrometer for determining a spectrum of a light by using a mirror to reflect the light so that the light forms an intensity standing wave pattern through superposition of an incident portion of the light and a reflected portion of the light. The spectrometer is equipped with an intensity detector whose thickness is less than a shortest wavelength of the light being examined and which is semitransparent over the spectrum. The spectrometer has a mechanism to provide relative movement between the mirror and the intensity detector such that the intensity detector registers a variation of the intensity standing wave pattern. An analyzer, such as a Fourier transform analyzer, is employed to determine the spectrum of the light from that variation of the intensity standing wave pattern.

Abstract: The ability to transport body liquids in consumer products such as diapers, incontinents and feminine napkins is a key factor in their performance. This invention is designed to provide specific high fluxes (volume of liquid/(time*mass of polymer) of aqueous liquids in designated directions using bundles of new specially designed fibers. The key factors for the bundles are a high specific adhesion for the liquid of interest, a high specific volume of the bundle itself, and alignment of the fibers within the bundle. The invention includes novel liquid acquisition/distribution systems and absorbent products that include a liquid acquisition/distribution system which may incorporate the novel bundles of fibers.

Abstract: Methods for determining the presence of double stranded nucleic acids in a sample are provided. In the subject methods, nucleic acids present in a fluid sample are translocated through a nanopore, e.g. by application of an electric field to the fluid sample. The current amplitude through the nanopore is monitored during the translocation process and changes in the amplitude are related to the passage of single- or double-stranded molecules through the nanopore. The subject methods find use in a variety of applications in which the detection of the presence of double-stranded nucleic acids in a sample is desired, e.g. in hybridization assays, such as Northern blot assays, Southern blot assays, array based hybridization assays, etc.

Abstract: An isolated protein which exhibits cytokinin oxidizing activity selected from the group consisting of SEQ. ID No. 1, a protein having an amino acid sequence which includes the amino acid sequence of SEQ. ID No. 1, a protein having an amino acid sequence which includes a portion of the amino acid sequence of SEQ. ID No. 1, the included portion being at least about 20 amino acid residues in length and conferring the cytokinin oxidizing activity on the protein, and a protein including an amino acid sequence with at least about 65% sequence identity to SEQ. ID No. 1, the remainder of amino acid residues being conservatively substituted. Nucleic acids encoding proteins which exhibit cytokinin oxidizing activity and related compositions and methods are also disclosed.

Abstract: Nucleic acid molecules, proteins and antibodies are provided which may be used in biological screens to identify therapeutic agents involved in the regulation of cell cycle progression and apoptotic cell death.

Abstract: Assay methodology of the invention allows for: (1) determining if a sample contains a conformation of a protein which is associated with disease and the concentration and amount of such if present; (2) determining the amount of protease resistant disease related protein in a sample and by subtracting that amount from the total amount of disease related protein present determining the amount of protease sensitive disease protein in the sample; and (3) determining the strain and incubation time of a disease related protein by (i) relating the relative amounts of protease resistant and protease sensitive protein to known strains to thereby determine the strain; and (ii) plotting the concentration of protease sensitive protein on a graph of incubation time versus concentration of protease sensitive protein for known strains to predict the incubation time of an unknown strain of pathogenic protein in a sample.

Abstract: Asthma is ameliorated, and mild or moderate asthma is prevented from progressing to more severe asthma by administering agents which prevent and/or accommodate for S-nitrosothiol breakdown.

Abstract: The invention provides compositions and methods related to human telomerase reverse transcriptase (hTRT), the catalytic protein subunit of human telomerase. The polynucleotides and polypeptides of the invention are useful for diagnosis, prognosis and treatment of human diseases, for changing the proliferative capacity of cells and organisms, and for identification and screening of compounds and treatments useful for treatment of diseases such as cancers.

Abstract: A process for introducing a textile treatment material into a textile treatment system, particularly a supercritical fluid carbon dioxide (SCF—CO2) treatment system. The process includes the steps of providing a preparation vessel in fluid communication with a textile treatment system; loading a textile treatment material into the preparation vessel; dissolving or suspending the textile treatment material in near-critical liquid carbon dioxide or supercritical fluid carbon dioxide in the preparation vessel; and introducing the dissolved or suspended textile treatment material into the textile treatment system. The textile treatment material can be selected from a group including a brightening agent, a whitening agent and a dye. A system suitable for use in carrying out the process is also disclosed.

Abstract: A methodology and concomitant system for three-dimensional near-field microscopy achieves subwavelength resolution of an object via total internal reflection. The features of this approach include: (i) the evanescent waves used for illumination encode on the scattered field the subwavelength structure of the scattering object—it is thus possible to obtain subwavelength resolved images of the sample as is done in other near-field techniques such as near-field scanning optical microscopy without the technical difficulties encountered with probe-sample interactions; and (ii) the results of the reconstruction are unambiguous in the sense that the relation between the scattered field and the three-dimensional structure of the sample, as described by the spatial dependence of the susceptibility, is made manifest.

Abstract: Miniature surgical forceps are formed from a one-piece tubular member by opposed longitudinal channels machined in a distal end thereof so as to establish a radially opposed pair of unitary forceps jaws. Most preferably, the opposed channels are formed in the distal end of the rigid tubular member by means of electron discharge machining (EDM) techniques. The resulting opposed cross-sectionally arcuate jaw sections may be bent and/or further shaped to achieve the desired final jaw configuration. The inner surfaces of the forceps jaws thereby established may have a filler material deposited in such a manner so as to change the overall shape and/or geometric configuration of the jaws and thereby engineer them to a specific surgical purpose.

Abstract: In cone-beam volume computed tomography or similar imaging techniques, the effects of x-ray scatter are reduced through using a beam compensation filter (a bow tie filter), air gap technique, and an antiscatter grid and corrected through the use of a beam stop array combined with interpolation or convolution operation. Images are taken with the beam stop array, and a larger number of images are taken without the beam stop array. The images taken with the beam stop array are spatially interpolated to derive scatter information, which is then angularly interpolated to provide as many scatter images as there are images taken without the beam stop array. The interpolations are performed through cubic spline interpolation or any other interpolation techniques or low-pass filtering operation (convolution operation with a selected kernel). Each scatter image is subtracted from a corresponding one of the images taken without the beam stop array to provide a sequence of scatter-corrected images.

Abstract: The invention provides compounds having the structure: where, R1 is a member selected from the group consisting of H and NH2; R2 is member selected from the group consisting of H, CO2H, OH and halogen; and R3 is a member selected from the group consisting of CO2H, NH2 and halogen. Also provided are methods of using the compounds and formulations containing the compounds.

Abstract: Bites from Amblyomma americanum, a hard tick, have been associated with a Lyme disease-like illness in the southeastern and south-central United States. Present in 2% of ticks collected in four states were uncultivable spirochetes. Through use of the polymerase chain reaction, partial sequences of the flagellin and 16s rRNA genes of microorganisms from Texas and New Jersey were obtained. The sequences showed that the spirochete was a Borrelia sp. but distinct from other known members of this genus, including B. burgdorferi, the agent of Lyme disease. Species-specific differences in the sequences of the flagellin protein, the flagellin gene and the 16s rRNA gene between the new Borrelia species and previously known species provide compositions and methods for assay for determining the presence of this new spirochete, or for providing evidence of past or present infection by this spirochete in animal reservoirs and humans.

Abstract: A method for enhancing the equilibrium solubility of boron and indium in silicon. The method involves first-principles quantum mechanical calculations to determine the temperature dependence of the equilibrium solubility of two important p-type dopants in silicon, namely boron and indium, under various strain conditions. The equilibrium thermodynamic solubility of size-mismatched impurities, such as boron and indium in silicon, can be raised significantly if the silicon substrate is strained appropriately. For example, for boron, a 1% compressive strain raises the equilibrium solubility by 100% at 1100° C.; and for indium, a 1% tensile strain at 1100° C., corresponds to an enhancement of the solubility by 200%.