Abstract: This invention relates to the chemical design and production of peptides, peptide structure and three dimensional conformation was assessed using NMR, circular dichroisin and pulsed field gradient NMR. In addition, this invention relates to peptides produced by these methods and to methods for using the peptides.

Abstract: A method of fabricating deposits of non-volatile substances, including biomacromolecules, in the form of spots and filing on a substrate surface by electrospray, where the deposits are used to determine the interaction of the deposited non-volatile substances to other substances. Also included in this method is the mass fabrication on a single chip of an array of single and multicomponent microsamples.

Abstract: This invention relates to treating or preventing pathogenic infections with an epidermal growth factor (EGF). EGF is capable of inhibiting pathogenic colonization of pathogens in a variety of tissue or cell types. Since pathogenic colonization is essential for pathogenic infection, EGF can be used as an effective preventive and therapeutic agent for pathogenic infections, particularly in the urogenital tract.

Abstract: The present invention provides for transposon vectors encoding expression control region-traps and gene-traps. Also provided are dicistronic vectors. Certain embodiments of the invention contain internal ribosome entry sites.

Abstract: The present invention provides a method of hybridization, differential methylation hybridization (DMH) for high throughput methylation analysis of multiple CpG island loci. DMH utilizes nucleic acid probes prepared from a cell sample to screen numerous CpG dinucleotide rich fragments affixed on a screening array. Positive hybridization signals indicate the presence of methylated sites. Methods of preparing the hybridization probes and screening array are also provided.

Abstract: Provided are low-cost, mechanically strong, highly electronically conductive porous substrates and associated structures for solid-state electrochemical devices, techniques for forming these structures, and devices incorporating the structures. The invention provides solid state electrochemical device substrates of novel composition and techniques for forming thin electrode/membrane/electrolyte coatings on the novel or more conventional substrates. In particular, in one embodiment the invention provides techniques for co-firing of device substrate (often an electrode) with an electrolyte or membrane layer to form densified electrolyte/membrane films 5 to 20 microns thick. In another embodiment, densified electrolyte/membrane films 5 to 20 microns thick may be formed on a pre-sintered substrate by a constrained sintering process. In some cases, the substrate may be a porous metal, alloy, or non-nickel cermet incorporating one or more of the transition metals Cr, Fe, Cu and Ag, or alloys thereof.

Abstract: Compositions and methods for ameliorating the clinical signs of an avian pneumovirus infection in a bird are disclosed. The compositions include immunologically effective amounts of an attenuated or inactivated avian pneumovirus. Methods for preparing an attenuated avian pneumovirus composition are also described.

Abstract: The present invention relates to an electroluminescent device including an anode and a cathode capable of being electrically connected to a power supply and a voltage regulator, and a multi-layered polymer structure, between the anode and cathode, including a first polymer layer which includes a hole transfer polymer contacting the anode and a second polymer layer which includes an n-type conjugated polymer contacting the cathode, wherein changes in the voltage of current passing through the electroluminescent device change the color of electroluminescent emissions from the multi-layered polymer structure.

Abstract: A mixed potential electrochemical sensor for the detection of gases has a ceria-based electrolyte with a surface for exposing to the gases to be detected, and with a reference wire electrode and a sensing wire electrode extending through the surface and fixed within the electrolyte as the electrolyte is compressed and sintered. The electrochemical sensor is formed by placing a wire reference electrode and a wire sensing electrode in a die, where each electrode has a first compressed planar section and a second section depending from the first section with the second section of each electrode extending axially within the die. The die is filled with an oxide-electrolyte powder and the powder is pressed within the die with the wire electrodes. The wire-electrodes and the pressed oxide-electrolyte powder are sintered to form a ceramic electrolyte base with a reference wire electrode and a sensing wire electrode depending therefrom.

Abstract: The present invention relates to a method of inhibiting desensitization of a cell to the effects of a compound. The method comprises contacting the cell with an agent capable of inhibiting phosphorylation, by a protein kinase, of a receptor for the compound present on the surface of the cell. The present invention also relates to a method of screening a compound for its ability to inhibit desensitization. The method comprises: i) contacting a receptor specific kinase-containing sample with the compound under conditions such that interaction between receptor specific kinase present in the sample and the compound can occur, and ii) determining the ability of the receptor specific kinase to phosphorylate the receptor for which it is specific.

Abstract: Processing element on a server performs a (wavelet) transform on an image held by the server storage device. Client user continuously specifies a foveal region with user input means dynamically, in realtime, which request is converted to a request for wavelet coefficients on the server corresponding to the foveal region. As the server continuously sends requested coefficients, client inverse wavelet transform means performs inverse wavelet transform on coefficients and continuously updates the image on the display.

Abstract: A method for regulating in vivo calcium transport in cardiac muscle of animals suffering from congestive heart failure is disclosed. According to the method, calcium ATPase activity (which decreases as congestive heart failure develops) and cardiac muscle contractility augmented by delivering a gene which operatively encodes the enzyme into the heart. Delivery systems (including recombinant expression vectors) are provided, as are methods for monitoring the expression and effect of the gene product on cardiac performance.

Abstract: Methods for evaluating catalysts, in which a multicell holder, e.g., a honeycomb or plate, or a collection of individual support particles, is treated with solutions/suspensions of catalyst ingredients to produce cells, spots or pellets holding each of a variety of combinations of the ingredients, is dried, calcined or treated as necessary to stabilize the ingredients in the cells, spots or pellets, then is contacted with a potentially reactive feed stream or batch, e.g., biochemical, gas oil, hydrogen plus oxygen, propylene plus oxygen, CCl2F2 and hydrogen, etc. The reaction occurring in each cell can be measured, e.g., by infrared thermography, spectroscopic detection of products or residual reactants, or by sampling, e.g., multistreaming through low volume tubing, from the vicinity of each combination, followed by analysis, e.g., spectral analysis, chromatography, etc., or by observing temperature change in the vicinity of the catalyst, e.g.

Abstract: A process for the preparation of 1,5-dideoxy-1,5-imino hexitols of a hexose sugars from novel hydroxyl protected oxime intermediates. The process includes formation of a lactam which is reduced to the hexitol. The hexitols are useful as drugs.

Abstract: Mitochondrial mutations occur as a product of contact of a person with an environmental pollutant. Mitochondrial mutations are readily detectable in body fluids. Measurement of mitochondrial mutations in body fluids can be used as a dosimeter to monitor exposure to the environmental pollutant. Mitochondrial mutations can also be detected in cancer patients. Probes and primers containing mutant mitochondrial sequences can be used to monitor patient condition.

Abstract: A fibre detector assembly comprising: (i) a scattering chamber body; (ii) means for drawing airborne particles through said body chamber, said means being adapted such the the particles tend to travel in single file with the longitudinal axis of particles with elongate shape substantially aligned with the direction of the air flow; (iii) means for illuminating the particle stream within the chamber body; (iv) an optical detector adapted to intercept and collect a portion of the light scattered by particles passing through the illuminating beam; (v) data processing means adapted to capture and process the signals from the optical detector; characterised in that the optical detector comprises a photodiode array consisting of a central opaque area surrounded by two or more annular rings of detector elements.

Abstract: A reflective panel for deflecting electromagnetic waves comprised of a resistive material varying in resistivity across the panel; a center portion on the panel, having a predetermined resistivity; a periphery portion on the panel having a higher resistivity than the center portion; and wherein the center portion of the panel is adapted to reflect the electromagnetic waves and wherein the periphery portion is adapted to minimize diffractions.

Abstract: An improved method for magnetic resonance imaging of a sample includes the following steps: producing a magnetic field to orient the magnetic dipoles of a sample along the z axis of an x,y,z Cartesian coordinate system; applying a first radio frequency (rf) pulse along a different axis, near the resonance frequency of the magnetic dipoles (for example, the hydrogen atoms in water); applying a gradient pulse for a time tg in order to modulate the magnetization along a preferred axis in space (for example, the z axis); allowing the magnetization to evolve for a time \zq, during which time the local variations in the susceptibility affect the excited spins; applying a second radio frequency pulse near the resonance frequency of the magnetic dipoles; allowing the sample to evolve for a second time interval TE to create observable magnetization; then detecting this magnetization, using gradients to spatially resolve the signal.

Abstract: Cardiovascular cell proliferation in a blood vessel subjected to trauma, such as angioplasty, vascular graft, anastomosis, or organ transplant, can be inhibited by contacting the vessel with a polymer consisting of from 6 to about 30 amino acid subunits, where at least 50% of the subunits are arginine, and the polymer contains at least six contiguous arginine subunits. Exemplary polymers for this purpose include arginine homopolymers 7 to 15 subunits in length.

Abstract: Vaccine compositions protective against Chlamydia psittaci infections in animals, including but not limited to humans and avian species, comprising an immunogenic amount of a C. psittaci major outer membrane protein (MOMP) polypeptide lacking regions VD1 and VD2 are provided. Nucleic acid vectors for the expression of MOMP polypeptides and MOMP polypeptide fusion proteins are disclosed. Nucleic acid vectors encoding a C. psittaci major outer membrane protein (MOMP) polypeptide lacking regions VD1 and VD2 useful for genetic, or “naked nucleic acid” vaccination are disclosed. Methods for preventing a Chlamydia psittaci infection in a subject using MOMP polypeptides, MOMP polypeptide-fusion proteins, or nucleic acid expression vectors are also provided.