Patents Assigned to Univerza v Ljubljani, Fakulteta za naravoslovje in technologijo, Oddelek za farmacijo
  • Heterocyclic acyldipeptides, processes for the preparation thereof and pharmaceutical compositions containing the same
    Patent number: 5824652
    Abstract: Heterocyclic acyldipeptides of the formula I ##STR1## wherein Z represents an oxygen or sulphur atom or a --CH.sub.2 -group;R.sub.1, R.sub.2 and R.sub.3 individually represent hydrogen or certain organic groups;R.sub.4 and R.sub.5, which are identical or different, represent an OR.sub.6 or NHR.sub.6 group, wherein R.sub.6 is hydrogen or certain organic groups;Y represents a --CH.sub.2 --, .dbd.CH-- or .dbd.N-- group;A represents a --(CH.sub.2).sub.3 -- group when Y is --CH.sub.2 --, the two rings being transcondensed, or a ##STR2## wherein R.sub.7 represents H, F, Br, Cl, nitro, or certain organic groups when Y is .dbd.CH-- or .dbd.N--; and their pharmaceutically acceptable salts are provided. These heterocyclic acyldipeptides and their salts are useful as active compounds in medicaments having immunostimulatory and antitumor activity.
    Type: Grant
    Filed: January 4, 1996
    Date of Patent: October 20, 1998
    Assignees: Univerza v Ljubljani, Fakulteta za naravoslovje in technologijo, Oddelek za farmacijo, LEK, tovarna farmacevtskih in kemicnih izdelkov, d.d.
    Inventors: Danijel Kikelj, Elizabeta Suhadolc, Alenka Rutar, Slavko Pecar, Alesa Puncuh, Uros Urleb, Vesna Leskovsek, Gasper Marc, Marija Sollner, Ales Krbavcic, Gregor Sersa, Srdjan Novakovic, Lucka Povsic, Anton Stalc