Abstract: The present invention relates to the new chemical compounds containing (Z)-1,2-diphenylethene moiety in the structures, particularly the new derivatives of cis-stilbene, the new derivatives of 4,5-diphenyl-1,3-oxazole, the new derivatives of 1-methyl-4,5-diphenyl-1H-imidazole and pharmaceutically acceptable salts thereof. The invention relates also to the application of aforementioned compounds as a microtubule-interfering agents (MIAs). The new derivatives, because of their potential antimitotic and antiangio-genic activity, can be used as ingredients in the preparations used in the treatment of cancer.
Type:
Grant
Filed:
March 28, 2013
Date of Patent:
September 4, 2018
Assignee:
Uniwersytet Medyczny IM. Karola Marcinkowskiego
Inventors:
Tomasz Stefański, Jakub Różański, Renata Mikstacka, Stanislaw Sobiak
Abstract: The invention relates to a novel class of quaternary ammonium salts containing tetra-hydro[1,3]oxazolo[2,3-b][1,3]oxazol-4-ium moiety in the structure, in particular the new derivatives of 4-methyltetrahydro[1,3]oxazolo[2,3-b][1,3]oxazol-4-ium, 4-(2-oxoethyl)tetrahydro[1,3]oxazolo[2,3-6][1,3]oxazol-4-ium, bis{4-methyltetrahydro[1,3]oxazoio[2,3-6][1,3]oxazol-4-ium}, bis{4-(2-oxoethyl)tetrahydro[1,3]oxazolo[2,3-b][1,3]oxazol-4-ium} and tris{4-methyltetrahydro[1,3]oxazolo[2,3-b][1,3]oxazol-4-ium} salts, process for the preparation of a novel class of quaternary ammonium salts and applications thereof.
Type:
Grant
Filed:
January 31, 2013
Date of Patent:
October 27, 2015
Assignee:
Uniwersytet Medyczny IM. Karola Marcinkowskiego
Inventors:
Jakub Różański, Agnieszka Gielara-Korzańska, Stanislaw Sobiak, Marcelina Maria Kubicka, Helena Kukuła
Abstract: The invention relates to a novel class of quaternary ammonium salts containing tetra-hydro[1,3]oxazolo[2,3-b][1,3]oxazol-4-ium moiety in the structure, in particular the new derivatives of 4-methyltetrahydro[1,3]oxazolo[2,3-b][1,3]oxazol-4-ium, 4-(2-oxoethyl)tetrahydro[1,3]oxazolo[2,3-6][1,3]oxazol-4-ium, bis{4-methyltetrahydro[1,3]oxazoio[2,3-6][1,3]oxazol-4-ium}, bis{4-(2-oxoethyl)tetrahydro[1,3]oxazolo[2,3-b][1,3]oxazol-4-ium} and tris{4-methyltetrahydro[1,3]oxazolo[2,3-b][1,3]oxazol-4-ium} salts, process for the preparation of a novel class of quaternary ammonium salts and applications thereof.
Type:
Application
Filed:
January 31, 2013
Publication date:
March 19, 2015
Applicant:
UNIWERSYTET MEDYCZNY IM. KAROLA MARCINKOWSKIEGO
Inventors:
Jakub Rózanski, Agnieszka Gielara-Korzanska, Stanislaw Sobiak, Marcelina Maria Kubicka, Helena Kukula
Abstract: The subject matters of this invention are a sequence of double-stranded RNA: ATN-RNA, intervention using interference RNA (iRNAi), use of a sequence of double-stranded RNA: ATN-RNA, a method of treating a brain tumor and a method of inhibiting a brain tumor cells which express tenascin, a kit for inhibiting cancer cell which expresses tenascin and a method for a kit preparation in a brain tumor therapy. Malignant gliomas preferentially express a number of surface markers that may be exploited as therapeutic targets, including tenascin-C, an extracellular matrix glycoprotein that is ubiquitously expressed by malignant gliomas and probably contributes to tumor cell adhesion, invasion, migration and proliferation. For tenascin-C inhibition, RNA interference intervention (iRNAi) approach have been applied.
Type:
Grant
Filed:
July 30, 2007
Date of Patent:
February 3, 2015
Assignees:
Instytut Chemii Bioorganicznej Pan, Uniwersytet Medyczny Im.Karola Marcinkowskiego, Bioinfobank Sp.Z O.O.
Inventors:
Jan Barciszewski, Miroslawa Barciszewska, Leszek Rychlewski, Eliza Wyszko, Iwona Gawronska, Ryszard Zukiel, Katarzyna Rolle, Stanisaw Nowak
Abstract: The subject matters of this invention are a sequence of double-stranded RNA: ATN-RNA, intervention using interference RNA (iRNAi), use of a sequence of double-stranded RNA: ATN-RNA, a method of treating a brain tumor and a method of inhibiting a brain tumor cells which express tenascin, a kit for inhibiting cancer cell which expresses tenascin and a method for a kit preparation in a brain tumor therapy. Malignant gliomas preferentially express a number of surface markers that may be exploited as therapeutic targets, including tenascin-C, an extracellular matrix glycoprotein that is ubiquitously expressed by malignant gliomas and probably contributes to tumor cell adhesion, invasion, migration and proliferation. For tenascin-C inhibition, RNA interference intervention (iRNAi) approach have been applied.
Type:
Application
Filed:
July 30, 2007
Publication date:
March 25, 2010
Applicants:
INSTYTUT CHEMII BIOORGANICZNEJ PAN, BIOINFOBANK SP. Z O.O., UNIWERSYTET MEDYCZNY IM.KAROLA MARCINKOWSKIEGO
Inventors:
Jan Barciszewski, Miroslawa Barciszewska, Leszek Rychlewski, Eliza Wyszko, Iwona Gawronska, Ryszard Zukiel, Katarzyna Rolle, Stanisaw Nowak