Abstract: The subject of the present invention is a method for controlling the spatial arrangement of domains of mesogenic compounds, exhibiting the ability to synchronise chirality by controlled synchronisation of conformational chirality, characterised in that an area of a thin film of a compound forming a conglomerate of domains is heated above the isotropisation temperature of a given compound until a specific chirality is obtained in a given area, and the shape of the heated area corresponds to a selected pattern enabling the control of the crystallisation front, wherein the heating is carried out by means of area illumination with laser light of a wavelength corresponding to the high absorbance of the melted compound and/or area heating of a substrate on which the thin film of the compound is placed and/or by area illumination with laser light of a wavelength corresponding to the high absorbance of a dye added to the film.

Abstract: The presented invention relates to a method of synthesis of carbon-supported platinum group metal or metal alloy nanoparticles, which comprises the following steps: adsorbing on carbon support complexes of a platinum group metal with a urea complexing agent selected from a group comprising urea, urea derivative, a mixture of urea with at least one urea derivative, and a mixture of at least two urea derivatives; and reducing the complexes adsorbed on the carbon support to metal nanoparticles, forming a product of carbon-supported metal nanoparticles. The invention also provides the use of the carbon-supported platinum group metal or metal alloy nanoparticles obtained by the method of the invention as catalyst. The present invention further relates to a method of adsorption of precursors of platinum group metals on the surface of a carbon support and use of complexes of platinum group metals with urea complexing agent for adsorption of platinum group metal precursors on carbon support.

Abstract: The invention relates to a system for the detection of biomarkers in the air exhaled from patient's lungs, comprising a leak-proof multipass cell provided with a gas inlet and outlet, into which a sample of the exhaled air is introduced by means of a pneumatic system, wherein the multipass cell is provided with one laser whose light beam is directed along a coaxial optical path to the multipass cell comprising at least two concave mirrors arranged in parallel and a gas inlet and outlet, which is filled with a sample of the analyzed exhaled gas, wherein the pneumatic system is connected to the gas inlet and outlet of the multipass cell by means of lines supplying the exhaled air, characterized in that the pneumatic system comprises a preliminary container of the exhaled air comprising an air inlet and outlet, wherein the air outlet additionally comprises an air flow meter, the preliminary container is further connected by an elastic line supplying the air to the multipass cell on one side and on the other side

Abstract: A receptor for the simultaneous removal of oxoanions and their counterions from aqueous phase, particularly containing radioactive wastes, containing amide groups specifically coordinating the oxoanions, as well as moieties specifically coordinating cations, according to the present invention is characterised in that it contains within one molecule domains binding oxoanions and domains binding cations, preferably adapting a molecular structure of a general formula: (I) wherein Z this is a group containing crown ether, preferably a benzocrown group, X is any substituent, including the Y—Z grouping, and Y is any substituent or 0 (i.e.

Abstract: The present invention relates to palladium-platinum system consisting of palladium layer covered with a platinum overlayer consisting of 1 to 10 platinum monolayers deposited on palladium for use as hydrogen storage. Such system can be used in fuel cells, hydride batteries and supercapacitors. A method for increasing hydrogen absorption kinetics of hydrogen absorption/desorption process is also disclosed.

Abstract: The invention is related to a sample holder for measurements of optically detected magnetic resonance, including a bottom plate, a top plate and a middle plate, wherein all the plates are made of a dielectric material. The top plate is provided with at least one top opening, enabling continuous optical access to the studied sample during measurements. The sample is placed in the central opening provided in the middle plate. The non-magnetic conductive strips provided on the surfaces of the bottom plate, the middle plate and the top plate ensure formation of an electrical circuit, which allows coupling of the studied sample with the generated microwave radiation to be achieved once the microwave sources is switched on. The invention also includes a sample holder for measurements of optically detected magnetic resonance, enabling formation of at least one loop of the electrical circuit.

Abstract: The subject of the invention is RNA analogs, their preparation and application, inter alia, in microscopic observations, study of the gene expression process and monitoring of enzyme activity.

Abstract: A device implementing polariton optical neural network, comprising: Input layer (100) consisting of optical elements ensuring linear pre-processing and distribution of input optical signals (102), middle layer (104), consisting of nonlinear optical elements, realizing nonlinear transformation of the pre-processed input signals (106), output layer (108) consisting of linear optical elements, realizing linear transformation of the signals that had been transformed nonlinearly (110) and generating output signals, passive optical systems (114) optically coupling the input layer (100), the middle layer (104), the output layer (108) characterized in that the nonlinear transformation in the middle layer occurs as a result of interaction of pre-processed input signals (106) with a nonlinear element or elements in the form of an optical microcavity or multiple optical microcavities hosting exciton-polaritons.

Abstract: The invention is related to a sample holder for measurements of optically detected magnetic resonance, including a bottom plate, a top plate and a middle plate, wherein all the plates are made of a dielectric material. The top plate is provided with at least one top opening, enabling continuous optical access to the studied sample during measurements. The sample is placed in the central opening provided in the middle plate. The non-magnetic conductive strips provided on the surfaces of the bottom plate, the middle plate and the top plate ensure formation of an electrical circuit, which allows coupling of the studied sample with the generated microwave radiation to be achieved once the microwave sources is switched on. The invention also includes a sample holder for measurements of optically detected magnetic resonance, enabling formation of at least one loop of the electrical circuit.

Abstract: The present invention is related to use of marimastat or a pharmaceutically acceptable salt, solvate or polymorph thereof in preventing or treating epileptogenesis in a subject that suffered a brain insult. Said brain insult is a stroke, traumatic brain injury, or a result of status epilepticus, evoked by structural or metabolic reasons. Marimastat or a pharmaceutically acceptable salt thereof is administered preferably within the first 24 hours after induction of epileptogenesis.

Abstract: The invention relates to a method for the preparation of cyclic compounds in the metathesis of olefins from acyclic dienes comprising terminal and/or non-terminal C?C double bonds; the invention also relates to the use of homogeneous ruthenium complexes and homogeneous ruthenium complexes deposited on a solid support as catalysts and/or pre-catalysts for the preparation of cyclic olefins in olefin metathesis reactions.

Abstract: Exemplary arrangements relate to receivers for receiving information using very weak light pulses. The exemplary arrangements include an input optical signal having a sequence of light pulses, optical elements, and a detector. The optical elements include at least one polarisation modulator, at least one polarisation splitting cube, an element with a different optical path length for different polarisations, and at least one polarization rotating plate. Part of the optical signal follows a shorter optical path length, and part of it follows a longer optical path length. The element with different optical path lengths is placed between two polarisation beam splitter cubes. The beam splitter cubes split and then merge the sequence of pulses reducing the sequence by half and forming an amplified signal readable by the detector. Exemplary arrangements also relate to a method for transmitting information using the exemplary arrangement.

Abstract: The present invention relates to nucleotides, analogs of mRNA 5?-end (cap) containing sulfur atom at the position 5? of 7-methylguanosine nucleoside. The disclosed compounds are recognized (bound and non-hydrolyzed) by DcpS enzyme (Decapping Scavenger), and thus may find therapeutic use as inhibitors thereof. DcpS is cap-specific enzyme with pyrophosphatase activity, which was identified as a therapeutic target in the treatment of spinal muscular atrophy (SMA). Some of the compounds disclosed have additional modifications in the phosphate chain, which modulate their affinity for DcpS enzyme.

Abstract: The invention pertains to novel hybrid peptidomimetics, pharmaceutical composition comprising thereof and use thereof in the treatment of neuropathic pain. The hybrid peptidomimetics according to the invention are comprised of two components: an opioid receptor agonist (OP) and a MC4 receptor antagonist, connected by a linker. The compounds of such a structure will allow to activate opioid receptors with simultaneous blocking of melanocortin type 4 receptors (MC4), which results in enhancing efficiency of the opioid therapy in neuropathic pain.

Abstract: The present invention relates to novel cyclic peptidomimetics, pharmaceutical compositions containing them and their use in the treatment of diseases associated with angiogenesis especially tumors and chronic inflammation in psoriasis, diabetes, degenerative diseases of the eye (ARMD), nephropathy and neuropathy.

Abstract: The object of the invention is a compound of formula (I), or a stereoisomer or salt thereof, wherein R1 and R2 are selected from the group consisting of N, N+—CH3, N+—C2H5, N+—C3H8, N+—C4H5, N+—CH2C6H5 wherein at least one of R1, R2 is not N. n and m are independently chosen from the group consisting of 0, 1 and 2; X is selected from the group consisting of O, NH, S, CH2 k is 1 or 2 Y is either void or selected from the group of —CH2—, —CH2CH2—, —CH2O—, —CH2S—, —CH2NH—, —CH2CH2O—, —CH2CH2NH—, —CH2CH2S— R3, R4, R5, R6 are selected from the group consisting of H, OH, OCH3, or OCH2CH3; wherein R3 and R4 may be the same or different; R5 and R6 may be the same or different; if either of R3, R4 is different than OH than R5 and R6 are both OH; if either of R5, R6 is different than OH than R3 and R4 are both OH.

Abstract: The invention relates to a method for the preparation of cyclic compounds in the metathesis of olefins from acyclic dienes comprising terminal and/or non-terminal C?C double bonds; the invention also relates to the use of homogeneous ruthenium complexes and homogeneous ruthenium complexes deposited on a solid support as catalysts and/or pre-catalysts for the preparation of cyclic olefins in olefin metathesis reactions.

Abstract: A method for synthesizing carbon nanocages, including N-doped carbon nanocages, includes a first step of forming a solution including a metal salt and an organic carbon source; a second step of drying the solution to obtain a precursor powder; and a third step of annealing the precursor powder to obtain a nanocage including a metal nanoparticle surrounded by a carbon shell. The metal nanoparticle is then removed from the carbon shell by applying an acid solution.

Abstract: We disclose novel peptidomimetics with antiangiogenic activity and their uses, particularly in the treatment of neoplasms and chronic inflammation (in particular of: rheumatoid arthritis, colitis), in eczema, diabetes, age-related macular degeneration (ARMD), nephropathy and neuropathy, in particular for use in the form of intravenous infusions or injections, or implants releasing the active ingredient.

Abstract: The present invention provides a catalyst comprising a layer of metallic palladium implant¬ed with an inert gas ions, an electrochemical system containing thereof, a palladium-inert gas alloy stable in the normal conditions, use thereof and a fuel cell containing thereof.