Abstract: Various embodiments disclosed relate to methods and compositions for antimicrobial treatment. In various embodiments, the present invention provides a method of antimicrobial treatment. The method includes at least one of exposing at least one microbe to a magnetic field, and contacting the at least one microbe with at least one nanoparticle including iron.
Type:
Grant
Filed:
September 3, 2021
Date of Patent:
April 30, 2024
Assignees:
UNM Rainforest Innovations, Board of Regents, The University of Texas System
Inventors:
Marek A. Osinski, Hugh D. C. Smyth, Leisha Marie Armijo, Hennaka Mudiyanselage Herath Nihal Bandara
Abstract: Techniques for large-scale Lagrangian monitoring of an aquatic resource are presented. The techniques use a system that includes an autonomous surface vehicle, where the autonomous surface vehicle includes: an electronic controller; a power source coupled to the electronic controller; a plurality of sensors communicatively coupled to the electronic controller, the plurality of sensors including: a water quality sensor and a GPS sensor; and a propulsion system communicatively coupled to the electronic controller, the propulsion system including a thruster and at least one rudder; where the system determines a velocity of water in the aquatic resource based on a plurality of position signals from the GPS sensor.
Abstract: The current invention is in the field of molecular biology/pharmacology and provides methods of using compounds that modulate the effects of GPR30/GPER for treating obesity and diabetes (preferably agonists) as well as disease states and/or conditions that result from excessive formation of reactive oxygen species (preferably antagonists). These compounds may function as agonists and/or antagonists of the disclosed estrogen receptor and/or modulate the expression/upregulation of nox and nox-associated reactive oxygen species (ROS).
Type:
Grant
Filed:
March 1, 2021
Date of Patent:
April 23, 2024
Assignee:
UNM RAINFOREST INNOVATIONS
Inventors:
Eric R. Prossnitz, Geetanjali Sharma, Matthias Barton, Matthias R. Meyer
Abstract: Methods and apparatus for long read, label-free, optical nanopore long chain molecule sequencing. In general, the present disclosure describes a novel sequencing technology based on the integration of nanochannels to deliver single long-chain molecules with widely spaced (>wavelength), ˜1-nm aperture “tortuous” nanopores that slow translocation sufficiently to provide massively parallel, single base resolution using optical techniques. A novel, directed self-assembly nanofabrication scheme using simple colloidal nanoparticles is used to form the nanopore arrays atop nanochannels that unfold the long chain molecules. At the surface of the nanoparticle array, strongly localized electromagnetic fields in engineered plasmonic/polaritonic structures allow for single base resolution using optical techniques.
Type:
Application
Filed:
December 5, 2023
Publication date:
April 11, 2024
Applicant:
UNM RAINFOREST INNOVATIONS
Inventors:
Steven R.J. BRUECK, Jeremy Scott EDWARDS, Alexander NEUMANN, Yuliya KUZNETSOVA, Edgar A. MENDOZA
Abstract: In one aspect, a method generally includes obtaining a dried silicified cell that has been stored for at least 24 hours without cryopreservation and rehydrating the dried silicified cell in a pharmaceutically acceptable carrier. The method can further include surface modifying the silicified cell with at least one immunogenic molecule. The method can further include administering the rehydrated silicified cell to a subject. In some embodiment, the dried silicified cell has been stored for at least 14 days without cryopreservation. In another aspect, a method of treating a tumor in a subject generally includes administering to the subject a chemotherapeutic agent effective to treat the tumor and administering to the subject a silicified cell vaccine effective to treat the tumor.
Abstract: The present invention provides a method of repairing one or more fractures in a wellbore cement by an electric field to move micelles from crude oil to the area to be repaired.
Type:
Grant
Filed:
July 1, 2020
Date of Patent:
April 9, 2024
Assignee:
UNM Rainforest Innovations
Inventors:
Ishtiaque Anwar, Mahmoud Reda Taha, John Stormont
Abstract: An optimal approach for computing convolutions and cross-correlations of large databases of images that can be arbitrarily large. Throughput is maximized by breaking each image into optimal blocks and then using overlap-and-add method to compute the final result. A parallelized 2D FFT is applied over each block that runs a thread for each physical core.
Type:
Grant
Filed:
February 26, 2021
Date of Patent:
April 9, 2024
Assignee:
UNM RAINFOREST INNOVATIONS
Inventors:
Marios Stephanou Pattichis, Cesar Carranza, Daniel Llamocca Obregon
Abstract: An optically responsive material including a composite matrix, and a plurality of colloidal nanowire geodes arranged within the composite matrix is disclosed. The optically responsive material has an optical resonance in at least one spectral region, such as in the ultraviolet spectral region, the infrared spectral region, the visible spectral region, or a combination thereof. The optically responsive material can include a composite matrix including a polymer, such as polyvinylidene fluoride. Each of the plurality of colloidal nanowire geodes further may include a hollow colloidal microsphere, and a nanowire coupled to an inner surface of the hollow colloidal microsphere. A method of fabricating optically responsive materials and a method of programming optically responsive materials is also described.
Type:
Application
Filed:
September 21, 2023
Publication date:
April 4, 2024
Applicant:
UNM RAINFOREST INNOVATIONS
Inventors:
Sang M. HAN, Sang Eon HAN, Michael FILLER, Vinothan N. MANOHARAN
Abstract: The present invention provides a formulation of Coenzyme Q10 that can be re-dispersed from a stable dry powder to formulation to yield a nanodispersion that can be readily aerosolized for inhalation.
Type:
Grant
Filed:
May 3, 2021
Date of Patent:
April 2, 2024
Assignee:
UNM Rainforest Innovations
Inventors:
Jason Thomas McConville, Thiago Cardoso Carvalho, Kristina Schonhoff
Abstract: Suspensions of magneto-responsive Janus colloids form chains and undergo alignment under the influence of a magnetic field. When the magnetic field is aligned with a light path, light transmission through the sample increases as compared to randomly or orthogonally oriented chains. The emissivity response of this suspension is presented as a function of particle concentration and magnetic field strength. A variation of the Beer-Lambert model and ray-tracing simulations capture the behavior of the experimentally measured difference in intensity between magnetically activated and non-activated Brownian suspensions. Experiments demonstrate up to 25% contrast in transmission of visible light, which may be further optimized through materials selection. Similar experiments when these Janus particle chains are suspended in carbon tetrachloride, demonstrate an emissivity variation in the near infrared of ˜10%.
Type:
Application
Filed:
September 21, 2023
Publication date:
March 28, 2024
Applicant:
UNM RAINFOREST INNOVATIONS
Inventors:
Sang Eon HAN, Sang M. HAN, James GILCHRIST, Jinghui GAO, Samuel WILSON-WHITFORD
Abstract: The present invention provides a sensor having, one or more optical slab waveguides having one or more target regions. The target regions may interact with gas molecules or trap, entrain or capture one or more targets of interest. The optical slab waveguides are adapted to receive one or more input optical beams from one or more light sources to create a plurality of propagating optical waves in optical slab waveguide. The propagating optical waves interact with said one or more target regions to create an optical output wavefront that may be in the form of a diffraction pattern. The target regions may be functionalized with an antibody, polymer, cell, tissue, or biological material.
Abstract: A magnetically insulated line oscillator (MILO) that is a high power microwave (HPM) source. A cross field device with a plurality of azimuthally extending spaced apart slats.
Abstract: A silicified cell replica includes a silicified cell or a silicified subcellular fragment. The silicified cell replica may be used to induce an immunological response, treat a bacterial infection, or treat a patient with cancer.
Type:
Grant
Filed:
September 13, 2018
Date of Patent:
February 13, 2024
Assignee:
UNM Rainforest Innovations
Inventors:
Rita E. Serda, C. Jeffrey Brinker, Jacob Ongudi Agola, Jimin Guo, Sarah Adams
Abstract: The present disclosure provides an antimicrobial substrate including a substrate and a polythiophene polymer. The polythiophene polymer has a number of repeated monomer units from n is 5-14 or 30 to 120, a number average molecular weight (Mn) from 1,000 to 4,000 or 10,000 to 40,000; and a polydispersity index (PDI) from 1 to 1.3. The present disclosure also provides the polythiophene polymer and uses thereof.
Type:
Grant
Filed:
September 23, 2021
Date of Patent:
January 30, 2024
Assignee:
UNM Rainforest Innovations
Inventors:
David G. Whitten, Dylan Brown, Jianzhong Yang, Edward Strach, Mohammed Khalil
Abstract: The invention is directed to an autonomous, self-authenticating and self-contained secure boot-up system and methods for field programmable gate arrays (FPGAs) that leverages physical unclonable functions (PUFs).
Abstract: The present invention relates to discovery that TBK1 phosphorylates Syntaxin 17 and that phosphorylation of Syntaxin 17 is intimate to control autophagy initiation. The present invention is directed to this discovery and the use of TBK1 inhibitors or inhibitors of Syntaxin 17 phosphorylation alone or in combination with additional bioactive agents to inhibit autophagy in the treatment of disease, especially the treatment of cancers. Methods of treating various cancers are disclosed using TBK1 inhibitors to patients with cancer and into cancerous tissues for the treatment of cancer including the inhibition, amelioration, reduction in metastasis and in recurrence of cancer in remission. Assays and methods for identifying compounds as inhibitors of Syntaxin 17 and as potential therapeutic agents for cancer and autoimmune diseases are also diseased herein.
Abstract: The present prevention provides a surface coating for cooling a surface by light scattering comprising a plurality of successive layers, each of the layers may be comprised of a plurality of spheres arranged to form a structure comprised of packed spheres. Each layer may have a different arrangement of packed spheres to create to a different light scattering property in each of the layers. The coating of the structures may also be formed by randomly packed spheres and the spheres may have a uniform diameter.
Abstract: A semiconductor photodetector comprising a closed loop configured to receive light from an external source adapted to trap light within said closed loop until absorption by the semiconductor.