Patents Assigned to Upjohn
  • Time-resolved fluorescence assay for the detection of multimeric forms of A-beta 1-40
    Patent number: 6846640
    Abstract: The present invention provides for a polypeptide aggregation screening assay for the purpose of detecting modulators of polypeptide aggregation, which can provide for new therapies in pathologic states associated with polypeptide aggregation, especially considered is Alzheimer's Disease.
    Type: Grant
    Filed: April 30, 2002
    Date of Patent: January 25, 2005
    Assignee: Pharmacia & Upjohn Company
    Inventors: Matthew L. Peach, Alice L. Laborde
  • Alzheimer's disease secretase, APP substrates therefor, and uses therefor
    Patent number: 6844148
    Abstract: The present invention provides the enzyme and enzymatic procedures for cleaving the ? secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. An enzyme that cleaves the ?-secretase site of APP also is provided. The invention further provides a modified APP protein and associated nucleic acids, peptides, vectors, cells, and cell isolates, and assays that are particularly useful for identifying candidate therapeutics for treatment or prevention of Alzheimer's disease.
    Type: Grant
    Filed: September 22, 2000
    Date of Patent: January 18, 2005
    Assignee: Pharmacia & Upjohn Company
    Inventors: Mark Gurney, Michael Jerome Bienkowski
  • Compounds for the treatment of addictive disorders
    Patent number: 6841557
    Abstract: The treatment of addictive disorders, psychoactive substance use disorders, intoxication disorders, inhalation disorders, alcohol addiction, tobacco addiction, and nicotine addiction using a heterocyclic amine, a phenylazacycloalkane, a cabergoline, or an aromatic bicyclic amine active agent, or a pharmaceutically acceptable derivative or salt of any said active agent is described herein.
    Type: Grant
    Filed: August 14, 2001
    Date of Patent: January 11, 2005
    Assignee: Pharmacia & Upjohn
    Inventors: Richard W. Anderson, Sylvia S. McBrinn, David W. Robertson, Robert C. Marshall
  • (5R)-5-(methylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]quinoline-2(1H)-thione
    Publication number: 20040266812
    Abstract: The present invention is a novel pharmaceutical agent, (5R)-5-(methylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]quinoline-2(1H)-thione 1
    Type: Application
    Filed: July 23, 2004
    Publication date: December 30, 2004
    Applicant: Pharmacia & Upjohn Company
    Inventors: Brad A. Acker, Richard Frederick Heier, Alan Q. Jin, Malcolm Wilson Moon
  • Alzheimer's disease secretase
    Patent number: 6835565
    Abstract: The present invention provides the enzyme and enzymatic procedures for cleaving the &bgr; secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays.
    Type: Grant
    Filed: September 17, 2001
    Date of Patent: December 28, 2004
    Assignee: Pharmacia & Upjohn Company
    Inventors: Mark E. Gurney, Michael Jerome Bienkowski, Robert Leroy Heinrikson, Luis A. Parodi, Riqiang Yan
  • Drosophila G protein coupled receptors, nucleic acids, and methods related to the same
    Patent number: 6835546
    Abstract: The present invention provides a Drosophila melanogaster GPCR (DmGPCR) polypeptides and polynucleotides which identify and encode such a DmGPCR. In addition, the invention provides expression vectors, host cells and methods for its production. The invention also provides methods for the identification of homologs in other animals, and of DmGPCR agonists/antagonists, useful for the treatment of diseases in animals and for the control of insects that are injurious or harmful to plants or animals.
    Type: Grant
    Filed: October 20, 2000
    Date of Patent: December 28, 2004
    Assignee: Pharmacia & Upjohn Company
    Inventors: David E. Lowery, Valdin G. Smith, Teresa M. Kubiak, Martha J. Larsen
  • Polymorphs of pyrrole substituted 2-indolinone protein kinase inhibitors
    Publication number: 20040259929
    Abstract: The present invention relates to polymorphs of the 3-pyrrole substituted 2-indolinone compound 5-(5-fluoro-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-pyrrolidin-1-yl-ethyl)-amide.
    Type: Application
    Filed: February 12, 2004
    Publication date: December 23, 2004
    Applicant: Pharmacis & Upjohn Company
    Inventors: Changquan Sun, Todd P. Foster, Fusen Han, Michael Hawley, Tom Thamann
  • Human caspase-12 materials and methods
    Patent number: 6833248
    Abstract: The present invention provides novel human caspase-12 polynucleotides and polypeptides; constructs and recombinant host cells incorporating the polynucleotides; the human caspase-12 polypeptides encoded by the polynucleotides; antibodies to the polypeptides; and methods of making and using all of the foregoing.
    Type: Grant
    Filed: May 8, 2001
    Date of Patent: December 21, 2004
    Assignee: Pharmacia & Upjohn Company
    Inventors: Rolf F. Kletzien, Ilene M. Reardon, Katherine L. Weiland
  • Methods of producing oxazolidinone compounds
    Patent number: 6833453
    Abstract: Methods of synthesizing pharmacologically useful oxazolidinones are disclosed, and, in particular, a method of manufacturing a 5-(tert-butylcarbamoyl)-aminomethyl-oxazolidinone by condensing a carbamate with a tert-butylcarbamoyl protected derivative of glycidylamine or 3-amino-1-halopropanol.
    Type: Grant
    Filed: October 17, 2001
    Date of Patent: December 21, 2004
    Assignee: Pharmacia & Upjohn Company
    Inventors: William R. Perrault, Robert C. Gadwood
  • Substrates and assays for beta-secretase
    Publication number: 20040254341
    Abstract: The present invention is directed to novel substrates for Hu-Asp. More particularly, the invention provides peptide substrates and fusion polypeptide substrates comprising a &bgr;-secretase cleavage site. Methods and compositions for making and using the peptides are disclosed.
    Type: Application
    Filed: March 16, 2004
    Publication date: December 16, 2004
    Applicant: Pharmacia & Upjohn Company, a Delaware corporation
    Inventors: Riqiang Yan, Alfredo G. Tomasselli, Mark E. Gurney, Thomas L. Emmons, Michael Jerome Bienkowski, Robert L. Heinrikson
  • Substrates and assays for beta-secretase
    Publication number: 20040253706
    Abstract: The present invention is directed to novel substrates for Hu-Asp. More particularly, the invention provides peptide substrates and fusion polypeptide substrates comprising a &bgr;-secretase cleavage site. Methods and compositions for making and using the peptides are disclosed.
    Type: Application
    Filed: March 16, 2004
    Publication date: December 16, 2004
    Applicant: Pharmacia & Upjohn Company, a Delaware corporation
    Inventors: Riqiang Yan, Alfredo G. Tomasselli, Mark E. Gurney, Thomas L. Emmons, Michael Jerome Bienkowski, Robert L. Heinrikson
  • Substrates and assays for beta-secretase
    Publication number: 20040254342
    Abstract: The present invention is directed to novel substrates for Hu-Asp. More particularly, the invention provides peptide substrates and fusion polypeptide substrates comprising a &bgr;-secretase cleavage site. Methods and compositions for making and using the peptides are disclosed.
    Type: Application
    Filed: March 16, 2004
    Publication date: December 16, 2004
    Applicant: Pharmacia & Upjohn Company, a Delaware corporation
    Inventors: Riqiang Yan, Alfredo G. Tomasselli, Mark E. Gurney, Thomas L. Emmons, Michael Jerome Bienkowski, Robert L. Heinrikson
  • 4-Oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxamides as antiviral agents
    Patent number: 6831081
    Abstract: The present invention provides a compound of formula as described herein, which are useful as antiviral agents, in particular, as agents against viruses of the herpes family.
    Type: Grant
    Filed: August 27, 2003
    Date of Patent: December 14, 2004
    Assignee: Pharmacia & Upjohn
    Inventors: Mark E. Schnute, Fred L. Ciske, Michael J. Genin, Joseph Walter Strohbach, Suvit Thaisrivongs
  • Antimicrobial thiadiazinone derivatives and their application for treatment of bacterial infections
    Patent number: 6828317
    Abstract: The present invention provides certain thiadiazinone derivatives of oxazolidinones of the following formula I: or pharmaceutically acceptable salts thereof that are antibacterial agents, pharmaceutical compositions containing them, methods for their use, and methods for preparing these compounds.
    Type: Grant
    Filed: February 4, 2003
    Date of Patent: December 7, 2004
    Assignee: Pharmacia & Upjohn Company
    Inventors: Gary W. Leuhr, Mikhail F. Gordeev, Dinesh V. Patel
  • Quinuclidine-substituted hetero-bicyclic aromatic compounds for the treatment of disease
    Patent number: 6828330
    Abstract: The invention provides compounds of Formula I: wherein W0 is a bicyclic moiety and is These compounds may be in the form of pharmaceutical salts or compositions, may be in pure enantiomeric form or racemic mixtures, and are useful to treat diseases or conditions in which &agr;7 is known to be involved.
    Type: Grant
    Filed: June 6, 2002
    Date of Patent: December 7, 2004
    Assignee: Pharmacia & Upjohn Company
    Inventors: Daniel Patrick Walker, Donn G. Wishka, David W. Piotrowski, Vincent E. Groppi, Jr.
  • Alzheimer's disease secretase, APP substrates therefor, and uses therefor
    Patent number: 6828117
    Abstract: The present invention provides the enzyme and enzymatic procedures for cleaving the &bgr; secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. The invention further provides a modified APP protein and associated nucleic acids, peptides, vectors, cells, and cell isolates, and assays that are particularly useful for identifying candidate therapeutics for treatment or prevention of Alzheimer's disease.
    Type: Grant
    Filed: February 27, 2001
    Date of Patent: December 7, 2004
    Assignee: Pharmacia & Upjohn Company
    Inventors: Mark E. Gurney, Michael J. Bienkowski, Robert L. Heinrikson, Luis A. Parodi, Riqiang Yan
  • Process to prepare 11&bgr;, 17&agr;,21-trihydroxy-6&agr;-methylpregna-1,4-diene-3,20-dione 21-acetate
    Patent number: 6828120
    Abstract: The present invention is a novel process for the transformation of 17&agr;-hydroxy-6&agr;-methylpregn-4-ene-3,20-dione 17-acetate (I) to 11&bgr;,17&agr;,21-trihydroxy-6&agr;-methylpregna-1,4-diene-3,20-dione 21-acetate (VI)
    Type: Grant
    Filed: June 14, 2002
    Date of Patent: December 7, 2004
    Assignee: Pharmacia and Upjohn Company
    Inventors: Bruce Allen Pearlman, Michael J. White, Ivan G. Gilbert
  • Substrates and assays for beta-secretase
    Publication number: 20040241792
    Abstract: The present invention is directed to novel substrates for Hu-Asp. More particularly, the invention provides peptide substrates and fusion polypeptide substrates comprising a &bgr;-secretase cleavage site. Methods and compositions for making and using the peptides are disclosed.
    Type: Application
    Filed: March 16, 2004
    Publication date: December 2, 2004
    Applicant: Pharmacia & Upjohn Company, a Delaware corporation
    Inventors: Riqiang Yan, Alfredo G. Tomasselli, Mark E. Gurney, Thomas L. Emmons, Michael Jerome Bienkowski, Robert L. Heinrikson
  • Alzheimer's disease secretase, APP substrates therefor, and uses therefor
    Patent number: 6825023
    Abstract: The present invention provides the enzyme and enzymatic procedures for cleaving the &bgr; secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. The invention further provides a modified APP protein and associated nucleic acids, peptides, vectors, cells, and cell isolates, and assays that are particularly useful for identifying candidate therapeutics for treatment or prevention of Alzheimer's disease.
    Type: Grant
    Filed: April 12, 2000
    Date of Patent: November 30, 2004
    Assignee: Pharmacia & Upjohn Company
    Inventors: Mark E. Gurney, Michael J. Bienkowski, Robert L. Heinrikson, Luis A. Parodi, Riqiang Yan
  • Bicyclic isoxazolinones as antibacterial agents
    Patent number: 6825225
    Abstract: The present invention provides compounds of formula I useful as anti microbial agents wherein X, Y, R1, and n are as defined in thereof.
    Type: Grant
    Filed: November 14, 2001
    Date of Patent: November 30, 2004
    Assignee: Pharmacia & Upjohn Company
    Inventors: Michael J. Genin, Michael Robert Barbachyn, Jackson B. Hester, Jr., Paul D. Johnson, Fred L. Ciske