Patents Assigned to Upjohn
  • Benzyloxy prodigiosine compounds
    Patent number: 6369096
    Abstract: A compound, having utility as an immunomodulating agent, which is a prodigiosine of formula (I): wherein R1 is hydrogen or C1-C5 alkyl; and R2 is a C1-C5 alkyl; or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: October 7, 1999
    Date of Patent: April 9, 2002
    Assignee: Pharmacia & Upjohn S.p.A.
    Inventors: Roberto D'Alessio, Ermes Vanotti, Alberto Bargiotti, Marcellino Tibolla, Mario Ferrari, Anna Maria Isetta, Francesco Colotta
  • Benzosultam oxazolidinone antibacterial agents
    Patent number: 6365612
    Abstract: The present invention provides a compound of formula I which have potent antibacterial activities.
    Type: Grant
    Filed: March 27, 2001
    Date of Patent: April 2, 2002
    Assignee: Pharmacia & Upjohn Company
    Inventors: Michael J. Genin, Fred L. Ciske
  • Alzheimer's disease secretase, APP substrates therefor, and uses therefor
    Publication number: 20020037315
    Abstract: The present invention provides the enzyme and enzymatic procedures for cleaving the &bgr; secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. The invention further provides a modified APP protein and associated nucleic acids, peptides, vectors, cells, and cell isolates, and assays that are particularly useful for identifying candidate therapeutics for treatment or prevention of Alzheimer's disease.
    Type: Application
    Filed: February 27, 2001
    Publication date: March 28, 2002
    Applicant: Pharmacia & Upjohn Company
    Inventors: Mark E. Gurney, Michael J. Bienkowski, Robert L. Heinrikson, Luis A. Parodi, Riqiang Yan
  • Phthalamide compounds
    Patent number: 6362334
    Abstract: The present invention includes a number of novel intermediates such as the (S)-secondary alcohol of formula (VIIIA) X2—CH2—C*H(OH)—CH2—NH—CO—RN  (VIIIA) and processes for production of pharmacologically useful oxazolidinones.
    Type: Grant
    Filed: April 10, 2000
    Date of Patent: March 26, 2002
    Assignee: Pharmacia & Upjohn Company
    Inventor: Bruce Allen Pearlman
  • Oxazolidinone antibacterial agents having a thiocarbonyl functionality
    Patent number: 6362189
    Abstract: The present invention provides compounds of Formula 1 or pharmaceutical acceptable salts thereof wherein A, G and R1 are as defined in the claims which are antibacterial agents.
    Type: Grant
    Filed: November 14, 2000
    Date of Patent: March 26, 2002
    Assignee: Pharmacia and Upjohn Company
    Inventors: Jackson B. Hester, Jr., Eldon George Nidy, Salvatore Charles Perricone
  • Injectable intraocular lens
    Patent number: 6361561
    Abstract: Polysiloxanes suitable for the preparation of intraocular lenses by a crosslinking reaction, having a specific gravity of greater than about 1.0, a refractive index suitable for restoring the refractive power of the natural crystalline lens and a viscosity suitable for injection through a standard cannula are provided. Moreover, injectable intraocular lens material based on these polysiloxanes and methods of preparing intraocular lenses by direct injection into the capsular bag of the eye are also disclosed.
    Type: Grant
    Filed: October 13, 1999
    Date of Patent: March 26, 2002
    Assignee: Pharmacia & Upjohn AB
    Inventors: Peter P. Huo, Stephen Q. Zhou, Christine J. Y. Liau, Sverker Norrby
  • Phenyloxazolidinones having a c-c bond 4-8 membered heterocyclic rings
    Patent number: 6358942
    Abstract: A compound of Formula (I): or pharmaceutical acceptable salts thereof wherein X is NR1; R1 is H, C1-6 alkyl optionally substituted with one or more OH, CN, or halo, or R1 is —(CH2)h-aryl, —COR1-1, —COOR1-2, —CO—(CH2)h—COR1-1, C1-6 alkyl sulfonyl, —SO2—(CH2)h-aryl, or —(CO)i-Het; R2 is H, C1-6 alkyl, —(CH2)h-aryl, or halo; R3 and R4 are independently H or halo; R5 is H, C1-12 alkyl optionally substituted with one or more halo, C3-12 cycloalkyl, C1-6 alkoxy; m and n taken together are 1 or 2. The compounds are useful antimicrobial agents.
    Type: Grant
    Filed: November 15, 2000
    Date of Patent: March 19, 2002
    Assignee: Pharmacia & Upjohn Company
    Inventors: Richard C. Thomas, Toni-Jo Poel
  • Crystallization and structure determination of Staphylococcus aureus UDP-N-acetylenolpyruvylglucosamine reductase (S. aureus MurB)
    Patent number: 6356845
    Abstract: The substrate free form of Staphylococcus aureus UDP-N-acetylenolpyruvylglucosamine reductase (S. aureus MurB) has been crystallized, and the three dimensional x-ray crystal structure has been solved to 2.3 Å resolution. The x-ray crystal structure is useful for solving the structure of other molecules or molecular complexes, and designing inhibitors of S. aureus MurB.
    Type: Grant
    Filed: August 4, 2000
    Date of Patent: March 12, 2002
    Assignee: Pharmacia & Upjohn Company
    Inventors: Timothy E. Benson, Melissa S. Harris
  • Process to prepare (5R)-(methylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]-quinolin-2(1h)-one
    Patent number: 6355802
    Abstract: The present invention is an improved prosess to prepare (5R)-(methylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one the compound of formula (VII).
    Type: Grant
    Filed: January 31, 2000
    Date of Patent: March 12, 2002
    Assignee: Pharmacia & Upjohn COmpany
    Inventor: Peter Guillaume Marie Wuts
  • Inhibitors of protein tyrosine phosphatase
    Patent number: 6353023
    Abstract: The present invention comprises small molecular weight, non-peptidic inhibitors of formula I and II of Protein Tyrosine Phosphatase 1 (PTP1) which are useful for the treatment and/or prevention of Non-Insulin Dependent Diabetes Mellitus (NIDDM).
    Type: Grant
    Filed: August 24, 1998
    Date of Patent: March 5, 2002
    Assignee: Pharmacia & Upjohn Company
    Inventors: Scott D. Larsen, Paul D. May, John E. Bleasdale, Charlotta Liljebris, Heinrich Josef Schostarez, Tjeerd Barf
  • Treatments for nervous disorders
    Patent number: 6352986
    Abstract: This patent application describes the treatment of Addictive Disorders, Psychoactive Substance Use Disorders, Intoxication disorders, Inhalation disorders, Alcohol addiction, Tobacco Addiction and or Nicotine Addiction; and Attention Deficit Hyperactivity Disorder (ADHD); comprising administering a therapeutically effective, nontoxic dose of Reboxetine and derivatives and or pharmaceutically acceptable salts thereof to a patient.
    Type: Grant
    Filed: May 5, 2000
    Date of Patent: March 5, 2002
    Assignee: Pharmacia & Upjohn Company
    Inventors: Fred Hassan, John Michael McCall, Duncan Paul Taylor, Philip F. Von Voigtlander, Erik Ho Fong Wong
  • Sultam and sultone derived oxazolidinones
    Patent number: 6348459
    Abstract: The present invention provides a compound of formula I These compounds are useful as antibiotic agents.
    Type: Grant
    Filed: October 30, 2000
    Date of Patent: February 19, 2002
    Assignee: Pharmacia and Upjohn Company
    Inventors: David John Anderson, Jackson B. Hester, Jr.
  • Non-anaphylactic forms of allergens and their use
    Publication number: 20020018779
    Abstract: An immunogen derived from a protein allergen, characterized in that said immunogen comprises:
    Type: Application
    Filed: July 3, 2001
    Publication date: February 14, 2002
    Applicant: Pharmacia & UpJohn Diagnostics AB
    Inventors: Rudolf Valenta, Susanne Vrtala, Luca Vangelista, Hans-Georg Eichler, Wolfgang R. Sperr, Peter Valent, Christof Ebner, Dietrich Kraft, Hans Gronlund
  • Heterocycle carboxamides as antiviral agents
    Publication number: 20020019397
    Abstract: The present invention provides a compound of formula I 1
    Type: Application
    Filed: June 22, 2001
    Publication date: February 14, 2002
    Applicant: Pharmacia & Upjohn Company
    Inventors: Mark E. Schnute, Valerie A. Vaillancourt, Scott D. Larsen
  • Oxazolidinone antibacterial agents having a thiocarbonyl functionality
    Publication number: 20020016323
    Abstract: The present invention provides compounds of Formula 1 1
    Type: Application
    Filed: March 30, 2001
    Publication date: February 7, 2002
    Applicant: Pharmacia & Upjohn Company
    Inventors: Jackson B. Hester, Eldon George Nidy, Salvatore Charles Perricone, Toni-Jo Poel
  • Oxazolidinone antibacterial agents having a thiocarbonyl functionality
    Patent number: 6342513
    Abstract: The present invention provides compounds of Formula 1: or pharmaceutical acceptable salts thereof wherein A, G and R1 are as defined in the claims which are antibacterial agents.
    Type: Grant
    Filed: November 15, 2000
    Date of Patent: January 29, 2002
    Assignee: Pharmacia and Upjohn Company
    Inventors: Jackson B. Hester, Jr., Eldon George Nidy, Salvatore Charles Perricone
  • Method for marking ingestible compressible objects in a package
    Publication number: 20020009523
    Abstract: Method for marking an object where the object is placed in a package whereby a pattern in said package is caused to make a marking in said object. Objects being marked with the above method. The invention is especially useful for marking solid or semi-solid formulations of drugs, candy and food-stuff. Specifically the invention is useful to mark nicotine-containing chewing gums. Other solid or semi-solid objects can equally well be marked using the present invention.
    Type: Application
    Filed: October 1, 2001
    Publication date: January 24, 2002
    Applicant: Pharmacia & Upjohn AB
    Inventor: Stig Gustaesson
  • Oxazinoquinolones useful for the treatment of viral infections
    Patent number: 6340680
    Abstract: The present invention provides a compound of formula I These compounds are useful as antiviral agents, in particular, as agents against viruses of the herpes family.
    Type: Grant
    Filed: September 28, 2000
    Date of Patent: January 22, 2002
    Assignee: Pharmacia and Upjohn Company
    Inventors: Steven Ronald Turner, Suvit Thaisrivongs
  • 4-OXO-4,7-dihydro-thieno[2,3-b]pyridine-5-carboxamides as antiviral agents
    Publication number: 20020006937
    Abstract: The invention provides a compound of formula I: 1
    Type: Application
    Filed: April 2, 2001
    Publication date: January 17, 2002
    Applicant: PHARMACIA & UPJOHN COMPANY
    Inventors: Mark E. Schnute, Michele M. Cudahy, Allen Scott
  • Oxazolidinones to treat eye infections
    Patent number: 6337329
    Abstract: The present invention involves a method of treating an ophthalmic infection in a useful warm blooded mammal who is in need of such treatment which comprises topical administration of an ophthalmologically effective amount of an OXAZOLIDINONE.
    Type: Grant
    Filed: July 7, 1999
    Date of Patent: January 8, 2002
    Assignee: Pharmacia & UpJohn Company
    Inventors: Robert J. Cochran, Charles W. Ford