Abstract: The present invention relates to protein and peptide chemistry. In particular, the present invention relates to the discovery and isolation of novel peptides whose sequences derive from microorganism by-products including biosurfactants. The invention is also directed to the use of these novel peptides in the inhibition of infections caused by pathogens.
Type:
Grant
Filed:
August 3, 2001
Date of Patent:
April 27, 2004
Assignee:
Urex Biotech, Inc.
Inventors:
Jeffrey Howard, Gregor Reid, Bing Siang Gan
Abstract: The invention relates to probiotic microbes, including but not limited to Lactobacillus species and Bifidobacteria species, and their compositions and methods of employing said compositions for treating and preventing intestinal and other infections which originate from the intestine, in newborn infants. The invention also invention relates to the ability of probiotic organisms, either in viable or nonviable state, or their by-products, to interfere with pathogenic infection through short and long term colonization of the intestine, inhibition of growth of the pathogens, and assisting the host to fight off the infecting organisms.
Type:
Grant
Filed:
February 9, 2001
Date of Patent:
September 2, 2003
Assignee:
Urex Biotech, Inc.
Inventors:
Gregor Reid, Andrew W. Bruce, Victor Han
Abstract: The invention relates to probiotic microbes, including but not limited to Lactobacillus species and Bifidobacteria species, and their compositions and methods of employing said compositions for treating and preventing intestinal and other infections which originate from the intestine, in newborn infants. The invention also invention relates to the ability of probiotic organisms, either in viable or nonviable state, or their by-products, to interfere with pathogenic infection through short and long term colonization of the intestine, inhibition of growth of the pathogens, and assisting the host to fight off the infecting organisms.
Type:
Application
Filed:
February 9, 2001
Publication date:
November 1, 2001
Applicant:
UREX BIOTECH INC.
Inventors:
Gregor Reid, Andrew W. Bruce, Victor Han
Abstract: This invention relates to lactobacillus compositions and methods of employing said compositions for treating or preventing urinary tract infections. More particularly, this invention relates to the ability of certain strains of lactobacilli to adhere to uroepithelial or vaginal epithelial cells and to exhibit inhibitory activity against the growth of pathogenic bacteria.
Abstract: The present invention is directed towards isolated lactobacillus biosurfactants and the process for producing same. The present invention is also directed to methods for preventing urogenital infection in mammals using the isolated lactobacillus biosurfactant. The present invention is further directed to methods of inhibiting microbial biofilm formation using the isolated lactobacillus biosurfactant to prevent the formation of bacterial biofilms, and to displace adherent biofilm-forming bacteria from surfaces.
Type:
Grant
Filed:
May 30, 1997
Date of Patent:
April 18, 2000
Assignee:
Urex Biotech, Inc.
Inventors:
Gregor Reid, Andrew W. Bruce, Henk J. Busscher, Henny C. Van der Mei
Abstract: This invention relates to lactobacillus, skim milk, lactobacillus growth factor (LGF) and lactobacillus compositions and methods of employing said composition for preventing urogenital infections. More particularly, this invention relates to the ability of strains of hydrophobic or hydrophilic lactobacillus to adhere to biomaterials, intestinal, vaginal and uroepithelial cells, to resist the action of certain anti-microbial agents and to dominate the urogenital flora.