Abstract: A new process for the preparation of Ropinirole (1) and pharmaceutically acceptable hydrochloride salt thereof comprising reacting the compound (V) with nitromethane to obtain the compound of formula (II), which is reduced to compound (III) and alkylated to obtain compound (IV). The oxidation of the indole ring provides the compound of formula (I).
Type:
Application
Filed:
October 13, 2004
Publication date:
February 8, 2007
Applicant:
URGUIMA S.A.
Inventors:
Joan Bosch Cartés, Xavier Pujol Olle, Jose Del Rio Pericacho, Yolanda Alonso Marin, Merce Bessa Sanchez