Patents Assigned to Urologix, Inc.
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Patent number: 8728068Abstract: A device for treating tissue adjacent to a body lumen includes a catheter shaft and an energy emitting assembly. The catheter shaft is insertable into the body lumen and includes a plurality of cooling lumens arranged generally circumjacent a generally central lumen. At least some of the circumjacent cooling lumens are in fluid communication with the central lumen and the energy emitting assembly extends through the central lumen. The central lumen and at least one portion of the energy emitting assembly are configured to direct a flow of cooling fluid about an outer surface of the at least one portion of the energy emitting assembly within the central lumen.Type: GrantFiled: April 9, 2010Date of Patent: May 20, 2014Assignee: Urologix, Inc.Inventors: Neil Nye, Eric Rudie, Jonathan Achenbach
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Patent number: 8409109Abstract: A reusable temperature sensing probe assembly comprises a temperature sensor strip extending from one end of a handle. The temperature sensor strip carries at least one temperature sensor for measuring temperature within a body cavity of a person, such as the rectum. The handle/temperature sensor strip is reversibly positionable within a unitary balloon/sleeve assembly comprised of a balloon portion and a sleeve portion. The balloon portion is comprised of a first interior space configured to hold the temperature sensor stip and a second interior space separate from the first interior space that is configured for inflation. An inflation tube has one portion sealed within the second interior space of the balloon portion and a second portion which extends through the sleeve portion for connection to a fluid source.Type: GrantFiled: March 28, 2005Date of Patent: April 2, 2013Assignee: Urologix, Inc.Inventors: Scott R. Tiesma, David A. Montecalvo
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Patent number: 8301264Abstract: A thermal therapy of body tissue with electromagnetic energy is controlled by feedback from one or more temperature sensors placed in the vicinity of the tissue to be treated. The temperature sensors are calibrated by comparing stabilized temperature values of the one or more temperature sensors against a normal range of body temperature and adjusting sensed temperature to a value within a normal body temperature range if the actual temperature value of a stabilized temperature sensor is less than the normal body temperature range. The temperature adjustment to the temperature sensor is maintained throughout the thermal therapy which reduces the risk of thermal damage to healthy tissue located near the tissue to be treated.Type: GrantFiled: April 27, 2009Date of Patent: October 30, 2012Assignee: Urologix, Inc.Inventors: Jonathan Achenbach, James E. Burgett, Claude Tihon, Allen Putnam
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Publication number: 20050222517Abstract: A reusable temperature sensing probe assembly comprises a temperature sensor strip extending from one end of a handle. The temperature sensor strip carries at least one temperature sensor for measuring temperature within a body cavity of a person, such as the rectum. The handle/temperature sensor strip is reversibly positionable within a unitary balloon/sleeve assembly comprised of a balloon portion and a sleeve portion. The balloon portion is comprised of a first interior space configured to hold the temperature sensor stip and a second interior space separate from the first interior space that is configured for inflation. An inflation tube has one portion sealed within the second interior space of the balloon portion and a second portion which extends through the sleeve portion for connection to a fluid source.Type: ApplicationFiled: March 28, 2005Publication date: October 6, 2005Applicant: Urologix, Inc.Inventors: Scott Tiesma, David Montecalvo
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Patent number: 6740108Abstract: A thermal therapy catheter for preferentially treating tissue adjacent to a body lumen includes a catheter shaft that is insertable into the body lumen. An energy-emitting element is carried by the catheter shaft, and is operable to radiate a generally symmetrical energy pattern. The catheter shaft includes a plurality of cooling lumens around the energy-emitting element, configured for circulation of a fluid therethrough. An attenuating element is located in at least one of the plurality of cooling lumens and is arranged to modify the generally symmetrical energy pattern radiated by the energy-emitting element to deliver an asymmetrical energy pattern to the tissue adjacent to the body lumen.Type: GrantFiled: April 3, 2002Date of Patent: May 25, 2004Assignee: Urologix, Inc.Inventors: Dale Just, Eric N. Rudie, Jonathan L. Flachman, Scott Stockmoe, Aaron Hjelle, Bruce W. Ebner, Joel Crabb, Stanley E. Kluge
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Patent number: 6496737Abstract: A thermal therapy catheter includes a catheter shaft having an outer surface that is insertable into the body lumen. The catheter shaft carries an energy-emitting element. A multi-lobe balloon is positioned around the outer surface of the catheter shaft adjacent to the energy-emitting element, with opposing ends of the multi-lobe balloon being sealingly connected to the catheter shaft to form a chamber between the multi-lobe balloon and the outer surface of the catheter shaft. Fluid is circulated between the outer surface of the catheter shaft and the multi-lobe balloon in a defined fluid flow path to firmly contact the wall of the body lumen and thereby cool the body lumen tissue while thermally treating targeted tissue at a depth from the body lumen wall.Type: GrantFiled: December 8, 2000Date of Patent: December 17, 2002Assignee: Urologix, Inc.Inventors: Eric N. Rudie, Scott Stockmoe, Aaron Hjelle, Bruce W. Ebner, Joel Crabb, Jonathan L. Flachman, Stan Kluge, Satish Ramadhyani, Bruce Neilson
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Patent number: 6490488Abstract: A thermal therapy method includes inserting an applicator including an energy-emitting device into a body cavity such as a urethra adjacent a targeted tissue region such as a prostate, energizing the energy-emitting device, and circulating coolant between the energy-emitting device and a wall of the body cavity. The therapy is controlled by decreasing a temperature of the coolant and continually adjusting coolant temperature based on therapy parameters. The applicator, or selected tissue at a predetermined depth from the wall of the body cavity, is maintained at a temperature corresponding to a predetermined applicator temperature profile by adjusting a power level provided to the energy-emitting device.Type: GrantFiled: April 20, 2000Date of Patent: December 3, 2002Assignee: Urologix, Inc.Inventors: Eric N. Rudie, Jonathan L. Flachman, James E. Burgett, Thayne R. Larson
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Patent number: 6348039Abstract: A rectal thermosensing unit includes, according to one aspect thereof, an elongate member having an inflation lumen extending therethrough. An inflatable balloon is supported by the elongate member. An interior of the inflatable balloon is in fluid communication with the inflation lumen. An insertion lumen extends through the elongate member. An introducer is insertable into the insertion lumen. At least one temperature sensing device is supported by the inflatable balloon. The rectal thermosensing probe is located in a rectum by inserting the introducer into the inflation lumen, inserting the inflatable balloon supported by the elongate member having the introducer inserted in the insertion lumen therein into the rectum, removing the introducer from the insertion lumen, and inflating the inflatable balloon by providing fluid through the inflation lumen.Type: GrantFiled: April 7, 2000Date of Patent: February 19, 2002Assignee: Urologix, Inc.Inventors: Jonathan L. Flachman, James V. Kauphusman, Jonathan R. McGrath, Gregg S. Sutton
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Patent number: 6312391Abstract: A non-invasive method of determining a temperature distribution in a targeted tissue volume treated with thermal therapy involves determining a baseline perfusion characteristic of the targeted tissue volume. A temperature distribution is calculated in the targeted tissue volume based on the baseline perfusion characteristic of the tissue, a microwave power input and a coolant temperature input. A perfusion characteristic of the targeted tissue volume is iteratively adjusted based on the calculated temperature distribution, and the temperature distribution is iteratively recalculated based on the adjusted perfusion characteristic, the microwave power input and the coolant temperature input throughout the thermal therapy.Type: GrantFiled: February 16, 2000Date of Patent: November 6, 2001Assignee: Urologix, Inc.Inventors: Satish Ramadhyani, Jonathan L. Flachman, Eric N. Rudie
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Patent number: 6272384Abstract: The invention relates to an apparatus for treating the prostate. The apparatus includes a urethral probe, a microwave generator, and coolant circulating system. The urethral probe has microwave antenna and ducts for circulating a coolant. The microwave generator applies microwave energy to the microwave antenna. The coolant circulating system circulates the coolant and controls the temperature of the coolant.Type: GrantFiled: October 1, 1999Date of Patent: August 7, 2001Assignee: Urologix, Inc.Inventors: Eric Simon, Olivier Lassal
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Patent number: 6223085Abstract: A method and apparatus for reducing restenosis of a stenotic region of a blood vessel after performing a dilatation angioplasty treatment is disclosed. The method includes radiating microwave energy from a microwave antenna to kill a medial tissue layer of the blood vessel in the stenotic region. The radiation is applied during or after inflation of dilatation balloon to permanently dilate the stenotic region. When radiation is applied during dilatation of the stenotic region, the dilatation balloon forms a seal against the inner wall surface of the blood vessel to exclude blood in the vessel from contacting the stenotic region. The method preferably further includes cooling the blood circulating in the blood vessel about a shaft of the catheter with cooling fluid circulating within cooling lumens of the catheter and cooling an inner wall surface of the blood vessel in the stenotic region during the application of radiation to the medial cell layer.Type: GrantFiled: May 6, 1997Date of Patent: April 24, 2001Assignee: Urologix, Inc.Inventors: Mitchell Dann, Scott P. Thome, Jonathan R. McGrath, Eric N. Rudie, Jonathan L. Flachman, Teruo T. Hirose
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Patent number: 6161049Abstract: A thermal therapy catheter includes a catheter shaft having an outer surface that is insertable into the body lumen. The catheter shaft carries an energy-emitting element. A multi-lobe balloon is positioned around the outer surface of the catheter shaft adjacent to the energy-emitting element, with opposing ends of the multi-lobe balloon being sealingly connected to the catheter shaft to form a chamber between the multi-lobe balloon and the outer surface of the catheter shaft. A fluid is circulated between the outer surface of the catheter shaft and the multi-lobe balloon in a defined fluid flow path to firmly contact the wall of the body lumen and thereby conductively cool the body lumen tissue while thermally treating targeted tissue at a depth from the body lumen wall.Type: GrantFiled: April 30, 1999Date of Patent: December 12, 2000Assignee: Urologix, Inc.Inventors: Eric N. Rudie, Scott Stockmoe, Aaron Hjelle, Bruce W. Ebner, Joel Crabb
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Patent number: 6148236Abstract: A system for treatment of a target volume of cancerous tissue comprises a probe carrying a microwave antenna positioned in a body cavity proximate the target volume. At least one energy-emitting element is placed in the target volume. The microwave antenna is energized so that energy emitted from the antenna and the energy-emitting element necroses cancerous tissue in the target volume.Type: GrantFiled: November 4, 1998Date of Patent: November 14, 2000Assignee: Urologix, Inc.Inventor: Mitchell Dann
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Patent number: 6123083Abstract: Tissue surrounding a bodily conduit, such as a urethra, is thermally treated while preventing restrictions of the bodily conduit due to heat-induced shrinkage of collagen rich tissue surrounding the bodily conduit. A select volume of collagen-containing tissue surrounding the urethra is heated to destroy the tissue and to cause the tissue to be capable of being plastically remodeled into a selected shape. The selected shape is defined while the tissue is heated, and the tissue is allowed to cool while continuing to define the selected shape to cause plastic remodeling of the tissue into the selected shape. The method also includes performing a thermal therapy treatment without causing the surrounding tissue to exceed a collagen transition temperature of the tissue during the heating step of the treatment session.Type: GrantFiled: August 29, 1997Date of Patent: September 26, 2000Assignee: Urologix, Inc.Inventors: Jonathan R. McGrath, Mitchell Dann
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Patent number: 6122551Abstract: A thermal therapy method includes inserting a microwave antenna-containing applicator into a body cavity such as a urethra adjacent a targeted tissue region such as a prostate, energizing the microwave antenna, and circulating coolant between the microwave antenna and a wall of the body cavity. The therapy is controlled by decreasing a temperature of the coolant and continually adjusting coolant temperature based on other parameters. The applicator is maintained at a predetermined temperature set point by adjusting a power level provided to the microwave antenna. In one embodiment involving treatment of the prostate, rectal temperature is monitored and, upon sensing a rectal temperature that exceeds a predetermined threshold, the temperature of the coolant is increased to force a reduction in power provided to the microwave antenna to maintain the applicator at the predetermined temperature set point.Type: GrantFiled: December 11, 1998Date of Patent: September 19, 2000Assignee: Urologix, Inc.Inventors: Eric N. Rudie, Jonathan L. Flachman, James E. Burgett, Thayne R. Larson
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Patent number: 6067475Abstract: A microwave energy delivery system for microwave thermal therapy includes an antenna and a transmission line connected to the antenna. A microwave generating source includes a generator connected to the transmission line and a dual directional coupler for detecting forward power delivered to the antenna and reverse power reflected from the antenna with low uncertainty.Type: GrantFiled: November 5, 1998Date of Patent: May 23, 2000Assignee: Urologix, Inc.Inventors: Kenneth L. Graves, Eric N. Rudie
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Patent number: 6036631Abstract: A device and method for treatment of cancerous tissue from a body conduit involves insertion into the body conduit of a probe including an energy-emitting element for delivering ionizing energy. The body conduit is dilated to decrease a distance between at least a portion of the body conduit and the cancerous tissue. Ionizing energy is delivered from the energy-emitting element to selectively injure the cancerous tissue, with dilation of the body conduit minimizing the radiation dose delivered to the body conduit for a given radiation dose delivered to the cancerous tissue.Type: GrantFiled: March 9, 1998Date of Patent: March 14, 2000Assignee: Urologix, Inc.Inventors: Jonathan R. McGrath, Michael R. Forman
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Patent number: 6032078Abstract: A catheter shaft carries a coaxial cable, the terminal end of which contains a dipole antenna with opposing first and second helical elements. The first and second helical elements originate from a common connection to an outer conductor of the coaxial cable. The first and second helical elements are formed by winding flat wire around an outer insulator of the coaxial cable near a terminal end of the coaxial cable. A variable, controllable impedance is connected between an inner conductor of the coaxial cable and a point on the second helical element where the resistive component of the antenna's impedance matches the characteristic impedance of the coaxial cable. The impedance match minimizes reflective losses of the antenna, thereby maximizing power transferred to the antenna. The antenna has an effective electrical length which is equal to one-half the wavelength of the radiation emitted, independent of the physical length of the antenna.Type: GrantFiled: October 22, 1997Date of Patent: February 29, 2000Assignee: Urologix, Inc.Inventor: Eric N. Rudie
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Patent number: 6007571Abstract: A liquid coolant supply system for supplying a liquid coolant to a thermal therapy catheter includes a sensor control unit, a liquid coolant containment unit and mounts. The sensor control unit includes a pump, a cooling device, a temperature sensor and a pressure sensor. The liquid coolant containment unit includes a sealed reservoir, a coolant-sensor interface module and a pump interface fluidly coupled to the thermal therapy catheter. The coolant-sensor interface module includes a body defining a fluid chamber, a temperature interface supported adjacent the fluid chamber within the body, and a pressure interface supported adjacent the fluid chamber within the body. The mounts removably support the sealed reservoir, pump interface, temperature interface and pressure interface of the containment unit adjacent the cooling device, the pump, the temperature sensor and the pressure sensor.Type: GrantFiled: July 14, 1997Date of Patent: December 28, 1999Assignee: Urologix, Inc.Inventors: Bruce H. Neilson, James V. Kauphusman
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Patent number: 6009351Abstract: A system and method for treating a prostate of a patient is disclosed. The system includes a rectal probe for insertion into a rectum of the patient. A fluid supply system connected to the rectal probe supplies fluid to the rectal probe. A microwave radiation system, which is positioned anterior to the rectum of the patient, heats tumorous tissue of the prostate. The combination of the microwave radiation system and the fluid supplied to the rectal probe creates an asymmetrical heating pattern about a urethra of the patient and protects tissue adjacent to the rectal probe from thermal damage during radiation of the tumorous tissue.Type: GrantFiled: July 14, 1997Date of Patent: December 28, 1999Assignee: Urologix, Inc.Inventor: Jonathan L. Flachman