Abstract: A handheld endoscope has a disposable, single-use portion that includes a fluid hub, cannula and distal tip and a re-usable portion that includes a handle and display module. The electrical connection between the single-use and reusable portions is distally spaced from their mechanical connection and from the fluid hub. The distal tip includes LED illumination and an imaging module that feeds live video to the display module that is rotatable to allow viewing by the operator and others. The cannula and fluid hub are rotatable relative to the handle and includes separate lumens for fluid flow and an electrical cable. The fit resists rotation to maintain the relative positions of the cannula and handle until the application of a torque threshold. The single-use and re-usable portions mate and un-mate with each other via the physically separated mechanical and electrical connectors. Extruded cannula and molded distal tip parts can be separately formed which aids in manufacturing and assembly.