Abstract: The present disclosure provides compositions and methods to treat diseases and conditions related to smooth muscle dysfunction, or to ameliorate symptoms thereof comprising gene therapy, wherein one or more polynucleotides encoding one or more subunits of the Maxi-K channel, or mutants, variants, functional fragments, or derivatives thereof (e.g., fusions and chimaeras) are administered to a subject in need thereof, and wherein the administration of the polypeptides result in the expression of functional Maxi-K channels in the targeted smooth muscle. In some aspects, the composition of the disclosure comprise plasmid vectors containing at least one nucleic acid encoding a Maxi-K channel peptide. Also disclosed are pharmaceutical compositions, articles or manufacture, and kits.
Abstract: The present disclosure is directed to a method of treating or preventing pain associated with irritable bowel syndrome comprising orally administering to a subject in need thereof vibegron.
Type:
Application
Filed:
May 23, 2019
Publication date:
July 1, 2021
Applicant:
UROVANT SCIENCES GMBH
Inventors:
Paul N. MUDD, JR., Cornelia HAAG-MOLKENTELLER, Jihao ZHOU, Chris SCHAUMBURG, Jean Paul Abrian NICANDRO