Abstract: The protective headwear and garment assembly/system facilitates the formation of a secure interface/connection/fit between the protective headwear system and (preferably) a gas mask that is intended to be worn with the garment assembly. The system includes a tensioner system that is configured to ensure a tight, secure fit between a (preferably) neoprene facial seal component of the protective headwear, and the gas mask. The system also includes a tightening element to securely fit the protective headwear to the neck and body of the user.

Abstract: Graft copolymer polyelectrolyte complexes are disclosed for the efficient delivery of anionic, cationic or polyelectrolyte therapeutic agents into biological cells, and for maintaining the biological activity of these molecules while in serum and other aqueous environments are provided. Such complexes comprise (1) an anionic graft copolymer containing an anionic polymer backbone, with pendent carboxylic acid groups and pendant chains containing amphipathic or hydrophilic polymers covalently bonded to a portion of the pendant carboxylic acid groups, (2) one or more anionic, cationic or polyelectrolyte therapeutic agents, and (3) optionally a liposome optionally containing an additional therapeutic agent. Also disclosed are functional nanoparticles containing the complexes.

Abstract: Disclosed are endovascular stents in which a portion of the stents have a bioactive coating for promoting repair of damaged vessels, systems comprising the stents, and methods of using the stents to promote occlusion of aneurysms and/or repair damaged vessels.

Abstract: Provided are methods of diagnosing IgA nephropathy in a subject. Optionally, the methods comprise isolating an IgG from the subject and determining whether the IgG binds to a galactose-deficient IgA1. Optionally, the methods comprise providing a biological sample from the subject and detecting in the sample a mutation in a IGH gene, wherein the mutation is in a nucleotide sequence encoding a complementarity determining region 3 (CDR3) of a IGH variable region. Optionally, the methods comprise determining a level of IgG specific for a galactose-deficient IgA1 in the subject. Also provided are methods of treating or reducing the risk of developing IgA nephropathy in a subject.

Abstract: A system for simulating one or more hemorrhages in order to provide a more dynamic and realistic hemorrhage simulation in order to train medical personnel and other critical care givers, such as first responders, medics, and emergency medical technicians (EMTs) on treating hemorrhages. The system includes a reservoir, a flow controller, and at least one conduit connected to at least one simulated wound site wherein the system supplies fluid to the simulated wound site in order to simulate a hemorrhage. The system may further include a plurality of wound sites that have their respective fluid flows controlled by the fluid flow controller. In at least one embodiment, the reservoir and the flow controller are housed within a bag. In at least one embodiment, the system further includes an audio system for providing audio cues to the simulation participants to enhance the realism of the simulation.

Abstract: Graft copolymer polyelectrolyte complexes are disclosed for the efficient delivery of anionic, cationic or polyelectrolyte therapeutic agents into biological cells, and for maintaining the biological activity of these molecules while in serum and other aqueous environments are provided. Such complexes comprise (1) an anionic graft copolymer containing an anionic polymer backbone, with pendent carboxylic acid groups and pendant chains containing amphipathic or hydrophilic polymers covalently bonded to a portion of the pendant carboxylic acid groups, (2) one or more anionic, cationic or polyelectrolyte therapeutic agents, and (3) optionally a liposome optionally containing an additional therapeutic agent. Also disclosed are functional nanoparticles containing the complexes.

Abstract: A system to detect subsurface activity. The system employs vibration sensor pairs, with each sensor pair having a shallow sensor and a deep sensor. Outputs of the sensors of a pair are processed together and events are detected based on the relative values detected by the sensors of the pair. When signal energy departs from a detected background level, the relative amplitude and frequency content of vibrations measured at the shallow and deep sensors may be compared. The comparison may be performed, at least in part, using a classifier that discriminates between subsurface activity and surface activity. The outputs of sensor pairs may be aggregated to make a determination of whether subsurface activity exists and/or its location. Aggregation may involve comparing the outputs of the same sensor pair at multiple time intervals or may involve comparing the outputs of arrayed sensor pairs.

Abstract: This invention provides fusion proteins comprising a Filovirus glycoprotein segment and an immunoglobulin polypeptide segment. The fusion proteins are useful in immunogenic compositions to protect against infections by Filoviruses, such as Ebola virus, in both humans and non-human animals. The fusion proteins are also useful in diagnostic assays to detect Filovirus infections.

Abstract: A system to detect subsurface activity. The system employs vibration sensor pairs, with each sensor pair having a shallow sensor and a deep sensor. Outputs of the sensors of a pair are processed together and events are detected based on the relative values detected by the sensors of the pair. When signal energy departs from a detected background level, the relative amplitude and frequency content of vibrations measured at the shallow and deep sensors may be compared. The comparison may be performed, at least in part, using a classifier that discriminates between subsurface activity and surface to activity. The outputs of sensor pairs may be aggregated to make a determination of whether subsurface activity exists and/or its location. Aggregation may involve comparing the outputs of the same sensor pair at multiple time intervals or may involve comparing the outputs of arrayed sensor pairs.

Abstract: Apparatus for multiplying layers in a composite polymer stream includes an intermediate section having open conduits sandwiched between housing sections that close the conduits. The conduits have respective first stages separated by a first blade extending to a first face, and respective second stages separated by a second blade extending to a second face. The first stages separate the stream into sub-streams and compress and shift the sub-streams in a first dimension, whereas the second stages shift the sub-streams in a second dimension. In order to maintain a constant cross-sectional area of the sub-streams, the housing sections may be provided with complementary open channels. The apparatus can be used to multiply layers which are side-by-side or one-over-another by changing orientation in the direction of flow.

Abstract: A portable acousto-optical (AO) spectrometer system comprised of at least one AO crystal cell device specially designed for cancellation of side-lobe noise at a desired tuned wavelength of operation. Each AO crystal cell device has a transducer attached and forms an AO tunable filter (AOTF) and forms part of a photo-head assembly. The system can include an optical fiber link between the AO spectrometer photo-head assembly and additional features such as an optical alignment coupling attachment that couple an excitation source such as a laser that operates in either pulse or continuous mode, a probing fiber that provides a hand-held member that can emit a source radiation and in turn observe radiation reflected from an observed sample. There are two embodiment of the AO crystal cell device. Either embodiment of the AO crystal cell design can be used in the system, providing a vibration-insensitive AO spectrometer instrument having high sensitivity, accuracy and resolution capabilities.

Abstract: A probe for monitoring groundwater flow seepage velocity and direction has an electrical heater and a plurality of temperature sensors located equidistant from the heater. The probe with the heater and temperature sensors is lowered into a monitoring well and positioned so as to be immersed in the groundwater. Energy is sent to the heater, and the temperature response at the temperature sensors is measured and recorded. From the measured response to temperature, the groundwater flow velocity and direction are computed and recorded. The temperature sensors may be resistance temperature detectors, thermocouples, or any other state-of-the-art temperature sensing device.