Patents Assigned to US ARMY, SECRETARY OF THE ARMY
  • Graft copolymer polyelectrolyte complexes for drug delivery
    Patent number: 9789194
    Abstract: Graft copolymer polyelectrolyte complexes are disclosed for the efficient delivery of anionic, cationic or polyelectrolyte therapeutic agents into biological cells, and for maintaining the biological activity of these molecules while in serum and other aqueous environments are provided. Such complexes comprise (1) an anionic graft copolymer containing an anionic polymer backbone, with pendent carboxylic acid groups and pendant chains containing amphipathic or hydrophilic polymers covalently bonded to a portion of the pendant carboxylic acid groups, (2) one or more anionic, cationic or polyelectrolyte therapeutic agents, and (3) optionally a liposome optionally containing an additional therapeutic agent. Also disclosed are functional nanoparticles containing the complexes.
    Type: Grant
    Filed: February 29, 2016
    Date of Patent: October 17, 2017
    Assignees: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY, US ARMY, SECRETARY OF THE ARMY
    Inventors: David Devore, Charles Roth
  • SYSTEM AND STENT FOR REPAIRING ENDOVASCULAR DEFECTS AND METHODS OF USE
    Publication number: 20170189584
    Abstract: Disclosed are endovascular stents in which a portion of the stents have a bioactive coating for promoting repair of damaged vessels, systems comprising the stents, and methods of using the stents to promote occlusion of aneurysms and/or repair damaged vessels.
    Type: Application
    Filed: March 20, 2017
    Publication date: July 6, 2017
    Applicants: Purdue Research Foundation, The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., US Army, Secretary of the Army
    Inventors: Jean Paul Allain, Lisa Reece, Zhangcan Yang, Rocco Armonda, Ravindra Kempaiah, Teodoro Tigno
  • Graft copolymer polyelectrolyte complexes for drug delivery
    Patent number: 9271933
    Abstract: Graft copolymer polyelectrolyte complexes are disclosed for the efficient delivery of anionic, cationic or polyelectrolyte therapeutic agents into biological cells, and for maintaining the biological activity of these molecules while in serum and other aqueous environments are provided. Such complexes comprise (1) an anionic graft copolymer containing an anionic polymer backbone, with pendent carboxylic acid groups and pendant chains containing amphipathic or hydrophilic polymers covalently bonded to a portion of the pendant carboxylic acid groups, (2) one or more anionic, cationic or polyelectrolyte therapeutic agents, and (3) optionally a liposome optionally containing an additional therapeutic agent. Also disclosed are functional nanoparticles containing the complexes.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: March 1, 2016
    Assignees: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY, US ARMY, SECRETARY OF THE ARMY
    Inventors: David Devore, Charles Roth