Abstract: The inventive subject matter includes an antimicrobial peptide vectored composition made of a bacterial protein expression vehicle expressing one or more recombinant antimicrobial peptide effector molecules. More specifically these novel recombinant antimicrobial peptide effector molecules exhibit preferential antimicrobial activity. In some embodiments, the antimicrobial activity is facilitated via interaction with the lipid bilayer of the parasitic cell form, leading to membrane pore formation and resulting in cell lysis. The utility of the current inventive subject matter has demonstrated a reduced viability of Eimeira acervulina sporozoites was shown in vitro using a sporozoite killing assay.

Abstract: The inventive subject matter includes a viral-vectored composition made of a bacterial expression vehicle expressing one or more recombinant viral protein antigens and its method of use. In particular, this invention relates to a vaccine for oral administration. Preferably, the bacterial expression vehicle is Bacillus subtilis.

Abstract: The inventive subject matter includes an antimicrobial peptide vectored composition made of a bacterial protein expression vehicle expressing one or more recombinant antimicrobial peptide effector molecules. More specifically these novel recombinant antimicrobial peptide effector molecules exhibit preferential anti-microbial activity. The utility of the current inventive subject matter has demonstrated a reduced viability of Eimeira acervulina sporozoites in vitro using a sporozoite killing assay. More specifically, the antimicrobial peptide vectored composition is a bacterial protein expression vehicle expressing one or more recombinant antimicrobial peptide effector molecules, wherein the one or more recombinant antimicrobial peptide effector molecules are engineered from a NK-lysin gene and the one or more recombinant antimicrobial peptide effector molecules are engineered to express functionally active NK-2.

Abstract: Through the use of a universal anti-tick antigens, multiple tick-borne diseases that occur over a significant area can be targeted for eradication. The novel reservoir targeted anti-tick treatment is designed to reduce tick numbers and thereby blocking transmission of tick-borne diseases.

Abstract: The inventive subject matter includes an antimicrobial peptide vectored composition made of a bacterial protein expression vehicle expressing one or more recombinant antimicrobial peptide effector molecules. More specifically these novel recombinant antimicrobial peptide effector molecules exhibit preferential anti¬microbial activity. The utility of the current inventive subject matter has demonstrated a reduced viability of Eimeira acervulina sporozoites in vitro using a sporozoite killing assay. More specifically, the antimicrobial peptide vectored composition is a bacterial protein expression vehicle expressing one or more recombinant antimicrobial peptide effector molecules, wherein the one or more recombinant antimicrobial peptide effector molecules are engineered from a NK-lysin gene and the one or more recombinant antimicrobial peptide effector molecules are engineered to express functionally active NK-2.

Abstract: Provided herein are mechanisms and methods for the automated distribution of active ingredients (whether oral or contact based) to wild and domestic animal populations as well as a method for monitoring animal activity and estimating consumption and/or application of such ingredients within the population through the utilization of the mechanisms themselves. The inventive device pertains to a manner of delivering either an active oral ingredient or active contact ingredient within a bait pellet or like substrate for ingestion or external contact and/or coating of a target population. The device allows for controlled access of such a bait pellet (or like substrate) for such a target population coupled with the ability to retain freshness thereof for multiple timed access events without the need for human involvement. A properly sized, configured, and automated delivery device is thus provided to meet these needs. Delivery components are also encompassed herein.

Abstract: Through the use of a universal anti-tick antigens, multiple tick-borne diseases that occur over a significant area can be targeted for eradication. The novel reservoir targeted anti-tick treatment is designed to reduce tick numbers and thereby blocking transmission of tick-borne diseases.

Abstract: The presently disclosed subject matter relates to a composition and method of using the composition for oral delivery of a bioactive agent to a subject. More particularly, the presently disclosed subject matter relates to a composition comprising an effective amount of at least one bioactive agent layered over a substrate and a method of reducing zoonotic infectious disease by administering the composition to a subject. The presently disclosed subject matter further relates to a method of preparing the composition.

Abstract: Provided herein are mechanisms and methods for the automated distribution of active ingredients (whether oral or contact based) to wild and domestic animal populations as well as a method for monitoring animal activity and estimating consumption and/or application of such ingredients within the population through the utilization of the mechanisms themselves. The inventive device pertains to a manner of delivering either an active oral ingredient or active contact ingredient within a bait pellet or like substrate for ingestion or external contact and/or coating of a target population. The device allows for controlled access of such a bait pellet (or like substrate) for such a target population coupled with the ability to retain freshness thereof for multiple timed access events without the need for human involvement. A properly sized, configured, and automated delivery device is thus provided to meet these needs. Delivery components are also encompassed herein.

Abstract: The presently disclosed subject matter relates to a composition and method of using the composition for oral delivery of a bioactive agent to a subject. More particularly, the presently disclosed subject matter relates to a composition comprising an effective amount of at least one bioacitve agent layered over a substrate and a method of reducing zoonotic infectious disease by administering the composition to a subject. The presently disclosed subject matter further relates to a method of preparing the composition.