Abstract: The inventive subject matter includes an antimicrobial peptide vectored composition made of a bacterial protein expression vehicle expressing one or more recombinant antimicrobial peptide effector molecules. More specifically these novel recombinant antimicrobial peptide effector molecules exhibit preferential anti¬microbial activity. The utility of the current inventive subject matter has demonstrated a reduced viability of Eimeira acervulina sporozoites in vitro using a sporozoite killing assay. More specifically, the antimicrobial peptide vectored composition is a bacterial protein expression vehicle expressing one or more recombinant antimicrobial peptide effector molecules, wherein the one or more recombinant antimicrobial peptide effector molecules are engineered from a NK-lysin gene and the one or more recombinant antimicrobial peptide effector molecules are engineered to express functionally active NK-2.
Type:
Application
Filed:
June 14, 2021
Publication date:
August 31, 2023
Applicants:
US Biologic, Inc., The United States of America as represented by the Secretary of Agriculture
Inventors:
Jolieke Gerdy van Oosterwijk, Luciana Meirelles Richer, Douglas Steven Zatechka, Woohyun Kim, Hyun Soon Lillehoj, Cyril Gray, Christopher Anthony Przybyszewski
Abstract: The presently disclosed subject matter relates to a composition and method of using the composition for oral delivery of a bioactive agent to a subject. More particularly, the presently disclosed subject matter relates to a composition comprising an effective amount of at least one bioactive agent layered over a substrate and a method of reducing zoonotic infectious disease by administering the composition to a subject. The presently disclosed subject matter further relates to a method of preparing the composition.
Type:
Grant
Filed:
April 15, 2020
Date of Patent:
February 14, 2023
Assignee:
US Biologic, Inc.
Inventors:
Douglas Steven Zatechka, Mason Kauffman, Chris Przybyszewski
Abstract: Provided herein are mechanisms and methods for the automated distribution of active ingredients (whether oral or contact based) to wild and domestic animal populations as well as a method for monitoring animal activity and estimating consumption and/or application of such ingredients within the population through the utilization of the mechanisms themselves. The inventive device pertains to a manner of delivering either an active oral ingredient or active contact ingredient within a bait pellet or like substrate for ingestion or external contact and/or coating of a target population. The device allows for controlled access of such a bait pellet (or like substrate) for such a target population coupled with the ability to retain freshness thereof for multiple timed access events without the need for human involvement. A properly sized, configured, and automated delivery device is thus provided to meet these needs. Delivery components are also encompassed herein.
Type:
Grant
Filed:
April 19, 2017
Date of Patent:
August 3, 2021
Assignee:
US Biologic, Inc.
Inventors:
Robert Shane Luttrell, Mason Kauffman, Steven Zatechka, Christopher Przybyszewski
Abstract: The presently disclosed subject matter relates to a composition and method of using the composition for oral delivery of a bioactive agent to a subject. More particularly, the presently disclosed subject matter relates to a composition comprising an effective amount of at least one bioacitve agent layered over a substrate and a method of reducing zoonotic infectious disease by administering the composition to a subject. The presently disclosed subject matter further relates to a method of preparing the composition.
Type:
Grant
Filed:
December 21, 2016
Date of Patent:
May 19, 2020
Assignee:
US Biologic, Inc.
Inventors:
Douglas Steven Zatechka, Mason Kauffman, Chris Przybyszewski