Patents Assigned to USTAV ANORGANICKE CHEMIE AKADEMIE VED CESKE REPUBLIKY, V.V.I.
  • Carbonic anhydrase inhibitors and method of their production
    Patent number: 9290529
    Abstract: Derivatives of boron cluster compounds of general formula I and their pharmaceutically acceptable salts and solvates, and their specific inhibition effect on the enzyme carbonic anhydrase IX, a protein overexpressed in cancer tissues. Methods of synthesis and the use of the novel derivatives. These inhibitors of human carbonic anhydrase IX can be used as active compounds of pharmaceuticals for diagnostics and/or therapy of cancer diseases.
    Type: Grant
    Filed: October 24, 2012
    Date of Patent: March 22, 2016
    Assignees: USTAV ORGANICKE CHEMIE A BIOCHEMIE AKADEMIE VED CESKE REPUBLIKY, V.V.I., USTAV MOLEKULARNI GENETIKY AKADEMIE VED CESKE REPUBLIKY, V.V.I., USTAV ANORGANICKE CHEMIE AKADEMIE VED CESKE REPUBLIKY, V.V.I., UNIVERZITA PALACKEHO V OLOMOUCI
    Inventors: Jiri Brynda, Petr Cigler, Bohumir Gruner, Pavlina Maloy Rezacova, Pavel Mader, Vaclav Sicha, Mario Bakardjiev, Josef Holub, Petr Dzubak, Marian Hajduch