Patents Assigned to USV Limited, BSD MARG.
  • Process for the preparation of 1-benzyl-4(5,6-dimethoxy-1-indanon)-2-yl) methyl piperidine hydrochloride (Donepezil HCL)
    Patent number: 6649765
    Abstract: A process for the preparation of 1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine hydrochloride (Donepezil HCl). 5,6-Dimethoxy-2-(pyridin-4-yl)methylene inda-1-one is hydrogenated with a noble metal oxide catalyst in an organic solvent at 20-50° C. and 10-45 psi gauge pressure. The resulting 4-[(5,6-dimethoxy-1-indanon)-2-yl]methyl piperidine is alkylated with an alkylating agent in an organic solvent at 30-80° C.
    Type: Grant
    Filed: February 12, 2003
    Date of Patent: November 18, 2003
    Assignee: USV Limited, BSD MARG.
    Inventors: Joshi Shreerang Vidyadhar, Naidu Avinash Venkatraman, Sutar Rajiv Pandurang