Abstract: Methods, systems and devices are provided for utilizing user movement data obtained from one or more wearable sensors during physical activity to compare individualized changes overtime, for example typical versus atypical movement patterns, with subgroup analyses for assessing changes between other users in order to develop an assessment of movement for, for example, tracking injury risk, performance, and/or rehabilitation. The movement information may comprise multi-sensor, high dimensional datasets. Techniques are provided for integrating human movement data from one or more wearable sensor with one or more additional data sources to define an individualized movement profile of a user's movements. The user or another individual may be notified when the user's movements deviate from this individualized movement profile.

Abstract: Systems and methods for affecting spin qubits. In a resonator, an optical field is generated using photons. The optical field causes a stress field to form in the resonator as portions of the resonator oscillates. These oscillations, tunable using lasers and/or injection locking, drive spin transitions to thereby affect the population of specific NV spin qubits present in the resonator.

Abstract: Silica modified vaterite Janus nanoparticles are provided, together with methods for the synthesis of such particles. The disclosed methods make use of a Pickering emulsion, in a scalable aqueous process. The silica-modified surface is amenable to chemical modification, for example with physiologically acceptable labels.

Abstract: Compositions, formulations and methods of use thereof for treating, preventing and improving the condition and aesthetic appearance of skin are described. Compositions, formulations and methods of use thereof for treatment of dermis wounds, aged dermis, diseased dermis or damaged dermis are also described. The present compositions and formulations comprise a peptide with an amino acid sequence of QHREDGS (SEQ ID NO: 1) and methods of use thereof.

Abstract: A method of treating a mammalian subject having hematologic, non-tumorous cancer cells is disclosed. The method comprises the steps of: (A) administering to such a mammalian subject a therapeutically effective amount of a halogenated xanthene, a pharmaceutically acceptable salt or a C1-C4 alkyl ester thereof as a first cancer cytotoxic agent dissolved or dispersed in a pharmaceutically acceptable aqueous medium. The mammalian subject is maintained for a period of time sufficient to induce death of hematologic, non-tumorous cancer cells. A contemplated administration is typically repeated. A contemplated treatment method can also be carried out in conjunction with administration to said mammalian subject of a second therapeutically effective amount of a second, differently-acting cancer cytotoxic agent dissolved or dispersed in a pharmaceutically acceptable medium. The second cancer cytotoxic agent can be a small molecule or an intact antibody or paratope-containing portion thereof.

Abstract: An MOF film comprising an MOF and an organic scaffold. The MOF is attached to the organic scaffold by hydrogen bonds. The MOF film may be a PCMOF and/or HKUST and may have proton conductive properties. The MOF film may comprise a coordinated metal. The organic scaffold may comprise cellulose material. The MOF film may be free standing without physical support from another material or structure, may be formed into shapes, and may be bent or folded. The MOF film may comprise an MOF and an organic scaffold at different weight ratios.

Abstract: A mechanical transmission system that transmits motions and forces from one location to another while allowing the relative position/orientation of the two locations to change continuously is disclosed. The system can be used to actuate the joints and tooling of a robotic arm using stationary motors in the robot's base. Since the motors do not contribute any weight or inertia to the arm, this yields a lightweight and agile arm that is more human safe. The transmission includes a controller hydraulic cylinder connected to a remote cylinder by a tubing assembly, which contains hydraulic fluid, and a wire cable. The fluid transmits pushing forces between pistons of the cylinders, while the cable transmits pulling forces. The tubing assembly allows the cylinders to move in space relative to one another.

Abstract: A method of inducing a Type I interferon response in a mammalian subject that presents with a microbial infection, cancerous tumor or hematological malignancy that comprises administering an amount of a halogenated xanthene as discussed above, effective to induce the Type I interferon response. A method of enhancing a mammalian immunogen-specific immune response that comprises contacting mammalian cells, in vivo or present in a mammalian cell growth supporting medium, with an adjuvant-effective amount of a halogenated xanthene, and an immunogen to which that response is to be enhanced. A mammalian HX compound-adjuvanted vaccine composition that contains an immunogen present in a vaccine-effective amount along with an adjuvant-effective amount of a halogenated xanthene (HX) compound and one or more excipients present at about 0.001% by weight to 10% by weight of the vaccine composition dissolved or dispersed in a pharmaceutically acceptable diluent.

Abstract: The present invention provides compounds having store overload-induced Ca2+ release (SOICR) inhibitory activity and methods for producing and using the same. In particular, compounds of the invention is of the formula: R1—X1-L-X2—R2, wherein R1, X1, L, X2, and R2 are those defined herein.

Abstract: An example a method of manufacturing a film is provided. The method involves dissolving a backbone material in a non-aqueous solvent to form a non-aqueous solution. The method further involves adding the non-aqueous solution to an aqueous solution to form a liquid-liquid interface and injecting a particulate proximate to the liquid-liquid interface the non-aqueous solution is then evaporated to form a film containing the particulate. The film may be used in devices such as sensor devices for detecting hydrocarbons.

Abstract: A method of treating a pediatric cancerous solid tumor in a mammalian subject is disclosed that comprises intralesionally administering an amount of a halogenated xanthene or a pharmaceutically acceptable salt thereof, preferably Rose Bengal disodium, that elicits ablation of tumor cells of the administered tumor. Another contemplated method comprises the steps of intralesionally administering an amount of a halogenated xanthene or a pharmaceutically acceptable salt thereof, preferably Rose Bengal disodium, that elicits ablation of tumor cells of the administered tumor and systemically administering a tumor-inhibiting effective amount of a systemic anti-cancer medication that provides synergistic cytotoxicity with the halogenated xanthene. The two administrations can occur concurrently, or one prior to the other.

Abstract: A method of treating a mammalian subject having hematologic, non-tumorous cancer cells is disclosed. The method comprises the steps of: (A) administering to such a mammalian subject a therapeutically effective amount of a halogenated xanthene, a pharmaceutically acceptable salt or a C1-C4 alkyl ester thereof as a first cancer cytotoxic agent dissolved or dispersed in a pharmaceutically acceptable aqueous medium. The mammalian subject is maintained for a period of time sufficient to induce death of hematologic, non-tumorous cancer cells. A contemplated administration is typically repeated. A contemplated treatment method can also be carried out in conjunction with administration to said mammalian subject of a second therapeutically effective amount of a second, differently-acting cancer cytotoxic agent dissolved or dispersed in a pharmaceutically acceptable medium. The second cancer cytotoxic agent can be a small molecule or an intact antibody or paratope-containing portion thereof.

Abstract: This disclosure provides compositions and methods for promoting the formation, expansion and recruitment of TR1 cells and/or B cells in an antigen-specific manner and treating diseases and disorders in a subject in need thereof.

Abstract: A method for treating a viral infection of a mammalian subject that comprises administering a virus-inhibiting amount of a halogenated xanthene, a pharmaceutically acceptable salt, an alkyl ester or amide or aromatic ester or amide derivative thereof as disclosed within, to that mammalian subject. A method of inducing a type I interferon response in a mammalian subject that presents with a microbial infection, cancerous tumor or hematological malignancy that comprises administering an amount of a halogenated xanthene as discussed above, effective to induce the type I interferon response. A method of enhancing a mammalian immunogen-specific immune response that comprises contacting mammalian cells, in vivo or present in a mammalian cell growth supporting medium, with an adjuvant-effective amount of a halogenated xanthene as discussed above, and an immunogen to which that response is to be enhanced.

Abstract: A method of treating a pediatric cancerous solid tumor in a mammalian subject is disclosed that comprises intralesionally administering an amount of a halogenated xanthene or a pharmaceutically acceptable salt thereof, preferably Rose Bengal disodium, that elicits ablation of tumor cells of the administered tumor. Another contemplated method comprises the steps of intralesionally administering an amount of a halogenated xanthene or a pharmaceutically acceptable salt thereof, preferably Rose Bengal disodium, that elicits ablation of tumor cells of the administered tumor and systemically administering a tumor-inhibiting effective amount of a systemic anti-cancer medication that provides synergistic cytotoxicity with the halogenated xanthene. The two administrations can occur concurrently, or one prior to the other.

Abstract: A method of inducing a Type I interferon response in a mammalian subject that presents with a microbial infection, cancerous tumor or hematological malignancy that comprises administering an amount of a halogenated xanthene as discussed above, effective to induce the Type I interferon response. A method of enhancing a mammalian immunogen-specific immune response that comprises contacting mammalian cells, in vivo or present in a mammalian cell growth supporting medium, with an adjuvant-effective amount of a halogenated xanthene, and an immunogen to which that response is to be enhanced. A mammalian HX compound-adjuvanted vaccine composition that contains an immunogen present in a vaccine-effective amount along with an adjuvant-effective amount of a halogenated xanthene (HX) compound and one or more excipients present at about 0.001% by weight to 10% by weight of the vaccine composition dissolved or dispersed in a pharmaceutically acceptable diluent.

Abstract: A method of treating a mammalian subject having hematologic, non-tumorous cancer cells is disclosed. The method comprises the steps of: (A) administering to such a mammalian subject a therapeutically effective amount of a halogenated xanthene, a pharmaceutically acceptable salt or a C1-C4 alkyl ester thereof as a first cancer cytotoxic agent dissolved or dispersed in a pharmaceutically acceptable aqueous medium. The mammalian subject is maintained for a period of time sufficient to induce death of hematologic, non-tumorous cancer cells. A contemplated administration is typically repeated. A contemplated treatment method can also be carried out in conjunction with administration to said mammalian subject of a second therapeutically effective amount of a second, differently-acting cancer cytotoxic agent dissolved or dispersed in a pharmaceutically acceptable medium. The second cancer cytotoxic agent can be a small molecule or an intact antibody or paratope-containing portion thereof.

Abstract: System and method for guiding a drill using a subsurface model generated by successive full waveform inversions (FWI) on surface data and seismic-while-drilling (SWD) data. A server receives surface data from at least one surface sensor that records elastic energy radiated from surface seismic source and SWD data from at least one surface or at least one subsurface crosswell sensor (i.e., deployed in a nearby well). The server also receives top-drive measurements. A drillbit source signature estimation is performed, on the SWD data, by the server by blind deconvolution or by using drill string modeling and top-drive measurements. The server then performs FWI on the surface data by using the background subsurface velocity obtained by kinematic analysis of surface seismic data, to obtain an updated approximation of the subsurface velocity. The new approximation along with the drillbit source signature is then used when performing FWI on the SWD data.

Abstract: An apparatus for increasing readout speed for Complimentary Metal Oxide Semiconductor (CMOS) image sensors. The apparatus is useful with CMOS image sensors in all high-tech industries and used to capture images digitally. Specifically, the apparatus provides a CMOS image sensor which employs an analog network-on-chip for increasing readout speed. The apparatus includes an array of carrier signal generators which are used to modulate the pixel exposure to allow all pixels to be read and discerned simultaneously.

Abstract: Systems and methods related to gyroscope related applications. A platform having at least one torus shaped channel that is filled with a liquid is used in conjunction with at least one marker to determine the direction of forces applied to the platform. Each marker is neutrally buoyant within the liquid and a marker tracking system is used to determine the displacement of the marker from its resting place after a force has been applied to the platform. The tracking system may be based on at least one digital camera in conjunction with suitable image processing software to determine the marker's position before, during, and after the force has been applied. A gyroscope can be constructed using three such platforms with each platform being orthogonal to the other two. Each platform may have multiple concentric channels with a common center with each channel having a different sensitivity to the applied forces.