Abstract: A chondroitin or a chondroitin sulfate covalently or ionically bonded to a drug substance of the group consisting of chloramphenicol, methotrexate, adriamycin, vinblastine, vincristine, vindesine, 6-mercaptopurine, 5-fluorouracil, the penicillin antibiotics, the cephalosporin antibiotics, and the 1-oxacephalosporin antibiotics to form a prodrug which, when injected into animal tissue, undergoes natural conversion in the physiological environment to provide controlled release of the drug or an active drug complex.
Type:
Grant
Filed:
March 1, 1983
Date of Patent:
December 18, 1984
Assignee:
Valcor Scientific Ltd.
Inventors:
Alan G. Walton, Randall V. Sparer, Nnochiro Ekwuribe